NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1061899715|ref|NP_001317913|]
View 

transmembrane protein 230 isoform 2 [Homo sapiens]

Protein Classification

TMEM134/230 family protein( domain architecture ID 7010)

TMEM134/230 family protein is a DUF872 domain-containing protein similar to human transmembrane protein 230 that is involved in trafficking and recycling of synaptic vesicles

PubMed:  22855487
TCDB:  9.B.232.1.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TMEM_230_134 super family cl05468
Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins ...
 2-118 1.25e-16

Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2. TMEM 230 is involved in trafficking and recycling of synaptic vesicles.


The actual alignment was detected with superfamily member pfam05915:

Pssm-ID: 399128  Cd Length: 115  Bit Score: 69.77  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899715   2 MPSRTNLATGIPSSKVKYSRLSSTDDGYIDLQFKKTppKIPYKAIALATVLFLIGAFLIIIGSLLLSGYISkggADRAVP 81
Cdd:pfam05915   4 LENEDDDSLYGNSSQYSPSTLSSTPQRSYWTRHPLV--KKNWKVVLAAFLLLLLGLVLLFTGIFIFINPHE---GVSSAV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1061899715  82 VLIIGILVFLPGFYHLRIAYYASKGYRGYSYDDIPDF 118
Cdd:pfam05915  79 FFVPGFLCFIPGFYHVRYIYCAVRGRRGYRFFYLPYF 115
 
Name Accession Description Interval E-value
TMEM_230_134 pfam05915
Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins ...
 2-118 1.25e-16

Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2. TMEM 230 is involved in trafficking and recycling of synaptic vesicles.


Pssm-ID: 399128  Cd Length: 115  Bit Score: 69.77  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899715   2 MPSRTNLATGIPSSKVKYSRLSSTDDGYIDLQFKKTppKIPYKAIALATVLFLIGAFLIIIGSLLLSGYISkggADRAVP 81
Cdd:pfam05915   4 LENEDDDSLYGNSSQYSPSTLSSTPQRSYWTRHPLV--KKNWKVVLAAFLLLLLGLVLLFTGIFIFINPHE---GVSSAV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1061899715  82 VLIIGILVFLPGFYHLRIAYYASKGYRGYSYDDIPDF 118
Cdd:pfam05915  79 FFVPGFLCFIPGFYHVRYIYCAVRGRRGYRFFYLPYF 115
 
Name Accession Description Interval E-value
TMEM_230_134 pfam05915
Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins ...
 2-118 1.25e-16

Transmembrane proteins 230/134; This family consists of the eukaryotic transmembrane proteins 230 and 134 (TMEM230 and 134). TMEM134 function is unknown, but it has been shown to interact with E virus ORF2. TMEM 230 is involved in trafficking and recycling of synaptic vesicles.


Pssm-ID: 399128  Cd Length: 115  Bit Score: 69.77  E-value: 1.25e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061899715   2 MPSRTNLATGIPSSKVKYSRLSSTDDGYIDLQFKKTppKIPYKAIALATVLFLIGAFLIIIGSLLLSGYISkggADRAVP 81
Cdd:pfam05915   4 LENEDDDSLYGNSSQYSPSTLSSTPQRSYWTRHPLV--KKNWKVVLAAFLLLLLGLVLLFTGIFIFINPHE---GVSSAV 78

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1061899715  82 VLIIGILVFLPGFYHLRIAYYASKGYRGYSYDDIPDF 118
Cdd:pfam05915  79 FFVPGFLCFIPGFYHVRYIYCAVRGRRGYRFFYLPYF 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH