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Conserved domains on  [gi|1063759736|ref|NP_001318121|]
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putative transporter SVOPL isoform 3 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
1-389 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17442:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 375  Bit Score: 558.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKYRG 80
Cdd:cd17442    44 MVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGHSQGLIIKTEFLPTKYRG 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrs 160
Cdd:cd17442   124 YMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIILIVVFKFIP---------------------------- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 161 vmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVvvTGGDSGESQ 240
Cdd:cd17442   176 ---------------------------RTTLQIWVIWLGISFAYYGVILASSELLERNLLCGSDPSDEE--AGIKHIESE 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 241 SPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAAN 320
Cdd:cd17442   227 SPCYCHMFNPSDYQTMIISTLGEIALNPLNILGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGLTIFLFMLRALVSAN 306
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063759736 321 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17442   307 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASVLGALCLFSSVCIVCAISAFTLP 375
 
Name Accession Description Interval E-value
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
1-389 0e+00

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 558.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKYRG 80
Cdd:cd17442    44 MVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGHSQGLIIKTEFLPTKYRG 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrs 160
Cdd:cd17442   124 YMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIILIVVFKFIP---------------------------- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 161 vmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVvvTGGDSGESQ 240
Cdd:cd17442   176 ---------------------------RTTLQIWVIWLGISFAYYGVILASSELLERNLLCGSDPSDEE--AGIKHIESE 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 241 SPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAAN 320
Cdd:cd17442   227 SPCYCHMFNPSDYQTMIISTLGEIALNPLNILGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGLTIFLFMLRALVSAN 306
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063759736 321 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17442   307 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASVLGALCLFSSVCIVCAISAFTLP 375
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
2-397 7.66e-73

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 236.07  E-value: 7.66e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   2 VFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHS-QGLIIKTEFLPTKYRG 80
Cdd:TIGR00898 136 FFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWvQAVVLNTEFLPKKQRA 215
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLAsVIIPtiGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRS 160
Cdd:TIGR00898 216 IVGTLIQVFFSLGLVLLPLVA-YFIP--DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGK 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 161 VMPEGKLVEPVLE------KRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtG 233
Cdd:TIGR00898 293 KLPAEVLSLSLEKdlssskKQYSFLDLFRTPNLRkTTLCLMMLWFTTAFSYYGLVLDLGNL------------------G 354
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 234 GdsgesqspcychmfapSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAG--LIGFLF 311
Cdd:TIGR00898 355 G----------------NIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYflRTALAV 418
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 312 MLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQvLMSASILGALCLFSSVCVVCAISAFTLPiE 391
Cdd:TIGR00898 419 LGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVY-LGEKWLFLPLVLFGGLALLAGILTLFLP-E 496

                  ....*.
gi 1063759736 392 TKGRAL 397
Cdd:TIGR00898 497 TKGVPL 502
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-393 8.03e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 84.15  E-value: 8.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYR 79
Cdd:COG2271    53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGfFPAALKLIAEWFPPKER 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  80 GYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAfkfipesarfnvstgntraalatlervakmnr 159
Cdd:COG2271   133 GRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL-------------------------------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 160 svmpegklvepvlekrgrfadlldakylrTTLQIWVIWLGISFAYYGVILASAELLERDLVCgSKSDSAVVVTGgdsges 239
Cdd:COG2271   181 -----------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL-SLAQAGLLLSL------ 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 240 qspcychmfapsdyrTMIISTIGEIALNPLnilgINFLGRR--LSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALV 317
Cdd:COG2271   225 ---------------PFLAGIVGSLLGGWL----SDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGL 285
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063759736 318 AANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA-SILGALCLFSSVCVVCAISAFTLPIETK 393
Cdd:COG2271   286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFLLLAALALLAALLALLLLRETR 362
Sugar_tr pfam00083
Sugar (and other) transporter;
1-400 1.31e-16

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 81.16  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLIS---FLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKT-EFLPT 76
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvlFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYIsEIAPK 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  77 KYRGYMLPLSQVFWLAGSLL--IIGLASVII-PTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGN---TRAALAT 150
Cdd:pfam00083 134 KLRGALGSLYQLAITFGILLayIFGLGLNKTsNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRleeAREVLAK 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 151 LERVAKMNRSVMPEG-KLVEPVLEKRGRFADLLDAKYLRTTLQIWVIWLGI-------SFAYYG-VILASAELlerdlvc 221
Cdd:pfam00083 214 LRGVPDVDRELDEIKdSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFqqltginAIFYYStTIFENLGL------- 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 222 gSKSDSAVVVTGGdsgesqspcychmfapsdyrTMIISTIGEIALnplnilgINFLGRRLSLSITMGCTALFFLLLNICT 301
Cdd:pfam00083 287 -SDSFLVTIIVGV--------------------VNFVFTFIAIFL-------VDRFGRRPLLLLGAAGMAICFVILGIVA 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 302 ---------SSAGLIGFLFMLRALVAANFNTV-YIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA-SILGA 370
Cdd:pfam00083 339 llgvsksdwAGIVAIVFIALFIAFFAMGWGPVpWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAiGLGYT 418
                         410       420       430
                  ....*....|....*....|....*....|
gi 1063759736 371 LCLFSSVCVVCAISAFTLPIETKGRALQQI 400
Cdd:pfam00083 419 FFIFAGLLVLFIIFVFFFVPETKGRTLEEI 448
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
4-388 3.17e-10

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 61.52  E-value: 3.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   4 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLI-IKTEFLPTKYRGym 82
Cdd:PRK11551   61 LGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIaLTSEAVGPRLRG-- 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  83 lplsqvfwLAGSLLIIG------LASVIIPTI----GWRWLIRVASI-PGIILIVAFKFIPESARFNVSTGNTRAALATL 151
Cdd:PRK11551  139 --------TAVSLMYCGvpfggaLASVIGVLAagdaAWRHIFYVGGVgPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVL 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 152 ErvakmnrsvmpegklvepVLEKRGRfadlldakyLRTTLQIWVIWLGISFAYYGVI--LASAeLLERDLvcgSKSDSAV 229
Cdd:PRK11551  211 R------------------ALFGEGR---------ATATLLLWISYFFTLIVLYFLLnwLPSL-LVGQGL---SRSQAGL 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 230 VVTGGDSGesqspcychmfapsdyrtmiiSTIGEIALNPLnilgINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGF 309
Cdd:PRK11551  260 VQIAFNIG---------------------GALGSLLIGAL----MDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 310 LFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSS--VCVVCAISAFT 387
Cdd:PRK11551  315 GFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASipVILVAALAALL 394

                  .
gi 1063759736 388 L 388
Cdd:PRK11551  395 L 395
 
Name Accession Description Interval E-value
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
1-389 0e+00

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 558.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKYRG 80
Cdd:cd17442    44 MVFFGYMVFSILLGLLADRYGRWKILLLSFVWGAYFSLLTSFAPSYIWFVFLRCMVGCGVSGHSQGLIIKTEFLPTKYRG 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrs 160
Cdd:cd17442   124 YMLPLSQIFWLAGSLLIIGLASVVIPTLGWRWLIRFASIPGIILIVVFKFIP---------------------------- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 161 vmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVvvTGGDSGESQ 240
Cdd:cd17442   176 ---------------------------RTTLQIWVIWLGISFAYYGVILASSELLERNLLCGSDPSDEE--AGIKHIESE 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 241 SPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAAN 320
Cdd:cd17442   227 SPCYCHMFNPSDYQTMIISTLGEIALNPLNILGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGLTIFLFMLRALVSAN 306
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063759736 321 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17442   307 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASVLGALCLFSSVCIVCAISAFTLP 375
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
1-388 2.22e-161

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 457.77  E-value: 2.22e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKYRG 80
Cdd:cd17372    42 VVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASWYLEFLPAKSRG 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrs 160
Cdd:cd17372   122 TWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTP---------------------------- 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 161 vmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSavvvtggDSGESQ 240
Cdd:cd17372   174 ---------------------------KTTLLLWVIWFGNAFAYYGVVLLTTELNNSHNVCGSKSDS-------DSGESP 219
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 241 SPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAAN 320
Cdd:cd17372   220 TEKQCRNSNDVDYRDVFIATFAEFPGLLISAAMIDRLGRKASMASMLFTCCIFLLLLLICQSPFILTVLLFGGRACISAA 299
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736 321 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTL 388
Cdd:cd17372   300 FTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAILCPFIAQVLVHGSQTIALLLFSVVCLVSAICVCLL 367
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
2-397 7.66e-73

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 236.07  E-value: 7.66e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   2 VFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHS-QGLIIKTEFLPTKYRG 80
Cdd:TIGR00898 136 FFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWvQAVVLNTEFLPKKQRA 215
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLAsVIIPtiGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRS 160
Cdd:TIGR00898 216 IVGTLIQVFFSLGLVLLPLVA-YFIP--DWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKILQRIAKINGK 292
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 161 VMPEGKLVEPVLE------KRGRFADLLDAKYLR-TTLQIWVIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtG 233
Cdd:TIGR00898 293 KLPAEVLSLSLEKdlssskKQYSFLDLFRTPNLRkTTLCLMMLWFTTAFSYYGLVLDLGNL------------------G 354
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 234 GdsgesqspcychmfapSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAG--LIGFLF 311
Cdd:TIGR00898 355 G----------------NIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYflRTALAV 418
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 312 MLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQvLMSASILGALCLFSSVCVVCAISAFTLPiE 391
Cdd:TIGR00898 419 LGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVY-LGEKWLFLPLVLFGGLALLAGILTLFLP-E 496

                  ....*.
gi 1063759736 392 TKGRAL 397
Cdd:TIGR00898 497 TKGVPL 502
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
2-389 2.84e-66

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 215.06  E-value: 2.84e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   2 VFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKYRGY 81
Cdd:cd17441    43 VFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPIYSWILVLRGLVGFGIGGVPQSVTLYAEFLPMKSRAK 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFnvstgntraalatlervakmnrsv 161
Cdd:cd17441   123 CILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLIFAVLCFWLPESARY------------------------ 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 162 mpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVvvtggdsgESQS 241
Cdd:cd17441   179 --------------------------WTTILLWFIWFSNAFSYYGLVLLTTELFQAGDVCSGSSGKKV--------EGKC 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 242 PCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANF 321
Cdd:cd17441   225 SLECEYLTTSDYMDLLWTTLSEFPGLLVTLWIIDRFGRKKTMALCFFVFSFCTLLLFSCVGRFSLTVLLFIARAFISGGF 304
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736 322 NTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17441   305 QAAYVYTPEVYPTATRALGLGTCSGMARVGALITPFIAQVMLESSVYLTLSVYSGCCLLAAIASCFLP 372
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
3-389 8.81e-34

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 128.47  E-value: 8.81e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGY 81
Cdd:cd17317    35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGiFTVGFVLGMEIVGPKYRSF 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIPtigWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrsv 161
Cdd:cd17317   115 VGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLLLLWWLP----------------------------- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 162 mpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtGGDsgesqs 241
Cdd:cd17317   163 --------------------------RRTIIVGLIWFVTSLVYYGLSLNSSNL------------------GGN------ 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 242 pcychmfapsDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNI---CTSSAGLIgFLFMLRALVA 318
Cdd:cd17317   193 ----------LYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALlpdDENTLALT-LALVGKFAIS 261
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063759736 319 ANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISqVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17317   262 AAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIV-LLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
1-393 1.01e-32

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 128.38  E-value: 1.01e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIK-TEFLPTKYR 79
Cdd:cd17363    42 IVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFFLFCRLLSGIGIGGSIPIVFSYfAEFLAREKR 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  80 GYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRA 146
Cdd:cd17363   122 GEHLSWLCMFWMIGGLYASAMAWAIIPHYGwgfsmgtayqfhsWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDE 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 147 ALATLERVAKMNRSVMPEGKLVEPVLE-KRgrfadlldakylRTTLQIWVIWLGISFAYYGV------------------ 207
Cdd:cd17363   202 AWMILKQVHDTNMRAKGHPERVFTVSHiKR------------MNTLFLAIVWFTMSFSYYGLtvwfpdmikylqfedslf 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 208 ------------------ILASAELLERDLVCGSKSDSAVVvtgGDSGESQSPCYCHMF--APSDYRTMIISTIGEIALN 267
Cdd:cd17363   270 eecyfedvtstntffencTFINTVFYNTDLFEYKFIDSRFL---NSTFFLKEKCGCHLNddEENAYLIYLVSFLGSLSVL 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 268 PLNILGINFLGR--RLSL---SITMGCTALFFLLLniCTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGMG 342
Cdd:cd17363   347 PGNIVSALLMDKigRLKMiggSMLLSAVCCFFLFF--GNSESAMIGLQCLFCGVSIAAWNALDVVTVELYPTDKRATAFG 424
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063759736 343 TSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPiETK 393
Cdd:cd17363   425 FLNGLCKLAAILGNSIFGSFVGITKVIPILLASAALVCGGLLALKLP-ETR 474
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
4-363 5.11e-28

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 113.99  E-value: 5.11e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   4 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLI-IKTEFLPTKYRGYM 82
Cdd:TIGR00895  63 IGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNaLVSEYAPKRFRGTA 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  83 LPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASI-PGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR-- 159
Cdd:TIGR00895 143 VGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIaPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAea 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 160 -SVMPEGKLVEPVleKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVIlASAELLERDLvCGSKSDSAVVVTGGDSGe 238
Cdd:TIGR00895 223 qSALPEQKSTQGT--KRSVFKALFQGKTARITVLLWLLYFMLLVGVYFLT-NWLPKLMVEL-GFSLSLAATGGALFNFG- 297
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 239 sqspcychmfapsdyrtMIISTIGEIALnplnilgINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVA 318
Cdd:TIGR00895 298 -----------------GVIGSIIFGWL-------ADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVN 353
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1063759736 319 ANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLM 363
Cdd:TIGR00895 354 GGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYLL 398
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
3-388 1.47e-27

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 111.92  E-value: 1.47e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQG-LIIKTEFLPTKYRGY 81
Cdd:cd17316    46 FLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGaSTYVAEFAPSKRRGF 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIP----TIGWRWLIRVASIPGIILIVAFkfipesarfnvstgntraalatlervakm 157
Cdd:cd17316   126 ALGLLQSGWALGALLAALVASLLIPllsgDWGWRILFLIGALPALLALLLR----------------------------- 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 158 nrsvmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLerdlvcgsksdsaVVVTGGDSG 237
Cdd:cd17316   177 ------------------------------RRTLLLILLWFFISFGYYGLTTFLPTYL-------------QTVLGLSPA 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 238 ESqspcychmfapsdYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALF--FLLLNICTSSAGLIGFLFMLRA 315
Cdd:cd17316   214 TS-------------SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILalPLFYLLSGSPTLLLLLLFILSF 280
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1063759736 316 LVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTL 388
Cdd:cd17316   281 FVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
1-398 3.30e-27

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 113.92  E-value: 3.30e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGhSQGLIIK--TEFLPTKY 78
Cdd:TIGR01299 210 IVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGG-AIPIVFSyfAEFLAQEK 288
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  79 RGYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTR 145
Cdd:TIGR01299 289 RGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGwsfqmgsayqfhsWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHD 368
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 146 AALATLERVAKMN----------------RSVMPEGKLVE-----PVLEKR-------------GRFADLLDAKYLRTTL 191
Cdd:TIGR01299 369 EAWMILKLIHDTNmrakghpekvfsvnhiKTIHQEDELIEiesdtGTWYQRcfvralsegggiwGNFLRCFNPEVREITI 448
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 192 QIWVIWLGISFAYYGVI---------LASAEL--------------------LERDLVCGSKSDSAVV-------VTGGD 235
Cdd:TIGR01299 449 KLMGVWFTLSFGYYGLSvwfpdmikhLQADDYaaltknfpgdkvahfsfnftLENQIHRGGEYDNDKFiglkfksVSFED 528
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 236 S---------------------------------------GESQSPCYCH-------MFAPSDYRTMII---STIGEIAL 266
Cdd:TIGR01299 529 SlfeectfddvtssntffknctfidtlfentdfeeykfidSEFQNCSFLHnkegcpiDFDGDDEGAYMIyfvNFLGTLAV 608
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 267 NPLNILGINFLGR--RLSL---SITMGCTALFFLLLNicTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGM 341
Cdd:TIGR01299 609 LPGNIVSALLMDKigRLRMlagSMVLSCISCFFLSFG--NSESAMIALLCLFGGLSIAAWNALDVLTVELYPSDKRATAF 686
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063759736 342 GTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPiETKGRALQ 398
Cdd:TIGR01299 687 GFLNALCKAAAVLGILIFGSFVGITKAAPILFASAALACGGLLALKLP-DTRGQVLM 742
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
1-393 1.01e-25

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 108.47  E-value: 1.01e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGhSQGLIIK--TEFLPTKY 78
Cdd:cd17438    42 IVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFGIGG-SLPIVFAyfSEFLAREK 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  79 RGYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTR 145
Cdd:cd17438   121 RGEHLSWLCMFWMIGGLYASAMAWSIIPHYGwgfsmgtnyhfhsWRVFVIICALPCIASIIALKFMPESPRFLLEMGKHD 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 146 AALATLERVAKMNRSVMPEGKLVEPVLE-KRgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSK 224
Cdd:cd17438   201 EAWMILKNIHDTNMRAKGTPEKVFTVSNiKR------------KNTLFLAVVWFTMAFSYYGLTVWFPDMIRYLQKHVTF 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 225 SDSAVV------VTGGDS--------------------------------GESQSPCYCHMFAPSDYRTMIISTIGEIAL 266
Cdd:cd17438   269 EDSLFDecyfedVTSTDTyfknctiestifyntdlyehkfidcrfinstfLEQKEGCHMDFEEDNDFLIYLVSFLGSLSV 348
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 267 NPLNILGINFLGR--RLSL---SITMGCTALFFLLLNicTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALGM 341
Cdd:cd17438   349 LPGNIISALLMDKigRIKMiggSMLISAVCCFFLFFG--NSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNKRATAF 426
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063759736 342 GTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLPiETK 393
Cdd:cd17438   427 GILNGLCKFAAILGNSIFASFVGITKVIPILLASTALVGGGLISLRLP-ETR 477
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
5-389 1.40e-25

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 105.84  E-value: 1.40e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   5 GYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHS-QGLIIKTEFLPTKYRGYML 83
Cdd:cd17374    47 GLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISiNTLILGTEWTTPRHRALAI 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  84 PLSQVFWLAGSLLIIGLASVIiptIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrsvmp 163
Cdd:cd17374   127 TLTSCFFSIGQMLLAGLAYAI---RDWRLLQLVVSVPFFLFFLYSWWLP------------------------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 164 egklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILaSAELLERDLvcgsksdsavvvtggdsgesqspc 243
Cdd:cd17374   173 ------------------------KRTLILSFVWFANSFSYYGLSL-DLQHLGLNV------------------------ 203
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 244 ychmfapsdYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLN-ICTSSAGLIGFLFMLR-ALVAANF 321
Cdd:cd17374   204 ---------FLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIfVPQEMQTLRTVLAVLGkGSSAAAF 274
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736 322 NTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFIsQVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17374   275 TISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLI-MLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
1-389 1.81e-24

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 103.54  E-value: 1.81e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH-SQGLIIKTEFLPTKYR 79
Cdd:cd17371    42 VTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEwAAGAALMAEYVPARHR 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  80 GYMLPLSQVFWLAGSLLIIGLASVIIP----TIGWRWLIRVASIPGIILIVAFKFIPESARFNVStgntRAALATLERVA 155
Cdd:cd17371   122 GKALGYVQSGWAVGWLLATLLAALLFPllppEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQAA----RAARRHFADRP 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 156 KmnrsvmpegklvepvlekrgrFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELL--ERDLVCGSKSDSAVVVtg 233
Cdd:cd17371   198 S---------------------LRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLtgERGLSFEGSAGYLVVT-- 254
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 234 gdsgesqspcYCHMFapsdyrtmiistIGEIALNPLNILginfLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFL-FM 312
Cdd:cd17371   255 ----------ILGGF------------LGYLAGGFLADR----IGRRNNFALFALGSAISILLYFFLPLSPTLILILgFP 308
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063759736 313 LRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILG--ALCLFSSVCVVCAISAFTLP 389
Cdd:cd17371   309 LGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGtaIAVFAAVYYIAGLVLALLLP 387
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
1-389 3.01e-24

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 103.96  E-value: 3.01e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGhSQGLIIK--TEFLPTKY 78
Cdd:cd17439    42 IVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGG-SIPIVFSyfSEFLAQEK 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  79 RGYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTR 145
Cdd:cd17439   121 RGEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfqmgsayqfhsWRVFVLVCAFPSVFAIGALTTMPESPRFFLENGKHD 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 146 AALATLERVAKMNRSVMPEGKLVEPVLE-KRgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSK 224
Cdd:cd17439   201 EAWMVLKQVHDTNMRAKGHPERVFSVTHiKR------------RITLMMMAVWFTMSFSYYGLTVWFPDMIKHLQKSVVF 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 225 SDSAVV------VTGGDSGESQSPCYCHMFAPSD---------------------------------YRTMIISTIGEIA 265
Cdd:cd17439   269 EDSLFEecyfedITSSNTFFKNCTFISTLFYNTDlfeykfinsklinstflhnkegclldfsdennaYMIYFVSFLGTLA 348
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 266 LNPLNILGINFLG-----RRLSLSITMGCTALFFLLLNicTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMRALG 340
Cdd:cd17439   349 VLPGNIVSALLMDkigrlRMLAGSSVMSCVSCFFLSFG--NSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTA 426
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1063759736 341 MGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17439   427 FGFLNALCKLAAVLGISIFTSFVGITKAVPILLASAALAAGSSLALKLP 475
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
3-389 4.60e-24

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 101.73  E-value: 4.60e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHS-QGLIIKTEFLPTKYRGY 81
Cdd:cd17447    45 FAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSiISMVLCVEWVDIEHRTV 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIiptIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrsv 161
Cdd:cd17447   125 AGVLISLFWTVGNMLLALVAYLI---RDWRWLILAVTLPCAPGIITWWWVP----------------------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 162 mpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILAsaellerdlvcgsksdsavvVTGgdsgesqs 241
Cdd:cd17447   173 --------------------------KISLCTGIVWFGVAFTYYGISFN--------------------ISG-------- 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 242 pcychmFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLI--GFLFMLRALVAA 319
Cdd:cd17447   199 ------FGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEFTVVrtVIAVLGKGFSEA 272
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 320 NFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISqVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17447   273 AFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVI-LLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
1-389 5.83e-23

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 100.37  E-value: 5.83e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIK-TEFLPTKYR 79
Cdd:cd17440    42 IVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYfAEVLAREKR 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  80 GYMLPLSQVFWLAGSLLIIGLASVIIPTIG-------------WRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRA 146
Cdd:cd17440   122 GEHLSWLCMFWMIGGIYASAMAWAIIPHYGwsfsmgsayqfhsWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDE 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 147 ALATLERVAKMNrsvmpegklvepvLEKRGRFADLLDAKYL--RTTLQIWVIWLGISFAYYGV----------------- 207
Cdd:cd17440   202 AWMILKQIHDTN-------------MRARGQPEKVFTVNRIkkDNTIKLTIVWLTLSFGYYGLsvwfpdvikhlqfksvt 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 208 ------------------------ILASAELLERDLVCGSKSDSAVVvtggDSGESQSPCYCHMFAPSDYRT---MIIST 260
Cdd:cd17440   269 fedslfkscffedvtsvntyfrncTFIETVFYNTDLEDYKFIDSDFI----NCTFFHNKTGCQITFDDDYSAywiYFVNF 344
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 261 IGEIALNPLNI---LGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNTVYIYTAEVYPTTMR 337
Cdd:cd17440   345 LGTLAVLPGNIvsaLLMDRIGRLTMLGGSMVLSGISCFFLWFGTSESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRR 424
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063759736 338 ALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17440   425 ATGFGFLNALCKAAAVLGNLIFGSLVGITKAIPILLASTVLVCGGLVGLRLP 476
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
5-380 3.57e-20

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 90.55  E-value: 3.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   5 GYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHS-QGLIIKTEFLPTKYRGYML 83
Cdd:cd17446    45 GVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVlNSVSLNVEWMPTRVRAVVG 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  84 PLSQVFWLAGSLLIIGLASVIIPtigWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrsvmp 163
Cdd:cd17446   125 TLLGYCYTLGQLILAGVAYAIRD---WRWLQLAVSLPFFIFFLYSWWFP------------------------------- 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 164 egklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGvilasaelLERDLvcgsksdsavvvtggdsgesqspc 243
Cdd:cd17446   171 ------------------------RITFCLSLVWFSTSFAYYG--------LAMDL------------------------ 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 244 ycHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLL-------LNICTSSAGLIGflfmlRAL 316
Cdd:cd17446   195 --QKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILAnifvpqdLQTVRTALAVFG-----KGC 267
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063759736 317 VAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFIS-----QVLMSASILGALCLFSSVCVV 380
Cdd:cd17446   268 LAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKmlgeyYPFLPLIIYGAAPILSGIAAC 336
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
4-389 5.26e-19

