NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1142736531|ref|NP_001335460|]
View 

lysine-rich nucleolar protein 1 isoform b [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SMAP pfam15477
Small acidic protein family; This domain family is found in eukaryotes, and is approximately ...
 362-435 3.93e-23

Small acidic protein family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.


:

Pssm-ID: 464738 [Multi-domain]  Cd Length: 73  Bit Score: 92.36  E-value: 3.93e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1142736531 362 WDTAGFE-NEDQKLKFLRLMGGFKNLSPSfsrPASTIARPNMALGKKAADSLQQNLQRDYDRAMSW-KYSRGAGLG 435
Cdd:pfam15477   1 WDTAAFDgDAERQEKFLRLMGGKKAGSSG---SAESSTRPNMALSKKKQEKLQQDLEQQYEAAMKEtHGGRGVGLG 73
DUF5595 super family cl39478
Domain of unknown function (DUF5595); This domain is found in Nude C 80 (Ndc80) proteins which ...
 306-341 3.68e-03

Domain of unknown function (DUF5595); This domain is found in Nude C 80 (Ndc80) proteins which can be found in species such as Homo sapiens. Ndc80 protein complexes are a core component of the end-on attachment sites for kinetochore microtubules. Ndc80 is also known as Hec1, for highly expressed in cancer 1.


The actual alignment was detected with superfamily member pfam18077:

Pssm-ID: 465636 [Multi-domain]  Cd Length: 73  Bit Score: 36.14  E-value: 3.68e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1142736531 306 EETDTDLEVVLEKKGNMDEAHID--QVRRKALQEEIDR 341
Cdd:pfam18077  32 EEEDAELLSKLKELYNVDEALIEslEEEHKRLNEEIER 69
 
Name Accession Description Interval E-value
SMAP pfam15477
Small acidic protein family; This domain family is found in eukaryotes, and is approximately ...
 362-435 3.93e-23

Small acidic protein family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.


Pssm-ID: 464738 [Multi-domain]  Cd Length: 73  Bit Score: 92.36  E-value: 3.93e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1142736531 362 WDTAGFE-NEDQKLKFLRLMGGFKNLSPSfsrPASTIARPNMALGKKAADSLQQNLQRDYDRAMSW-KYSRGAGLG 435
Cdd:pfam15477   1 WDTAAFDgDAERQEKFLRLMGGKKAGSSG---SAESSTRPNMALSKKKQEKLQQDLEQQYEAAMKEtHGGRGVGLG 73
DUF5595 pfam18077
Domain of unknown function (DUF5595); This domain is found in Nude C 80 (Ndc80) proteins which ...
 306-341 3.68e-03

Domain of unknown function (DUF5595); This domain is found in Nude C 80 (Ndc80) proteins which can be found in species such as Homo sapiens. Ndc80 protein complexes are a core component of the end-on attachment sites for kinetochore microtubules. Ndc80 is also known as Hec1, for highly expressed in cancer 1.


Pssm-ID: 465636 [Multi-domain]  Cd Length: 73  Bit Score: 36.14  E-value: 3.68e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1142736531 306 EETDTDLEVVLEKKGNMDEAHID--QVRRKALQEEIDR 341
Cdd:pfam18077  32 EEEDAELLSKLKELYNVDEALIEslEEEHKRLNEEIER 69
 
Name Accession Description Interval E-value
SMAP pfam15477
Small acidic protein family; This domain family is found in eukaryotes, and is approximately ...
 362-435 3.93e-23

Small acidic protein family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. There is a single completely conserved residue G that may be functionally important.


Pssm-ID: 464738 [Multi-domain]  Cd Length: 73  Bit Score: 92.36  E-value: 3.93e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1142736531 362 WDTAGFE-NEDQKLKFLRLMGGFKNLSPSfsrPASTIARPNMALGKKAADSLQQNLQRDYDRAMSW-KYSRGAGLG 435
Cdd:pfam15477   1 WDTAAFDgDAERQEKFLRLMGGKKAGSSG---SAESSTRPNMALSKKKQEKLQQDLEQQYEAAMKEtHGGRGVGLG 73
DUF5595 pfam18077
Domain of unknown function (DUF5595); This domain is found in Nude C 80 (Ndc80) proteins which ...
 306-341 3.68e-03

Domain of unknown function (DUF5595); This domain is found in Nude C 80 (Ndc80) proteins which can be found in species such as Homo sapiens. Ndc80 protein complexes are a core component of the end-on attachment sites for kinetochore microtubules. Ndc80 is also known as Hec1, for highly expressed in cancer 1.


Pssm-ID: 465636 [Multi-domain]  Cd Length: 73  Bit Score: 36.14  E-value: 3.68e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1142736531 306 EETDTDLEVVLEKKGNMDEAHID--QVRRKALQEEIDR 341
Cdd:pfam18077  32 EEEDAELLSKLKELYNVDEALIEslEEEHKRLNEEIER 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH