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Conserved domains on  [gi|1149890070|ref|NP_001335838|]
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UDP-sugar transporter protein SLC35A5 isoform 3 [Homo sapiens]

Protein Classification

nucleotide-sugar transporter family protein( domain architecture ID 706477)

nucleotide-sugar transporter family protein may be involved in the transport of nucleotide sugars, similar to human UDP-galactose translocator and CMP-sialic acid transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nuc_sug_transp super family cl27775
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
 10-253 2.95e-26

Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.


The actual alignment was detected with superfamily member pfam04142:

Pssm-ID: 398009  Cd Length: 315  Bit Score: 105.49  E-value: 2.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070  10 IITTALLFRIVLKRRLNWIQWASLLTLFlsivaltAGTKTLQHNlagrgfhhdaffsPSNScllfrsecprkdnctakew 89
Cdd:pfam04142 120 ILTTALFSVLMLGRKLSTLQWMSLFLLM-------AGVALVQYQ-------------QASS------------------- 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070  90 tfPEAKWNTTARVFSHIRLGMGHVLIivQCFISSMANIYNEKILKEGNQlteSIFIQNSKLYFFGILFNGLTLGLqrSNR 169
Cdd:pfam04142 161 --TESNSAGAAAVEQNPILGFGAVLA--ACFSSGFAGVYFEKILKSSNV---SLWIRNIQLALFGIFFALLGAWL--YDG 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070 170 DQIKNCGFFYGHSAFSVALIFVTAFQGLSVAFILKFLDNMFHVLMAQVTTVIITTVSVLVFDFRPSLEFFLEAPSVLLSI 249
Cdd:pfam04142 232 SRISEKGFFFGYTYVVWIVVLLQAVGGLYIAVVVKYADNILKGFATSLSIILSTVASVLLFDFQITLTFALGAILVIAAI 311


                  ....
gi 1149890070 250 FIYN 253
Cdd:pfam04142 312 FLYG 315
 
Name Accession Description Interval E-value
Nuc_sug_transp pfam04142
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
 10-253 2.95e-26

Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.


Pssm-ID: 398009  Cd Length: 315  Bit Score: 105.49  E-value: 2.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070  10 IITTALLFRIVLKRRLNWIQWASLLTLFlsivaltAGTKTLQHNlagrgfhhdaffsPSNScllfrsecprkdnctakew 89
Cdd:pfam04142 120 ILTTALFSVLMLGRKLSTLQWMSLFLLM-------AGVALVQYQ-------------QASS------------------- 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070  90 tfPEAKWNTTARVFSHIRLGMGHVLIivQCFISSMANIYNEKILKEGNQlteSIFIQNSKLYFFGILFNGLTLGLqrSNR 169
Cdd:pfam04142 161 --TESNSAGAAAVEQNPILGFGAVLA--ACFSSGFAGVYFEKILKSSNV---SLWIRNIQLALFGIFFALLGAWL--YDG 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070 170 DQIKNCGFFYGHSAFSVALIFVTAFQGLSVAFILKFLDNMFHVLMAQVTTVIITTVSVLVFDFRPSLEFFLEAPSVLLSI 249
Cdd:pfam04142 232 SRISEKGFFFGYTYVVWIVVLLQAVGGLYIAVVVKYADNILKGFATSLSIILSTVASVLLFDFQITLTFALGAILVIAAI 311


                  ....
gi 1149890070 250 FIYN 253
Cdd:pfam04142 312 FLYG 315
nst TIGR00803
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10) ...
 97-252 2.91e-15

UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.


Pssm-ID: 129885  Cd Length: 222  Bit Score: 73.16  E-value: 2.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070  97 NTTARVFSHIRLGMGHVLIIVQCFISSMANIYNEKILKEGNQlteSIFIQNSKLYFFGILFngLTLGLQRSNRDQIKNCG 176
Cdd:TIGR00803  72 QSSAKTLMFGNPVVGLSAVLSALLSSGFAGVYFEKILKDGDT---MFWSRNLQLPLFGLFS--TFSVLLWSDGTLISNFG 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1149890070 177 FFYGHSAFSVALIFVTAFQGLSVAFILKFLDNMFHVLMAQVTTVIITTVSVLVFDFRPSLEFFLEAPSVLLSIFIY 252
Cdd:TIGR00803 147 FFIGYPTAVWIVGLLNVGGGLCIGGVVRYADNTTKSFVTALSIILSTLASVRLFDAKISSTFYLGAILVFLATFLY 222
 
Name Accession Description Interval E-value
Nuc_sug_transp pfam04142
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
 10-253 2.95e-26

Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.


Pssm-ID: 398009  Cd Length: 315  Bit Score: 105.49  E-value: 2.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070  10 IITTALLFRIVLKRRLNWIQWASLLTLFlsivaltAGTKTLQHNlagrgfhhdaffsPSNScllfrsecprkdnctakew 89
Cdd:pfam04142 120 ILTTALFSVLMLGRKLSTLQWMSLFLLM-------AGVALVQYQ-------------QASS------------------- 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070  90 tfPEAKWNTTARVFSHIRLGMGHVLIivQCFISSMANIYNEKILKEGNQlteSIFIQNSKLYFFGILFNGLTLGLqrSNR 169
Cdd:pfam04142 161 --TESNSAGAAAVEQNPILGFGAVLA--ACFSSGFAGVYFEKILKSSNV---SLWIRNIQLALFGIFFALLGAWL--YDG 231

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070 170 DQIKNCGFFYGHSAFSVALIFVTAFQGLSVAFILKFLDNMFHVLMAQVTTVIITTVSVLVFDFRPSLEFFLEAPSVLLSI 249
Cdd:pfam04142 232 SRISEKGFFFGYTYVVWIVVLLQAVGGLYIAVVVKYADNILKGFATSLSIILSTVASVLLFDFQITLTFALGAILVIAAI 311


                  ....
gi 1149890070 250 FIYN 253
Cdd:pfam04142 312 FLYG 315
nst TIGR00803
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10) ...
 97-252 2.91e-15

UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.


Pssm-ID: 129885  Cd Length: 222  Bit Score: 73.16  E-value: 2.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890070  97 NTTARVFSHIRLGMGHVLIIVQCFISSMANIYNEKILKEGNQlteSIFIQNSKLYFFGILFngLTLGLQRSNRDQIKNCG 176
Cdd:TIGR00803  72 QSSAKTLMFGNPVVGLSAVLSALLSSGFAGVYFEKILKDGDT---MFWSRNLQLPLFGLFS--TFSVLLWSDGTLISNFG 146

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1149890070 177 FFYGHSAFSVALIFVTAFQGLSVAFILKFLDNMFHVLMAQVTTVIITTVSVLVFDFRPSLEFFLEAPSVLLSIFIY 252
Cdd:TIGR00803 147 FFIGYPTAVWIVGLLNVGGGLCIGGVVRYADNTTKSFVTALSIILSTLASVRLFDAKISSTFYLGAILVFLATFLY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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