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 87.41  E-value: 5.26e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   4 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH-SQGLIIKTEFLPTKYRGYM 82
Cdd:cd17379    44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGwMTGYVLVTEFVGSKYRRTV 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  83 LPLSQVFWLAGSLLIIGLASViIPTigWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrsvm 162
Cdd:cd17379   124 GIVYQMFFTLGLLILPGIAYF-IPH--WRWLQLAVTLPNFLFLLYYWFIP------------------------------ 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 163 pegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAellerdlvcgsksdsavvVTGGDSgesqsp 242
Cdd:cd17379   171 -------------------------KHTFILMYAWFTSAVVYQGLIMRLG------------------ITGGNL------ 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 243 cychmfapsdYRTMIISTIGEIALNPLNILGINFLGRRLSLSIT-----MGCTALFFL-----LLNICTSSAGLIGflfm 312
Cdd:cd17379   202 ----------YLDFFISALVELPAAFIILLTIDRIGRRLPFAASnivagAACLITAFIppdlhWLKTTIACVGRLG---- 267
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063759736 313 lralVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17379   268 ----ITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYRLAEIWLELPLIVFGVLALVAGGLVLLLP 340
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-393 8.03e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 84.15  E-value: 8.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYR 79
Cdd:COG2271    53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGfFPAALKLIAEWFPPKER 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  80 GYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAfkfipesarfnvstgntraalatlervakmnr 159
Cdd:COG2271   133 GRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL-------------------------------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 160 svmpegklvepvlekrgrfadlldakylrTTLQIWVIWLGISFAYYGVILASAELLERDLVCgSKSDSAVVVTGgdsges 239
Cdd:COG2271   181 -----------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGL-SLAQAGLLLSL------ 224
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 240 qspcychmfapsdyrTMIISTIGEIALNPLnilgINFLGRR--LSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALV 317
Cdd:COG2271   225 ---------------PFLAGIVGSLLGGWL----SDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGL 285
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063759736 318 AANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA-SILGALCLFSSVCVVCAISAFTLPIETK 393
Cdd:COG2271   286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
3-358 5.10e-17

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 81.75  E-value: 5.10e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQ-GLIIKTEFLPTKYRGY 81
Cdd:cd17377    49 FAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMNGGMSLvAFVLLNECVGKSYWAL 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIPtigWRWLIRVASIPGIILIVAFKFIPEsarfnvstgntraalatlervakmnrsv 161
Cdd:cd17377   129 AGSLGGLFFAVGIAQYALLGYFIRS---WRTLAVVVNLQGTLVFLLSLFIPG---------------------------- 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 162 mpegklvepvlekrgrfadlldakylRTTLQIWvIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtGGDSgesqs 241
Cdd:cd17377   178 --------------------------RTLILMY-VWFVCSLVYYGLTLNAGDL------------------GGNI----- 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 242 pcychmfapsdYRTMIISTIGEIALNPLNILGIN--FLGRRLSLS--ITMGCTALFFLLLNICTSSAGLIGFL------F 311
Cdd:cd17377   208 -----------YLNLALSGLVELPAYPLCIYLINqkWSGRRRTLAgfLFLGGIACLLVMFVPEKKDSGVFAVVnstslsL 276
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1063759736 312 MLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFI 358
Cdd:cd17377   277 LGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFI 323
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
3-389 1.19e-16

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 80.32  E-value: 1.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLI-IKTEFLPTKYRGY 81
Cdd:cd17365    44 LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAItLVSEYAPARRRSL 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAfkfipesarfnvstgntraalatlervakmnrsv 161
Cdd:cd17365   124 AVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL---------------------------------- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 162 mpegklvepvlekrgrfadlldakyLRTTLQIWVIWLGISFAYYGVILASAELLerdlvcgsksdsavVVTGGDSGEsqs 241
Cdd:cd17365   170 -------------------------LRGTLLLWVTFFMGLLLVYLLNSWLPKLM--------------VEAGYSLSQ--- 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 242 pcychmfapsdyrtmiiSTIGEIALNPLNILGINFLGR-------RLSLSITMGCTALF-FLLLNICTSSAGLIGFLFML 313
Cdd:cd17365   208 -----------------ALTITLLLNIGGVIGSLLLGWladrfgpKRVLALFFALGAVSlALLGVSPASLVLLYVLVFLA 270
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736 314 RALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA--SILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17365   271 GACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAAglGPESVFLALAIPAALGALAVLLLR 348
Sugar_tr pfam00083
Sugar (and other) transporter;
1-400 1.31e-16

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 81.16  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLIS---FLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKT-EFLPT 76
Cdd:pfam00083  54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIAnvlFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYIsEIAPK 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  77 KYRGYMLPLSQVFWLAGSLL--IIGLASVII-PTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGN---TRAALAT 150
Cdd:pfam00083 134 KLRGALGSLYQLAITFGILLayIFGLGLNKTsNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRleeAREVLAK 213
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 151 LERVAKMNRSVMPEG-KLVEPVLEKRGRFADLLDAKYLRTTLQIWVIWLGI-------SFAYYG-VILASAELlerdlvc 221
Cdd:pfam00083 214 LRGVPDVDRELDEIKdSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQIFqqltginAIFYYStTIFENLGL------- 286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 222 gSKSDSAVVVTGGdsgesqspcychmfapsdyrTMIISTIGEIALnplnilgINFLGRRLSLSITMGCTALFFLLLNICT 301
Cdd:pfam00083 287 -SDSFLVTIIVGV--------------------VNFVFTFIAIFL-------VDRFGRRPLLLLGAAGMAICFVILGIVA 338
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 302 ---------SSAGLIGFLFMLRALVAANFNTV-YIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA-SILGA 370
Cdd:pfam00083 339 llgvsksdwAGIVAIVFIALFIAFFAMGWGPVpWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAiGLGYT 418
                         410       420       430
                  ....*....|....*....|....*....|
gi 1063759736 371 LCLFSSVCVVCAISAFTLPIETKGRALQQI 400
Cdd:pfam00083 419 FFIFAGLLVLFIIFVFFFVPETKGRTLEEI 448
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
3-358 2.35e-16

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 79.43  E-value: 2.35e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCG-VSGHSQGLIIKTEFLPTKYRGY 81
Cdd:cd17376    45 FVGVLLGSFISGQLSDRFGRKKVLFATMAVQTGFSFLQIFSPSWEMFTVLFVIVGMGqISNYVVAFVLGTEILGKSVRIL 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIPTigWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrsv 161
Cdd:cd17376   125 FSTLGVCIFYAIGYMLLPLFAYFIRD--WRMLLLALTLPGVLCVPLWWFIP----------------------------- 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 162 mpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtggdSGESQS 241
Cdd:cd17376   174 --------------------------ITTIMSLLLWMAISVGYFGLSLNTPNL---------------------HGDPYL 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 242 PCYchmfapsdyrtmiISTIGEIALNPLNILGINFLGRRLSLSITM--GCTALFFLLLnICTSSAGLIGFLFMLRAL-VA 318
Cdd:cd17376   207 NCF-------------LSAVIEVPAYIIAWLLLRSLPRRYSIAATLvlGGGVLLFIQL-VPTDLQVLATALVMLGKFgIT 272
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1063759736 319 ANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFI 358
Cdd:cd17376   273 AAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYF 312
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
1-400 3.68e-16

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 80.08  E-value: 3.68e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLIS---FLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKT-EFLPT 76
Cdd:TIGR00879  79 IFLVGGFIGALFAGWLSDRFGRKKSLLIIallFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLsEIAPK 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  77 KYRGYMLPLSQVFWLAGSLL--IIGLASVIIP-TIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAA---LAT 150
Cdd:TIGR00879 159 ALRGALTSLYQLAITFGILVayGFGSGKVSLNnTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEArksLAR 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 151 LERVAKMNRSVMPEGKLVEP--VLEKRGRFADLLDAKYLRTTLqIWVIWLGI------------SFAYYG-VILASAell 215
Cdd:TIGR00879 239 LRGTSGEDKELLDELELIDIkrSIEKRSVQPSWGSLFSSTRRI-RRRLFLGVvlqwfqqftginAIMYYSpTIFENA--- 314
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 216 erdlvcGSKSDSAVVVTGGdsgesqspCYCHMFAPSDYRTMIISTIGEialNPLNILGinFLGRRLSLSITMGCTalFFL 295
Cdd:TIGR00879 315 ------GVSTDHAFLVSII--------VGAVNFAFTFVAIFLVDRFGR---RPLLLIG--AAGMAICLFVLGILG--ASF 373
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 296 LLNICTSSAGLIGFLFMlraLVAANFNT-----VYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILG- 369
Cdd:TIGR00879 374 VTGSSKSSGNVAIVFIL---LFIAFFAMgwgpvPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGg 450
                         410       420       430
                  ....*....|....*....|....*....|.
gi 1063759736 370 ALCLFSSVCVVCAISAFTLPIETKGRALQQI 400
Cdd:TIGR00879 451 VFIFFGGLNVLGLIFVYFFLPETKGRTLEEI 481
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-355 1.06e-15

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 77.71  E-value: 1.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGY 81
Cdd:COG2814    55 LLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGAlFPAALALIADLVPPERRGR 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGII-LIVAFKFIPESARFnvstgntraalatlervakmnrs 160
Cdd:COG2814   135 ALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPA----------------------- 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 161 vmpegklvepvlEKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERdlVCGSKSDSAVVVtggdsgesq 240
Cdd:COG2814   192 ------------ARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE--VLGLSASAAGLL--------- 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 241 spcychmfapsdyrtMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAAN 320
Cdd:COG2814   249 ---------------LALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLL 313
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1063759736 321 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVA 355
Cdd:COG2814   314 FPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
3-395 3.26e-15

