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Conserved domains on  [gi|1149890074|ref|NP_001335840|]
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UDP-sugar transporter protein SLC35A5 isoform 5 [Homo sapiens]

Protein Classification

nucleotide-sugar transporter family protein( domain architecture ID 706477)

nucleotide-sugar transporter family protein may be involved in the transport of nucleotide sugars, similar to human UDP-galactose translocator and CMP-sialic acid transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nuc_sug_transp super family cl27775
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
 24-162 4.69e-13

Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.


The actual alignment was detected with superfamily member pfam04142:

Pssm-ID: 398009  Cd Length: 315  Bit Score: 66.59  E-value: 4.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890074  24 AIFIALSSSRILLVKYSANEENKYDYLPTTVNVCSELVKLVFCVLVSFCVIKKD--HQSRNLKYASWKEFSDFMKWSIPA 101
Cdd:pfam04142  11 VVLTVQNAALTLTLRYSRTRKDGPRYFSTTAVLMAEIIKLVVCFLLLYKETGSDarAFLRSLHEEIFGSPRETLKLAVPS 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1149890074 102 FLYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRRLNWIQWASLLTLFLSIV 162
Cdd:pfam04142  91 LIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVLMLGRKLSTLQWMSLFLLMAGVA 151
 
Name Accession Description Interval E-value
Nuc_sug_transp pfam04142
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
 24-162 4.69e-13

Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.


Pssm-ID: 398009  Cd Length: 315  Bit Score: 66.59  E-value: 4.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890074  24 AIFIALSSSRILLVKYSANEENKYDYLPTTVNVCSELVKLVFCVLVSFCVIKKD--HQSRNLKYASWKEFSDFMKWSIPA 101
Cdd:pfam04142  11 VVLTVQNAALTLTLRYSRTRKDGPRYFSTTAVLMAEIIKLVVCFLLLYKETGSDarAFLRSLHEEIFGSPRETLKLAVPS 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1149890074 102 FLYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRRLNWIQWASLLTLFLSIV 162
Cdd:pfam04142  91 LIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVLMLGRKLSTLQWMSLFLLMAGVA 151
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 101-167 1.09e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 42.14  E-value: 1.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1149890074 101 AFLYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRRLNWIQWASLLTLFLSIVALTAG 167
Cdd:COG0697    73 LLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGP 139
 
Name Accession Description Interval E-value
Nuc_sug_transp pfam04142
Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars ...
 24-162 4.69e-13

Nucleotide-sugar transporter; This family of membrane proteins transport nucleotide sugars from the cytoplasm into Golgi vesicles. Swiss:P78382 transports CMP-sialic acid, Swiss:P78381 transports UDP-galactose and Swiss:Q9Y2D2 transports UDP-GlcNAc.


Pssm-ID: 398009  Cd Length: 315  Bit Score: 66.59  E-value: 4.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1149890074  24 AIFIALSSSRILLVKYSANEENKYDYLPTTVNVCSELVKLVFCVLVSFCVIKKD--HQSRNLKYASWKEFSDFMKWSIPA 101
Cdd:pfam04142  11 VVLTVQNAALTLTLRYSRTRKDGPRYFSTTAVLMAEIIKLVVCFLLLYKETGSDarAFLRSLHEEIFGSPRETLKLAVPS 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1149890074 102 FLYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRRLNWIQWASLLTLFLSIV 162
Cdd:pfam04142  91 LIYTLQNNLLYVALSNLDAATYQVTYQLKILTTALFSVLMLGRKLSTLQWMSLFLLMAGVA 151
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 101-167 1.09e-04

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 42.14  E-value: 1.09e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1149890074 101 AFLYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRRLNWIQWASLLTLFLSIVALTAG 167
Cdd:COG0697    73 LLGLALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGP 139
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 101-162 1.13e-03

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 37.94  E-value: 1.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1149890074 101 AFLYFLDNLIVFYVLSYLQPAMAVIFSNFSIITTALLFRIVLKRRLNWIQWASLLTLFLSIV 162
Cdd:pfam00892  71 VLGTFLGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVL 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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