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Conserved domains on  [gi|1174098500|ref|NP_001337057|]
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protoporphyrinogen oxidase isoform 2 [Homo sapiens]

Protein Classification

protoporphyrinogen/coproporphyrinogen oxidase( domain architecture ID 11440906)

protoporphyrinogen/coproporphyrinogen oxidase is a FAD-dependent enzyme that catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX or the oxidation of coproporphyrinogen III to coproporphyrin III, respectively

CATH:  3.50.50.60|3.50.50.60|1.10.3110.10|3.90.660.20
EC:  1.-.-.-
Gene Ontology:  GO:0016491|GO:0009055|GO:0006779|GO:0071949
PubMed:  10944103
SCOP:  4000128|3000055|4000128

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-440 2.60e-76

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


:

Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 244.74  E-value: 2.60e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGI---RPAgalgARTLLlacgeq 79
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFltrDPE----VLELL------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  80 vSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTG---------LSPSLTLKVA--------------SLA------- 129
Cdd:COG1232    69 -RELGLGDELV-----WPNTRKSYIYYGGKLHPLPQGplallrsplLSLAGKLRALlellaprrppgedeSLAefvrrrf 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 130 --------MDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------WS 195
Cdd:COG1232   143 grevyerlVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfGY 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 196 LRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARALS 274
Cdd:COG1232   205 LRGGLGTLVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAALA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 275 AITAVSVAVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvLS 352
Cdd:COG1232   282 GIPYASVAVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----LS 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 353 QELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRlPLTLAGASYEGVAVNDCIESGRQ 432
Cdd:COG1232   356 DEELVALALADLRKLLGIDAEPVDTRVVRWPKAYPQYTVGHLERVAAIREALAALP-GLYLAGRAYDGVGLPDCIRSGRE 434


                  ....*...
gi 1174098500 433 AAVSVLGT 440
Cdd:COG1232   435 AAERILAE 442
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-440 2.60e-76

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 244.74  E-value: 2.60e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGI---RPAgalgARTLLlacgeq 79
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFltrDPE----VLELL------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  80 vSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTG---------LSPSLTLKVA--------------SLA------- 129
Cdd:COG1232    69 -RELGLGDELV-----WPNTRKSYIYYGGKLHPLPQGplallrsplLSLAGKLRALlellaprrppgedeSLAefvrrrf 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 130 --------MDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------WS 195
Cdd:COG1232   143 grevyerlVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfGY 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 196 LRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARALS 274
Cdd:COG1232   205 LRGGLGTLVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAALA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 275 AITAVSVAVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvLS 352
Cdd:COG1232   282 GIPYASVAVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----LS 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 353 QELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRlPLTLAGASYEGVAVNDCIESGRQ 432
Cdd:COG1232   356 DEELVALALADLRKLLGIDAEPVDTRVVRWPKAYPQYTVGHLERVAAIREALAALP-GLYLAGRAYDGVGLPDCIRSGRE 434


                  ....*...
gi 1174098500 433 AAVSVLGT 440
Cdd:COG1232   435 AAERILAE 442
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-438 5.59e-65

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 215.86  E-value: 5.59e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   3 RTVVVLGGGISGLAASYHLS--RAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGAlGARTLllacgeqV 80
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAYYLEkeIPELPVELTLVEASDRVGGKIQTVK-EDGYLIERGPDSFLERKK-SAPDL-------V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  81 SELGLDsevlPVRGDHPAAQnRFLYV-GGALHALPTGLSPSLTLKVASL------AMD---------------------- 131
Cdd:TIGR00562  74 KDLGLE----HVLVSDATGQ-RYVLVnRGKLMPVPTKIAPFVKTGLFSLggklraGMDfirpaspgkdesveefvrrrfg 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 132 ---------SLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLlgagRTPQPDSALIRQALAERWSQW--SLRGGL 200
Cdd:TIGR00562 149 devvenliePLLSGIYAGDPSKLSLKSTFPKFYQTEQKHGSLILGMK----KTRNLPQGSGLQLTAKKQGQDfqTLATGL 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 201 EMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVS 280
Cdd:TIGR00562 225 ETLPEEIEKRL--KLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELSNSASSHLDKIHSPP 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 281 VAVVNLQY-----QGAHlpvQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG-LRVTVMLGGSwlqtLEASGCVLSQE 354
Cdd:TIGR00562 303 VANVNLGFpegsvDGEL---EGFGFLISRSSKFAILGCIFTSKLFPNR--APPGkTLLTAYIGGA----TDESIVDLSEN 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 355 LFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAA 434
Cdd:TIGR00562 374 EIINIVLRDLKKVLNINNEPEMLCVTRWHRAIPQYHVGHDQRLKEARELLESAYPGVFLTGNSFEGVGIPDCIDQGKAAA 453