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 76.92  E-value: 3.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLIS---FLWGAYFSLLTSFAPSYIWFVFLRTMVG--CGVSGHSQGLIIkTEFLPTK 77
Cdd:cd17357    59 FIGGAIGSFISAFLANRFGRKNGLLISnalLVVSSLLMFLSKSAKSPELLIFGRFLVGiaCGLSTGFVPMYL-QEISPSE 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  78 YRGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVST-GNTRAALATLER- 153
Cdd:cd17357   138 LRGALGSLTQIGVTLGILLgqVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISkGDEEEAEKSLKFl 217
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 154 --VAKMNRSVMPEGKL--VEPVLEKRGRFADLL-DAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLvcGSKSDSA 228
Cdd:cd17357   218 rgIEDDVDQELEEIKKesEQMGDQKQVSLMQLLrDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENA--GFSPQLA 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 229 VVVTGGdsgesqspcychmfapsdyrTMIISTIGEIalnpLNILGINFLGRRLSLSITMGCTALFFLLLNICTS------ 302
Cdd:cd17357   296 EWANLG--------------------IGIVNVLSTI----VGPFLIEKVGRRPLLLISLSVCAVALLLMSVFLFlseqns 351
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 303 --SAGLIGFLFMLRALVAANFNTV-YIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCV 379
Cdd:cd17357   352 wmSYGCIVAIFLFIFFFAIGLGPIpWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPPLQSIGGGFVFIIFAIPCA 431
                         410
                  ....*....|....*.
gi 1063759736 380 VCAISAFTLPIETKGR 395
Cdd:cd17357   432 LFLLYLYRYLPETKGR 447
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
1-399 1.18e-13

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 72.22  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGL-IIKTEFLPTKYR 79
Cdd:cd17358    49 LLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVpVYIAEIAPKNVR 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  80 GYMLPLSQVFWLAGSLLIIGLASViiptIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNR 159
Cdd:cd17358   129 GALGSLNQLLVNIGILLGYVLGSF----LPWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLRGKDA 204
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 160 SVMPEGKLVEPVLE------KRGRFADLLDAKYLRTTlqiwVIWLGISFAY-----YGVILASAELLERDLVCGSKSDSA 228
Cdd:cd17358   205 DISKEAAEIQEELAelekeaKESSFSDLFQRKYLKPL----VIGLGLMLFQqlsgiNAVIFYASSIFDEAGSGLDPNTAT 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 229 VVVtggdsGESQSPCYCHMFAPSDY----RTMIISTIGeIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSA 304
Cdd:cd17358   281 III-----GVVQVVGTLVATLLVDRlgrrPLLLVSAIG-MGIGLLALGLYFYLQEHGALLSSVSWLPLVGLVIYIISFSI 354
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 305 GLIGFLFMLralvaanfntvyiyTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA-SILGALCLFSSVCVVCAI 383
Cdd:cd17358   355 GLGPLPWVI--------------MSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTFPFLTLAwGASGTFWIFAGICGLALV 420
                         410
                  ....*....|....*..
gi 1063759736 384 -SAFTLPiETKGRALQQ 399
Cdd:cd17358   421 fVLLFVP-ETKGKSLEE 436
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
4-136 2.62e-13

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 70.73  E-value: 2.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   4 FGYMVFSILFGLLADRYGRWKILLIS-FLWGAyFSLLTSFAPSYIWFVFLRTMVGCGVSGHS---QGLIikTEFLPTKYR 79
Cdd:cd17328    45 ISYMVLSPIFGYLGDRYNRKWILAVGiLIWSA-ATLLSSFAPNFWQLLLFRALVGIGEASYSpiaPTII--ADLFPKEKR 121
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736  80 GYMLPLSQVFWLAGSLLIIGLASVII-PTIGWRWLIRVASIPGIILIVAFKFIPESAR 136
Cdd:cd17328   122 TRALGVFYFAIPLGSGLGYVVGGLVAqATGGWRWAFRVTGVLGVLLAILLLLFVREPP 179
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
3-155 3.80e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 69.45  E-value: 3.80e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHS-QGLIIKTEFLPTKYRGY 81
Cdd:COG0477    59 LLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMpGALALIAELFPARERGR 138
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVA 155
Cdd:COG0477   139 ALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALA 212
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
3-389 2.62e-12

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 67.38  E-value: 2.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLAD-RYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRG 80
Cdd:cd17378    43 FVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGiGTCALVLATEPVGPKWRG 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLAsvIIPTIGWRWLIRVASIPGIILIVAFKFIPesarfnvstgntraalatlervakmnrs 160
Cdd:cd17378   123 QVGMSTFFFFVLGFMSLPGIA--YLNGSSWRVLYFWTSIPALIYCILVYLFA---------------------------- 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 161 vmpegklvepvlekrgrfadlldakylRTTLQIWVIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtggdsgesq 240
Cdd:cd17378   173 ---------------------------RRLLAVMVIGFGIGMVYYGIPLAVGNL-------------------------- 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 241 spcychmfAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLlnICTSSAGLIGFLFMLRALV--- 317
Cdd:cd17378   200 --------KFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLL--CFVLSIGGTTSLQIALELVgff 269
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063759736 318 --AANFNTVYIYTAEVYPTTMR--ALGMGTSGSlcRIGAMVAPFISQVLMSASILgALCLFSSVCVVCAISAFTLP 389
Cdd:cd17378   270 gaAGAFNLLYIYTVELFPTCVRnaALGMLRQAL--VVGGIFAPFIVSLGRKNAAL-SFGVFGVAILLLGLFALGLP 342
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
1-134 3.78e-12

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 67.21  E-value: 3.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVG--CGVSGHSQGLIIkTEFLPTKY 78
Cdd:cd17315    42 SLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGlgVGLASVLVPLYI-SEIAPAKI 120
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736  79 RGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPES 134
Cdd:cd17315   121 RGALGTLNQLMITFGILLayLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPES 178
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
1-144 4.61e-11

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 63.74  E-value: 4.61e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSqgLIIKT---EFLPTK 77
Cdd:cd17359    44 SALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGAS--ALVPMyiaEVAPAE 121
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063759736  78 YRGYMLPLSQVFWLAGSLL------IIGLASVIIPTI--GWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNT 144
Cdd:cd17359   122 IRGRLVSLNQLMIVFGQLLayivnyLIANAGGADWLGaeGWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGKP 196
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
3-386 9.39e-11

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.83  E-value: 9.39e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGY 81
Cdd:cd06174    41 SLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLiDPAVLALIADLFPERERGR 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVII--PTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLervakmnr 159
Cdd:cd06174   121 ALGLLQAFGSVGGILGPLLGGILAssLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSV-------- 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 160 svmpegklvepvlekrgrFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVvvtggdsges 239
Cdd:cd06174   193 ------------------LKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLL---------- 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 240 qspcychmfapsdyrtMIISTIGEIALNPL-NILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVA 318
Cdd:cd06174   245 ----------------LSLFGLAGALGSLLlGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG 308
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1063759736 319 ANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASI-LGALCLFSSVCVVCAISAF 386
Cdd:cd06174   309 GLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFgLTGAFLVLAVLLLLAAILL 377
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
4-388 3.17e-10

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 61.52  E-value: 3.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   4 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLI-IKTEFLPTKYRGym 82
Cdd:PRK11551   61 LGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIaLTSEAVGPRLRG-- 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  83 lplsqvfwLAGSLLIIG------LASVIIPTI----GWRWLIRVASI-PGIILIVAFKFIPESARFNVSTGNTRAALATL 151
Cdd:PRK11551  139 --------TAVSLMYCGvpfggaLASVIGVLAagdaAWRHIFYVGGVgPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVL 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 152 ErvakmnrsvmpegklvepVLEKRGRfadlldakyLRTTLQIWVIWLGISFAYYGVI--LASAeLLERDLvcgSKSDSAV 229
Cdd:PRK11551  211 R------------------ALFGEGR---------ATATLLLWISYFFTLIVLYFLLnwLPSL-LVGQGL---SRSQAGL 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 230 VVTGGDSGesqspcychmfapsdyrtmiiSTIGEIALNPLnilgINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGF 309
Cdd:PRK11551  260 VQIAFNIG---------------------GALGSLLIGAL----MDRLRPRRVVLLIYAGILASLAALAAAPSFAGMLLA 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 310 LFMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSS--VCVVCAISAFT 387
Cdd:PRK11551  315 GFAAGLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLALGRSTVGVIGASipVILVAALAALL 394

                  .
gi 1063759736 388 L 388
Cdd:PRK11551  395 L 395
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
4-137 5.92e-10

