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Conserved domains on  [gi|1112917096|ref|NP_001334633|]
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THO complex subunit 6 homolog isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
31-287 8.03e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 8.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  31 SVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSM-VSTD-RHLLSAG-DGEVKAWlwaemlk 107
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDL----------ATGKLLRTLTGHSGAVTSVaFSPDgKLLASGSdDGTVRLW------- 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 108 kgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALrerSPE---VL 184
Cdd:COG2319   190 ----DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrlLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 185 SGGEDGAVRLWDLRTAKEVQTIEvykheecsrpHNGRWIGCLAT--DSDWMVCGGG-PALTLWHLRSSTPTTIFPI-RAP 260
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLT----------GHSGGVNSVAFspDGKLLASGSDdGTVRLWDLATGKLLRTLTGhTGA 332

                         250       260
                  ....*....|....*....|....*....
gi 1112917096 261 QKHVTFYQD--LILSAGQGRCVNQWQLSG 287
Cdd:COG2319   333 VRSVAFSPDgkTLASGSDDGTVRLWDLAT 361
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
31-287 8.03e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 8.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  31 SVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSM-VSTD-RHLLSAG-DGEVKAWlwaemlk 107
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDL----------ATGKLLRTLTGHSGAVTSVaFSPDgKLLASGSdDGTVRLW------- 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 108 kgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALrerSPE---VL 184
Cdd:COG2319   190 ----DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrlLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 185 SGGEDGAVRLWDLRTAKEVQTIEvykheecsrpHNGRWIGCLAT--DSDWMVCGGG-PALTLWHLRSSTPTTIFPI-RAP 260
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLT----------GHSGGVNSVAFspDGKLLASGSDdGTVRLWDLATGKLLRTLTGhTGA 332

                         250       260
                  ....*....|....*....|....*....
gi 1112917096 261 QKHVTFYQD--LILSAGQGRCVNQWQLSG 287
Cdd:COG2319   333 VRSVAFSPDgkTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 27-285 6.33e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 6.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  27 IFSQSVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSMVSTDRH--LLSAG-DGEVKAWLWa 103
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDL----------ETGELLRTLKGHTGPVRDVAASADGtyLASGSsDKTIRLWDL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 104 emlkKGCKELWRrqppYRTSLEvpEINALLLVPKeNSLILAGG-DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPE 182
Cdd:cd00200    81 ----ETGECVRT----LTGHTS--YVSSVAFSPD-GRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 183 VLSGGEDGAVRLWDLRTAKEVQTIEvykheecsrPHNGrWIGCLATDSDW---MVCGGGPALTLWHLRSSTPTTIF---- 255
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLT---------GHTG-EVNSVAFSPDGeklLSSSSDGTIKLWDLSTGKCLGTLrghe 219

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1112917096 256 -PIRApqkhVTFYQD--LILSAGQGRCVNQWQL 285
Cdd:cd00200   220 nGVNS----VAFSPDgyLLASGSEDGTIRVWDL 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 2.00e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.00e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1112917096  157 TGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 1.76e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.76e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1112917096 158 GTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
31-287 8.03e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 92.28  E-value: 8.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  31 SVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSM-VSTD-RHLLSAG-DGEVKAWlwaemlk 107
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDL----------ATGKLLRTLTGHSGAVTSVaFSPDgKLLASGSdDGTVRLW------- 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 108 kgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALrerSPE---VL 184
Cdd:COG2319   190 ----DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrlLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 185 SGGEDGAVRLWDLRTAKEVQTIEvykheecsrpHNGRWIGCLAT--DSDWMVCGGG-PALTLWHLRSSTPTTIFPI-RAP 260
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLT----------GHSGGVNSVAFspDGKLLASGSDdGTVRLWDLATGKLLRTLTGhTGA 332

