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Conserved domains on  [gi|1063699396|ref|NP_001323950|]
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phosphatidic acid phosphatase 1 [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02715 PLN02715
lipid phosphate phosphatase
 1-327 0e+00

lipid phosphate phosphatase


:

Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 681.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396   1 MTIGSFFSSLLFWRNSQDQEAQRGRMQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMT 80
Cdd:PLN02715    1 MTIGSFFSSLLFWRNSQDQEAQRGRIQEIDLGVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  81 DLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPD 160
Cdd:PLN02715   81 DLKYPFKDNTVPIWSVPVYAVLLPIILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 161 GKELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRV 240
Cdd:PLN02715  161 GKELYDALGGVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVAKLCLVIFPLLAACLVGISRV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 241 DDYWHHWQDVFAGALIGTLVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMES 320
Cdd:PLN02715  241 DDYWHHWQDVFAGALIGILVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVASSQNGDALRAMSLQMDSTSLENMES 320


                  ....*..
gi 1063699396 321 GTSTAPR 327
Cdd:PLN02715  321 GTSTAPR 327
 
Name Accession Description Interval E-value
PLN02715 PLN02715
lipid phosphate phosphatase
 1-327 0e+00

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 681.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396   1 MTIGSFFSSLLFWRNSQDQEAQRGRMQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMT 80
Cdd:PLN02715    1 MTIGSFFSSLLFWRNSQDQEAQRGRIQEIDLGVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  81 DLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPD 160
Cdd:PLN02715   81 DLKYPFKDNTVPIWSVPVYAVLLPIILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 161 GKELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRV 240
Cdd:PLN02715  161 GKELYDALGGVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVAKLCLVIFPLLAACLVGISRV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 241 DDYWHHWQDVFAGALIGTLVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMES 320
Cdd:PLN02715  241 DDYWHHWQDVFAGALIGILVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVASSQNGDALRAMSLQMDSTSLENMES 320


                  ....*..
gi 1063699396 321 GTSTAPR 327
Cdd:PLN02715  321 GTSTAPR 327
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 80-268 9.59e-85

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 253.68  E-value: 9.59e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  80 TDLKYPFKDN-TVPIWSVPVYAVLLPIIVFVCFYLK-RTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRC 157
Cdd:cd03390     1 PSISYPFAESeTVPTWLLVIISVGIPLLVIILISLFfRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 158 FPDGK--ELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLV 235
Cdd:cd03390    81 FPDGGtpSDTLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLLAILV 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1063699396 236 GISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 268
Cdd:cd03390   161 AVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 128-269 1.23e-24

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 96.34  E-value: 1.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 128 LLFAVLITGVITDSIKVATGRPRPNFYWRCFPDgkelydalggvvcHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLS 207
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGL-------------VPAPSTLPGLGYSFPSGHSATAFALALLLALLLR 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063699396 208 GKIKAfnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQFY 269
Cdd:pfam01569  69 RLRKI-------VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
129-265 4.14e-18

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 78.54  E-value: 4.14e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  129 LFAVLITGVITDSIKVATGRPRPNFYWRCFpdgkelydalggVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSG 208
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGD------------ACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPA 68

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063699396  209 kikafnnegHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 265
Cdd:smart00014  69 ---------RAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 51-268 9.39e-15

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 71.61  E-value: 9.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  51 WIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLhhsiLGLLF 130
Cdd:COG0671     5 LLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLL----LLAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 131 AVLITGVITDSIKVATGRPRPNfywrcfpdgkelydalggVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLsgki 210
Cdd:COG0671    81 LLLLLLLLLLLLKYLFGRPRPF------------------VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLL---- 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063699396 211 kafnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 268
Cdd:COG0671   139 ---------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PLN02715 PLN02715
lipid phosphate phosphatase
 1-327 0e+00

