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Conserved domains on  [gi|1167803507|ref|NP_001336673|]
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transmembrane and coiled-coil domain-containing protein 3 isoform 5 precursor [Homo sapiens]

Protein Classification

cation:proton antiporter( domain architecture ID 11111152)

cation:proton antiporter functions in maintaining cation homeostasis and the pH of actively metabolizing cells; it may also be involved in regulating cell volume; similar to K(+) efflux antiporters that are involved in K(+) homeostasis and osmotic adjustment

CATH:  1.20.1530.20
Gene Ontology:  GO:0140828|GO:0015078
PubMed:  9537504
TCDB:  2.A.37

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RosB super family cl47355
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
267-563 3.73e-50

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


The actual alignment was detected with superfamily member COG4651:

Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 183.25  E-value: 3.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 267 DHHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRK 346
Cdd:COG4651     3 ETPLITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 347 VWKISLQGPCYMTLLMIAFGLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFLmgSARGdkEGDIDYSTVLLGMLVTQDV 426
Cdd:COG4651    83 VRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLL--EDRG--ELDTLHGRIAVGWLIVQDL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 427 QLGLFMAVMPTLIQAGASasssivvevlrILVLIGQILFSLAAVFLLCLVIKKYLIGPYYRKlhMESKGNKEILILGISA 506
Cdd:COG4651   159 AVVLMLVLLPALAGGGGG-----------LLGTLGLTLLKVALFVALMLVVGRRVIPWLLHR--VARTRSRELFLLAVLA 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1167803507 507 FIFLMLTVTELLDVSMELGCFLAGALVSSQGpvVTEEIATSIEPIRDFLAIVFFASI 563
Cdd:COG4651   226 ICLGVAYLAALFGLSFALGAFLAGMVLAESE--YSHQAAAELLPLRDAFAVLFFVSV 280
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
267-563 3.73e-50

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 183.25  E-value: 3.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 267 DHHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRK 346
Cdd:COG4651     3 ETPLITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 347 VWKISLQGPCYMTLLMIAFGLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFLmgSARGdkEGDIDYSTVLLGMLVTQDV 426
Cdd:COG4651    83 VRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLL--EDRG--ELDTLHGRIAVGWLIVQDL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 427 QLGLFMAVMPTLIQAGASasssivvevlrILVLIGQILFSLAAVFLLCLVIKKYLIGPYYRKlhMESKGNKEILILGISA 506
Cdd:COG4651   159 AVVLMLVLLPALAGGGGG-----------LLGTLGLTLLKVALFVALMLVVGRRVIPWLLHR--VARTRSRELFLLAVLA 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1167803507 507 FIFLMLTVTELLDVSMELGCFLAGALVSSQGpvVTEEIATSIEPIRDFLAIVFFASI 563
Cdd:COG4651   226 ICLGVAYLAALFGLSFALGAFLAGMVLAESE--YSHQAAAELLPLRDAFAVLFFVSV 280
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
274-560 1.26e-44

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 163.58  E-value: 1.26e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 274 IVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSI-VQVETLGEFGVFFTLFLVGLEFSPEKLRKVWKISL 352
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVdEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 353 QGPCYMTLLMIAF--GLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFLMGSARGDKegdiDYSTVLLGMLVTQDVQLGL 430
Cdd:pfam00999  81 LLALLGVLIPFVLigLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPE----RLGTLLLGESVLNDGVAVV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 431 FMAVMPTLIQAGASASSsivvevlriLVLIGQILFSLAAVFLLCLVIkkylIGPYYRKLHMESKGNKEILILGISAFIFL 510
Cdd:pfam00999 157 LLAVLLALAQGVGGGSD---------LGWLLLIFLVVAVGGLLLGLL----IGWLLRLITRFTDDDRELEVLLVLLLALL 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1167803507 511 MLTVTELLDVSMELGCFLAGALVSsqGPVVTEEIATSIEPIRDFLAIVFF 560
Cdd:pfam00999 224 AALLAEALGVSGILGAFLAGLVLS--EYPFANKLSEKLEPFGYGLFNPLF 271
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
284-563 3.40e-34

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 131.23  E-value: 3.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 284 CGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVWKISLQGpcymTLLMI 363
Cdd:TIGR00932   7 AVPLSRRLGIPSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGV----GVLQV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 364 AF-----GLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFLmgsaRGDKEGDIDYSTVLLGMLVTQDVQLGLFMAVMPTL 438
Cdd:TIGR00932  83 LVpgvllGLLLGHLLGLALGAAVVIGIILALSSTAVVVQVL----KERGLLKTPFGQTVLGILLFQDIAVVPLLALLPLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 439 iqaGASASSSivvevlriLVLIGQILFSLAAVFLLCLVIKKYLIGPYYRKLHmeSKGNKEILILGISAFIFLMLTVTELL 518
Cdd:TIGR00932 159 ---ATSASTE--------HVALALLLLKVFLAFLLLVLLGRWLLRPVLRLTA--ELRPSELFTAGSLLLMFGSAYFADLL 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1167803507 519 DVSMELGCFLAGALVSSQgpVVTEEIATSIEPIRDFLAIVFFASI 563
Cdd:TIGR00932 226 GLSMALGAFLAGVVLSES--EYRHKLESDLEPIGGVLLPLFFISV 268
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
292-563 5.20e-16

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 81.61  E-value: 5.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 292 GLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLrkvWKisLQGP-------------CYM 358
Cdd:PRK03659   28 GIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPSKL---WQ--LRRSifgvgaaqvllsaAVL 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 359 TLLMIAFGLLWghllrikpTQSVFISTCLSLSSTPLVSRFLMGSARGDKEGDIDYSTVLLgmlvTQDVQLGLFMAVMPTL 438
Cdd:PRK03659  103 AGLLMLTDFSW--------QAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLL----FQDLAVIPALALVPLL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 439 iqAGASASSSIVVevlrilvligQILFSLAAVFLLcLVIKKYLIGPYYRklHMESKGNKEI-------LILGISAFIflm 511
Cdd:PRK03659  171 --AGSADEHFDWM----------KIGMKVLAFAGM-LIGGRYLLRPLFR--FIAASGVREVftaaallLVLGSALFM--- 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1167803507 512 ltvtELLDVSMELGCFLAGALVSSqgpvvTE---EIATSIEPIRDFLAIVFFASI 563
Cdd:PRK03659  233 ----DALGLSMALGTFIAGVLLAE-----SEyrhELEIAIEPFKGLLLGLFFISV 278
 
Name Accession Description Interval E-value
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
267-563 3.73e-50

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 183.25  E-value: 3.73e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 267 DHHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRK 346
Cdd:COG4651     3 ETPLITTIALILGLAAVLGLLAQRLRQPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 347 VWKISLQGPCYMTLLMIAFGLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFLmgSARGdkEGDIDYSTVLLGMLVTQDV 426
Cdd:COG4651    83 VRKIALPGALLQIALTTLLGFGIALLLGWSLGESLVFGLALSLSSTVVLLKLL--EDRG--ELDTLHGRIAVGWLIVQDL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 427 QLGLFMAVMPTLIQAGASasssivvevlrILVLIGQILFSLAAVFLLCLVIKKYLIGPYYRKlhMESKGNKEILILGISA 506
Cdd:COG4651   159 AVVLMLVLLPALAGGGGG-----------LLGTLGLTLLKVALFVALMLVVGRRVIPWLLHR--VARTRSRELFLLAVLA 225
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1167803507 507 FIFLMLTVTELLDVSMELGCFLAGALVSSQGpvVTEEIATSIEPIRDFLAIVFFASI 563
Cdd:COG4651   226 ICLGVAYLAALFGLSFALGAFLAGMVLAESE--YSHQAAAELLPLRDAFAVLFFVSV 280
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
268-563 5.32e-49

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 175.72  E-value: 5.32e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 268 HHFIKDIVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKV 347
Cdd:COG0475     3 ASLLLQLGLLLLAAVLAGLLARRLGLPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 348 WKISLQGPCYMTLLMIAFGLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFL--MGSARGdkegdiDYSTVLLGMLVTQD 425
Cdd:COG0475    83 GRRALGIGLLQVLLPFLLGFLLALLLGLSLAAALFLGAALAATSTAIVLKVLkeLGLLKT------PLGQLILGVALFDD 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 426 VQLGLFMAVMPTLIQAGASASSsivvevlrilvlIGQILFSLAAVFLLCLVIKKYLIGPYYRklHMESKGNKEILILGIS 505
Cdd:COG0475   157 IAAILLLALVPALAGGGSVAGS------------LLLALLKALLFLALLLLVGRYLLRRLFR--LVARTRSRELFLLFAL 222
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1167803507 506 AFIFLMLTVTELLDVSMELGCFLAGALVSSQGPVvtEEIATSIEPIRDFLAIVFFASI 563
Cdd:COG0475   223 LLVLLAAALAELLGLSAALGAFLAGLVLAESEYR--HELEEKIEPFGDLFLPLFFVSV 278
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
274-560 1.26e-44

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 163.58  E-value: 1.26e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 274 IVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSI-VQVETLGEFGVFFTLFLVGLEFSPEKLRKVWKISL 352
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKLPPIVGLIIAGILLGPSGLGLISEVdEDLEVLSNLGLPPLLFLAGLELDLRELRKNGGSIL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 353 QGPCYMTLLMIAF--GLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFLMGSARGDKegdiDYSTVLLGMLVTQDVQLGL 430
Cdd:pfam00999  81 LLALLGVLIPFVLigLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPE----RLGTLLLGESVLNDGVAVV 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 431 FMAVMPTLIQAGASASSsivvevlriLVLIGQILFSLAAVFLLCLVIkkylIGPYYRKLHMESKGNKEILILGISAFIFL 510
Cdd:pfam00999 157 LLAVLLALAQGVGGGSD---------LGWLLLIFLVVAVGGLLLGLL----IGWLLRLITRFTDDDRELEVLLVLLLALL 223
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1167803507 511 MLTVTELLDVSMELGCFLAGALVSsqGPVVTEEIATSIEPIRDFLAIVFF 560
Cdd:pfam00999 224 AALLAEALGVSGILGAFLAGLVLS--EYPFANKLSEKLEPFGYGLFNPLF 271
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
284-563 3.40e-34

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 131.23  E-value: 3.40e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 284 CGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVWKISLQGpcymTLLMI 363
Cdd:TIGR00932   7 AVPLSRRLGIPSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGV----GVLQV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 364 AF-----GLLWGHLLRIKPTQSVFISTCLSLSSTPLVSRFLmgsaRGDKEGDIDYSTVLLGMLVTQDVQLGLFMAVMPTL 438
Cdd:TIGR00932  83 LVpgvllGLLLGHLLGLALGAAVVIGIILALSSTAVVVQVL----KERGLLKTPFGQTVLGILLFQDIAVVPLLALLPLL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 439 iqaGASASSSivvevlriLVLIGQILFSLAAVFLLCLVIKKYLIGPYYRKLHmeSKGNKEILILGISAFIFLMLTVTELL 518
Cdd:TIGR00932 159 ---ATSASTE--------HVALALLLLKVFLAFLLLVLLGRWLLRPVLRLTA--ELRPSELFTAGSLLLMFGSAYFADLL 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1167803507 519 DVSMELGCFLAGALVSSQgpVVTEEIATSIEPIRDFLAIVFFASI 563
Cdd:TIGR00932 226 GLSMALGAFLAGVVLSES--EYRHKLESDLEPIGGVLLPLFFISV 268
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
292-563 5.20e-16

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 81.61  E-value: 5.20e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 292 GLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLrkvWKisLQGP-------------CYM 358
Cdd:PRK03659   28 GIGAVLGYLLAGIAIGPWGLGFISDVDEILHFSELGVVFLMFIIGLELNPSKL---WQ--LRRSifgvgaaqvllsaAVL 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 359 TLLMIAFGLLWghllrikpTQSVFISTCLSLSSTPLVSRFLMGSARGDKEGDIDYSTVLLgmlvTQDVQLGLFMAVMPTL 438
Cdd:PRK03659  103 AGLLMLTDFSW--------QAAVVGGIGLAMSSTAMALQLMREKGMNRSESGQLGFSVLL----FQDLAVIPALALVPLL 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 439 iqAGASASSSIVVevlrilvligQILFSLAAVFLLcLVIKKYLIGPYYRklHMESKGNKEI-------LILGISAFIflm 511
Cdd:PRK03659  171 --AGSADEHFDWM----------KIGMKVLAFAGM-LIGGRYLLRPLFR--FIAASGVREVftaaallLVLGSALFM--- 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1167803507 512 ltvtELLDVSMELGCFLAGALVSSqgpvvTE---EIATSIEPIRDFLAIVFFASI 563
Cdd:PRK03659  233 ----DALGLSMALGTFIAGVLLAE-----SEyrhELEIAIEPFKGLLLGLFFISV 278
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
290-560 1.66e-14

