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Conserved domains on  [gi|1068937238|ref|NP_001332951|]
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ubiquitin carboxyl-terminal hydrolase 45 isoform a [Homo sapiens]

Protein Classification

zf-UBP and Peptidase_C19K domain-containing protein( domain architecture ID 10489803)

zf-UBP and Peptidase_C19K domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 603-811 1.49e-70

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


:

Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 233.43  E-value: 1.49e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 603 AFQTLS-QSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKnkqkyqeetsfaekkvegvytnARKQLLISAVPAV 681
Cdd:cd02667    95 PFLDLSlPRSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTK----------------------AKKQYLISKLPPV 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 682 LILHLKRFHQAGL-SLRKVNRHVDFPLMLDLAPFCSATCKNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRTPSRKL 760
Cdd:cd02667   153 LVIHLKRFQQPRSaNLRKVSRHVSFPEILDLAPFCDPKCNSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRL 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1068937238 761 SEHntkkKNVPGLKAADNESAGQWVHVSDTYLQVVPESRALSAQAYLLFYE 811
Cdd:cd02667   233 SDL----TKSKPAADEAGPGSGQWYYISDSDVREVSLEEVLKSEAYLLFYE 279
Peptidase_C19 super family cl02553
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 191-387 2.96e-38

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


The actual alignment was detected with superfamily member cd02667:

Pssm-ID: 470612 [Multi-domain]  Cd Length: 279  Bit Score: 144.07  E-value: 2.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAQTYTLTDLMNEikesstklkifpssdsqldplvvelsrpgpltsalflflhsmketekgpl 270
Cdd:cd02667     1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 271 SPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTeetkriqasilkafnnpttktaddetrkkvkaygkegvkmnFI 350
Cdd:cd02667    31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLRT-----------------------------------------FI 69

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1068937238 351 DRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEE 387
Cdd:cd02667    70 DSIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDE 106
zf-UBP pfam02148
Zn-finger in ubiquitin-hydrolases and other protein;
62-132 7.22e-17

Zn-finger in ubiquitin-hydrolases and other protein;


:

Pssm-ID: 460464  Cd Length: 63  Bit Score: 75.38  E-value: 7.22e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1068937238  62 CSECLkerrfydgqlvLTSDIWLCLKCGFQGCGKNSESqHSLKHFKSSRtepHCIIINLSTWIIWCYECDE 132
Cdd:pfam02148   1 CSLCG-----------NTSNLWLCLTCGHVGCGRYQNS-HALEHYEETG---HPLAVNLSTLTVYCYPCDD 56
 
Name Accession Description Interval E-value
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 603-811 1.49e-70

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 233.43  E-value: 1.49e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 603 AFQTLS-QSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKnkqkyqeetsfaekkvegvytnARKQLLISAVPAV 681
Cdd:cd02667    95 PFLDLSlPRSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTK----------------------AKKQYLISKLPPV 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 682 LILHLKRFHQAGL-SLRKVNRHVDFPLMLDLAPFCSATCKNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRTPSRKL 760
Cdd:cd02667   153 LVIHLKRFQQPRSaNLRKVSRHVSFPEILDLAPFCDPKCNSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRL 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1068937238 761 SEHntkkKNVPGLKAADNESAGQWVHVSDTYLQVVPESRALSAQAYLLFYE 811
Cdd:cd02667   233 SDL----TKSKPAADEAGPGSGQWYYISDSDVREVSLEEVLKSEAYLLFYE 279
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 191-387 2.96e-38

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 144.07  E-value: 2.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAQTYTLTDLMNEikesstklkifpssdsqldplvvelsrpgpltsalflflhsmketekgpl 270
Cdd:cd02667     1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 271 SPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTeetkriqasilkafnnpttktaddetrkkvkaygkegvkmnFI 350
Cdd:cd02667    31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLRT-----------------------------------------FI 69

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1068937238 351 DRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEE 387
Cdd:cd02667    70 DSIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDE 106
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
598-810 1.28e-29

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 119.85  E-value: 1.28e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 598 YSPQNAFQTLSQSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKNKQKYqeetsfaekkvegvytnarKQLLISA 677
Cdd:pfam00443 142 FEPFSDLSLPIPGDSAELKTASLQICFLQFSKLEELDDEEKYYCDKCGCKQDAI-------------------KQLKISR 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 678 VPAVLILHLKRFHQAGLSLRKVNRHVDFPLMLDLAPFCsATCKNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKvrtps 757
Cdd:pfam00443 203 LPPVLIIHLKRFSYNRSTWEKLNTEVEFPLELDLSRYL-AEELKPKTNNLQDYRLVAVVVHSGSLSSGHYIAYIK----- 276

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1068937238 758 rklsehntkkknvpglkaadNESAGQWVHVSDTYLQVVPESRA-LSAQAYLLFY 810
Cdd:pfam00443 277 --------------------AYENNRWYKFDDEKVTEVDEETAvLSSSAYILFY 310
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
191-812 9.51e-29

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 123.45  E-value: 9.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAQTYTLTD--LMNEIKESStklkifpssdSQLDPLVVElsrpGPLTSALFLFLHSMKETEKG 268
Cdd:COG5560   267 GLRNLGNTCYMNSALQCLMHTWELRDyfLSDEYEESI----------NEENPLGMH----GSVASAYADLIKQLYDGNLH 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 269 PLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRtEETKRIQasILKAFNNPTTKTADDETRKKV-KAYGKEGVKM 347
Cdd:COG5560   333 AFTPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGLH-EDLNRII--KKPYTSKPDLSPGDDVVVKKKaKECWWEHLKR 409

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 348 N--FIDRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEERV-SKPLLWGRMNKYRSLRETDHDRYSGNVTIENIHQP 424
Cdd:COG5560   410 NdsIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLPLPVSMVwKHTIVVFPESGRRQPLKIELDASSTIRGLKKLVDA 489

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 425 RAAKKHSSSKDKSQLIHDR---------KCIRKLSS--GETVTYQKNEN-------------LEMNGDSLMFASL---MN 477
Cdd:COG5560   490 EYGKLGCFEIKVMCIYYGGnynmlepadKVLLQDIPqtDFVYLYETNDNgievpvvhlriekGYKSKRLFGDPFLqlnVL 569

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 478 SESRLNESPTDDSEKEASHSESNV-DADSEPSesesaskQTGLFRSSSGsgvqPDGPLYPLSAGKllyTKETDSGDKEma 556
Cdd:COG5560   570 IKASIYDKLVKEFEELLVLVEMKKtDVDLVSE-------QVRLLREESS----PSSWLKLETEID---TKREEQVEEE-- 633

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 557 eaiselrlsstvtgdqdfDRENQPLNIsNNLCFLEGKHLRSYSPQNAFQTLSQSyITTSKECSIQSCLYQFTSMELLMGN 636
Cdd:COG5560   634 ------------------GQMNFNDAV-VISCEWEEKRYLSLFSYDPLWTIREI-GAAERTITLQDCLNEFSKPEQLGLS 693

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 637 NKLLCENCTKNKQkyqeetsfaekkvegvytnARKQLLISAVPAVLILHLKRFHQAGLSLRKVNRHVDFPLM-LDLAPFC 715
Cdd:COG5560   694 DSWYCPGCKEFRQ-------------------ASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPIDdLDLSGVE 754

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 716 SATcknasVGDKVLYGLYGIVEHSGSMREGHYTAYVKvrtpsrklsehntkkknvpglkaadNESAGQWVHVSDTYLQVV 795
Cdd:COG5560   755 YMV-----DDPRLIYDLYAVDNHYGGLSGGHYTAYAR-------------------------NFANNGWYLFDDSRITEV 804

                         650
                  ....*....|....*..
gi 1068937238 796 PESRALSAQAYLLFYER 812
Cdd:COG5560   805 DPEDSVTSSAYVLFYRR 821
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
190-386 1.46e-20

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 93.28  E-value: 1.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 190 RGITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDsqldpLVVELSRpgpltsalfLFLHSMKETEKGP 269
Cdd:pfam00443   1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSRYNKDIN-----LLCALRD---------LFKALQKNSKSSS 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 270 LSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEEtkriqasilkafnNPTTKTADDetrkkvkaygkegvkmNF 349
Cdd:pfam00443  67 VSPKMFKKSLGKLNPDFSGYKQQDAQEFLLFLLDGLHEDL-------------NGNHSTENE----------------SL 117

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1068937238 350 IDRIFIGELTSTVMCEECANISTVKDPFIDISLPIIE 386
Cdd:pfam00443 118 ITDLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPG 154
zf-UBP pfam02148
Zn-finger in ubiquitin-hydrolases and other protein;
62-132 7.22e-17

Zn-finger in ubiquitin-hydrolases and other protein;


Pssm-ID: 460464  Cd Length: 63  Bit Score: 75.38  E-value: 7.22e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1068937238  62 CSECLkerrfydgqlvLTSDIWLCLKCGFQGCGKNSESqHSLKHFKSSRtepHCIIINLSTWIIWCYECDE 132
Cdd:pfam02148   1 CSLCG-----------NTSNLWLCLTCGHVGCGRYQNS-HALEHYEETG---HPLAVNLSTLTVYCYPCDD 56
ZnF_UBP smart00290
Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;
62-122 2.33e-07

Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;


Pssm-ID: 197632  Cd Length: 50  Bit Score: 48.13  E-value: 2.33e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1068937238   62 CSECLkerrfydgqlvLTSDIWLCLKCGFQGCGkNSESQHSLKHFKSSRtepHCIIINLST 122
Cdd:smart00290   2 CSVCG-----------TIENLWLCLTCGQVGCG-RYQNGHALEHFEETG---HPLVVKLGT 47
 
Name Accession Description Interval E-value
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 603-811 1.49e-70

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 233.43  E-value: 1.49e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 603 AFQTLS-QSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKnkqkyqeetsfaekkvegvytnARKQLLISAVPAV 681
Cdd:cd02667    95 PFLDLSlPRSDEIKSECSIESCLKQFTEVEILEGNNKFACENCTK----------------------AKKQYLISKLPPV 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 682 LILHLKRFHQAGL-SLRKVNRHVDFPLMLDLAPFCSATCKNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRTPSRKL 760
Cdd:cd02667   153 LVIHLKRFQQPRSaNLRKVSRHVSFPEILDLAPFCDPKCNSSEDKSSVLYRLYGVVEHSGTMRSGHYVAYVKVRPPQQRL 232

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1068937238 761 SEHntkkKNVPGLKAADNESAGQWVHVSDTYLQVVPESRALSAQAYLLFYE 811
Cdd:cd02667   233 SDL----TKSKPAADEAGPGSGQWYYISDSDVREVSLEEVLKSEAYLLFYE 279
Peptidase_C19K cd02667
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 191-387 2.96e-38

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239132 [Multi-domain]  Cd Length: 279  Bit Score: 144.07  E-value: 2.96e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAQTYTLTDLMNEikesstklkifpssdsqldplvvelsrpgpltsalflflhsmketekgpl 270
Cdd:cd02667     1 GLSNLGNTCFFNAVMQNLSQTPALRELLSE-------------------------------------------------- 30

