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Conserved domains on  [gi|1129371469|ref|NP_001335027|]
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GDNF family receptor alpha-1 isoform a preproprotein [Homo sapiens]

Protein Classification

GDNF family receptor alpha( domain architecture ID 10658249)

glial cell line-derived neurotrophic factor (GDNF) family receptor alpha is a glycosylphosphatidylinositol-linked cell surface receptor for GDNF, the glial cell line-derived neurotrophic factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 243-337 2.75e-23

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 460537  Cd Length: 87  Bit Score: 93.36  E-value: 2.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469 243 CLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSClkENYADCLLAYsgligtVMTPNYIDSSSLSVAPWCDCSNSGNDL 322
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGC--PNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 1129371469 323 EECLKFLNFFKDNTC 337
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 154-233 1.38e-15

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 71.90  E-value: 1.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469  154 CLDAAKACNLDDICKKYRSAYITPCTTSVS-------NDVCNRRKCHKALRQFFDkvpaKHSYGMLFCSC---RDIACTE 223
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSsscpgenSEACLRAYCGLALRPFYD----DNSSVLLFCTCagnRDEECLE 76

                           90
                   ....*....|
gi 1129371469  224 RRRQTIVPVC 233
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 29-111 5.19e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


:

Pssm-ID: 197975  Cd Length: 86  Bit Score: 44.55  E-value: 5.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469   29 CVKASDQCLKEQSC-STKYRTLRQCVAGKETnfslASGLEAKDECRSAMEALKQKSLYN--------CRCKRgmKKEKNC 99
Cdd:smart00907   1 CLEALKACELDPVCrSRLADYLSACSPSPSS----SCPGENSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEEC 74

                           90
                   ....*....|..
gi 1129371469  100 LRIYWSMYQSLQ 111
Cdd:smart00907  75 LEFRRLFHSNPC 86
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 243-337 2.75e-23

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 93.36  E-value: 2.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469 243 CLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSClkENYADCLLAYsgligtVMTPNYIDSSSLSVAPWCDCSNSGNDL 322
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGC--PNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 1129371469 323 EECLKFLNFFKDNTC 337
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 243-337 5.49e-18

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 78.45  E-value: 5.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469  243 CLNLQDSCKTNYICRSRLADFFTNCQPesRSVSSCLKENYADCLLAYsglIGTVMTPNYIDSSslSVAPWCDCsnSGNDL 322
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSP--SPSSSCPGENSEACLRAY---CGLALRPFYDDNS--SVLLFCTC--AGNRD 71

                           90
                   ....*....|....*
gi 1129371469  323 EECLKFLNFFKDNTC 337
Cdd:smart00907  72 EECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 154-233 1.38e-15

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 71.90  E-value: 1.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469  154 CLDAAKACNLDDICKKYRSAYITPCTTSVS-------NDVCNRRKCHKALRQFFDkvpaKHSYGMLFCSC---RDIACTE 223
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSsscpgenSEACLRAYCGLALRPFYD----DNSSVLLFCTCagnRDEECLE 76

                           90
                   ....*....|
gi 1129371469  224 RRRQTIVPVC 233
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 154-233 6.20e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 67.17  E-value: 6.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469 154 CLDAAKACNLDDICKKYRSAYITPCTTSVS--NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSC-----RDIACTERRR 226
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPEscSGCPNPARCLRAYRMTPNYVDNLGTSLLLWCTCkgsgnQDEECEEFRR 80


                  ....*..
gi 1129371469 227 QTIVPVC 233
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 29-111 5.19e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 44.55  E-value: 5.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469   29 CVKASDQCLKEQSC-STKYRTLRQCVAGKETnfslASGLEAKDECRSAMEALKQKSLYN--------CRCKRgmKKEKNC 99
Cdd:smart00907   1 CLEALKACELDPVCrSRLADYLSACSPSPSS----SCPGENSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEEC 74

                           90
                   ....*....|..
gi 1129371469  100 LRIYWSMYQSLQ 111
Cdd:smart00907  75 LEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 29-107 5.91e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 44.44  E-value: 5.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469  29 CVKASDQCLKEQSCSTKYRT-LRQCVAGKETnfslASGLEAKDECRSAM-------EALKQKSLYNCRCKRGMKKEKNCL 100
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADfQSNCQPSPES----CSGCPNPARCLRAYrmtpnyvDNLGTSLLLWCTCKGSGNQDEECE 76


                  ....*..
gi 1129371469 101 RIYWSMY 107
Cdd:pfam02351  77 EFRRNFT 83
 
Name Accession Description Interval E-value
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 243-337 2.75e-23

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 93.36  E-value: 2.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469 243 CLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSClkENYADCLLAYsgligtVMTPNYIDSSSLSVAPWCDCSNSGNDL 322
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPESCSGC--PNPARCLRAY------RMTPNYVDNLGTSLLLWCTCKGSGNQD 72

                          90
                  ....*....|....*
gi 1129371469 323 EECLKFLNFFKDNTC 337
Cdd:pfam02351  73 EECEEFRRNFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 243-337 5.49e-18

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 78.45  E-value: 5.49e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469  243 CLNLQDSCKTNYICRSRLADFFTNCQPesRSVSSCLKENYADCLLAYsglIGTVMTPNYIDSSslSVAPWCDCsnSGNDL 322
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSP--SPSSSCPGENSEACLRAY---CGLALRPFYDDNS--SVLLFCTC--AGNRD 71

                           90
                   ....*....|....*
gi 1129371469  323 EECLKFLNFFKDNTC 337
Cdd:smart00907  72 EECLEFRRLFHSNPC 86
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 154-233 1.38e-15

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 71.90  E-value: 1.38e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469  154 CLDAAKACNLDDICKKYRSAYITPCTTSVS-------NDVCNRRKCHKALRQFFDkvpaKHSYGMLFCSC---RDIACTE 223
Cdd:smart00907   1 CLEALKACELDPVCRSRLADYLSACSPSPSsscpgenSEACLRAYCGLALRPFYD----DNSSVLLFCTCagnRDEECLE 76

                           90
                   ....*....|
gi 1129371469  224 RRRQTIVPVC 233
Cdd:smart00907  77 FRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 154-233 6.20e-14

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 67.17  E-value: 6.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469 154 CLDAAKACNLDDICKKYRSAYITPCTTSVS--NDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSC-----RDIACTERRR 226
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADFQSNCQPSPEscSGCPNPARCLRAYRMTPNYVDNLGTSLLLWCTCkgsgnQDEECEEFRR 80


                  ....*..
gi 1129371469 227 QTIVPVC 233
Cdd:pfam02351  81 NFTVNSC 87
GDNF smart00907
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 29-111 5.19e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 197975  Cd Length: 86  Bit Score: 44.55  E-value: 5.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469   29 CVKASDQCLKEQSC-STKYRTLRQCVAGKETnfslASGLEAKDECRSAMEALKQKSLYN--------CRCKRgmKKEKNC 99
Cdd:smart00907   1 CLEALKACELDPVCrSRLADYLSACSPSPSS----SCPGENSEACLRAYCGLALRPFYDdnssvllfCTCAG--NRDEEC 74

                           90
                   ....*....|..
gi 1129371469  100 LRIYWSMYQSLQ 111
Cdd:smart00907  75 LEFRRLFHSNPC 86
GDNF pfam02351
GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 ...
 29-107 5.91e-06

GDNF/GAS1 domain; This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.


Pssm-ID: 460537  Cd Length: 87  Bit Score: 44.44  E-value: 5.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1129371469  29 CVKASDQCLKEQSCSTKYRT-LRQCVAGKETnfslASGLEAKDECRSAM-------EALKQKSLYNCRCKRGMKKEKNCL 100
Cdd:pfam02351   1 CLEAAKACRADEVCRSRLADfQSNCQPSPES----CSGCPNPARCLRAYrmtpnyvDNLGTSLLLWCTCKGSGNQDEECE 76


                  ....*..
gi 1129371469 101 RIYWSMY 107
Cdd:pfam02351  77 EFRRNFT 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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