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 76.96  E-value: 1.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 290 AIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKLrkvWKI--------SLQ-GPCymTL 360
Cdd:PRK03562   26 RLGLGSVLGYLIAGCIIGPWGLRLVTDVESILHFAEFGVVLMLFVIGLELDPQRL---WKLrrsifgggALQmVAC--GG 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 361 LMIAFGLLWGHLLRIkptqSVFISTCLSLSSTP-----LVSRFLMGSARGDKEgdidystvlLGMLVTQDVQLGLFMAVM 435
Cdd:PRK03562  101 LLGLFCMLLGLRWQV----ALLIGLGLALSSTAiamqaMNERNLMVTQMGRSA---------FAILLFQDIAAIPLVAMI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 436 PTLIQAGAS-ASSSIVVEVLRILVLIgqilfslAAVFLLclviKKYLIGPYYRklHMESKGNKEI-------LILGISAf 507
Cdd:PRK03562  168 PLLAASGAStTLGAFALSALKVAGAL-------ALVVLG----GRYVTRPALR--FVARSGLREVftavalfLVFGFGL- 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1167803507 508 ifLMltvtELLDVSMELGCFLAGALVSSqgpvvTE---EIATSIEPIRDFLAIVFF 560
Cdd:PRK03562  234 --LM----EEVGLSMALGAFLAGVLLAS-----SEyrhALESDIEPFKGLLLGLFF 278
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
268-563 1.79e-11

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 67.05  E-value: 1.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 268 HHFIKDIVTIGM---LSLPCGWLCTAIGLPTMFGYIICGVLLGPSGLNSIKSIVQVETLGEFGVFFTLFLVGLEFSPEKL 344
Cdd:PRK10669    2 HHATPLITTIVGglvLAFILGMLANRLRISPLVGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGLHFSLKDL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 345 RKVWKISLQGPCYMTLLMIAFGLLWGHLLRIKPTQSVFISTCLSLSST-----PLVSRFLMGSARGDkegdidystVLLG 419
Cdd:PRK10669   82 MAVKSIAIPGAIAQIAVATLLGMALSAVLGWSLMTGIVFGLCLSTASTvvllrALEERQLIDSQRGQ---------IAIG 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 420 MLVTQDVQLGLFMAVMPTLIQAGASASSSIVVEVLRILVLIGQILfslaAVFLLCLVIKKYLIGPYYRKlhMESKGNKEI 499
Cdd:PRK10669  153 WLIVEDLVMVLTLVLLPAVAGMMEQGDVGFATLAVDLGITIGKVI----AFIAIMMLVGRRLVPWILAR--SAATGSREL 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1167803507 500 LILGISAFIF-LMLTVTELLDVSMELGCFLAGALVSSQGpvVTEEIATSIEPIRDFLAIVFFASI 563
Cdd:PRK10669  227 FTLSVLALALgIAFGAVELFDVSFALGAFFAGMVLNESE--LSHRAAHDTLPLRDAFAVLFFVSV 289
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
294-561 3.46e-05

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 47.19  E-value: 3.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 294 PTMFGYIICGVLLGPSGLNSIK----------SIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVWK----ISLQGPCYMT 359
Cdd:PLN03159   68 PRVISEILGGVILGPSVLGQSEvfantifplrSVMVLETMANLGLLYFLFLVGVEMDISVIRRTGKkalaIAIAGMALPF 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 360 LLMIAFGLLWGHLLRI--KPTQSVFISTCLSLSSTPLVSRFLMGSARGDKE-GDIDYSTVLLgmlvtQDVQLGLFMAVMP 436
Cdd:PLN03159  148 CIGLAFSFIFHQVSRNvhQGTFILFLGVALSVTAFPVLARILAEIKLINTElGRIAMSAALV-----NDMCAWILLALAI 222
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 437 TLIQAGASASSSivvevlrILVLIGQILFSLAAVFLLCLVIkKYLIgpyyRKLHmESKGNKEILILGISAFIFLMLTVTE 516
Cdd:PLN03159  223 ALAENDSTSLAS-------LWVLLSSVAFVLFCFYVVRPGI-WWII----RRTP-EGETFSEFYICLILTGVMISGFITD 289
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1167803507 517 LLDVSMELGCFLAGaLVSSQGPVVTeeiaTSIEPIRDF----LAIVFFA 561
Cdd:PLN03159  290 AIGTHSVFGAFVFG-LVIPNGPLGV----TLIEKLEDFvsglLLPLFFA 333
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
274-369 1.40e-03

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 41.49  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1167803507 274 IVTIGMLSLPCGWLCTAIGLPTMFGYIICGVLLGPsGLNSI--KSIVQVETLGEFGVFFTLFLVGLEFSPEKLRKVWKIS 351
Cdd:COG0025     7 ILLLLLLGLLSQWLARRLKLPAPLLLLLAGILLGP-GLGLEldPELGDLEPLLELFLPPLLFEAALNLDLRELRRNGRPI 85
                          90       100
                  ....*....|....*....|.
gi 1167803507 352 LQ---GPCYMTLLMIAFGLLW 369
Cdd:COG0025    86 LRlavVGVLLTTLAVALAAHW 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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