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Conserved domains on  [gi|1143076926|ref|NP_001335006|]
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dimethyladenosine transferase isoform 3 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
1-159 8.37e-88

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member PTZ00338:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 294  Bit Score: 258.39  E-value: 8.37e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPINFQEWDGLVRITFVR 80
Cdd:PTZ00338  134 MFQKEFALRLLAQPGDELYCRLSVNTQLLCRVTHLMKVSKNSFNPPPKVESSVVRIEPKNPPPDVDFEEWDGLLRICFSR 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926  81 KNKTLSAAFKSSAVQQLLEKNYRIHCSVHNIIIPEDFS-IADKIQQILTSTGFSDKRARSMDIDDFIRLLHGFNAEGIHF 159
Cdd:PTZ00338  214 KNKTLSAIFKTKSVLQTLEHNYKSWCTMINKKVPVSLEpFKEFIAEILEDSGMFEKRSVKLDIDDFLKLLLAFNKKGIHF 293
 
Name Accession Description Interval E-value
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
1-159 8.37e-88

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 258.39  E-value: 8.37e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPINFQEWDGLVRITFVR 80
Cdd:PTZ00338  134 MFQKEFALRLLAQPGDELYCRLSVNTQLLCRVTHLMKVSKNSFNPPPKVESSVVRIEPKNPPPDVDFEEWDGLLRICFSR 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926  81 KNKTLSAAFKSSAVQQLLEKNYRIHCSVHNIIIPEDFS-IADKIQQILTSTGFSDKRARSMDIDDFIRLLHGFNAEGIHF 159
Cdd:PTZ00338  214 KNKTLSAIFKTKSVLQTLEHNYKSWCTMINKKVPVSLEpFKEFIAEILEDSGMFEKRSVKLDIDDFLKLLLAFNKKGIHF 293
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
1-152 5.88e-37

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 127.35  E-value: 5.88e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPP-PINFQEWDGLVRITFV 79
Cdd:TIGR00755 128 MVQKEVAERLVAKPGSKDYGRLSVLVQYYANVEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPsPKDFALFEELLKAAFQ 207
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1143076926  80 RKNKTLSAAFKSSavqqlleknyrihcsvhniiIPEDFsiadkiqQILTSTGFS-DKRARSMDIDDFIRLLHGF 152
Cdd:TIGR00755 208 QRRKTLRNNLKNL--------------------LSELV-------ELLEELGIDpDKRVEQLSPEDFLRLANLL 254
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
1-148 7.01e-35

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 122.54  E-value: 7.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPP--PPINFQEWDGLVRITF 78
Cdd:COG0030   137 MVQKEVAERLVAKPGSKDYGRLSVLVQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPlvPVADEKLFFRVVKAAF 216
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1143076926  79 VRKNKTLSAAFKSSAvqqlleknyrihcsvhniiipedfsIADKIQQILTSTGFS-DKRARSMDIDDFIRL 148
Cdd:COG0030   217 SQRRKTLRNSLKSLF-------------------------SKERLEEALEAAGIDpTARAEELSVEEFARL 262
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
1-102 1.51e-30

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 110.92  E-value: 1.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPP--PPINFQEWDGLVRITF 78
Cdd:pfam00398 133 MLQKEFARRLLARPGSKLYSRLSVLRQAFTDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDphPVKDLDVYDSVVRKLF 212
                          90       100
                  ....*....|....*....|....
gi 1143076926  79 VRKNKTLSAAFKSSAVQQLLEKNY 102
Cdd:pfam00398 213 NRKRKTLSTSLKSLFPGGQLQAFS 236
rADc smart00650
Ribosomal RNA adenine dimethylases;
1-60 7.14e-27

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 99.12  E-value: 7.14e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926    1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKN 60
Cdd:smart00650 110 MVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPKVDSAVVRLERRP 169
 
Name Accession Description Interval E-value
PTZ00338 PTZ00338
dimethyladenosine transferase-like protein; Provisional
1-159 8.37e-88

dimethyladenosine transferase-like protein; Provisional


Pssm-ID: 240367 [Multi-domain]  Cd Length: 294  Bit Score: 258.39  E-value: 8.37e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPINFQEWDGLVRITFVR 80
Cdd:PTZ00338  134 MFQKEFALRLLAQPGDELYCRLSVNTQLLCRVTHLMKVSKNSFNPPPKVESSVVRIEPKNPPPDVDFEEWDGLLRICFSR 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926  81 KNKTLSAAFKSSAVQQLLEKNYRIHCSVHNIIIPEDFS-IADKIQQILTSTGFSDKRARSMDIDDFIRLLHGFNAEGIHF 159
Cdd:PTZ00338  214 KNKTLSAIFKTKSVLQTLEHNYKSWCTMINKKVPVSLEpFKEFIAEILEDSGMFEKRSVKLDIDDFLKLLLAFNKKGIHF 293
ksgA TIGR00755
ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, ...
1-152 5.88e-37