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 271 SPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTeetkriqasilkafnnpttktaddetrkkvkaygkegvkmnFI 350
Cdd:cd02667    31 TPKELFSQVCRKAPQFKGYQQQDSHELLRYLLDGLRT-----------------------------------------FI 69

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1068937238 351 DRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEE 387
Cdd:cd02667    70 DSIFGGELTSTIMCESCGTVSLVYEPFLDLSLPRSDE 106
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 612-811 2.31e-31

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 123.36  E-value: 2.31e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 612 ITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKnkqkyqeetsfaekkvegvyTNARKQLLISAVPAVLILHLKRFHQ 691
Cdd:cd02257    93 VKGLPQVSLEDCLEKFFKEEILEGDNCYKCEKKKK--------------------QEATKRLKIKKLPPVLIIHLKRFSF 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 692 AG-LSLRKVNRHVDFPLMLDLAPFCSATCKNASVGDK-VLYGLYGIVEHSG-SMREGHYTAYVKVRTPsrklsehntkkk 768
Cdd:cd02257   153 NEdGTKEKLNTKVSFPLELDLSPYLSEGEKDSDSDNGsYKYELVAVVVHSGtSADSGHYVAYVKDPSD------------ 220

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1068937238 769 nvpglkaadnesaGQWVHVSDTYLQVVPESRAL-----SAQAYLLFYE 811
Cdd:cd02257   221 -------------GKWYKFNDDKVTEVSEEEVLefgslSSSAYILFYE 255
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 619-810 1.75e-30

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 122.38  E-value: 1.75e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 619 SIQSCLYQFTSMELLMGNNKLLCENCTKnkqkyqeetsfaekkvegvYTNARKQLLISAVPAVLILHLKRFhqAGLSLRK 698
Cdd:cd02661   163 SLEDALEQFTKPEQLDGENKYKCERCKK-------------------KVKASKQLTIHRAPNVLTIHLKRF--SNFRGGK 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 699 VNRHVDFPLMLDLAPFCSatcKNASVGDKvlYGLYGIVEHSG-SMREGHYTAYVKvrtpsrklsehntkkknvpglkaad 777
Cdd:cd02661   222 INKQISFPETLDLSPYMS---QPNDGPLK--YKLYAVLVHSGfSPHSGHYYCYVK------------------------- 271

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1068937238 778 nESAGQWVHVSDTYLQVVPESRALSAQAYLLFY 810
Cdd:cd02661   272 -SSNGKWYNMDDSKVSPVSIETVLSQKAYILFY 303
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
598-810 1.28e-29

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 119.85  E-value: 1.28e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 598 YSPQNAFQTLSQSYITTSKECSIQSCLYQFTSMELLMGNNKLLCENCTKNKQKYqeetsfaekkvegvytnarKQLLISA 677
Cdd:pfam00443 142 FEPFSDLSLPIPGDSAELKTASLQICFLQFSKLEELDDEEKYYCDKCGCKQDAI-------------------KQLKISR 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 678 VPAVLILHLKRFHQAGLSLRKVNRHVDFPLMLDLAPFCsATCKNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKvrtps 757
Cdd:pfam00443 203 LPPVLIIHLKRFSYNRSTWEKLNTEVEFPLELDLSRYL-AEELKPKTNNLQDYRLVAVVVHSGSLSSGHYIAYIK----- 276

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1068937238 758 rklsehntkkknvpglkaadNESAGQWVHVSDTYLQVVPESRA-LSAQAYLLFY 810
Cdd:pfam00443 277 --------------------AYENNRWYKFDDEKVTEVDEETAvLSSSAYILFY 310
UBP12 COG5560
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
191-812 9.51e-29

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227847 [Multi-domain]  Cd Length: 823  Bit Score: 123.45  E-value: 9.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAQTYTLTD--LMNEIKESStklkifpssdSQLDPLVVElsrpGPLTSALFLFLHSMKETEKG 268
Cdd:COG5560   267 GLRNLGNTCYMNSALQCLMHTWELRDyfLSDEYEESI----------NEENPLGMH----GSVASAYADLIKQLYDGNLH 332

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 269 PLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRtEETKRIQasILKAFNNPTTKTADDETRKKV-KAYGKEGVKM 347
Cdd:COG5560   333 AFTPSGFKKTIGSFNEEFSGYDQQDSQEFIAFLLDGLH-EDLNRII--KKPYTSKPDLSPGDDVVVKKKaKECWWEHLKR 409

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 348 N--FIDRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEERV-SKPLLWGRMNKYRSLRETDHDRYSGNVTIENIHQP 424
Cdd:COG5560   410 NdsIITDLFQGMYKSTLTCPGCGSVSITFDPFMDLTLPLPVSMVwKHTIVVFPESGRRQPLKIELDASSTIRGLKKLVDA 489

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 425 RAAKKHSSSKDKSQLIHDR---------KCIRKLSS--GETVTYQKNEN-------------LEMNGDSLMFASL---MN 477
Cdd:COG5560   490 EYGKLGCFEIKVMCIYYGGnynmlepadKVLLQDIPqtDFVYLYETNDNgievpvvhlriekGYKSKRLFGDPFLqlnVL 569

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 478 SESRLNESPTDDSEKEASHSESNV-DADSEPSesesaskQTGLFRSSSGsgvqPDGPLYPLSAGKllyTKETDSGDKEma 556
Cdd:COG5560   570 IKASIYDKLVKEFEELLVLVEMKKtDVDLVSE-------QVRLLREESS----PSSWLKLETEID---TKREEQVEEE-- 633