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 681.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396   1 MTIGSFFSSLLFWRNSQDQEAQRGRMQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMT 80
Cdd:PLN02715    1 MTIGSFFSSLLFWRNSQDQEAQRGRIQEIDLGVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  81 DLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPD 160
Cdd:PLN02715   81 DLKYPFKDNTVPIWSVPVYAVLLPIILFVCFYLKRRCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 161 GKELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRV 240
Cdd:PLN02715  161 GKELYDALGGVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNGEGHVAKLCLVIFPLLAACLVGISRV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 241 DDYWHHWQDVFAGALIGTLVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENMES 320
Cdd:PLN02715  241 DDYWHHWQDVFAGALIGILVAAFCYRQFYPNPYHEEGWGPYAYFKAAQERGVPVASSQNGDALRAMSLQMDSTSLENMES 320


                  ....*..
gi 1063699396 321 GTSTAPR 327
Cdd:PLN02715  321 GTSTAPR 327
PLN02250 PLN02250
lipid phosphate phosphatase
 26-325 4.90e-152

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 428.96  E-value: 4.90e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  26 MQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPI 105
Cdd:PLN02250    1 MPEIQLGAHTIRSHGVKVARTHMHDWLILLLLVVIEVVLNVIEPFHRFVGKDMLTDLSYPLQDNTIPFWAVPLIAILLPF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 106 IVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDAL-GGVVCHGKAAEVKEGH 184
Cdd:PLN02250   81 AVILVYYFIRRDVYDLHHAILGLLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPVtTDVLCTGAKSVIKEGH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 185 KSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFC 264
Cdd:PLN02250  161 KSFPSGHTSWSFAGLGFLSLYLSGKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFC 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1063699396 265 YRQFYPNPYHEEGWGPYAYFKAAQERGVPVTSSQNGDALRAMSLQMDSTSLENmESGTSTA 325
Cdd:PLN02250  241 YLQFFPPPYDIDGWGPHAYFQMLAESRNGAQSSNGINHLSVQQTELESVYIDS-QHGMETS 300
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 25-291 2.01e-142

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 405.57  E-value: 2.01e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  25 RMQEIDLSVHTIKSHGGRVASKHKHDWIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLP 104
Cdd:PLN02731   19 RMREAQLGGHTLRSHGMTVARTHMHDWIILVLLVILECVLLIIHPFYRFVGKDMMTDLSYPLKSNTVPIWSVPVYAMLLP 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 105 IIVFVCFYLKRTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYDALGGVVCHGKAAEVKEGH 184
Cdd:PLN02731   99 LVIFIFIYFRRRDVYDLHHAVLGLLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSLGDVICHGDKSVIREGH 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 185 KSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFC 264
Cdd:PLN02731  179 KSFPSGHTSWSFSGLGFLSLYLSGKIQAFDGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTIC 258

                         250       260       270
                  ....*....|....*....|....*....|
gi 1063699396 265 YRQFYPNPYHEEGWGPYAYFK---AAQERG 291
Cdd:PLN02731  259 YLQFFPPPYHTEGWGPYAYFQvleAARVQG 288
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 80-268 9.59e-85

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 253.68  E-value: 9.59e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  80 TDLKYPFKDN-TVPIWSVPVYAVLLPIIVFVCFYLK-RTCVYDLHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRC 157
Cdd:cd03390     1 PSISYPFAESeTVPTWLLVIISVGIPLLVIILISLFfRRSLWDLHTSLLGLLLSVSLNGVITNVLKNYAGRPRPDFLARC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 158 FPDGK--ELYDALGGVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNNEGHVAKLCLVIFPLLAACLV 235
Cdd:cd03390    81 FPDGGtpSDTLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHIFDPRGSSWRLLLALLPLLLAILV 160

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1063699396 236 GISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 268
Cdd:cd03390   161 AVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 129-263 4.51e-32