                         250       260
                  ....*....|....*....|....*....
gi 1112917096 261 QKHVTFYQD--LILSAGQGRCVNQWQLSG 287
Cdd:COG2319   333 VRSVAFSPDgkTLASGSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
31-248 2.65e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.04  E-value: 2.65e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  31 SVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSMV-STD-RHLLSAG-DGEVKAWlwaemlk 107
Cdd:COG2319   211 AFSPDGKLLASGSADGTVRLWDL----------ATGKLLRTLTGHSGSVRSVAfSPDgRLLASGSaDGTVRLW------- 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 108 kgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEVLSGG 187
Cdd:COG2319   274 ----DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1112917096 188 EDGAVRLWDLRTAKEVQTIevykheecsRPHNGrWIGCLA--TDSDWMVCGGGP-ALTLWHLRS 248
Cdd:COG2319   350 DDGTVRLWDLATGELLRTL---------TGHTG-AVTSVAfsPDGRTLASGSADgTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
27-199 8.32e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 8.32e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  27 IFSQSVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSMV-STD-RHLLSAG-DGEVKAWlwa 103
Cdd:COG2319   249 VRSVAFSPDGRLLASGSADGTVRLWDL----------ATGELLRTLTGHSGGVNSVAfSPDgKLLASGSdDGTVRLW--- 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 104 emlkkgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPEV 183
Cdd:COG2319   316 --------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                         170
                  ....*....|....*.
gi 1112917096 184 LSGGEDGAVRLWDLRT 199
Cdd:COG2319   388 ASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
70-287 1.97e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 1.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  70 VTFQAHDGPVYSMVSTDRHLLSAGDGEVKAWLWAemlkkgckeLWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQ 149
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLD---------AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 150 LHTMDLETGTFTRVLRGHTDYIHCLALrerSPE---VLSGGEDGAVRLWDLRTAKEVQTIevykheecsRPHNGrWIGCL 226
Cdd:COG2319   102 VRLWDLATGLLLRTLTGHTGAVRSVAF---SPDgktLASGSADGTVRLWDLATGKLLRTL---------TGHSG-AVTSV 168

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1112917096 227 A--TDSDWMVCGGG-PALTLWHLRssTPTTIFPIRAPQKHVT---FYQD--LILSAGQGRCVNQWQLSG 287
Cdd:COG2319   169 AfsPDGKLLASGSDdGTVRLWDLA--TGKLLRTLTGHTGAVRsvaFSPDgkLLASGSADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 27-285 6.33e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 6.33e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  27 IFSQSVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSMVSTDRH--LLSAG-DGEVKAWLWa 103
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDL----------ETGELLRTLKGHTGPVRDVAASADGtyLASGSsDKTIRLWDL- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 104 emlkKGCKELWRrqppYRTSLEvpEINALLLVPKeNSLILAGG-DCQLHTMDLETGTFTRVLRGHTDYIHCLALRERSPE 182
Cdd:cd00200    81 ----ETGECVRT----LTGHTS--YVSSVAFSPD-GRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 183 VLSGGEDGAVRLWDLRTAKEVQTIEvykheecsrPHNGrWIGCLATDSDW---MVCGGGPALTLWHLRSSTPTTIF---- 255
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLT---------GHTG-EVNSVAFSPDGeklLSSSSDGTIKLWDLSTGKCLGTLrghe 219

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1112917096 256 -PIRApqkhVTFYQD--LILSAGQGRCVNQWQL 285
Cdd:cd00200   220 nGVNS----VAFSPDgyLLASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-196 4.39e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 4.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  31 SVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSM-VSTD--RHLLSAGDGEVKAWlwaEMLK 107
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDL----------RTGKCVATLTGHTGEVNSVaFSPDgeKLLSSSSDGTIKLW---DLST 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 108 KGCKELWRRQPPYrtslevpeINALLLVPkeNSLILAGGDCQLHTM--DLETGTFTRVLRGHTDYIHCLALRERSPEVLS 185
Cdd:cd00200   209 GKCLGTLRGHENG--------VNSVAFSP--DGYLLASGSEDGTIRvwDLRTGECVQTLSGHTNSVTSLAWSPDGKRLAS 278

                         170
                  ....*....|.
gi 1112917096 186 GGEDGAVRLWD 196
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 161-285 1.72e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 1.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096 161 TRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRTAKEVQTIEVykHEecsrpHNGRWIGCLAtDSDWMVCGGGP- 239
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG--HT-----GPVRDVAASA-DGTYLASGSSDk 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1112917096 240 ALTLWHLRSSTPTTIF-----PIRApqkhVTFYQD--LILSAGQGRCVNQWQL 285
Cdd:cd00200    74 TIRLWDLETGECVRTLtghtsYVSS----VAFSPDgrILSSSSRDKTIKVWDV 122
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 2.00e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 2.00e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1112917096  157 TGTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 1.76e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.76e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1112917096 158 GTFTRVLRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
15-100 6.43e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112917096  15 EVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLssalsseakeESKKPVVTFQAHDGPVYSMV-STD-RHLLSA 92
Cdd:COG2319   321 KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL----------ATGELLRTLTGHTGAVTSVAfSPDgRTLASG 390


                  ....*....
gi 1112917096  93 G-DGEVKAW 100
Cdd:COG2319   391 SaDGTVRLW 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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