NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1072314148|ref|NP_001333155|]
View 

WD repeat-containing protein 48 isoform 5 [Homo sapiens]

Protein Classification

WD repeat WDR48 family protein( domain architecture ID 10078073)

WD repeat WDR48 family protein similar to WD repeat-containing protein 48, a regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 452-616 4.73e-60

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


:

Pssm-ID: 463358  Cd Length: 171  Bit Score: 197.90  E-value: 4.73e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 452 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHASSGAKTL- 523
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 524 ------KKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKeediavlAEEKIELLCQDQVLDPNMDL 597
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 1072314148 598 RTVKHFIWKSGGDLTLHYR 616
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-229 1.54e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.45  E-value: 1.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  17 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALT 96
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  97 asnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGT 176
Cdd:cd00200   130 ---------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1072314148 177 IRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDI 229
Cdd:cd00200   201 IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253
 
Name Accession Description Interval E-value
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 452-616 4.73e-60

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 197.90  E-value: 4.73e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 452 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHASSGAKTL- 523
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 524 ------KKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKeediavlAEEKIELLCQDQVLDPNMDL 597
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 1072314148 598 RTVKHFIWKSGGDLTLHYR 616
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-229 1.54e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.45  E-value: 1.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  17 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALT 96
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  97 asnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGT 176
Cdd:cd00200   130 ---------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1072314148 177 IRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDI 229
Cdd:cd00200   201 IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
11-219 6.53e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.48  E-value: 6.53e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  11 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 90
Cdd:COG2319   197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  91 TLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLS 170
Cdd:COG2319   277 TGELLR---------TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1072314148 171 GSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAFT----HVYSGGRDRKI 219
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSV----AFSpdgrTLASGSADGTV 396
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 504-616 2.01e-48

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 163.99  E-value: 2.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 504 KFNKIPFYLQPHASSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTtsssnnekpgeqekeediAVLAEEK 581
Cdd:cd17041     1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1072314148 582 IELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYR 616
Cdd:cd17041    63 LELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 56-229 1.53e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 64.34  E-value: 1.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  56 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAlTASNNTVTTSSLSGnKDSIYSLAMNQ-LGTIIVSGSTEKV 134
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIK-DGRDIHYPVVELAS-RSKLSGICWNSyIKSQVASSNFEGV 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 135 LRVWDPRTCAKLMKLKGHTDNVKAL-LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVhDEGVWALQV-NDAFTHVYS 212
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                         170
                  ....*....|....*..
gi 1072314148 213 GGRDRKIYCTDLRNPDI 229
Cdd:PLN00181  636 GSADHKVYYYDLRNPKL 652
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-181 5.38e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 5.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1072314148  142 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 181
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
146-181 1.61e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1072314148 146 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 181
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
DUF3337 pfam11816
Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. ...
 452-616 4.73e-60

Domain of unknown function (DUF3337); This family of proteins are functionally uncharacterized. This family is only found in eukaryotes. This presumed domain is typically between 285 to 342 amino acids in length.


Pssm-ID: 463358  Cd Length: 171  Bit Score: 197.90  E-value: 4.73e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 452 VPPHTPVIFGE-----AGGRTLFRLLCRDSGGETEsmLLNETVPQWVIDITVDKNMP--KFNKIPFYLQPHASSGAKTL- 523
Cdd:pfam11816   1 LPPDTTIIISEespdsGGGRDLYRGTVGDIGEDVD--LLEEVAPMWLGDVLLYNKIPpkEPVKISFVLQPWPGSDLPPDk 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 524 ------KKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKeediavlAEEKIELLCQDQVLDPNMDL 597
Cdd:pfam11816  79 lpelpnKNSRLNANRMLRVRKILAYVAEKLESLTPEMKPPSPDEDENADKKLK-------PEEYLELLCNDQVLPPNMTL 151