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 557 eaiselrlsstvtgdqdfDRENQPLNIsNNLCFLEGKHLRSYSPQNAFQTLSQSyITTSKECSIQSCLYQFTSMELLMGN 636
Cdd:COG5560   634 ------------------GQMNFNDAV-VISCEWEEKRYLSLFSYDPLWTIREI-GAAERTITLQDCLNEFSKPEQLGLS 693

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 637 NKLLCENCTKNKQkyqeetsfaekkvegvytnARKQLLISAVPAVLILHLKRFHQAGLSLRKVNRHVDFPLM-LDLAPFC 715
Cdd:COG5560   694 DSWYCPGCKEFRQ-------------------ASKQMELWRLPMILIIHLKRFSSVRSFRDKIDDLVEYPIDdLDLSGVE 754

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 716 SATcknasVGDKVLYGLYGIVEHSGSMREGHYTAYVKvrtpsrklsehntkkknvpglkaadNESAGQWVHVSDTYLQVV 795
Cdd:COG5560   755 YMV-----DDPRLIYDLYAVDNHYGGLSGGHYTAYAR-------------------------NFANNGWYLFDDSRITEV 804

                         650
                  ....*....|....*..
gi 1068937238 796 PESRALSAQAYLLFYER 812
Cdd:COG5560   805 DPEDSVTSSAYVLFYRR 821
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 616-811 1.16e-28

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 114.69  E-value: 1.16e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 616 KECSIQSCLYQFTSMELLMGNNKLLCENCTKNkqkyqeetsfaekkvegvyTNARKQLLISAVPAVLILHLKRFHQAGLS 695
Cdd:cd02674    82 PKVTLEDCLRLFTKEETLDGDNAWKCPKCKKK-------------------RKATKKLTISRLPKVLIIHLKRFSFSRGS 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 696 LRKVNRHVDFPL-MLDLAPFCSATCKNASvgdkVLYGLYGIVEHSGSMREGHYTAYVKvrtpsrklsehntkkknvpglk 774
Cdd:cd02674   143 TRKLTTPVTFPLnDLDLTPYVDTRSFTGP----FKYDLYAVVNHYGSLNGGHYTAYCK---------------------- 196

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1068937238 775 aadNESAGQWVHVSDTYLQVVPESRALSAQAYLLFYE 811
Cdd:cd02674   197 ---NNETNDWYKFDDSRVTKVSESSVVSSSAYILFYE 230
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 619-810 3.21e-27

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 113.24  E-value: 3.21e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 619 SIQSCLYQFTSMELLmGNNKLLCENCtknkqkyqeetsfaekkveGVYTNARKQLLISAVPAVLILHLKRF-HQAGLSLR 697
Cdd:cd02660   177 TLSDCLDRFTRPEKL-GDFAYKCSGC-------------------GSTQEATKQLSIKKLPPVLCFQLKRFeHSLNKTSR 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 698 KVNRHVDFPLMLDLAPFCSATC-----KNASVGDKVlYGLYGIVEHSGSMREGHYTAYVKVRTpsrklsehntkkknvpg 772
Cdd:cd02660   237 KIDTYVQFPLELNMTPYTSSSIgdtqdSNSLDPDYT-YDLFAVVVHKGTLDTGHYTAYCRQGD----------------- 298

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1068937238 773 lkaadnesaGQWVHVSDTYLQVVPESRALSAQAYLLFY 810
Cdd:cd02660   299 ---------GQWFKFDDAMITRVSEEEVLKSQAYLLFY 327
UCH pfam00443
Ubiquitin carboxyl-terminal hydrolase;
190-386 1.46e-20

Ubiquitin carboxyl-terminal hydrolase;


Pssm-ID: 425685 [Multi-domain]  Cd Length: 310  Bit Score: 93.28  E-value: 1.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 190 RGITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSDsqldpLVVELSRpgpltsalfLFLHSMKETEKGP 269
Cdd:pfam00443   1 TGLVNLGNTCYMNSVLQSLFSIPPFRDYLLRISPLSEDSRYNKDIN-----LLCALRD---------LFKALQKNSKSSS 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 270 LSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEEtkriqasilkafnNPTTKTADDetrkkvkaygkegvkmNF 349
Cdd:pfam00443  67 VSPKMFKKSLGKLNPDFSGYKQQDAQEFLLFLLDGLHEDL-------------NGNHSTENE----------------SL 117

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1068937238 350 IDRIFIGELTSTVMCEECANISTVKDPFIDISLPIIE 386
Cdd:pfam00443 118 ITDLFRGQLKSRLKCLSCGEVSETFEPFSDLSLPIPG 154
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 619-813 7.99e-20

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 91.55  E-value: 7.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 619 SIQSCLYQFTSMELLMGNNKLLCENCtknkqkyqeetsfaEKKVEgvytnARKQLLISAVPAVLILHLKRFHQAGLSLR- 697
Cdd:cd02659   152 NLEESLDAYVQGETLEGDNKYFCEKC--------------GKKVD-----AEKGVCFKKLPPVLTLQLKRFEFDFETMMr 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 698 -KVNRHVDFPLMLDLAPFCSATCKNASVGDKV------LYGLYGIVEHSGSMREGHYTAYVKVRTPSR----------KL 760
Cdd:cd02659   213 iKINDRFEFPLELDMEPYTEKGLAKKEGDSEKkdsesyIYELHGVLVHSGDAHGGHYYSYIKDRDDGKwykfnddvvtPF 292

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1068937238 761 SEHNTKKKNVPGlkaadnesagqwvHVSDTYLQVVPESRALSAQAYLLFYERV 813
Cdd:cd02659   293 DPNDAEEECFGG-------------EETQKTYDSGPRAFKRTTNAYMLFYERK 332
Peptidase_C19F cd02662
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 670-811 3.71e-17