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 116.96  E-value: 4.51e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 129 LFAVLITGVITDSIKVATGRPRPNFYWRCFPDgkelYDALG----------GVVCHGKAAEVKEGHKSFPSGHTSWSFAG 198
Cdd:cd03384    10 LFGLFATQLLTDLGKYVTGRLRPHFLDVCKPN----YTDLTcsldhqyiadCTCCTGDPDLIREARLSFPSGHASLSMYA 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063699396 199 LTFLSLYLSGKIKAFNNegHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAF 263
Cdd:cd03384    86 AVFLALYLQARLKLRGS--RLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALF 148
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 121-265 3.75e-28

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 105.62  E-value: 3.75e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 121 LHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELYdalggvvchgkaaeVKEGHKSFPSGHTSWSFAGLT 200
Cdd:cd01610     1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPDGDPLL--------------LTEGGYSFPSGHAAFAFALAL 66

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063699396 201 FLSLYLSGKIkafnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 265
Cdd:cd01610    67 FLALLLPRRL---------LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 128-269 1.23e-24

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 96.34  E-value: 1.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 128 LLFAVLITGVITDSIKVATGRPRPNFYWRCFPDgkelydalggvvcHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLS 207
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGL-------------VPAPSTLPGLGYSFPSGHSATAFALALLLALLLR 68

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1063699396 208 GKIKAfnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQFY 269
Cdd:pfam01569  69 RLRKI-------VRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
129-265 4.14e-18

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 78.54  E-value: 4.14e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  129 LFAVLITGVITDSIKVATGRPRPNFYWRCFpdgkelydalggVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSG 208
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGD------------ACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYLPA 68

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1063699396  209 kikafnnegHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 265
Cdd:smart00014  69 ---------RAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 121-265 1.15e-15

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 71.59  E-value: 1.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 121 LHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRcfpdgkelydalggvvchgkaaevkeGHKSFPSGHTSWSFAGLT 200
Cdd:cd03394     1 DREGLLILAEAAALTAAVTEGLKFAVGRARPDGSNN--------------------------GYRSFPSGHTASAFAAAT 54

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063699396 201 FLSlYLSGKIKAfnneGHVAklclvifpLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCY 265
Cdd:cd03394    55 FLQ-YRYGWRWY----GIPA--------YALASLVGASRVVANRHWLSDVLAGAAIGILVGYLVT 106
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 51-268 9.39e-15

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 71.61  E-value: 9.39e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  51 WIILVILIAIEIGLNLISPFYRYVGKDMMTDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTCVYDLhhsiLGLLF 130
Cdd:COG0671     5 LLLALLLLLLLLADLLALALLALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLL----LLAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 131 AVLITGVITDSIKVATGRPRPNfywrcfpdgkelydalggVVCHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLsgki 210
Cdd:COG0671    81 LLLLLLLLLLLLKYLFGRPRPF------------------VVPDLELLLGTAGGYSFPSGHAAAAFALALVLALLL---- 138

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1063699396 211 kafnneghvAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 268
Cdd:COG0671   139 ---------PRRWLAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 97-265 9.35e-13

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 65.71  E-value: 9.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  97 PVYAVLLPIIVFVCFYLKRTcvydlHHSILGLLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKelydalggvvchgk 176
Cdd:cd03392    41 PAVLLIIVLLLALLLLLKRR-----RRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLVPEGGY-------------- 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 177 aaevkeghkSFPSGHTSWSFAGLTFLSLYLSGKIKAFnneghVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALI 256
Cdd:cd03392   102 ---------SFPSGHAMGATVLYGFLAYLLARRLPRR-----RVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLL 167


                  ....*....
gi 1063699396 257 GTLVAAFCY 265
Cdd:cd03392   168 GLAWLALLI 176
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 80-268 2.10e-09

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 56.12  E-value: 2.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  80 TDLKYPFKDNTVPIWSVPVYAVLLPIIVFVCFYLKRTcvydlhHSILGLLFAVLITGVITDSI-----KVATGRPRPnfy 154
Cdd:cd03395    15 GTLVHPLLDDLMPFLTGKKLSVPIFLLLALFILFRKG------PIGLLILLLVLLAVGFADQLasgflKPLVARLRP--- 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 155 wrCFPDgkELYDALGGVVCHGKAaevkeghkSFPSGHTSWSFAGLTFLSLYLSgkikafnneghvaKLCLVIFPLLAACL 234
Cdd:cd03395    86 --CNAL--DGVRLVVLGDQGGSY--------SFASSHAANSFALALFIWLFFR-------------RGLFSPVLLLWALL 140

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1063699396 235 VGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 268
Cdd:cd03395   141 VGYSRVYVGVHYPGDVIAGALIGIISGLLFYLLF 174
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 128-268 2.22e-09

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 56.18  E-value: 2.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 128 LLFAVLITGVITDSIKVATGRPRPNFYwrcFPDGkelydALGGVVCHGKAAevkegHKSFPSGHTSWSFAGLTFLSLyls 207
Cdd:cd03389    74 LFATVALSGILVNLLKFIIGRARPKLL---FDDG-----LYGFDPFHADYA-----FTSFPSGHSATAGAAAAALAL--- 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1063699396 208 gkikafnneghvaklclvIFP------LLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQF 268
Cdd:cd03389   138 ------------------LFPryrwafILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 125-263 3.45e-08

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 51.94  E-value: 3.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 125 ILGLLFAVLITGVItdsiKVATGRPRPnfyWRCFPDgkeLYDALGgvvchgkaaevkEGHKSFPSGHTSWSFAGLTFLSL 204
Cdd:cd03391    53 LLGLLLDIITVAIL----KALVRRRRP---AYNSPD---MLDYVA------------VDKYSFPSGHASRAAFVARFLLN 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1063699396 205 YLsgkikafnneghVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAF 263
Cdd:cd03391   111 HL------------VLAVPLRVLLVLWATVVGISRVLLGRHHVLDVLAGAFLGYLEALL 157
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 187-265 3.12e-06

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 46.50  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 187 FPSGH--TSWSFAGLTFLSLYLSGKikafNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFC 264
Cdd:cd03382    83 MPSSHsqFMGFFAVYLLLFIYLRLG----RLNSLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGILW 158


                  .
gi 1063699396 265 Y 265
Cdd:cd03382   159 F 159
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 94-266 4.20e-06

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 46.52  E-value: 4.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396  94 WSVPVYAVLLPIIVFVCFYLKRtcvydLHHSILGLLFAVLITGVITDSI---KVATGRPRPN------------FYWRCF 158
Cdd:cd03396    40 LLSIALAVLLLALALLFFRRKR-----LRRRRRALLLLILVIGLGLLVVailKSHWGRPRPWdltefggdapytPLFSGP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 159 PDGKElydalggvvchgkaaevkeGHKSFPSGHTSwsfAGLTFLSLYLSGKIKAFnnegHVAKLCLViFPLLAACLVGIS 238
Cdd:cd03396   115 SNGCG-------------------KGCSFPSGHAS---AGFALLALYFLFRRRRP----RLARLVLA-AGLALGALMGLA 167

                         170       180
                  ....*....|....*....|....*...
gi 1063699396 239 RVDDYWHHWQDVFAGALIGTLVAAFCYR 266
Cdd:cd03396   168 RMARGAHFLSDVLWSLLLVWLIALLLYR 195
PAP2_BcrC_like cd03385
PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as ...
 186-266 2.53e-04

PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from Bacillus subtilis posesses undecaprenyl pyrophosphate (UPP) phospatase activity, and it is hypothesized that it competes with bacitracin for UPP, increasing the cell's resistance to bacitracin.


Pssm-ID: 239480  Cd Length: 144  Bit Score: 40.70  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 186 SFPSGHTS--WSFAgltfLSLYLSGKIKAfnneghvaklclVIFPLLAACLVGISRVddyW--HHWQ-DVFAGALIGTLV 260
Cdd:cd03385    78 SFPSDHTTlfFSIA----FSLLLRRRKWA------------GWILLILALLVAWSRI---YlgVHYPlDMLGAALVAVLS 138


                  ....*.
gi 1063699396 261 AAFCYR 266
Cdd:cd03385   139 ALLVFQ 144
PAP2_like_1 cd03380
PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium ...
 128-262 3.83e-04

PAP2_like_1 proteins, a sub-family of PAP2, containing bacterial acid phosphatase, vanadium chloroperoxidases and vanadium bromoperoxidases.