                  ....
gi 1174098500 435 VSVL 438
Cdd:TIGR00562 454 SDVL 457
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 3-439 1.24e-49

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 174.65  E-value: 1.24e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIrpagaLGARTLLLACgeqVSE 82
Cdd:PRK11883    1 KKVAIIGGGITGLSAAYRLHKKGPDADITLLEASDRLGGKIQTVR-KDGFPIELGPESF-----LARKPSAPAL---VKE 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  83 LGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTG--------LSPSLTLKVASLA------------------------- 129
Cdd:PRK11883   72 LGLEDELV-----ANTTGQSYIYVNGKLHPIPPGtvmgiptsIAPFLFAGLVSPIgklraaadlrpprwkpgqdqsvgaf 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 130 -------------MDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglLLGAGRTPQPDSALIRQALAerwsqwSL 196
Cdd:PRK11883  147 frrrfgdevvenlIEPLLSGIYAGDIDTLSLRATFPQLAQAEDKYGSL----LRGMRKALPKEKKKTKGVFG------TL 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 197 RGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGrWKVSLRDSS-LEADHVISAIPASVLSELLPAEAAplARALSA 275
Cdd:PRK11883  217 KGGLQSLIEALEEKL--PAGTIHKGTPVTKIDKSGDG-YEIVLSNGGeIEADAVIVAVPHPVLPSLFVAPPA--FALFKT 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 276 ITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG---LRVTVmlgGSWLQTLEASgcvL 351
Cdd:PRK11883  292 IPSTSVATVALAFPESATNLpDGTGFLVARNSDYTITACTWTSKKWPHT--TPEGkvlLRLYV---GRPGDEAVVD---A 363

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 352 SQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLtAHRLPLTLAGASYEGVAVNDCIESGR 431
Cdd:PRK11883  364 TDEELVAFVLADLSKVMGITGDPEFTIVQRWKEAMPQYGVGHIERVAELRAGL-PHYPGLYVAGASFEGVGLPDCIAQAK 442


                  ....*...
gi 1174098500 432 QAAVSVLG 439
Cdd:PRK11883  443 RAAARLLA 450
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 12-438 1.73e-38

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 144.56  E-value: 1.73e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  12 ISGLAASYHLSRAPcpPKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALgARTLLlacgeqvSELGLDSEVlp 91
Cdd:pfam01593   1 LAGLAAARELLRAG--HDVTVLEARDRVGGRIRTVRDD-GFLIELGAMWFHGAQPP-LLALL-------KELGLEDRL-- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  92 vRGDHPAAQNRFLYVGG-----ALHALPTGLSPSLTLKVASLAMDSLCRGVFA-------------GNSRELSIRSCFPS 153
Cdd:pfam01593  68 -VLPDPAPFYTVLFAGGrrypgDFRRVPAGWEGLLEFGRLLSIPEKLRLGLAAlasdaldefdlddFSLAESLLFLGRRG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 154 LFQAEQTHRSILLGLLLG-----AGRTPQPDSALIRQALAERW-------SQWSLRGGLEMLPQALETHLtsRGVSVLRG 221
Cdd:pfam01593 147 PGDVEVWDRLIDPELFAAlpfasGAFAGDPSELSAGLALPLLWallgeggSLLLPRGGLGALPDALAAQL--LGGDVRLN 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 222 QPVCGLSLQAEGRwKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQgf 298
Cdd:pfam01593 225 TRVRSIDREGDGV-TVTLTDgEVIEADAVIVTVPLGVLKriLFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL-- 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 299 GHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLG-GSWLQTLEAsgcvLSQELFQQRAQEAAATQLG--LKEMPS 375
Cdd:pfam01593 302 GLLGLLSELLTGLGTAFSWLTFPNRAPPGKGLLLLVYVGpGDRARELEG----LSDEELLQAVLRDLRKLFGeeAPEPLR 377

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 376 HCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLP---LTLAGAS----YEGVaVNDCIESGRQAAVSVL 438
Cdd:pfam01593 378 VLVSDWHTDPWPRGSYSLPQYGPGHDDYRPLARTPdpgLFFAGEHtstgYPGT-VEGAIESGRRAARAVL 446
 
Name Accession Description Interval E-value
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-440 2.60e-76