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239127 [Multi-domain]  Cd Length: 240  Bit Score: 81.64  E-value: 3.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 670 RKQLLISAVPAVLILHLKR--FHQAGLSLRKvNRHVDFPLMLDlapfcsatcknasvgdKVLYGLYGIVEHSGSMREGHY 747
Cdd:cd02662   118 RCQTVIVRLPQILCIHLSRsvFDGRGTSTKN-SCKVSFPERLP----------------KVLYRLRAVVVHYGSHSSGHY 180

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1068937238 748 TAYVKVRTPSRKLSEHNTKKknvpgLKAADNESAGQWVHVSDTYLQVVPESRAL-SAQAYLLFYE 811
Cdd:cd02662   181 VCYRRKPLFSKDKEPGSFVR-----MREGPSSTSHPWWRISDTTVKEVSESEVLeQKSAYMLFYE 240
zf-UBP pfam02148
Zn-finger in ubiquitin-hydrolases and other protein;
62-132 7.22e-17

Zn-finger in ubiquitin-hydrolases and other protein;


Pssm-ID: 460464  Cd Length: 63  Bit Score: 75.38  E-value: 7.22e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1068937238  62 CSECLkerrfydgqlvLTSDIWLCLKCGFQGCGKNSESqHSLKHFKSSRtepHCIIINLSTWIIWCYECDE 132
Cdd:pfam02148   1 CSLCG-----------NTSNLWLCLTCGHVGCGRYQNS-HALEHYEETG---HPLAVNLSTLTVYCYPCDD 56
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 616-811 6.04e-15

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 76.19  E-value: 6.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 616 KECSIQSCLYQFTSMELLMGNNKLLCENCtknkQKYQEetsfaekkvegvytnARKQLLISAVPAVLILHLKRFHQAGls 695
Cdd:cd02663   145 QNTSITSCLRQFSATETLCGRNKFYCDEC----CSLQE---------------AEKRMKIKKLPKILALHLKRFKYDE-- 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 696 lrKVNRH------VDFPLMLDLapfcSATCKNASVGDKvLYGLYGIVEHSGS--MReGHYTAYVKvrtpsrklsehntkk 767
Cdd:cd02663   204 --QLNRYiklfyrVVFPLELRL----FNTTDDAENPDR-LYELVAVVVHIGGgpNH-GHYVSIVK--------------- 260

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1068937238 768 knvpglkaadneSAGQWV--------HVSDTYLQVVPESRALSAQAYLLFYE 811
Cdd:cd02663   261 ------------SHGGWLlfddetveKIDENAVEEFFGDSPNQATAYVLFYQ 300
Peptidase_C19D cd02660
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 190-392 2.69e-14

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239125 [Multi-domain]  Cd Length: 328  Bit Score: 74.72  E-value: 2.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 190 RGITNLGNTCFFNAVMQNLAQTYTLTDLMneikeSSTKLKIFPSSDSQLDPLVVELSRpgpltsaLFLFLHSMKETEkgP 269
Cdd:cd02660     1 RGLINLGATCFMNVILQALLHNPLLRNYF-----LSDRHSCTCLSCSPNSCLSCAMDE-------IFQEFYYSGDRS--P 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 270 LSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRiqasilkafnnpttktaddetrkkVKAYGKEGVKMNF 349
Cdd:cd02660    67 YGPINLLYLSWKHSRNLAGYSQQDAHEFFQFLLDQLHTHYGGD------------------------KNEANDESHCNCI 122

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1068937238 350 IDRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEERVSKP 392
Cdd:cd02660   123 IHQTFSGSLQSSVTCQRCGGVSTTVDPFLDLSLDIPNKSTPSW 165
Peptidase_C19H cd02664
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 618-811 8.50e-14

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239129 [Multi-domain]  Cd Length: 327  Bit Score: 73.29  E-value: 8.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 618 CSIQSCLYQFTSMELLMGNNKLLCENCTKNKQkyqeetsfAEKKVEgvytnarkqllISAVPAVLILHLKRFH--QAGLS 695
Cdd:cd02664   134 PSVQDLLNYFLSPEKLTGDNQYYCEKCASLQD--------AEKEMK-----------VTGAPEYLILTLLRFSydQKTHV 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 696 LRKVNRHVDFPLMLDLaPFCSATCKNASVGDK---------------VLYGLYGIVEHSG-SMREGHYTAYVKVRTPSRK 759
Cdd:cd02664   195 REKIMDNVSINEVLSL-PVRVESKSSESPLEKkeeesgddgelvtrqVHYRLYAVVVHSGySSESGHYFTYARDQTDADS 273

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1068937238 760 lsehnTKKKNVPGLKAADNESAGQWVHVSDTYlqvVPESRALSAQ----------AYLLFYE 811
Cdd:cd02664   274 -----TGQECPEPKDAEENDESKNWYLFNDSR---VTFSSFESVQnvtsrfpkdtPYILFYE 327
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 626-752 1.01e-13

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 73.00  E-value: 1.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 626 QFTSMELLMGNNKLLCENCTKnkqkyqeetsfaekkvegvYTNARKQLLISAVPAVLILHLKRFHQAGLS------LRKV 699
Cdd:cd02671   188 QFASVERIVGEDKYFCENCHH-------------------YTEAERSLLFDKLPEVITIHLKCFAANGSEfdcyggLSKV 248

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1068937238 700 NRHVDFPLMLDLAPFCSATcknasvgDKVLYGLYGIVEHSG-SMREGHYTAYVK 752
Cdd:cd02671   249 NTPLLTPLKLSLEEWSTKP-------KNDVYRLFAVVMHSGaTISSGHYTAYVR 295
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 587-752 8.72e-13

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 70.14  E-value: 8.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 587 LCFLEGKHLRSYSP--QNAFQTLSQ---SYITTSKEC---------------------SIQSCLYQFTSMELLMGNNKLL 640
Cdd:cd02668    99 LSLLEAKLSKSKNPdlKNIVQDLFRgeySYVTQCSKCgresslpskfyelelqlkghkTLEECIDEFLKEEQLTGDNQYF 178

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 641 CENCTKNkqkyqeetsfaekkvegvyTNARKQLLISAVPAVLILHLKR--FHQAGLSLRKVNRHVDFPLMLDLAPFCSAT 718
Cdd:cd02668   179 CESCNSK-------------------TDATRRIRLTTLPPTLNFQLLRfvFDRKTGAKKKLNASISFPEILDMGEYLAES 239

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1068937238 719 CKNASVgdkvlYGLYGIVEHSG-SMREGHYTAYVK 752
Cdd:cd02668   240 DEGSYV-----YELSGVLIHQGvSAYSGHYIAHIK 269
Peptidase_C19E cd02661
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 190-384 4.23e-12

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239126 [Multi-domain]  Cd Length: 304  Bit Score: 67.69  E-value: 4.23e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 190 RGITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSsdsqldplvvelsrpgpLTSALFLFLHSMKETEKGP 269
Cdd:cd02661     2 AGLQNLGNTCFLNSVLQCLTHTPPLANYLLSREHSKDCCNEGFC-----------------MMCALEAHVERALASSGPG 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 270 LSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAvrteetkrIQASILKAFNNpttktaDDETRKKVKAYgkegvkmNF 349
Cdd:cd02661    65 SAPRIFSSNLKQISKHFRIGRQEDAHEFLRYLLDA--------MQKACLDRFKK------LKAVDPSSQET-------TL 123

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1068937238 350 IDRIFIGELTSTVMCEECANISTVKDPFIDISLPI 384
Cdd:cd02661   124 VQQIFGGYLRSQVKCLNCKHVSNTYDPFLDLSLDI 158
COG5077 COG5077
Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, ...
 619-752 7.40e-12

Ubiquitin carboxyl-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227409 [Multi-domain]  Cd Length: 1089  Bit Score: 69.13  E-value: 7.40e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238  619 SIQSCLYQFTSMELLMGNNKLLCEnctknKQKYQEetsfaekkvegvytnARKQLLISAVPAVLILHLKRFHQAGLS--L 696
Cdd:COG5077    339 NLQESFRRYIQVETLDGDNRYNAE-----KHGLQD---------------AKKGVIFESLPPVLHLQLKRFEYDFERdmM 398

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1068937238  697 RKVNRHVDFPLMLDLAPFCSATCKNASVGDKVlYGLYGIVEHSGSMREGHYTAYVK 752
Cdd:COG5077    399 VKINDRYEFPLEIDLLPFLDRDADKSENSDAV-YVLYGVLVHSGDLHEGHYYALLK 453
COG5533 COG5533
Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];
644-812 4.08e-11

Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444284 [Multi-domain]  Cd Length: 284  Bit Score: 64.44  E-value: 4.08e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 644 CTKNKQKYQ--EETSFAEKKVEGVYTNARKQLLISAV--PAVLILHLKRFHQAGlSLRKVNRHVDFPLMLDLAPfcsatC 719
Cdd:COG5533   141 EFIDNMEELvdDETGVKAKENEELEVQAKQEYEVSFVklPKILTIQLKRFANLG-GNQKIDTEVDEKFELPVKH-----D 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 720 KNASVGDKVLYGLYGIVEHSGSMREGHYTAYVKVRtpsrklsehntkkknvpglkaadnesaGQWVHVSDTYLQVVPESR 799
Cdd:COG5533   215 QILNIVKETYYDLVGFVLHQGSLEGGHYIAYVKKG---------------------------GKWEKANDSDVTPVSEEE 267

                         170
                  ....*....|....*.
gi 1068937238 800 AL---SAQAYLLFYER 812
Cdd:COG5533   268 AInekAKNAYLYFYER 283
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 191-375 7.04e-11

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 64.27  E-value: 7.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLaqtYTLTDLMNEIKESSTKLKifpSSDSQLDPLVVELSRpgpltsalfLFlHSMKETEKgPL 270
Cdd:cd02657     1 GLTNLGNTCYLNSTLQCL---RSVPELRDALKNYNPARR---GANQSSDNLTNALRD---------LF-DTMDKKQE-PV 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 271 SPKVLFNQLCQKAPRFKDFQ------QQDSQELLhylldavrteetkriqASILKAFNNpttktaddetrkkvkAYGKEG 344
Cdd:cd02657    64 PPIEFLQLLRMAFPQFAEKQnqggyaQQDAEECW----------------SQLLSVLSQ---------------KLPGAG 112

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1068937238 345 VKMNFIDRIFIGELTSTVMCEECANISTVKD 375
Cdd:cd02657   113 SKGSFIDQLFGIELETKMKCTESPDEEEVST 143
Peptidase_C19A cd02657
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 648-767 1.98e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239122 [Multi-domain]  Cd Length: 305  Bit Score: 62.73  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 648 KQKYQEETsfaEKKVEGVYTNA--RKQLLISAVPAVLILHLKRFHQAGLSLR--KVNRHVDFPLMLDLAPFCSATCknas 723
Cdd:cd02657   167 KKGLEEEI---EKHSPTLGRDAiyTKTSRISRLPKYLTVQFVRFFWKRDIQKkaKILRKVKFPFELDLYELCTPSG---- 239