ribosomal RNA small subunit methyltransferase A; In both E. coli and Saccharomyces cerevisiae, this protein is responsible for the dimethylation of two adjacent adenosine residues in a conserved hairpin of 16S rRNA in bacteria, 18S rRNA in eukaryotes. This adjacent dimethylation is the only rRNA modification shared by bacteria and eukaryotes. A single member of this family is present in each of the first 20 completed microbial genomes. This protein is essential in yeast, but not in E. coli, where its deletion leads to resistance to the antibiotic kasugamycin. Alternate name: S-adenosylmethionine--6-N',N'-adenosyl (rRNA) dimethyltransferase [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273252 [Multi-domain]  Cd Length: 254  Bit Score: 127.35  E-value: 5.88e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPP-PINFQEWDGLVRITFV 79
Cdd:TIGR00755 128 MVQKEVAERLVAKPGSKDYGRLSVLVQYYANVEIVFKVPPSAFYPPPKVDSAVVRLVPLKRKPsPKDFALFEELLKAAFQ 207
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1143076926  80 RKNKTLSAAFKSSavqqlleknyrihcsvhniiIPEDFsiadkiqQILTSTGFS-DKRARSMDIDDFIRLLHGF 152
Cdd:TIGR00755 208 QRRKTLRNNLKNL--------------------LSELV-------ELLEELGIDpDKRVEQLSPEDFLRLANLL 254
RsmA COG0030
16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase ...
1-148 7.01e-35

16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) [Translation, ribosomal structure and biogenesis]; 16S rRNA A1518 and A1519 N6-dimethyltransferase RsmA/KsgA/DIM1 (may also have DNA glycosylase/AP lyase activity) is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439801 [Multi-domain]  Cd Length: 270  Bit Score: 122.54  E-value: 7.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPP--PPINFQEWDGLVRITF 78
Cdd:COG0030   137 MVQKEVAERLVAKPGSKDYGRLSVLVQYYADVEILFTVPPEAFYPPPKVDSAVVRLTPRPEPlvPVADEKLFFRVVKAAF 216
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1143076926  79 VRKNKTLSAAFKSSAvqqlleknyrihcsvhniiipedfsIADKIQQILTSTGFS-DKRARSMDIDDFIRL 148
Cdd:COG0030   217 SQRRKTLRNSLKSLF-------------------------SKERLEEALEAAGIDpTARAEELSVEEFARL 262
RrnaAD pfam00398
Ribosomal RNA adenine dimethylase;
1-102 1.51e-30

Ribosomal RNA adenine dimethylase;


Pssm-ID: 395321 [Multi-domain]  Cd Length: 263  Bit Score: 110.92  E-value: 1.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPP--PPINFQEWDGLVRITF 78
Cdd:pfam00398 133 MLQKEFARRLLARPGSKLYSRLSVLRQAFTDVKLVAKVPPSIFSPPPKVDSALVRLERHDPDphPVKDLDVYDSVVRKLF 212
                          90       100
                  ....*....|....*....|....
gi 1143076926  79 VRKNKTLSAAFKSSAVQQLLEKNY 102
Cdd:pfam00398 213 NRKRKTLSTSLKSLFPGGQLQAFS 236
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
1-93 2.62e-28

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 104.98  E-value: 2.62e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926   1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPINFQE-WDGLVRITFV 79
Cdd:PRK14896  122 MYQKEFAERMVAKPGTKEYGRLSVMVQYYADVEIVEKVPPGAFSPKPKVDSAVVRLTPREPKYEVYDEDfFDDFVKALFQ 201
                          90
                  ....*....|....
gi 1143076926  80 RKNKTLSAAFKSSA 93
Cdd:PRK14896  202 HRRKTLRNALKNSA 215
rADc smart00650
Ribosomal RNA adenine dimethylases;
1-60 7.14e-27

Ribosomal RNA adenine dimethylases;


Pssm-ID: 128898  Cd Length: 169  Bit Score: 99.12  E-value: 7.14e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143076926    1 MFQREFALRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKN 60
Cdd:smart00650 110 MVQKEVARRLAAKPGSKDYGRLSVLLQPYADVKILFKVPPSAFRPPPKVDSAVVRLERRP 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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