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 60.44  E-value: 5.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   4 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGL-IIKTEFLPTKYRGYM 82
Cdd:cd17362    50 LGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAApVYIAETSPSHIRGLL 129
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063759736  83 LPLSQVFWLAGSLLIIGLASVIIPTI-GWRWLIRVASIPGIILIVAFKFIPESARF 137
Cdd:cd17362   130 VSLKELFIVLGILLGYVSGYAFADVVgGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-396 1.23e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 59.51  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH---SQGLIIKteFLPTK 77
Cdd:COG2223    48 IPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSfavGIALVSK--WFPPD 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  78 YRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIP-GIILIVAFKFIPESARFNVSTgntraalatlervak 156
Cdd:COG2223   126 RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILlLVVAVLAWLFLRDPPAGAAAA--------------- 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 157 mnrsvmpegklvepvleKRGRFADLLDAKYLRTTLQIWVIWLGISFAYYGVILASAELLeRDLVCGSKSDSAVVVTGGds 236
Cdd:COG2223   191 -----------------AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYL-VDQFGLSAATAGLLAALF-- 250
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 237 gesqspcychmfapsdyrtmiisTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGL-IGFLFMLRA 315
Cdd:COG2223   251 -----------------------ALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLfLVLFLLLGL 307
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 316 LVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA--SILGALCLFSSVCVVCAISAFTLPIETK 393
Cdd:COG2223   308 ALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDAtgSYTAAFLVFAVLALVALVLTLLLYRRPR 387

                  ...
gi 1063759736 394 GRA 396
Cdd:COG2223   388 RAA 390
MFS_1 pfam07690
Major Facilitator Superfamily;
3-133 4.35e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 57.43  E-value: 4.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGY 81
Cdd:pfam07690  42 SLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGAlFPAALALIADWFPPEERGR 121
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPE 133
Cdd:pfam07690 122 ALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRP 173
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
4-357 8.91e-09

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 56.68  E-value: 8.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   4 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH-SQGLIIKTEFLPTKYRGYM 82
Cdd:cd17375    46 LGVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYlVVVFVYVTEFTGIKARTWA 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  83 LPLSQVFWLAGsLLIIGLASviiptigwrWLIRVASIPGIIL-IVAFKFIpesarfnvstgntraalatlervakmnrsv 161
Cdd:cd17375   126 SMHVHAFFAVG-IMVVALVG---------YLVRTWWIYQIILsLVTIPFI------------------------------ 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 162 mpegkLVEPVLEKRgrfadlldakylrtTLQIWVIWLGISFAYYGVILASAELlerdlvcgsksdsavvvtGGDsgesqs 241
Cdd:cd17375   166 -----LCCWMLPKR--------------TITVWLIWFTGSLGYYVFSLGSVNL------------------GGN------ 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 242 pcychmfapsDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFML--RALVAA 319
Cdd:cd17375   203 ----------EYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQDYEVLTIVLSMtgKFAIAI 272
                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1063759736 320 NFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPF 357
Cdd:cd17375   273 AFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPF 310
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
3-132 1.07e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.42  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYG-RWKILLISFLWGAyFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLI-IKTEFLPTKYRG 80
Cdd:cd17319    48 FLGYALFQVPGGWLLDRFGaRKVLAVSMLLWSL-FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIkALAEWFPARERG 126
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIIL-IVAFKFIP 132
Cdd:cd17319   127 RATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLaVLWWFYLR 179
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
3-388 1.33e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 56.05  E-value: 1.33e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQ-GLIIKTEFLPTKYRGY 81
Cdd:cd17325    41 ALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPaAMALIADIAPPEERGR 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  82 MLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGII-LIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRS 160
Cdd:cd17325   121 AMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLaLVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRR 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 161 VmpegklvepvlekrgrfadlldakylrttLQIWVIWLGISFAYYGVILASAeLLERDLVCGSKSDSAVVVTggdsgesq 240
Cdd:cd17325   201 L-----------------------------LALFLAIFVLAFAFGALEPFLP-LYAAELGGLSPAQIGLLFG-------- 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 241 spcychmfapsdyrtmiISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAAN 320
Cdd:cd17325   243 -----------------AQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLV 305
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736 321 FNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTL 388
Cdd:cd17325   306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
1-136 3.99e-08

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 54.58  E-value: 3.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLIS---FLWGAyfsLLTSFAPSYIWFVFLRTMVGCGVSGHSQGL-IIKTEFLPT 76
Cdd:cd17360    43 STVAGAAVGAAIGGWLNDRFGRRPCILLAdalFTIGA---IVMAAAPNKEVLIVGRVLVGLGVGIASMTVpLYIAEAAPP 119
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063759736  77 KYRGYMLPLSQVFWLAGSLL--IIGLASVIIPtIGWRWLIRVASIPGIILIVAFKFIPESAR 136
Cdd:cd17360   120 RIRGRLVTINVLFITGGQFVayVINGAFSYLP-GGWRWMLGLAAVPAVLQFIGLLFLPESPR 180
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-132 1.40e-07

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 52.93  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCG-----VSGHSQGLIiktefLP 75
Cdd:COG0738    51 AFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGlglldVAANPYVAA-----LG 125
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  76 TKYRGYMLPLSQVFWLAGSLLIIGLASVII---PTIGWRWLIRVASIPGIILIVAFKFIP 132
Cdd:COG0738   126 PETAASRLNLLHAFFSLGALLGPLLGGLLIllgLSLSWHLPYLILAVLLLLLALLFLRSK 185
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
1-133 2.31e-07

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 52.19  E-value: 2.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVS---GHSQGLIikTEFLPTK 77
Cdd:cd17323    42 LFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSsplAIGAGTI--ADLFTPE 119
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063759736  78 YRGYMLPLSQVFWLAGSLL--IIGlaSVIIPTIGWRWLIRVASI-PGIILIVAFKFIPE 133
Cdd:cd17323   120 ERGKAMGVYSLGPLLGPALgpIIG--GFITQSLGWRWIFWFLAIiSGFCLILIFLFLPI 176
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
5-145 3.73e-07

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 51.95  E-value: 3.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   5 GYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSF---APSYIWFVFLRTMVGCgVSGHSQGLI--IKTEFLPTKYR 79
Cdd:cd17431    62 GGMIGSFSVGLFVNRFGRRNSMLYNNLLAFAGAALMGLsklAKSYEMLILGRFIIGL-YCGLTTGLVpmYIGEISPTALR 140
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736  80 GYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTR 145
Cdd:cd17431   141 GALGTLHQLGIVVGILIsqIFGLEFILGTEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEE 208
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
3-128 5.43e-07

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 51.08  E-value: 5.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAP--SYIWFVFLRTMVGCGvsghsQGLI------IKTEFL 74
Cdd:cd17318    66 FYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLA-----QGVTfpamhaLWAKWA 140
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063759736  75 PTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAF 128
Cdd:cd17318   141 PPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW 194
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
4-119 1.61e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 49.93  E-value: 1.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   4 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKYRGYML 83
Cdd:cd06179    43 LAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQ 122
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1063759736  84 PLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASI 119
Cdd:cd06179   123 GVVNLVASPGSALgpLIAGALVEANAAGWRWIFYINAI 160
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
7-389 1.94e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.49  E-value: 1.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   7 MVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG---HSQGLIikTEFLPTKYRGYML 83
Cdd:cd17473    49 ALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGimtLATALI--GDYFEGEERAKML 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  84 PLSQVFWLAGSLLIIGLASVIIpTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATlervAKMNRSVMP 163
Cdd:cd17473   127 GLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGAATAA----ALPWKRVLP 201
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 164 egklvepvlekrgrfadlldakylrttlqIWVIWLGISFAYYGVILASAELLERDLVCGSKSDSAVVVTGGdsgesqspc 243
Cdd:cd17473   202 -----------------------------IYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIAS--------- 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 244 ychmfapsdyrtmIISTIGEIALNPLnilgINFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFLFMLRALVAANFNT 323
Cdd:cd17473   244 -------------LAGAIGALLFGRL----KRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPT 306
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736 324 VYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSA--SILGALCLFSSVCVVCAISAFTLP 389
Cdd:cd17473   307 LNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLtgGLSGAFLILGVLALVLAIVLLLLR 374
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
7-132 2.38e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 49.11  E-value: 2.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   7 MVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGLIIKTEFLPTKyrgyMLPLS 86
Cdd:cd17504    45 AVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPE----RVPVA 120
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063759736  87 QVfWLAGSLLIIG-----LASVIIPTIGWRWLIRVASIPGIILIVAFKFIP 132
Cdd:cd17504   121 QG-ILSATFGIGAgiglpLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLID 170
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
2-148 3.39e-06

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 48.64  E-value: 3.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   2 VFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVS-GHSQGLIIKTEFLPTKYRG 80
Cdd:cd17435    45 LLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLGSLLLVCSVSYTVLIVGRIAIGVSISlSSIATCVYIAEIAPQHRRG 124
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  81 YMLPLSQVFWLAGSLL--IIGLASVIIPTiGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAAL 148
Cdd:cd17435   125 LLVSLNELMIVIGILLayISNYAFANVSN-GWKYMFGLVIPLAALQAIAMYFLPPSPRFLVMKDNMRARL 193
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
3-128 4.11e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 48.41  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVG--CGVSGHSQGLIIKTefLPTKYRG 80
Cdd:cd17391    46 FLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGvfSGYVPNATALIASQ--TPKEKSG 123
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLASVIIPTIGWRwliRVASIPGIILIVAF 128
Cdd:cd17391   124 WALGTLSTGVVAGTLIGPLLGGFLADLFGIR---NVFFITGGLLFLAF 168
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
4-151 5.67e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.93  E-value: 5.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   4 FGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH-SQGLIIKTEFLPTKYRGYM 82
Cdd:cd17324    45 LGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADLVPPEKRGRA 124
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  83 LPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAF-KFIPESARFNVSTGNTRAALATL 151
Cdd:cd17324   125 IGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLwRLLPSLPPKKPGSLGLLSSLLLL 194
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
7-137 6.46e-06

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 47.78  E-value: 6.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   7 MVFSILFGLLADRYGR-WKILLIS--FLWGAyfsLLTSFAPSYIWFVFLRTMVGCGVSghsQGLIIK----TEFLPTKYR 79
Cdd:cd17437    46 LVGSLAAGRTSDWIGRrYTIALAAliFFVGA---LLMGVAPNYPVLMVGRFVAGIGVG---FALMIApvytAEVAPASSR 119
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063759736  80 GYMLPLSQVFWLAGSLL--IIGLASVIIPT-IGWRWLIRVASIPGIILIVAFKFIPESARF 137
Cdd:cd17437   120 GFLTSFPEIFINIGILLgyVSNYAFSGLPLhVGWRLMLGVGAVPSLFLAIGVLAMPESPRW 180
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
5-120 9.53e-06

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 47.08  E-value: 9.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   5 GYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGL-IIKTEFLPTKYRGYML 83
Cdd:cd17445    48 GFASGYLCLGYTADRLGRRRTLLLSLTLAVPFGVLVAVAASPSLFMAMRFLLGAALAGVYLTLyLTRLELCDPPQRLLVA 127
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1063759736  84 PLSQVFWLAGSLLIIGLAsviIPTIGWRWLIRVASIP 120
Cdd:cd17445   128 MAGGLTMVGGHFLLLGLA---LGCGSWRVLQGTITAP 161
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
1-388 1.77e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 46.41  E-value: 1.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYM----VFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLP 75
Cdd:cd17474    38 LLITAFTlpaaVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGlGPLALTLIGDLFE 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  76 TKYRgymlplSQVFWLAGSLLIIGLASV-----IIPTIGWRWLIRVASIPGIILIVAFKFIPESarfnvstgntraalat 150
Cdd:cd17474   118 GGER------AKAMGLYEAALGLGIAVGpllggLLAAISWRYPFFLLAALIPVAFLAILFLLPE---------------- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 151 lervakmnrsvmPEGKLVEPVLEKRGRFADLLDAKYLRTTLqiWVIWLGIsFAYYGVILASAELLERDLvcgsksDSAVV 230
Cdd:cd17474   176 ------------PKEKAKSSSATKLRDLKKALRGRGLLTFL--VSAFLYF-FLYFAFLTYLPFLLELLY------GISPI 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 231 VTGGdsgesqspcychMFAPSDYRTMIISTIGEIALNPlnilginFLGRRLSLSITMGCTALFFLLLNICTSSAGLIGFL 310
Cdd:cd17474   235 IIGL------------LFAGWSVLLALGSLFVGRLLKK-------RFGARRILVIGLLLYALSLLLLGFVPSLALLLIAI 295
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1063759736 311 FMLRALVAANFNTVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSSVCVVCAISAFTL 388
Cdd:cd17474   296 VLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
3-135 1.86e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 46.41  E-value: 1.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGhsqGLIIKTEFLPTKYRGym 82
Cdd:cd17320    44 LLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAA---GSVVARAIVRDLYSG-- 118
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1063759736  83 LPLSQVFWLAGslLIIGLASVIIPTIG--------WR---WLIRVASIpgIILIVAFKFIPESA 135
Cdd:cd17320   119 AELAKIFSLLM--MILAIAPALAPLLGgllllffgWRaifVFLALLGL--LLLLLVLLFLPETL 178
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
5-126 2.42e-05

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 45.92  E-value: 2.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   5 GYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGL-IIKTEFLPTKYRGYML 83
Cdd:cd17443    48 GWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTLAGVFLSLyIARLELCDPSHRLMVS 127
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1063759736  84 PLSQVFWLAGSLLIIGLASVIiptIGWRWLIRVASIPGIILIV 126
Cdd:cd17443   128 MGAGFFSVAGELLLPGLAVLC---RDWRVLQGVGTLPLLLLLL 167
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
3-400 2.71e-05

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 46.26  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSY------IWFVFLRTMVGCGVSG-HSQGLIIKTEFLP 75
Cdd:TIGR00887  66 SIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLSPGSspksvmATLCFWRFWLGVGIGGdYPLSAIITSEFAT 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  76 TKYRGYMlpLSQVF------WLAGSLLII-----------------GLASVIIPTIG--WRWLIRVASIPGIILIVAFKF 130
Cdd:TIGR00887 146 KKWRGAM--MAAVFamqgfgILAGAIVALivlagfkhsleaaadeaSCTGSCVPAVDymWRILIGFGAVPALLALYFRLT 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 131 IPESARFNVSTG-NTRAALATLERVAKMNRSVMPE-----GKLVE-PVLEKRGRFADLLDAKYLRTTLQIWVIWLGISFA 203
Cdd:TIGR00887 224 IPETPRYTADVAkDVEQAASDMSAVLQVKIEAEPDevekaSTAVEvPKASWSDFFTHFFKWRHGKHLLGTAGSWFLLDIA 303
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 204 YYGVILASAELLerdlvcgsksdSAVvvtgGDSGESQSPCYCHMFAPSDYRTMIISTIGEIALNPLNILGINFLGRRLSL 283
Cdd:TIGR00887 304 FYGVNLNQKVIL-----------SAI----GYSPPAATNNAYEELYKTAVGNLIIALAGTVPGYWVTVFLVDIIGRKPIQ 368
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 284 SITMGCTALFFLLLNICTSSAGLIGFLFMLR-ALVAANFN---TVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFIS 359
Cdd:TIGR00887 369 LMGFFILTVLFFVLGFAYNHLSTHGFLAIYVlAQFFANFGpnaTTFIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFGF 448
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1063759736 360 QVLMSAS--------------ILGALCLFSSVCVVCaisAFTLPiETKGRALQQI 400
Cdd:TIGR00887 449 LYLAQHGdptkgyptgiwmghVLEIFALFMFLGILF---TLLIP-ETKGKSLEEL 499
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
3-134 2.72e-05

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 46.09  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLI---SFLWGAyfsLLTSFAPSyIWFVFL-RTMVGCGVSGHSQGL-IIKTEFLPTK 77
Cdd:cd17361    61 YLAGLVASLLASYVTRKWGRKPSMLIggvLFLVGA---ALNAAAQN-IAMLIVgRILLGFGVGFGNQAVpLYLSEMAPAK 136
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063759736  78 YRGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPES 134
Cdd:cd17361   137 LRGALNIGFQLAITIGILIanLINYGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPET 195
PRK03893 PRK03893
putative sialic acid transporter; Provisional
11-137 3.77e-05

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 45.84  E-value: 3.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  11 ILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYiWFVFL-RTMVGCGVSG-HSQGLIIKTEFLPTKYRGYmlplSQV 88
Cdd:PRK03893   73 LLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGY-WTLFIaRLVIGMGMAGeYGSSATYVIESWPKHLRNK----ASG 147
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1063759736  89 FWLAGSLLIIGLA----SVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARF 137
Cdd:PRK03893  148 FLISGFSIGAVVAaqvySLVVPVWGWRALFFIGILPIIFALWLRKNLPEAEDW 200
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
2-145 7.36e-05

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 44.41  E-value: 7.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   2 VFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGHSQGL-IIKTEFLPTKYRG 80
Cdd:cd17436    45 LLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVGFAISVSSMACcIYVSEMVTPHQRG 124
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1063759736  81 YMLPLSQVFWLAGSLLIIGLASVIIPTI-GWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTR 145
Cdd:cd17436   125 LLVSLYEAGITVGILISYALNYFFSNVLtGWRYMFGLAIIPAAIQFASILLLPKKPEVLNIKDNMR 190
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-128 8.49e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 44.48  E-value: 8.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVsGHSQGL---IIKTEFlPTK 77
Cdd:COG2807    61 LPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGI-AVGNVLlpgLIKRWF-PDR 138
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1063759736  78 yRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAF 128
Cdd:COG2807   139 -VGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLW 188
xylE PRK10077
D-xylose transporter XylE; Provisional
14-154 9.82e-05