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1068937238 724 vgdkvLYGLYGIVEHSG-SMREGHYTAYVKVRTPSR-------KLSEHNTKK 767
Cdd:cd02657   240 -----YYELVAVITHQGrSADSGHYVAWVRRKNDGKwikfdddKVSEVTEED 286
Peptidase_C19O cd02671
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 187-391 5.45e-10

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239136 [Multi-domain]  Cd Length: 332  Bit Score: 61.83  E-value: 5.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 187 LSVRGITNLGNTCFFNAVMQNLaqtYTLTDLMNEIKESSTKLkifpSSDSQLdplvvelsrpgpltSALFLFLHSMKETE 266
Cdd:cd02671    22 LPFVGLNNLGNTCYLNSVLQVL---YFCPGFKHGLKHLVSLI----SSVEQL--------------QSSFLLNPEKYNDE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 267 KGPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRteetkriqasilkafnnpttktaddetrkkvkaygkegvk 346
Cdd:cd02671    81 LANQAPRRLLNALREVNPMYEGYLQHDAQEVLQCILGNIQ---------------------------------------- 120

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1068937238 347 mNFIDRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEERVSK 391
Cdd:cd02671   121 -ELVEKDFQGQLVLRTRCLECETFTERREDFQDISVPVQESELSK 164
Peptidase_C19G cd02663
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 191-384 1.99e-09

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239128 [Multi-domain]  Cd Length: 300  Bit Score: 59.63  E-value: 1.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAQT---YTLTDLMNEIKESSTKLkifpssdsqldplvvelsrpgpltsalflflhsmketek 267
Cdd:cd02663     1 GLENFGNTCYCNSVLQALYFEnllTCLKDLFESISEQKKRT--------------------------------------- 41

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 268 GPLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLdavrteetkriqasilkafnNPTTKTADDEtRKKVKAYGKEGVKM 347
Cdd:cd02663    42 GVISPKKFITRLKRENELFDNYMHQDAHEFLNFLL--------------------NEIAEILDAE-RKAEKANRKLNNNN 100

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1068937238 348 ------NFIDRIFIGELTSTVMCEECANISTVKDPFIDISLPI 384
Cdd:cd02663   101 naepqpTWVHEIFQGILTNETRCLTCETVSSRDETFLDLSIDV 143
Peptidase_C19 cd02257
Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ...
 191-384 3.25e-09

Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239072 [Multi-domain]  Cd Length: 255  Bit Score: 58.65  E-value: 3.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAqtytltdlmneikesstklkifpssdsqldplvvelsrpgpltsalflflhsmketekgpl 270
Cdd:cd02257     1 GLNNLGNTCYLNSVLQALF------------------------------------------------------------- 19

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 271 spkvlfnqlcqkaprfkdFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNpttktaddetrkkvkaygkegvkmNFI 350
Cdd:cd02257    20 ------------------SEQQDAHEFLLFLLDKLHEELKKSSKRTSDSSSLK------------------------SLI 57

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1068937238 351 DRIFIGELTSTVMCEECANISTVKDPFIDISLPI 384
Cdd:cd02257    58 HDLFGGKLESTIVCLECGHESVSTEPELFLSLPL 91
Peptidase_C19H cd02664
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 191-402 4.16e-09

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239129 [Multi-domain]  Cd Length: 327  Bit Score: 59.04  E-value: 4.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAQTytlTDLMNEIkessTKLKIFPSSDSQLDPLVVELsrpgpltsaLFLFLHSMKETEKGPl 270
Cdd:cd02664     1 GLINLGNTCYMNSVLQALFMA---KDFRRQV----LSLNLPRLGDSQSVMKKLQL---------LQAHLMHTQRRAEAP- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 271 sPKVLFNQlcQKAPRFKDFQQQDSQELLHYLLDAVRTeetkriqasilkafnnpttktaddetrkkvkaygkegvkmnFI 350
Cdd:cd02664    64 -PDYFLEA--SRPPWFTPGSQQDCSEYLRYLLDRLHT-----------------------------------------LI 99

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1068937238 351 DRIFIGELTSTVMCEECANISTVKD--PFIDISLP----IIEERVSKPLLWGRmNKYR 402
Cdd:cd02664   100 EKMFGGKLSTTIRCLNCNSTSARTErfRDLDLSFPsvqdLLNYFLSPEKLTGD-NQYY 156
peptidase_C19C cd02659
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 191-384 5.02e-08

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239124 [Multi-domain]  Cd Length: 334  Bit Score: 55.73  E-value: 5.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLaqtYTLTDLMNEIkesstkLKIFPSSDSQLDPlvvelSRPGPLTSaLFLFLHSMKEtekgpl 270
Cdd:cd02659     4 GLKNQGATCYMNSLLQQL---YMTPEFRNAV------YSIPPTEDDDDNK-----SVPLALQR-LFLFLQLSES------ 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 271 spKVLFNQLCQKAPRFKD-----FQQQDSQELLHYLLDAVRTeetkriqasilkafnnpttktaddetrkKVKAYGKEGV 345
Cdd:cd02659    63 --PVKTTELTDKTRSFGWdslntFEQHDVQEFFRVLFDKLEE----------------------------KLKGTGQEGL 112

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1068937238 346 kmnfIDRIFIGELTSTVMCEECANISTVKDPFIDISLPI 384
Cdd:cd02659   113 ----IKNLFGGKLVNYIICKECPHESEREEYFLDLQVAV 147
ZnF_UBP smart00290
Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;
62-122 2.33e-07

Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger;