                         170
                  ....*....|....*....
gi 1072314148 598 RTVKHFIWKSGGDLTLHYR 616
Cdd:pfam11816 152 ATVKTFIWKSGGDIVLHYR 170
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-229 1.54e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 179.45  E-value: 1.54e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  17 HTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALT 96
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  97 asnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGT 176
Cdd:cd00200   130 ---------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1072314148 177 IRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDI 229
Cdd:cd00200   201 IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
11-219 6.53e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.48  E-value: 6.53e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  11 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 90
Cdd:COG2319   197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  91 TLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLS 170
Cdd:COG2319   277 TGELLR---------TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1072314148 171 GSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAFT----HVYSGGRDRKI 219
Cdd:COG2319   348 GSDDGTVRLWDLATGELLRTLTGHTGAVTSV----AFSpdgrTLASGSADGTV 396
Ubl_WDR48 cd17041
Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar ...
 504-616 2.01e-48

Ubiquitin-like (Ubl) domain found in WD repeat-containing protein 48 (WDR48) and similar proteins; WDR48, also termed USP1-associated factor 1 (UAF1), or WD repeat endosomal protein, or p80, is required for the histone deubiquitination activity. It stimulates activity of ubiquitin-specific proteases USP1, USP12, and USP46.As potential tumor suppressor, WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). WDR48 also functions as a novel interaction partner of E1 helicase from anogenital human papillomavirus (HPV) types, and plays an essential role in anogenital HPV DNA replication. WDR48 contains a WD40 domain and a ubiquitin-like domain that shows high sequence and structural similarity with RING finger- and WD40-associated ubiquitin-like (RAWUL) domain.


Pssm-ID: 340561  Cd Length: 97  Bit Score: 163.99  E-value: 2.01e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 504 KFNKIPFYLQPHASSGA--KTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTtsssnnekpgeqekeediAVLAEEK 581
Cdd:cd17041     1 EFPKISFFLQPHPSSGLppKTLKNDKLSASRMLRVRKVMEYVAEKLLGQEPESQD------------------ASNPEEK 62

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1072314148 582 IELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYR 616
Cdd:cd17041    63 LELLCNDQVLDPNMTLATVKHFIWKSGGDLVLHYR 97
WD40 COG2319
WD40 repeat [General function prediction only];
11-226 1.31e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 1.31e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  11 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 90
Cdd:COG2319   155 LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  91 TLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLS 170
Cdd:COG2319   235 TGKLLR---------TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1072314148 171 GSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRN 226
Cdd:COG2319   306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
11-182 3.58e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 3.58e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  11 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 90
Cdd:COG2319   239 LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  91 TLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLS 170
Cdd:COG2319   319 TGKLLR---------TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                         170
                  ....*....|..
gi 1072314148 171 GSSDGTIRLWSL 182
Cdd:COG2319   390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-181 5.72e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.39  E-value: 5.72e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  11 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 90
Cdd:cd00200   128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  91 TLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLS 170
Cdd:cd00200   208 TGKCLG---------TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         170
                  ....*....|.
gi 1072314148 171 GSSDGTIRLWS 181
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
11-219 4.38e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 4.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  11 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 90
Cdd:COG2319    29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  91 TLTALTAsnntvttssLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLS 170
Cdd:COG2319   109 TGLLLRT---------LTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLAS 179

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1072314148 171 GSSDGTIRLWSLGQQRCIATYRVHDEGVWALqvndAF----THVYSGGRDRKI 219
Cdd:COG2319   180 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSV----AFspdgKLLASGSADGTV 228
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 52-225 7.54e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 7.54e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  52 CMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALT------------------------ASNNTV----- 102
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRtlkghtgpvrdvaasadgtylasgSSDKTIrlwdl 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 103 ----TTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIR 178
Cdd:cd00200    81 etgeCVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1072314148 179 LWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLR 225
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
WD40 COG2319
WD40 repeat [General function prediction only];
11-142 1.98e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 1.98e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  11 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVN 90
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1072314148  91 TLTALTasnntvttsSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRT 142
Cdd:COG2319   361 TGELLR---------TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
67-219 7.59e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 7.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  67 AYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttssLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKL 146
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLL---------LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALL 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1072314148 147 MKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKI 219
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 56-229 1.53e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 64.34  E-value: 1.53e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  56 LRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTAlTASNNTVTTSSLSGnKDSIYSLAMNQ-LGTIIVSGSTEKV 134
Cdd:PLN00181  479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIK-DGRDIHYPVVELAS-RSKLSGICWNSyIKSQVASSNFEGV 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 135 LRVWDPRTCAKLMKLKGHTDNVKAL-LLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVhDEGVWALQV-NDAFTHVYS 212
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFpSESGRSLAF 635