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 244.74  E-value: 2.60e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGpNGAIFELGPRGI---RPAgalgARTLLlacgeq 79
Cdd:COG1232     2 KRVAVIGGGIAGLTAAYRLAKAGH--EVTVLEASDRVGGLIRTVEV-DGFRIDRGPHSFltrDPE----VLELL------ 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  80 vSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTG---------LSPSLTLKVA--------------SLA------- 129
Cdd:COG1232    69 -RELGLGDELV-----WPNTRKSYIYYGGKLHPLPQGplallrsplLSLAGKLRALlellaprrppgedeSLAefvrrrf 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 130 --------MDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSillglllgagrtpqpdsaLIRQALAERWSQ------WS 195
Cdd:COG1232   143 grevyerlVEPLLEGVYAGDPDELSADWAFPRLKRLELEHGS------------------LIKGALALRKGAkagevfGY 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 196 LRGGLEMLPQALETHLtsRGVSVLRGQPVCGLSlQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPAEAAPLARALS 274
Cdd:COG1232   205 LRGGLGTLVEALAEAL--EAGEIRLGTRVTAIE-REGGGWRVTTSDgETIEADAVVSATPAPALARLLAPLPPEVAAALA 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 275 AITAVSVAVVNLQYQGAHL-PVQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPGLR-VTVMLGGSWLQTLEAsgcvLS 352
Cdd:COG1232   282 GIPYASVAVVALGFDRPDLpPPDGFGWLVPRDEGVPILAVTFSSNKWPHR--APDGKVlLRLEVGGAGDPELWQ----LS 355

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 353 QELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRlPLTLAGASYEGVAVNDCIESGRQ 432
Cdd:COG1232   356 DEELVALALADLRKLLGIDAEPVDTRVVRWPKAYPQYTVGHLERVAAIREALAALP-GLYLAGRAYDGVGLPDCIRSGRE 434


                  ....*...
gi 1174098500 433 AAVSVLGT 440
Cdd:COG1232   435 AAERILAE 442
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 3-438 5.59e-65

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 215.86  E-value: 5.59e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   3 RTVVVLGGGISGLAASYHLS--RAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGAlGARTLllacgeqV 80
Cdd:TIGR00562   3 KHVVIIGGGISGLCAAYYLEkeIPELPVELTLVEASDRVGGKIQTVK-EDGYLIERGPDSFLERKK-SAPDL-------V 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  81 SELGLDsevlPVRGDHPAAQnRFLYV-GGALHALPTGLSPSLTLKVASL------AMD---------------------- 131
Cdd:TIGR00562  74 KDLGLE----HVLVSDATGQ-RYVLVnRGKLMPVPTKIAPFVKTGLFSLggklraGMDfirpaspgkdesveefvrrrfg 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 132 ---------SLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSILLGLLlgagRTPQPDSALIRQALAERWSQW--SLRGGL 200
Cdd:TIGR00562 149 devvenliePLLSGIYAGDPSKLSLKSTFPKFYQTEQKHGSLILGMK----KTRNLPQGSGLQLTAKKQGQDfqTLATGL 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 201 EMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLARALSAITAVS 280
Cdd:TIGR00562 225 ETLPEEIEKRL--KLTKVYKGTKVTKLSHRGSNYTLELDNGVTVETDSVVVTAPHKAAAGLLSELSNSASSHLDKIHSPP 302

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 281 VAVVNLQY-----QGAHlpvQGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG-LRVTVMLGGSwlqtLEASGCVLSQE 354
Cdd:TIGR00562 303 VANVNLGFpegsvDGEL---EGFGFLISRSSKFAILGCIFTSKLFPNR--APPGkTLLTAYIGGA----TDESIVDLSEN 373

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 355 LFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYEGVAVNDCIESGRQAA 434
Cdd:TIGR00562 374 EIINIVLRDLKKVLNINNEPEMLCVTRWHRAIPQYHVGHDQRLKEARELLESAYPGVFLTGNSFEGVGIPDCIDQGKAAA 453


                  ....
gi 1174098500 435 VSVL 438
Cdd:TIGR00562 454 SDVL 457
PRK11883 PRK11883
protoporphyrinogen oxidase; Reviewed
 3-439 1.24e-49

protoporphyrinogen oxidase; Reviewed


Pssm-ID: 237009 [Multi-domain]  Cd Length: 451  Bit Score: 174.65  E-value: 1.24e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   3 RTVVVLGGGISGLAASYHLSRAPCPPKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIrpagaLGARTLLLACgeqVSE 82
Cdd:PRK11883    1 KKVAIIGGGITGLSAAYRLHKKGPDADITLLEASDRLGGKIQTVR-KDGFPIELGPESF-----LARKPSAPAL---VKE 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  83 LGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTG--------LSPSLTLKVASLA------------------------- 129
Cdd:PRK11883   72 LGLEDELV-----ANTTGQSYIYVNGKLHPIPPGtvmgiptsIAPFLFAGLVSPIgklraaadlrpprwkpgqdqsvgaf 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 130 -------------MDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSIllglLLGAGRTPQPDSALIRQALAerwsqwSL 196
Cdd:PRK11883  147 frrrfgdevvenlIEPLLSGIYAGDIDTLSLRATFPQLAQAEDKYGSL----LRGMRKALPKEKKKTKGVFG------TL 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 197 RGGLEMLPQALETHLtsRGVSVLRGQPVCGLSLQAEGrWKVSLRDSS-LEADHVISAIPASVLSELLPAEAAplARALSA 275
Cdd:PRK11883  217 KGGLQSLIEALEEKL--PAGTIHKGTPVTKIDKSGDG-YEIVLSNGGeIEADAVIVAVPHPVLPSLFVAPPA--FALFKT 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 276 ITAVSVAVVNLQYQGAHLPV-QGFGHLVPSSEDPGVLGIVYDSVAFPEQdgSPPG---LRVTVmlgGSWLQTLEASgcvL 351
Cdd:PRK11883  292 IPSTSVATVALAFPESATNLpDGTGFLVARNSDYTITACTWTSKKWPHT--TPEGkvlLRLYV---GRPGDEAVVD---A 363

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 352 SQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLtAHRLPLTLAGASYEGVAVNDCIESGR 431
Cdd:PRK11883  364 TDEELVAFVLADLSKVMGITGDPEFTIVQRWKEAMPQYGVGHIERVAELRAGL-PHYPGLYVAGASFEGVGLPDCIAQAK 442


                  ....*...
gi 1174098500 432 QAAVSVLG 439
Cdd:PRK11883  443 RAAARLLA 450
PLN02576 PLN02576
protoporphyrinogen oxidase
 2-438 4.20e-43

protoporphyrinogen oxidase


Pssm-ID: 215314 [Multi-domain]  Cd Length: 496  Bit Score: 158.25  E-value: 4.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   2 GRTVVVLGGGISGLAASYHLSRAPCPpKVVLVESSERLGGWIRSVRGpNGAIFELGPRGIRPAGALgartLLLACgeqvs 81
Cdd:PLN02576   12 SKDVAVVGAGVSGLAAAYALASKHGV-NVLVTEARDRVGGNITSVSE-DGFIWEEGPNSFQPSDPE----LTSAV----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  82 ELGL-DSEVLPVrgdhPAAqNRFLYVGGALHALPTGLSPSLTLKVASL-------------------------------- 128
Cdd:PLN02576   81 DSGLrDDLVFPD----PQA-PRYVVWNGKLRPLPSNPIDLPTFDLLSApgkiraglgafgwkrppppgreesvgefvrrh 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 129 --------AMDSLCRGVFAGNSRELSIRSCFPSLFQAEQTHRSI-----LLGLLLGAGRTPQP-DSALIRQalaERWSQW 194
Cdd:PLN02576  156 lgdevferLIDPFVSGVYAGDPSSLSMKAAFPKLWNLEKRGGSIiggaiKAIQEAKKNPKPEPrDPRLPKP---KGQTVG 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 195 SLRGGLEMLPQALETHLTSRGVSVlrGQPVCGLSLQAEGRWKVSLRD----SSLEADHVISAIPASVLSELLPAEAAPLA 270
Cdd:PLN02576  233 SFRGGLQTLPDALAKRLGKDKVKL--NWKVLSLSKNDDGGYSLTYDTpegkVNVTAKAVVMTAPLYVVSEMLRPKSPAAA 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 271 RALSAITAVSVAVVNLQY--------QGAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPeqDGSPPGLRV-TVMLGGSWL 341
Cdd:PLN02576  311 DALPEFYYPPVAAVTTSYpkeavkreRLIDGPLEGFGQLHPRKQGVKTLGTIYSSSLFP--DRAPEGRVLlLNYIGGSRN 388

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 342 QTL-EASgcvlSQELFQqrAQEAAATQLGLKEMPSHCLVHLHK---NCIPQYTLGHWQKLESARQFLTAHRLP-LTLAGA 416
Cdd:PLN02576  389 TGIaSAS----EEELVE--AVDRDLRKLLLKPGAPPPKVVGVRvwpKAIPQYLLGHLDVLEAAEKMEKDLGLPgLFLGGN 462

                         490       500
                  ....*....|....*....|..
gi 1174098500 417 SYEGVAVNDCIESGRQAAVSVL 438
Cdd:PLN02576  463 YRGGVALGKCVESGYEAADLVI 484
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 12-438 1.73e-38

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 144.56  E-value: 1.73e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  12 ISGLAASYHLSRAPcpPKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALgARTLLlacgeqvSELGLDSEVlp 91
Cdd:pfam01593   1 LAGLAAARELLRAG--HDVTVLEARDRVGGRIRTVRDD-GFLIELGAMWFHGAQPP-LLALL-------KELGLEDRL-- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  92 vRGDHPAAQNRFLYVGG-----ALHALPTGLSPSLTLKVASLAMDSLCRGVFA-------------GNSRELSIRSCFPS 153
Cdd:pfam01593  68 -VLPDPAPFYTVLFAGGrrypgDFRRVPAGWEGLLEFGRLLSIPEKLRLGLAAlasdaldefdlddFSLAESLLFLGRRG 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 154 LFQAEQTHRSILLGLLLG-----AGRTPQPDSALIRQALAERW-------SQWSLRGGLEMLPQALETHLtsRGVSVLRG 221
Cdd:pfam01593 147 PGDVEVWDRLIDPELFAAlpfasGAFAGDPSELSAGLALPLLWallgeggSLLLPRGGLGALPDALAAQL--LGGDVRLN 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 222 QPVCGLSLQAEGRwKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAPLARALSAITAVSVAVVNLQYQGAHLPVQgf 298
Cdd:pfam01593 225 TRVRSIDREGDGV-TVTLTDgEVIEADAVIVTVPLGVLKriLFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWPDL-- 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 299 GHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGLRVTVMLG-GSWLQTLEAsgcvLSQELFQQRAQEAAATQLG--LKEMPS 375
Cdd:pfam01593 302 GLLGLLSELLTGLGTAFSWLTFPNRAPPGKGLLLLVYVGpGDRARELEG----LSDEELLQAVLRDLRKLFGeeAPEPLR 377

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 376 HCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLP---LTLAGAS----YEGVaVNDCIESGRQAAVSVL 438
Cdd:pfam01593 378 VLVSDWHTDPWPRGSYSLPQYGPGHDDYRPLARTPdpgLFFAGEHtstgYPGT-VEGAIESGRRAARAVL 446
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
2-288 2.47e-22

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 98.84  E-value: 2.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   2 GRTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGP-NGAIFELGPRGIRPagalgARTLLLAcgeQV 80
Cdd:COG1231     7 GKDVVIVGAGLAGLAAARELRKAGL--DVTVLEARDRVGGRVWTLRFGdDGLYAELGAMRIPP-----SHTNLLA---LA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  81 SELGLDSEVLPvrgdhPAAQNRFLYVGGALHalPTGLSPSLTLKVASL---AMDSLCRGVFAGNSR-----ELSIRSCFP 152
Cdd:COG1231    77 RELGLPLEPFP-----NENGNALLYLGGKRV--RAGEIAADLRGVAELlakLLRALAAALDPWAHPaaeldRESLAEWLR 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 153 SLFQAEQTHRSILLGLLLGAGRTPQPDSAL--IRQALAERWS--QWSLRGGLEMLPQALETHLTSRgvsVLRGQPVCGLS 228
Cdd:COG1231   150 RNGASPSARRLLGLLGAGEYGADPDELSLLdlLRYAASAGGGaqQFRIVGGMDQLPRALAAELGDR---IRLGAPVTRIR 226

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1174098500 229 lQAEGRWKVSLRD-SSLEADHVISAIPASVLS--ELLPAEAAPLARALSAITAVSVAVVNLQY 288
Cdd:COG1231   227 -QDGDGVTVTTDDgGTVRADAVIVTVPPSVLRriEFDPPLPAAKRAAIQRLPYGAAIKVFLQF 288
PRK12416 PRK12416
protoporphyrinogen oxidase; Provisional
 3-440 2.52e-22

protoporphyrinogen oxidase; Provisional


Pssm-ID: 183516  Cd Length: 463  Bit Score: 98.75  E-value: 2.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   3 RTVVVLGGGISGLAASYHLSRAP----CPPKVVLVESSERLGGWIRSVRGpNGAIFELGprgirpAGALGARTLLLAcgE 78
Cdd:PRK12416    2 KTVVVIGGGITGLSTMFYLEKLKkdynIDLNLILVEKEEYLGGKIHSVEE-KDFIMESG------ADSIVARNEHVM--P 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  79 QVSELGLDSEVLpvrgdHPAAQNRFLYVGGALHALPTGLSPSLTLKVASLAMDSLCR----------------------- 135
Cdd:PRK12416   73 LVKDLNLEEEMV-----YNETGISYIYSDNTLHPIPSDTIFGIPMSVESLFSSTLVStkgkivalkdfitknkeftkdts 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 136 -----------------------GVFAGNSRELSIRSCFPSLFQAEQTHRSILlglllgagrtpqpdsalirQALAERWS 192
Cdd:PRK12416  148 lalflesflgkelverqiapvlsGVYSGKLNELTMASTLPYLLDYKNKYGSII-------------------KGFEENKK 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 193 QW---------SLRGGLEMLPQALETHLTSrgVSVLRGQPVCGLSLQAEgRWKVSLRD-SSLEADHVISAIPASVLSELL 262
Cdd:PRK12416  209 QFqsagnkkfvSFKGGLSTIIDRLEEVLTE--TVVKKGAVTTAVSKQGD-RYEISFANhESIQADYVVLAAPHDIAETLL 285

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 263 paEAAPLARALSAITAVSVAVVNLQYQ--GAHLPVQGFGHLVPSSEDPGVLGIVYDSVAFPEQDGSPPGL-RVTVMLGGS 339
Cdd:PRK12416  286 --QSNELNEQFHTFKNSSLISIYLGFDilDEQLPADGTGFIVTENSDLHCDACTWTSRKWKHTSGKQKLLvRMFYKSTNP 363

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 340 WLQTLEAsgcvLSQELFQQRAQEAAATQLGLKEMPSHCLVHLHKNCIPQYTLGHWQKLESARQFLTAHRLPLTLAGASYE 419
Cdd:PRK12416  364 VYETIKN----YSEEELVRVALYDIEKSLGIKGEPEVVEVTNWKDLMPKYHLEHNQAVQSLQEKMMNLYPNIYLAGASYY 439

                         490       500
                  ....*....|....*....|.
gi 1174098500 420 GVAVNDCIESGRQAAVSVLGT 440
Cdd:PRK12416  440 GVGIGACIGNGKNTANEIIAT 460
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-298 2.22e-17

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 83.75  E-value: 2.22e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   1 MGRTVVVLGGGISGLAASYHLSRAPCPpkVVLVESSERLGGWIRSVRGPN-GAIFELGPRGIrpagaLGARTLLLAcgeQ 79
Cdd:COG3349     2 MPPRVVVVGGGLAGLAAAVELAEAGFR--VTLLEARPRLGGRARSFPDPDtGLPIDNGQHVL-----LGCYRNTLD---L 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  80 VSELGLDSEVLP------VRGDHPAAQNRFLYVGGALHALP-----TGLSPSLTLKVASLAMDSLCRGVFAGnsRELSIR 148
Cdd:COG3349    72 LRRIGAADNLVGpeplqfPLPGGRRWTLRAPRLPAPLHLLRallraPGLSLADRLALLRLLTACRERRWREL--DDISVA 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 149 SCFPSLFQAEQTHRSILLGLLLGAGRTPqPDSA-------LIRQALA---ERWSQWSLRGGL-EMLPQALETHLTSRGVS 217
Cdd:COG3349   150 DWLRRHGQSPRLIRRLWEPLLLAALNTP-PEQAsarlaltVLRETLLagpAASDLLVPRGPLsELFVDPALAYLEARGGE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 218 VLRGQPVCGLSLQAEGRWKVSLRD-SSLEADHVISAIPASVLSELLPA-EAAPLARALSAITAVSVAVVNLQYQG----A 291
Cdd:COG3349   229 VRLGTRVRALEFDGGRVTGLVLADgETVPADAVVLAVPPEVAARLLPElARLPELGLLAPLEYSPIVNVHLWLDRpvtlG 308


                  ....*..
gi 1174098500 292 HLPVQGF 298
Cdd:COG3349   309 PPPFAGL 315
COG1233 COG1233
Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and ...
 1-286 2.43e-10