Pssm-ID: 197632  Cd Length: 50  Bit Score: 48.13  E-value: 2.33e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1068937238   62 CSECLkerrfydgqlvLTSDIWLCLKCGFQGCGkNSESQHSLKHFKSSRtepHCIIINLST 122
Cdd:smart00290   2 CSVCG-----------TIENLWLCLTCGQVGCG-RYQNGHALEHFEETG---HPLVVKLGT 47
Peptidase_C19R cd02674
A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 191-392 1.16e-06

A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239139 [Multi-domain]  Cd Length: 230  Bit Score: 50.36  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAQtytltdlmneikesstklkifpssdsqldplvvelsrpgpltsalflflhsmketekgpl 270
Cdd:cd02674     1 GLRNLGNTCYMNSILQCLSA------------------------------------------------------------ 20

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 271 spkvlfnqlcqkaprfkdfQQQDSQELLHYLLDAVRteetkriqasilkafnnpttktaddetrkkvkaygkegvkmNFI 350
Cdd:cd02674    21 -------------------DQQDAQEFLLFLLDGLH-----------------------------------------SII 40

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1068937238 351 DRIFIGELTSTVMCEECANISTVKDPFIDISLPIIEERVSKP 392
Cdd:cd02674    41 VDLFQGQLKSRLTCLTCGKTSTTFEPFTYLSLPIPSGSGDAP 82
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 191-321 1.84e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 50.78  E-value: 1.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLAQTYTLTDLMNEIKESSTKLKIFPSSD--SQLDPLVVEL-----SRPGPLTSalflflhSMK 263
Cdd:cd02658     1 GLRNLGNSCYLNSVLQVLFSIPSFQWRYDDLENKFPSDVVDPANDlnCQLIKLADGLlsgrySKPASLKS-------END 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1068937238 264 ETEKGpLSPKVLFNQLCQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAF 321
Cdd:cd02658    74 PYQVG-IKPSMFKALIGKGHPEFSTMRQQDALEFLLHLIDKLDRESFKNLGLNPNDLF 130
Peptidase_C19B cd02658
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 657-811 6.17e-06

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239123 [Multi-domain]  Cd Length: 311  Bit Score: 48.86  E-value: 6.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 657 FAEKKVE------GVYTNARKQLLISAVPAVLILHLKRFH-QAGLSLRKVNRHVDFPLMLDLAPfcsatcknasvgdkvl 729
Cdd:cd02658   188 FAPETIEdfcstcKEKTTATKTTGFKTFPDYLVINMKRFQlLENWVPKKLDVPIDVPEELGPGK---------------- 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 730 YGLYGIVEHSG-SMREGHYTAYVKvrtpsrklsehntkkknvpglKAADNEsaGQWVHVSDTYLQVVPESRALSAQAYLL 808
Cdd:cd02658   252 YELIAFISHKGtSVHSGHYVAHIK---------------------KEIDGE--GKWVLFNDEKVVASQDPPEMKKLGYIY 308


                  ...
gi 1068937238 809 FYE 811
Cdd:cd02658   309 FYQ 311
Peptidase_C19L cd02668
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 191-384 1.02e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239133 [Multi-domain]  Cd Length: 324  Bit Score: 45.10  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 191 GITNLGNTCFFNAVMQNLaqtYTLTDLMN-----EIKESSTKLKIFPSSDSQLDPLVVELSRpgpltsaLFLFLHSmkeT 265
Cdd:cd02668     1 GLKNLGATCYVNSFLQLW---FMNLEFRKavyecNSTEDAELKNMPPDKPHEPQTIIDQLQL-------IFAQLQF---G 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 266 EKGPLSPKVLFNQLcqkapRFKDFQQQDSQELLHYLLDAvrteetkrIQASILKAFNNpttktaddetrkKVKaygkegv 345
Cdd:cd02668    68 NRSVVDPSGFVKAL-----GLDTGQQQDAQEFSKLFLSL--------LEAKLSKSKNP------------DLK------- 115

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1068937238 346 kmNFIDRIFIGELTSTVMCEECANISTVKDPFIDISLPI 384
Cdd:cd02668   116 --NIVQDLFRGEYSYVTQCSKCGRESSLPSKFYELELQL 152
Peptidase_C19N cd02670
A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are ...
 675-811 1.67e-04

A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl group of the C-terminal Gly residue of ubiquitin. The purpose of the de-ubiquitination is thought to be editing of the ubiquitin conjugates, which could rescue them from degradation, as well as recycling of the ubiquitin. The ubiquitin/proteasome system is responsible for most protein turnover in the mammalian cell, and with over 50 members, family C19 is one of the largest families of peptidases in the human genome.


Pssm-ID: 239135 [Multi-domain]  Cd Length: 241  Bit Score: 44.05  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 675 ISAVPAVLILHLKRFHQAGLSLRKVNRHVDFPLMLDLAPF----------CSATCKNASVGD-------KVLYGLYGIVE 737
Cdd:cd02670    95 FAKAPSCLIICLKRYGKTEGKAQKMFKKILIPDEIDIPDFvaddpracskCQLECRVCYDDKdfsptcgKFKLSLCSAVC 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1068937238 738 HSGSMRE-GHYTAYVKVrtpsrklsehNTKKKNVPGLKAADNesagQWVHVSD-------TYLQVVPESRALSaQAYLLF 809
Cdd:cd02670   175 HRGTSLEtGHYVAFVRY----------GSYSLTETDNEAYNA----QWVFFDDmadrdgvSNGFNIPAARLLE-DPYMLF 239


                  ..
gi 1068937238 810 YE 811
Cdd:cd02670   240 YQ 241
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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