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Conserved domains on  [gi|1172222021|ref|NP_001336950|]
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junctional cadherin 5-associated protein isoform 2 [Homo sapiens]

Protein Classification

JCAD domain-containing protein( domain architecture ID 12173170)

JCAD domain-containing protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1210 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


:

Pssm-ID: 434658  Cd Length: 1358  Bit Score: 2000.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021    1 MAQAHSLPVHVREGPWEVGGRSEHVMKKPVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGERLFQDLYPFIQGE 80
Cdd:pfam15351  140 MAQAHSLPVHVREGPWEVGGRTEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEKLFQDLYPFIQGE 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021   81 HVLNSQNKGKSRSLPRVLSPESLSCTEIPIPLNERHS---PKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKP 157
Cdd:pfam15351  220 HVLTSQNKGKSQSLPRVLSPESLSCMEIPIPLNDGHLpgvPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKP 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  158 PSYSSHQQSRGGADSSDSQDSQQMDAYV--------PRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYLEDTVPINVC 229
Cdd:pfam15351  300 PSYESHQQSRGGVENSDYQDSQQADLCVsyltrtsdPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVS 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  230 GGHSQQQSPTEKAGASGQPPSGPPGTGNEYGVSPRLPQGLPAHPRPVTAYDGFVQYIPFDDPRLRHFKLAQPQGFCEDIK 309
Cdd:pfam15351  380 GGHSQQQHPTEKPGASCQLPSGSLGTGNEYGASPRSPRGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETK 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  310 LDDKSYNSSPVTAQEPAHGGMQPDGAIWNPQSLIPPSGDERGLVLADSSPRWLWGQPPGDGENSGLPNQRDRCVARGQWP 389
Cdd:pfam15351  460 LDDKSYSSGPVTAQEPARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWP 539

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  390 DVRGSQHGHTGRQVSSPYSQGESTCETQTKLKKFQTGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDNNDLKPSA 469
Cdd:pfam15351  540 DVRGSQHGHAEGQVSSPSPQGESTCETQTKLKKFETGIQTKKSSKKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSA 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  470 DQKNGSDKSPALQEQSLLSMSSTDLELQALTGSMGGRTEFQKQDLGEPEEDRQTNDLSFIHLTKHRELKHSGSWPGHRYR 549
Cdd:pfam15351  620 DKKNGLDKSGALQEQSLLSMSSTDLELQALTGSMAGRTELQKQDLGEPEEDKQTNDLRFIHPAKHRELKYSGSWPGHQYR 699

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  550 DQQTQTSFSEEPQSSQLLPGAKLGGPSRAALSPKCSDPAASEAQTHTAFPTGDHKQRPSARNLKGHRSLSPSSNSAFSRT 629
Cdd:pfam15351  700 DQQTQTSFTEESKSSQLLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRT 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  630 SLSVDQAPTPKAGRSQPCVDVHGLGAHPGPKREVVKGEPTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQeeEE 709
Cdd:pfam15351  780 SSSINQAPVPKAGQSQPCVDVRGRGASPVPRGEVVKGETTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQ--EE 857

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  710 SSSSSSSSSSSSEESEAEPQQENRAHCRQEDVGFRGNSPEMRVEPQPRMWVPESPVCRSGRGESKSESWSEELQPGHPRA 789
Cdd:pfam15351  858 EESSSSSSGSSSEDSEAEWQPEDCADSRPKSPGFREDSQEMRVEQQPRRLVPEDPVFRSGRVKSKSESWSEEPKPGHPCA 937

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  790 WPPSPGRFRVEEGGGAPFCSADGSTSAEKRHLEVSNGMDELAGSPFPVTR-MSSRSSDAKPLPASYPAEPREPQESPKIT 868
Cdd:pfam15351  938 CPQSPGPSQVEDGRGEPFLSADGSLITEKRKQEVGNRINELAVSPGPVKRiTSSRSSDTKPVPPSYPAELREPQESQKLP 1017

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  869 SAFSSVKPSEAVPRKFDSGGERGAGLPLSLSNKNRGLSAPDLRSVGLTPGQEQGASELEGSLGEASTIEIPPGESLQARA 948
Cdd:pfam15351 1018 DALSSVQLSKAAPPRAGGGEERGTAVPLSLASKSRGLSAPDLRSVGLTPGQEQSASKLDGSLGEASAIEIPPNESLQARA 1097