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 44.30  E-value: 9.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  14 GLLADRYGRWKILLIS---FLWGAYFS-----LLTSFAP---SYIW-FVFLRTMVGCGV---SGHSQGLIikTEFLPTKY 78
Cdd:PRK10077   76 GYCSNRFGRRDSLKIAavlFFISALGSawpefGFTSIGPdntGYVPeFVIYRIIGGIGVglaSMLSPMYI--AEIAPAHI 153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  79 RGYMLPLSQVFWLAGSLLII--------GLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALAT 150
Cdd:PRK10077  154 RGKLVSFNQFAIIFGQLVVYfvnyfiarSGDASWLNTDGWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGI 233

                  ....
gi 1063759736 151 LERV 154
Cdd:PRK10077  234 LRKI 237
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
1-153 1.08e-04

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 44.14  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSF---APSYIWFVFLRTMVG--CGVSGHSQGLIIkTEFLP 75
Cdd:cd17432    58 IFPLGGLFGSLLVGPLVIRLGRKGTLLLNNIFAIVAAILMGLskiAKSFEMIIVGRFLVGinAGISLNVVPMYL-GESAP 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  76 TKYRGYMLPLSQVFWLAGSLL--IIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFN-VSTGNTRAALATLE 152
Cdd:cd17432   137 KNLRGAVGLVPAIFITLGILLgqVLGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLlIEKGDEEAARKALQ 216

                  .
gi 1063759736 153 R 153
Cdd:cd17432   217 R 217
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
3-130 1.35e-04

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 43.70  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   3 FFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAP--SYIWFVFLRTMVGCGvsghsQGLIIKTEF------L 74
Cdd:cd17380    44 FWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAysSLPLLILSRILLGLG-----EGVHFPSMTslfsrwV 118
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1063759736  75 PTKYRGYMLPLSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIVAFKF 130
Cdd:cd17380   119 PVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLI 174
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
1-400 1.49e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 43.78  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFL-RTMVGCGVSGHS-QGLIIKTEFLPTKY 78
Cdd:cd17356    53 IVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGKWYQLIVgRIIAGLGVGFASvLVPVYQSEVAPKHI 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  79 RGYMLPLSQVFWLAGSLLIIGL---ASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFnvstgntraalatLERVa 155
Cdd:cd17356   133 RGTLVSLYQLAITIGILVAYCInygTHKLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRW-------------LYRT- 198
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 156 kmnrsvmpegklvepvlekrgrfadlldakYLRTTLQIWVIWLGISFA-YYGV-ILASAELLERDlvcgsksdsavvvtg 233
Cdd:cd17356   199 ------------------------------ILGIMLQLFQQLTGINYFfYYGTtIFQSTGLTGSS--------------- 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 234 gdsgesqspcychmfapsDYRTMIISTIGEIALNPLNILGINFLGRRLSLSITMGCTALFFLLLNICT------------ 301
Cdd:cd17356   234 ------------------PLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIGAAGMSICLFIYAAVGvrylipnpqsgt 295
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736 302 ----SSAGLIGFLFMLRALVAANFN-TVYIYTAEVYPTTMRALGMGTSGSLCRIGAMVAPFISQVLMSASILGALCLFSS 376
Cdd:cd17356   296 snksAGNGMIVFICLFIFSFATTWGpIAWVYVAEVFPLRVRSKGMALATAFNWLWNFLISFFTPFIIGSIGFKYYYIFAG 375
                         410       420
                  ....*....|....*....|....
gi 1063759736 377 VCVVCAISAFTLPIETKGRALQQI 400
Cdd:cd17356   376 CNLLAFIVVFFFVPETKGLTLEEI 399
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
6-126 2.12e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.93  E-value: 2.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   6 YMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGYMLP 84
Cdd:cd17321    44 FAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRGRALG 123
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1063759736  85 LSQVFWLAGSLLIIGLASVIIPTIGWRWLIRVASIPGIILIV 126
Cdd:cd17321   124 LWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALL 165
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
15-185 3.29e-04

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 42.51  E-value: 3.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  15 LLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGC--GVSGHSQGLIIkTEFLPTKYRGYMLPLSQVFWLA 92
Cdd:cd17434    63 FLNDRLGRKLSIMFSAVPSALGYLLMGSAQGIWMLLLGRFLTGFagGITAASIPVYV-SEISHPGVRGALGACPQIMAVF 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  93 GSLLIIGLAsVIIPtigWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATLERVAKMNRSVMPEGKLVEPVL 172
Cdd:cd17434   142 GSLALYALG-LLLP---WRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNTDYMTEFEQIKDNI 217
                         170
                  ....*....|...
gi 1063759736 173 EKRGRFADLLDAK 185
Cdd:cd17434   218 RKQSSRLSWAELK 230
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
9-62 3.71e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 42.25  E-value: 3.71e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1063759736   9 FSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG 62
Cdd:cd17476    49 FILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAF 102
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
8-112 4.00e-04

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 42.17  E-value: 4.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   8 VFSILFGLLADRYGRWKILLIS---FLWGayfSLLTSFAPSYIWFVFLRTMVGCGVSGHSQG-LIIKTEFLPTKYRGYML 83
Cdd:cd17502    45 AFQPIYGKLSDLFGRKWVLLIAiviFELG---SLLCGLAPNMTMLIVGRAIQGIGGGGLMSLaFIIIADLVPPRERGKYQ 121
                          90       100       110
                  ....*....|....*....|....*....|.
gi 1063759736  84 PLSQVFWLAGSLL--IIGlaSVIIPTIGWRW 112
Cdd:cd17502   122 GYIGAVFGIASVAgpLIG--GAFTDHLSWRW 150
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
1-151 4.85e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 42.17  E-value: 4.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYGR-WKILLISFLWGAYFSLLTsfAPSYIWFVF---LRTMVGCGVSGHSQGLIIkTEFLPT 76
Cdd:cd17433    49 VVTLGAAAGGVLGGWIVDRAGRkLSLMLCSVPFIAGFTVIT--AAQNVWMLYvgrLLTGLASGVTSLVVPVYI-SEIAHP 125
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063759736  77 KYRGYMLPLSQVFWLAGslliIGLASVIIPTIGWRWLIRVASIPGIILIVAFKFIPESARFNVSTGNTRAALATL 151
Cdd:cd17433   126 RVRGTLGSCVQLMVVIG----IMGAYLAGLVLDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAAL 196
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
1-154 1.40e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 40.68  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   1 MVFFGYMVFSILFGLLADRYG-RWKILLISFLWGAYFsLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKY 78
Cdd:cd17475    39 ALNLGVAVSMLPAGWLLDRFGeRRVLAVGLLLMGAAA-LLMALVGSYPVLLVLLFLVGAGYGSvQPGGGRAIMRWFPPRE 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  79 RGYMLPLSQvfwlAGSLLIIGLASVIIPTI----GWRWLIRVASIPGIIL-IVAFKFIPESARFNVSTGNTRAALATLER 153
Cdd:cd17475   118 RGLAMGIRQ----TGVPLGGALAAALLPPLalhyGWRAAFVVAGLVSILAaVLFWLFYREPPAASAATESASTLLRSLKE 193

                  .
gi 1063759736 154 V 154
Cdd:cd17475   194 V 194
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
12-156 1.63e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.23  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  12 LFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSG-HSQGLIIKTEFLPTKYRGYMlplsQVFW 90
Cdd:cd17478    50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAfHPEGARLASQAAGGRRGLAM----SIFS 125
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063759736  91 LAGSL------LIIGLASVIIPTIGWRWLIRVASIpgIILIVAFKFIPESARFNVSTGNTRAALATLERVAK 156
Cdd:cd17478   126 VGGNLgfalgpLIAAALVALFGGLGLLILLIIPGL--AVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWR 195
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
6-128 3.18e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.45  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736   6 YMVFSILFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGVSGH-SQGLIIKTEFLPTKYRGYMLP 84
Cdd:cd17370   247 YALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYG 326
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1063759736  85 LSQ----VFWLAGSLliigLASVIIPTIGWRWLIRVASIPGIILIVAF 128
Cdd:cd17370   327 LFNtvvgIGWLLASL----IAGYLWDLISPSAAFLFSAVLALIALLLL 370
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
12-133 5.24e-03

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 38.90  E-value: 5.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063759736  12 LFGLLADRYGRWKILLISFLWGAYFSLLTSFAPSYIWFVFLRTMVGCGvSGHSQGLIIKTEFL--PTKYRGYMLPLSQVF 89
Cdd:TIGR00711  56 LTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFG-GGPLIPLSFSTLLNiyPPEKRGRAMAIWGLT 134
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1063759736  90 WLAGSLLIIGLASVIIPTIGWRWLIRVASIPGII-LIVAFKFIPE 133
Cdd:TIGR00711 135 VLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIvVVVAFFILPR 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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