Pssm-ID: 239475  Cd Length: 209  Bit Score: 40.88  E-value: 3.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 128 LLFAVLITGVITDSIKVATGRPRPNfywrcfpdgkELYDALGGVVChgKAAEVKEGHKSFPSGHTSWSFAGLTFLSLyls 207
Cdd:cd03380    98 LARALTDAGIATWDAKYHYNRPRPF----------VAIRLQWLPIC--TPEEGTPKHPSYPSGHATFGGAAALVLAE--- 162

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1063699396 208 gkikafnneghvaklclvIFPLLAACL------VGISRVddywH---HWQ-DVFAGALIGTLVAA 262
Cdd:cd03380   163 ------------------LFPERAAELlaraaeAGNSRV----VagvHWPsDVEAGRILGEAIAA 205
PAP2_diacylglycerolkinase cd03383
PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like ...
 188-268 7.39e-04

PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be determined.


Pssm-ID: 239478 [Multi-domain]  Cd Length: 109  Bit Score: 38.46  E-value: 7.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 188 PSGHTSWSFAGLTFLSLylsgkikafNNEGHVaklcLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGTLVAAFCYRQ 267
Cdd:cd03383    42 PSGHAAIAFSIATAISL---------ITNNPI----ISILSVLLAVMVAHSRVEMKIHTMWEVVVGAILGALITLLIFKI 108


                  .
gi 1063699396 268 F 268
Cdd:cd03383   109 F 109
COG3907 COG3907
Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction ...
 100-270 1.20e-03

Membrane-associated enzyme, PAP2 (acid phosphatase) superfamily [General function prediction only];


Pssm-ID: 443113  Cd Length: 236  Bit Score: 39.88  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 100 AVLLPIIVFVCFYLKRtcvYDLHHSILGLLFAVLITGVITDSI-KVATGRPRPnfyWRCfpdgkelyDALGGVVCH---- 174
Cdd:COG3907    75 AVLLLLLLLASFKRPR---LRRYRRRLLYLLLSLALGLLVVSLlKSHTGRPCP---WDL--------VEFGGDAPYvplf 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 175 GKAAEVKEGHKSFPSGHTSwsfAGLTFLSLYLsgkikAFNNEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGA 254
Cdd:COG3907   141 EPGPAGAGPGRCFPAGHAS---AGFALLALYF-----LLRRRRPRLARLGLAAGLALGLLMGLAQMLRGAHFLSHTLWSA 212

                         170
                  ....*....|....*.
gi 1063699396 255 LIGTLVAAFCYRQFYP 270
Cdd:COG3907   213 WICWLVALLLYWLLLR 228
PAP2_haloperoxidase cd03398
PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as ...
 183-263 4.05e-03

PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen peroxide forming dioxygen. They are likely to participate in the biosynthesis of halogenated natural products, such as volatile halogenated hydrocarbons, chiral halogenated terpenes, acetogenins and indoles.


Pssm-ID: 239492  Cd Length: 232  Bit Score: 38.17  E-value: 4.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1063699396 183 GHKSFPSGHTSWSFAGLTFLSlYLSGKIKAFNNEGHVAKLCLVIFPLL-------AACLVGISRVddyWH--HWQ-DVFA 252
Cdd:cd03398   143 PHPSYPSGHATFAGAAATVLK-ALFGSDKVPDTVSEPDEGGPSTGVTRvwaelneLADEVAISRV---YAgvHFRsDDAA 218

                          90
                  ....*....|.
gi 1063699396 253 GALIGTLVAAF 263
Cdd:cd03398   219 GAALGEQIGAA 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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