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  949 ARILGIEVAVESLLPGIRRAGQNQPAEPDASACTPESPQEELLSRPAPADVPRVSTDAFYGRRKCGWTKSPLFVGDRDSA 1028
Cdd:pfam15351 1098 ARILGIEVAVESLLPGARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERDSA 1177

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021 1029 RRAPQAFEHSDVDGVVTSTDPVPEPEPSPLESKFFEQKDVETKPPFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEK 1108
Cdd:pfam15351 1178 RRAPQASEHSGVDGVVPSQAPSPEPQPSPLESKSFEQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEK 1257

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021 1109 LASPPRRADPDRLMRMKEVSSVSRMRVLSFRNADSQEDAEELKAtTRGQAGLPGGLVSPGSGDRAQRLGHSLSVSKDSIS 1188
Cdd:pfam15351 1258 LASPPRRADPDRLMRMKEVSSVSRMRLLSSRSADSGEEAEELKA-ERGQAGQPGGPVSLNGGDRARKAGHSLSVSKGIIS 1336

                         1210      1220
                   ....*....|....*....|..
gi 1172222021 1189 REEKEHPAAQKEKSMDQDFWCP 1210
Cdd:pfam15351 1337 LEENGHPAAQREKNGDQDFWCP 1358
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1210 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 2000.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021    1 MAQAHSLPVHVREGPWEVGGRSEHVMKKPVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGERLFQDLYPFIQGE 80
Cdd:pfam15351  140 MAQAHSLPVHVREGPWEVGGRTEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEKLFQDLYPFIQGE 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021   81 HVLNSQNKGKSRSLPRVLSPESLSCTEIPIPLNERHS---PKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKP 157
Cdd:pfam15351  220 HVLTSQNKGKSQSLPRVLSPESLSCMEIPIPLNDGHLpgvPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKP 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  158 PSYSSHQQSRGGADSSDSQDSQQMDAYV--------PRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYLEDTVPINVC 229
Cdd:pfam15351  300 PSYESHQQSRGGVENSDYQDSQQADLCVsyltrtsdPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVS 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  230 GGHSQQQSPTEKAGASGQPPSGPPGTGNEYGVSPRLPQGLPAHPRPVTAYDGFVQYIPFDDPRLRHFKLAQPQGFCEDIK 309
Cdd:pfam15351  380 GGHSQQQHPTEKPGASCQLPSGSLGTGNEYGASPRSPRGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETK 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  310 LDDKSYNSSPVTAQEPAHGGMQPDGAIWNPQSLIPPSGDERGLVLADSSPRWLWGQPPGDGENSGLPNQRDRCVARGQWP 389
Cdd:pfam15351  460 LDDKSYSSGPVTAQEPARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWP 539

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  390 DVRGSQHGHTGRQVSSPYSQGESTCETQTKLKKFQTGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDNNDLKPSA 469
Cdd:pfam15351  540 DVRGSQHGHAEGQVSSPSPQGESTCETQTKLKKFETGIQTKKSSKKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSA 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  470 DQKNGSDKSPALQEQSLLSMSSTDLELQALTGSMGGRTEFQKQDLGEPEEDRQTNDLSFIHLTKHRELKHSGSWPGHRYR 549
Cdd:pfam15351  620 DKKNGLDKSGALQEQSLLSMSSTDLELQALTGSMAGRTELQKQDLGEPEEDKQTNDLRFIHPAKHRELKYSGSWPGHQYR 699

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  550 DQQTQTSFSEEPQSSQLLPGAKLGGPSRAALSPKCSDPAASEAQTHTAFPTGDHKQRPSARNLKGHRSLSPSSNSAFSRT 629
Cdd:pfam15351  700 DQQTQTSFTEESKSSQLLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRT 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  630 SLSVDQAPTPKAGRSQPCVDVHGLGAHPGPKREVVKGEPTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQeeEE 709
Cdd:pfam15351  780 SSSINQAPVPKAGQSQPCVDVRGRGASPVPRGEVVKGETTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQ--EE 857