                         170
                  ....*....|....*..
gi 1072314148 213 GGRDRKIYCTDLRNPDI 229
Cdd:PLN00181  636 GSADHKVYYYDLRNPKL 652
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 149-238 7.48e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.43  E-value: 7.48e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 149 LKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPD 228
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                          90
                  ....*....|.
gi 1072314148 229 -IRVLICEEKA 238
Cdd:cd00200    85 cVRTLTGHTSY 95
PTZ00421 PTZ00421
coronin; Provisional
 29-143 2.66e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.36  E-value: 2.66e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  29 NGKTLISASSDTTVKVWN-AHKGFCMST------LRTHKDYVKALAY-AKDKELVASAGLDRQIFLWDVNTLTALTasnn 100
Cdd:PTZ00421   87 DPQKLFTASEDGTIMGWGiPEEGLTQNIsdpivhLQGHTKKVGIVSFhPSAMNVLASAGADMVVNVWDVERGKAVE---- 162

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1072314148 101 tvTTSSLSgnkDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTC 143
Cdd:PTZ00421  163 --VIKCHS---DQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-181 5.38e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 5.38e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1072314148  142 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 181
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Ubiquitin_like_fold cd00196
Beta-grasp ubiquitin-like fold; Ubiquitin is a protein modifier that is involved in various ...
 521-616 6.05e-07

Beta-grasp ubiquitin-like fold; Ubiquitin is a protein modifier that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair in eukaryotes. The ubiquitination process comprises a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C-terminus of ubiquitin and the epsilon-amino group of a substrate lysine. Ubiquitin-like proteins have similar ubiquitin beta-grasp fold and attach to other proteins in a ubiquitin-like manner but with biochemically distinct roles. Ubiquitin and ubiquitin-like proteins conjugate and deconjugate via ligases and peptidases to covalently modify target polypeptides. Some other ubiquitin-like domains have adaptor roles in ubiquitin-signaling by mediating protein-protein interaction. In addition to Ubiquitin-like (Ubl) domain, Ras-associating (RA) domain, F0/F1 sub-domain of FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, TGS (ThrRS, GTPase and SpoT) domain, Ras-binding domain (RBD), Ubiquitin regulatory domain X (UBX), Dublecortin-like domain, and RING finger- and WD40-associated ubiquitin-like (RAWUL) domain have beta-grasp ubiquitin-like folds, and are included in this superfamily.


Pssm-ID: 340450  Cd Length: 68  Bit Score: 46.93  E-value: 6.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 521 KTLKKDRLSASDMLQVRKVMEHVYEKIInldnesqttsssnnekpgeqekeediavLAEEKIELLCQDQVLDPNMDLRTv 600
Cdd:cd00196     6 PSLKKIVVAVPPSTTLRQVLEKVAKRIG----------------------------LPPDVIRLLFNGQVLDDLMTAKQ- 56

                          90
                  ....*....|....*.
gi 1072314148 601 khfiWKSGGDLTLHYR 616
Cdd:cd00196    57 ----VGLEPGEELHFV 68
WD40 pfam00400
WD domain, G-beta repeat;
146-181 1.61e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.03  E-value: 1.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1072314148 146 LMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWS 181
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 11-46 2.27e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 2.27e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1072314148   11 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 46
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
11-46 7.13e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 7.13e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1072314148  11 IASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWN 46
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-88 1.65e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.65e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1072314148   49 KGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 88
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
50-88 4.79e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 4.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1072314148  50 GFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 88
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 26-182 7.53e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 7.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  26 LCCNG--KTLISASS-DTTVKVWNAHKGFCMSTLRTHKDYVKALAYAK-DKELVASAGLDRQIFLWDVNTLTALTASNNT 101
Cdd:PLN00181  538 ICWNSyiKSQVASSNfEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTK 617

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148 102 VTTSSLSGNKDSIYSLAMnqlgtiivsGSTEKVLRVWDPRTCA-KLMKLKGHTDNVKALLLnRDGTQCLSGSSDGTIRLW 180
Cdd:PLN00181  618 ANICCVQFPSESGRSLAF---------GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLW 687