Phytoene dehydrogenase-related protein [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440846 [Multi-domain]  Cd Length: 491  Bit Score: 62.17  E-value: 2.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   1 MGRTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRGPnGAIFELGPRGIRPAGALgartlllacgEQV 80
Cdd:COG1233     2 MMYDVVVIGAGIGGLAAAALLARAGY--RVTVLEKNDTPGGRARTFERP-GFRFDVGPSVLTMPGVL----------ERL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  81 -SELGLDSEV----LPVRGDHPAAQNRFLYVGG---ALHALPTGLSP----------SLTLKVASLAMDSLCRGVFAGNS 142
Cdd:COG1233    69 fRELGLEDYLelvpLDPAYRVPFPDGRALDLPRdleRTAAELERLFPgdaeayrrflAELRRLYDALLEDLLYRPLLSLR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 143 RELSIRSCFP--------------SLFQAEQTHRSILLGLLLGAGRTPQPDSALIRQALAER-WSQWSLRGGLEMLPQAL 207
Cdd:COG1233   149 DLLRPLALARllrlllrslrdllrRYFKDPRLRALLAGQALYLGLSPDRTPALYALIAYLEYaGGVWYPKGGMGALADAL 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 208 ETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRD-SSLEADHVISAI-PASVLSELLPAEAAP--LARALSAIT-AVSVA 282
Cdd:COG1233   229 ARLAEELGGEIRTGAEVERILVEGGRATGVRLADgEEIRADAVVSNAdPAHTYLRLLGEEALParYRRRLERFRySPSAF 308


                  ....
gi 1174098500 283 VVNL 286
Cdd:COG1233   309 KLYL 312
PRK07233 PRK07233
hypothetical protein; Provisional
 4-284 9.28e-10

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 60.29  E-value: 9.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500   4 TVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWirsvrgpnGAIFELGprgirpaG----------ALGARTLL 73
Cdd:PRK07233    1 KIAIVGGGIAGLAAAYRLAKRGH--EVTVFEADDQLGGL--------AASFEFG-------GlpierfyhhiFKSDEALL 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  74 lacgEQVSELGLDSEVLPVRGdhpaaQNRFlYVGGALHALPT--------GLSPSLTLKVASLAMdsLCRGVFAGNS--- 142
Cdd:PRK07233   64 ----ELLDELGLEDKLRWRET-----KTGY-YVDGKLYPLGTplellrfpHLSLIDKFRLGLLTL--LARRIKDWRAldk 131

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 143 -------RELSIRSCFPSLFQaeqthrsillglllgagrtpqPdsaLIRQALAERWSQ------WS-------------- 195
Cdd:PRK07233  132 vpaeewlRRWSGEGVYEVFWE---------------------P---LLESKFGDYADDvsaawlWSrikrrgnrryslfg 187

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 196 -----LRGGLEMLPQALETHLTSRGVSVLRGQPVCGLSLQAEGRWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPLA 270
Cdd:PRK07233  188 eklgyLEGGFATLIDALAEAIEARGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILARLVPDLPADVL 267

                         330
                  ....*....|....
gi 1174098500 271 RALSAITAVSVAVV 284
Cdd:PRK07233  268 ARLRRIDYQGVVCM 281
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-73 1.96e-09

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 53.69  E-value: 1.96e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1174098500   7 VLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIRSVRgPNGAIFELGPRGIRPAGALGARTLL 73
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGF--RVLVLEKRDRLGGNAYSYR-VPGYVFDYGAHIFHGSDEPNVRDLL 64
PLN02268 PLN02268
probable polyamine oxidase
 4-43 8.70e-06

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 47.76  E-value: 8.70e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1174098500   4 TVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWI 43
Cdd:PLN02268    2 SVIVIGGGIAGIAAARALHDASF--KVTLLESRDRIGGRV 39
HpnE TIGR03467
squalene-associated FAD-dependent desaturase; The sequences in this family are members of the ...
 16-291 1.16e-05

squalene-associated FAD-dependent desaturase; The sequences in this family are members of the pfam01593 superfamily of flavin-containing amine oxidases which include the phytoene desaturases. These sequences also include a FAD-dependent oxidoreductase domain, pfam01266. The genes of the family modeled here are generally in the same locus with genes involved in the biosynthesis and elaboration of squalene, the condensation product of the polyisoprenoid farnesyl pyrophosphate. This gene and its association with hopene biosynthesis in Zymomonas mobilis has been noted in the literature where the gene symbol hpnE was assigned. This gene is also found in contexts where the downstream conversion of squalene to hopenes is not evidence. The precise nature of the reaction catalyzed by this enzyme is unknown at this time.


Pssm-ID: 274593 [Multi-domain]  Cd Length: 419  Bit Score: 47.36  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  16 AASYHLSRAPCPpkVVLVESSERLGGWIRSV-RGPNGAIFELGPRGIrpagaLGARTLLLACGEQV-SELGLDSEVLPVR 93
Cdd:TIGR03467   1 SAAVELARAGAR--VTLFEARPRLGGRARSFeDGGLGQTIDNGQHVL-----LGAYTNLLALLRRIgAEPRLQGPRLPLP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500  94 GDHPAAQNRFL---------YVGGALHALPtGLSPSLTLKVAsLAMDSLCRGVFAGNSrELSIRSCFPSLFQAEQTHRSI 164
Cdd:TIGR03467  74 FYDPGGRLSRLrlsrlpaplHLARGLLRAP-GLSWADKLALA-RALLALRRTRFRALD-DTTVGDWLQAAGQSERLIERL 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 165 LLGLLLGAGRTPQPDSAL------IRQALAERWSQ---WSLRGGL-EMLPQALETHLTSRGVSVLRGQPVCGLSLQAEG- 233
Cdd:TIGR03467 151 WEPLLLSALNTPPERASAalaakvLRDSFLAGRAAsdlLLPRVPLsELFPEPARRWLDSRGGEVRLGTRVRSIEANAGGi 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1174098500 234 RWKVSLRDSSLEADHVISAIPASVLSELLPAEAAPlaRALSAITAVSVAVVNLQYQGA 291
Cdd:TIGR03467 231 RALVRSGGETLPADAVVLAVPPRHAASLLPGEDLG--ALLTALGYSPITTVHLRLDRA 286
Ppro0129 COG2907
Predicted flavin-containing amine oxidase [General function prediction only];
1-41 3.16e-05

Predicted flavin-containing amine oxidase [General function prediction only];


Pssm-ID: 442151 [Multi-domain]  Cd Length: 423  Bit Score: 45.88  E-value: 3.16e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1174098500   1 MGRTVVVLGGGISGLAASYHLSRApcpPKVVLVESSERLGG 41
Cdd:COG2907     2 ARMRIAVIGSGISGLTAAWLLSRR---HDVTLFEANDRLGG 39
PRK07208 PRK07208
hypothetical protein; Provisional
 202-275 3.24e-05

hypothetical protein; Provisional


Pssm-ID: 235967 [Multi-domain]  Cd Length: 479  Bit Score: 46.04  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1174098500 202 MLPQALETHLTSRGVSVLRGQPVCGLSLQAEGR-WKVSLRDS-----SLEADHVISAIPASVLSELLPAEAAPLARALSA 275
Cdd:PRK07208  219 QLWETAAEKLEALGGKVVLNAKVVGLHHDGDGRiAVVVVNDTdgteeTVTADQVISSMPLRELVAALDPPPPPEVRAAAA 298
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 5-42 5.34e-05

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 45.24  E-value: 5.34e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1174098500   5 VVVLGGGISGLAASYHLSRApCPPkVVLVESSERLGG-W 42
Cdd:COG2072     9 VVVIGAGQAGLAAAYHLRRA-GID-FVVLEKADDVGGtW 45
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
3-44 9.21e-05

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 44.85  E-value: 9.21e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1174098500   3 RTVVVLGGGISGLAASYHLSRAPCppKVVLVESSERLGGWIR 44
Cdd:COG1148   141 KRALVIGGGIAGMTAALELAEQGY--EVYLVEKEPELGGRAA 180
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 5-41 8.30e-04

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 41.23  E-value: 8.30e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1174098500   5 VVVLGGGISGLAASYHLSRApcPPKVVLVESSERLGG 41
Cdd:pfam01266   2 VVVIGGGIVGLSTAYELARR--GLSVTLLERGDDPGS 36
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
5-62 1.00e-03

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 41.04  E-value: 1.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1174098500   5 VVVLGGGISGLAASYHLSRAPCppKVVLVE-------SSERLGGWIRSVRGP--NGAIFELGPRGIR 62
Cdd:COG0665     5 VVVIGGGIAGLSTAYHLARRGL--DVTVLErgrpgsgASGRNAGQLRPGLAAlaDRALVRLAREALD 69
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
3-40 3.13e-03

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 39.94  E-value: 3.13e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1174098500   3 RTVVVLGGGISGLAASYHLSR-APCPPKVVLVESSERLG 40
Cdd:COG4529     6 KRIAIIGGGASGTALAIHLLRrAPEPLRITLFEPRPELG 44
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 2-44 5.26e-03

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 39.09  E-value: 5.26e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1174098500   2 GRTVVVLGGGISGLAASYHLSRApcPPKVVLVESSERLGGWIR 44
Cdd:PRK12771  137 GKRVAVIGGGPAGLSAAYHLRRM--GHAVTIFEAGPKLGGMMR 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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