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  710 SSSSSSSSSSSSEESEAEPQQENRAHCRQEDVGFRGNSPEMRVEPQPRMWVPESPVCRSGRGESKSESWSEELQPGHPRA 789
Cdd:pfam15351  858 EESSSSSSGSSSEDSEAEWQPEDCADSRPKSPGFREDSQEMRVEQQPRRLVPEDPVFRSGRVKSKSESWSEEPKPGHPCA 937

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  790 WPPSPGRFRVEEGGGAPFCSADGSTSAEKRHLEVSNGMDELAGSPFPVTR-MSSRSSDAKPLPASYPAEPREPQESPKIT 868
Cdd:pfam15351  938 CPQSPGPSQVEDGRGEPFLSADGSLITEKRKQEVGNRINELAVSPGPVKRiTSSRSSDTKPVPPSYPAELREPQESQKLP 1017

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  869 SAFSSVKPSEAVPRKFDSGGERGAGLPLSLSNKNRGLSAPDLRSVGLTPGQEQGASELEGSLGEASTIEIPPGESLQARA 948
Cdd:pfam15351 1018 DALSSVQLSKAAPPRAGGGEERGTAVPLSLASKSRGLSAPDLRSVGLTPGQEQSASKLDGSLGEASAIEIPPNESLQARA 1097

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  949 ARILGIEVAVESLLPGIRRAGQNQPAEPDASACTPESPQEELLSRPAPADVPRVSTDAFYGRRKCGWTKSPLFVGDRDSA 1028
Cdd:pfam15351 1098 ARILGIEVAVESLLPGARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERDSA 1177

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021 1029 RRAPQAFEHSDVDGVVTSTDPVPEPEPSPLESKFFEQKDVETKPPFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEK 1108
Cdd:pfam15351 1178 RRAPQASEHSGVDGVVPSQAPSPEPQPSPLESKSFEQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEK 1257

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021 1109 LASPPRRADPDRLMRMKEVSSVSRMRVLSFRNADSQEDAEELKAtTRGQAGLPGGLVSPGSGDRAQRLGHSLSVSKDSIS 1188
Cdd:pfam15351 1258 LASPPRRADPDRLMRMKEVSSVSRMRLLSSRSADSGEEAEELKA-ERGQAGQPGGPVSLNGGDRARKAGHSLSVSKGIIS 1336

                         1210      1220
                   ....*....|....*....|..
gi 1172222021 1189 REEKEHPAAQKEKSMDQDFWCP 1210
Cdd:pfam15351 1337 LEENGHPAAQREKNGDQDFWCP 1358
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1210 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 2000.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021    1 MAQAHSLPVHVREGPWEVGGRSEHVMKKPVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGERLFQDLYPFIQGE 80
Cdd:pfam15351  140 MAQAHSLPVHVREGPWEVGGRTEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEKLFQDLYPFIQGE 219

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021   81 HVLNSQNKGKSRSLPRVLSPESLSCTEIPIPLNERHS---PKMPPYPPTCAPNLDSTRNSEKSGCSAPFPRPKFGRPLKP 157
Cdd:pfam15351  220 HVLTSQNKGKSQSLPRVLSPESLSCMEIPIPLNDGHLpgvPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGRPLKP 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  158 PSYSSHQQSRGGADSSDSQDSQQMDAYV--------PRHELCLSDPGLEPPVYVPPPSYRSPPQNIPNPYLEDTVPINVC 229
Cdd:pfam15351  300 PSYESHQQSRGGVENSDYQDSQQADLCVsyltrtsdPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVPRHVS 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  230 GGHSQQQSPTEKAGASGQPPSGPPGTGNEYGVSPRLPQGLPAHPRPVTAYDGFVQYIPFDDPRLRHFKLAQPQGFCEDIK 309
Cdd:pfam15351  380 GGHSQQQHPTEKPGASCQLPSGSLGTGNEYGASPRSPRGLPPHPRPVTAYDGSVQYIPFDDPRIRHIKLAQPQGFCEETK 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  310 LDDKSYNSSPVTAQEPAHGGMQPDGAIWNPQSLIPPSGDERGLVLADSSPRWLWGQPPGDGENSGLPNQRDRCVARGQWP 389
Cdd:pfam15351  460 LDDKSYSSGPVTAQEPARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVVRGQWP 539

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  390 DVRGSQHGHTGRQVSSPYSQGESTCETQTKLKKFQTGTRTKKSSKKKMNETIFCLVSIPVKSESHLPDRDMDNNDLKPSA 469
Cdd:pfam15351  540 DVRGSQHGHAEGQVSSPSPQGESTCETQTKLKKFETGIQTKKSSKKKMNETIFCLVSIPVKSESHLPDTDTNNNDLKQSA 619

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  470 DQKNGSDKSPALQEQSLLSMSSTDLELQALTGSMGGRTEFQKQDLGEPEEDRQTNDLSFIHLTKHRELKHSGSWPGHRYR 549
Cdd:pfam15351  620 DKKNGLDKSGALQEQSLLSMSSTDLELQALTGSMAGRTELQKQDLGEPEEDKQTNDLRFIHPAKHRELKYSGSWPGHQYR 699

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  550 DQQTQTSFSEEPQSSQLLPGAKLGGPSRAALSPKCSDPAASEAQTHTAFPTGDHKQRPSARNLKGHRSLSPSSNSAFSRT 629
Cdd:pfam15351  700 DQQTQTSFTEESKSSQLLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNSAFSRT 779

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  630 SLSVDQAPTPKAGRSQPCVDVHGLGAHPGPKREVVKGEPTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQeeEE 709
Cdd:pfam15351  780 SSSINQAPVPKAGQSQPCVDVRGRGASPVPRGEVVKGETTGPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKELQ--EE 857

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  710 SSSSSSSSSSSSEESEAEPQQENRAHCRQEDVGFRGNSPEMRVEPQPRMWVPESPVCRSGRGESKSESWSEELQPGHPRA 789
Cdd:pfam15351  858 EESSSSSSGSSSEDSEAEWQPEDCADSRPKSPGFREDSQEMRVEQQPRRLVPEDPVFRSGRVKSKSESWSEEPKPGHPCA 937

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  790 WPPSPGRFRVEEGGGAPFCSADGSTSAEKRHLEVSNGMDELAGSPFPVTR-MSSRSSDAKPLPASYPAEPREPQESPKIT 868
Cdd:pfam15351  938 CPQSPGPSQVEDGRGEPFLSADGSLITEKRKQEVGNRINELAVSPGPVKRiTSSRSSDTKPVPPSYPAELREPQESQKLP 1017

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  869 SAFSSVKPSEAVPRKFDSGGERGAGLPLSLSNKNRGLSAPDLRSVGLTPGQEQGASELEGSLGEASTIEIPPGESLQARA 948
Cdd:pfam15351 1018 DALSSVQLSKAAPPRAGGGEERGTAVPLSLASKSRGLSAPDLRSVGLTPGQEQSASKLDGSLGEASAIEIPPNESLQARA 1097

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021  949 ARILGIEVAVESLLPGIRRAGQNQPAEPDASACTPESPQEELLSRPAPADVPRVSTDAFYGRRKCGWTKSPLFVGDRDSA 1028
Cdd:pfam15351 1098 ARILGIEVAVESLLPGARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFVGERDSA 1177

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021 1029 RRAPQAFEHSDVDGVVTSTDPVPEPEPSPLESKFFEQKDVETKPPFRSTLFHFVERTPSVAGSEKRLRSPSKVIESLQEK 1108
Cdd:pfam15351 1178 RRAPQASEHSGVDGVVPSQAPSPEPQPSPLESKSFEQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVIESLQEK 1257

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1172222021 1109 LASPPRRADPDRLMRMKEVSSVSRMRVLSFRNADSQEDAEELKAtTRGQAGLPGGLVSPGSGDRAQRLGHSLSVSKDSIS 1188
Cdd:pfam15351 1258 LASPPRRADPDRLMRMKEVSSVSRMRLLSSRSADSGEEAEELKA-ERGQAGQPGGPVSLNGGDRARKAGHSLSVSKGIIS 1336

                         1210      1220
                   ....*....|....*....|..
gi 1172222021 1189 REEKEHPAAQKEKSMDQDFWCP 1210
Cdd:pfam15351 1337 LEENGHPAAQREKNGDQDFWCP 1358
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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