                  ..
gi 1072314148 181 SL 182
Cdd:PLN00181  688 DL 689
PTZ00421 PTZ00421
coronin; Provisional
 33-145 7.56e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 7.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1072314148  33 LISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSlsgnKD 112
Cdd:PTZ00421  141 LASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKS----QR 216

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1072314148 113 SIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAK 145
Cdd:PTZ00421  217 CLWAKRKDLIITLGCSKSQQRQIMLWDTRKMAS 249
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 105-139 6.59e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 6.59e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1072314148  105 SSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 139
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
104-139 1.53e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1072314148 104 TSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWD 139
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
RAWUL pfam16207
RAWUL domain RING finger- and WD40-associated ubiquitin-like; The RAWUL domain is found at the ...
 581-616 5.19e-03

RAWUL domain RING finger- and WD40-associated ubiquitin-like; The RAWUL domain is found at the C-terminus of poly-comb group RING finger proteins. It is a ubiquitin-like domain. RAWUL binds directly to PUFD, a domain on BCOR proteins (BCL6 corepressor). BCOR has emerged as an important player in development and health.


Pssm-ID: 465067  Cd Length: 66  Bit Score: 36.00  E-value: 5.19e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1072314148 581 KIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYR 616
Cdd:pfam16207  31 IVEILYNGEPLPDSYTLDVAYIKYWKRNAPLELYYR 66
RAWUL_PCGF_like cd16102
RRING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in PCGF1-6, RING1 and -2, ...
 578-616 7.56e-03

RRING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in PCGF1-6, RING1 and -2, DRIP and similar proteins; structurally similar to a beta-grasp ubiquitin-like fold; The family includes six Polycomb Group (PcG) RING finger homologs (PCGF1/NSPc1, PCGF2/Mel-18, PCGF3, PCGF4/BMI1, PCGF5, and PCGF6/MBLR) that use epigenetic mechanisms to maintain or repress expression of their target genes. They were first discovered in fruit flies that can remodel chromatin such that epigenetic silencing of genes takes place, and are well known for silencing Hox genes through modulation of chromatin structure during embryonic development in fruit flies. PCGF homologs play important roles in cell proliferation, differentiation, and tumorigenesis. They all have been found to associate with ring finger protein 2 (RNF2). The RNF2-PCGF heterodimer is catalytically competent as an E3 ubiquitin transferase and is the scaffold for the assembly of additional components. Moreover, PCGF homologs are critical components in the assembly of distinct Polycomb Repression Complex 1 (PRC1) related complexes which are involved in the maintenance of gene repression and target different genes through distinct mechanisms. The Drosophila PRC1 core complex is formed by the Polycomb (Pc), Polyhomeotic (Ph), Posterior sex combs (Psc), and Sex combs extra (Sce, also known as Ring) subunits. In mammals, the composition of PRC1 is much more diverse and varies depending on the cellular context. All PRC1 complexes contain homologs of the Drosophila Ring protein. Ring1A/RNF1 and Ring1B/RNF2 are E3 ubiquitin ligases that mark lysine 119 of histone H2A with a single ubiquitin group (H2AK119ub). Mammalian homologs of the Drosophila Psc protein, such as PCGF2/Mel-18 or PCGF4/BMI1, regulate PRC1 enzymatic activity. PRC1 complexes can be divided into at least two classes according to the presence or absence of CBX proteins, which are homologs of Drosophila Pc. Canonical PRC1 complexes contain CBX proteins that recognize and bind H3K27me3, the mark deposited by PRC2. Therefore, canonical PRC1 complexes and PRC2 can act together to repress gene transcription and maintain this repression through cell division. Non-canonical PRC1 complexes, containing RYBP (together with additional proteins, such as L3mbtl2 or Kdm2b) rather than the CBX proteins, have recently been described in mammals. PCGF homologs contain a C3HC4-type RING-HC finger, and a RAWUL domain that might be responsible for interaction with Cbx members of the Polycomb repression complexes.


Pssm-ID: 340519  Cd Length: 87  Bit Score: 36.10  E-value: 7.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1072314148 578 AEEKIELLCQDQVLDPNMDLRTVKHFIW-KSGGDLTLHYR 616
Cdd:cd16102    48 SEQDLDILCRGELLGKEHTLKFIWRTRWrKQDGPLVLQYR 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH