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Conserved domains on  [gi|1175460259|ref|NP_001337145|]
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leucine-rich repeat-containing protein 7 isoform 3 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12156045)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
176-452 2.08e-48

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 178.97  E-value: 2.08e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  176 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFgelpevLDQIQNLRELWMDN 255
Cdd:COG4886     49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  256 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 335
Cdd:COG4886    123 NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  336 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPrEIGSCKNVTVMSLRSNKLEFLPEEiGQMQKLRVLNLS 415
Cdd:COG4886    203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLS 280

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1175460259  416 DNRLKNLpfsftKLKELAALWLSDNQSKALIPLQTEA 452
Cdd:COG4886    281 NNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLE 312
PDZ_canonical super family cl49608
canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs ...
 1439-1470 1.36e-16

canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


The actual alignment was detected with superfamily member cd06749:

Pssm-ID: 483948 [Multi-domain]  Cd Length: 87  Bit Score: 76.21  E-value: 1.36e-16
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1175460259 1439 FCVRIEKNPGLGFSISGGISGQGNPFKPSDKG 1470
Cdd:cd06749      1 IRVRIEKNPGLGFSISGGIGSQGNPFRPDDDG 32
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
16-281 5.68e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.59  E-value: 5.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   16 QRSPCKEvrAALRKRPEEELQ-CLEMTTKRKIIGRL----VPCRCfrgEEEIIS-VLDYSHcsLQQVPKevfNFERTLEE 89
Cdd:PRK15370   155 KEAPAKE--AANREEAVQRMRdCLKNNKTELRLKILglttIPACI---PEQITTlILDNNE--LKSLPE---NLQGNIKT 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   90 LYLDANQIEELPKQLFNCQALRKLSIpdNDLSNLPTTIASLvnLKELDISKNGVQEFPENIKccKCLTIIEASVNPISKL 169
Cdd:PRK15370   225 LYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLPSA--LQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTL 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  170 PDGFTQllNLTQLYLNDAFLEFLPANFGrlVKLRILELRENHLKTLPKSMHklAQLERLDLGNNEFGELPEVLDqiQNLR 249
Cdd:PRK15370   299 PAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTIT 370

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1175460259  250 ELWMDNNALQVLPGSIGklKMLVYLDMSKNRI 281
Cdd:PRK15370   371 TLDVSRNALTNLPENLP--AALQIMQASRNNL 400
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
176-452 2.08e-48

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 178.97  E-value: 2.08e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  176 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFgelpevLDQIQNLRELWMDN 255
Cdd:COG4886     49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  256 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 335
Cdd:COG4886    123 NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  336 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPrEIGSCKNVTVMSLRSNKLEFLPEEiGQMQKLRVLNLS 415
Cdd:COG4886    203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLS 280

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1175460259  416 DNRLKNLpfsftKLKELAALWLSDNQSKALIPLQTEA 452
Cdd:COG4886    281 NNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLE 312
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-447 5.63e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 116.49  E-value: 5.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   75 QVPKEVFNFeRTLEELYLDANQIE-ELPKQLFNCQALRKL---------SIPDN--DLSNL--------------PTTIA 128
Cdd:PLN00113   203 QIPRELGQM-KSLKWIYLGYNNLSgEIPYEIGGLTSLNHLdlvynnltgPIPSSlgNLKNLqylflyqnklsgpiPPSIF 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  129 SLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEASVNPIS-KLPDGFTQL--LNLTQLYLNDaFLEFLPANFGRLVKLRI 204
Cdd:PLN00113   282 SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLprLQVLQLWSNK-FSGEIPKNLGKHNNLTV 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  205 LELRENHLK-TLPKSMHKLAQLERLDLGNNEF-GELPEVLDQIQNLRELWMDNNALQ-VLPGSIGKLKMLVYLDMSKN-- 279
Cdd:PLN00113   361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNnl 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  280 --RIETVDMDISGCEALEdlLLSSNMLQQLPDSIGLlKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELESlpst 356
Cdd:PLN00113   441 qgRINSRKWDMPSLQMLS--LARNKFFGGLPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSG---- 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  357 igylhslrtlavdenflpELPREIGSCKNVTVMSLRSNKLE-FLPEEIGQMQKLRVLNLSDNRLK-NLPFSFTKLKELAA 434
Cdd:PLN00113   514 ------------------EIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQ 575

                          410
                   ....*....|...
gi 1175460259  435 LWLSDNQSKALIP 447
Cdd:PLN00113   576 VNISHNHLHGSLP 588
PDZ_densin_erbin-like cd06749
PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95) ...
 1439-1470 1.36e-16

PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of densin, erbin, and related domains. Densin (also known as leucine-rich repeat-containing protein 7, LRRC7, densin-180, protein LAP1) and erbin (also known as densin-180-like protein, Erbb2-interacting protein, protein LAP2) belong to the LAP (leucine-rich repeat and PDZ domain) family of scaffolding proteins that play roles in the maintenance of cell shape and apical-basal polarity. Densin and erbin are components of the excitatory postsynaptic compartment and are regulators of dendritic morphology and postsynaptic structure. The densin PDZ domain binds CaV1.3 alpha1 subunit, delta-catenin, and MAGUIN-1. Binding partners of the erbin PDZ domain include ErbB receptor tyrosine kinase ErbB2, HTLV-1 Tax1, Cav1.3 Ca2+channels, and constituents of the cadherin:catenin cell adhesion complex, in particular delta-catenin, p0071 and ARVCF. The erbin PDZ domain binds Smad3, a transductor of the TGFbeta pathway, possibly by a novel interface of binding. Erbin and two other LAP proteins (scribble and lano) redundantly regulate epithelial polarity and apical adhesion complex. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This densin and erbin-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged as beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467231 [Multi-domain]  Cd Length: 87  Bit Score: 76.21  E-value: 1.36e-16
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1175460259 1439 FCVRIEKNPGLGFSISGGISGQGNPFKPSDKG 1470
Cdd:cd06749      1 IRVRIEKNPGLGFSISGGIGSQGNPFRPDDDG 32
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
16-281 5.68e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.59  E-value: 5.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   16 QRSPCKEvrAALRKRPEEELQ-CLEMTTKRKIIGRL----VPCRCfrgEEEIIS-VLDYSHcsLQQVPKevfNFERTLEE 89
Cdd:PRK15370   155 KEAPAKE--AANREEAVQRMRdCLKNNKTELRLKILglttIPACI---PEQITTlILDNNE--LKSLPE---NLQGNIKT 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   90 LYLDANQIEELPKQLFNCQALRKLSIpdNDLSNLPTTIASLvnLKELDISKNGVQEFPENIKccKCLTIIEASVNPISKL 169
Cdd:PRK15370   225 LYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLPSA--LQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTL 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  170 PDGFTQllNLTQLYLNDAFLEFLPANFGrlVKLRILELRENHLKTLPKSMHklAQLERLDLGNNEFGELPEVLDqiQNLR 249
Cdd:PRK15370   299 PAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTIT 370

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1175460259  250 ELWMDNNALQVLPGSIGklKMLVYLDMSKNRI 281
Cdd:PRK15370   371 TLDVSRNALTNLPENLP--AALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 148-344 3.21e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.36  E-value: 3.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  148 ENIKCCKCLTIIEASVNPISKLPdGFTQLLNLTQLYLNDAFLEFLPaNFGRLVKLrilelrenhlktlpksmhklaqlER 227
Cdd:cd21340     18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNL-----------------------KK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  228 LDLGNNEFGELpEVLDQIQNLRELWMDNNALQ------VLPGSIGKLKM-LVYLDMSKNRIETVDmDISGCEALEDLLLS 300
Cdd:cd21340     73 LYLGGNRISVV-EGLENLTNLEELHIENQRLPpgekltFDPRSLAALSNsLRVLNISGNNIDSLE-PLAPLRNLEQLDAS 150

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1175460259  301 SNMLQQLPDSIGLLKK---LTTLKVDDNQLTMLP----NTIGNLSLLEEFD 344
Cdd:cd21340    151 NNQISDLEELLDLLSSwpsLRELDLTGNPVCKKPkyrdKIILASKSLEVLD 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-252 1.86e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.36  E-value: 1.86e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   90 LYLDANQIEELPKqLFNCQALRKLSIPDNDLSNLPTtIASLVNLKELDISKNGVQEFpENIKCCKCLTIIEASVNPISKL 169
Cdd:cd21340      7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  170 pDGFTQLLNLTQLYL------NDAFLEFLPANFGRLVK-LRILELRENHLKTLpKSMHKLAQLERLDLGNNEFGELPEVL 242
Cdd:cd21340     84 -EGLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170
                   ....*....|
gi 1175460259  243 DQIQNLRELW 252
Cdd:cd21340    162 DLLSSWPSLR 171
LRR_8 pfam13855
Leucine rich repeat;
178-235 4.89e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 4.89e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  178 NLTQLYLNDAFLEFL-PANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEF 235
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
85-141 9.60e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 9.60e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1175460259   85 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNL-PTTIASLVNLKELDISKN 141
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
176-452 2.08e-48

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 178.97  E-value: 2.08e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  176 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFgelpevLDQIQNLRELWMDN 255
Cdd:COG4886     49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  256 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 335
Cdd:COG4886    123 NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  336 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPrEIGSCKNVTVMSLRSNKLEFLPEEiGQMQKLRVLNLS 415
Cdd:COG4886    203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLS 280

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1175460259  416 DNRLKNLpfsftKLKELAALWLSDNQSKALIPLQTEA 452
Cdd:COG4886    281 NNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLE 312
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-436 5.22e-46

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 171.66  E-value: 5.22e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   82 NFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNgvqefpENIKCCKCLTIIEA 161
Cdd:COG4886     47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDL 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  162 SVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEV 241
Cdd:COG4886    121 SGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEP 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  242 LDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDmDISGCEALEDLLLSSNMLQQLPDSIGlLKKLTTLK 321
Cdd:COG4886    201 LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLD 278

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  322 VDDNQLTMLP----NTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLE 397
Cdd:COG4886    279 LSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 1175460259  398 FLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALW 436
Cdd:COG4886    359 LSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
169-441 8.17e-44

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 165.49  E-value: 8.17e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  169 LPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNL 248
Cdd:COG4886      1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  249 relwmDNNALQVLPGSIGKLKMLVYLDMSKNRietvdmDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLT 328
Cdd:COG4886     81 -----LLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  329 MLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQK 408
Cdd:COG4886    150 DLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTN 229

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1175460259  409 LRVLNLSDNRLKNLPfSFTKLKELAALWLSDNQ 441
Cdd:COG4886    230 LETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQ 261
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
87-376 9.71e-43

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 162.41  E-value: 9.71e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   87 LEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPI 166
Cdd:COG4886    115 LESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  167 SKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPkSMHKLAQLERLDLGNNEFGELPEvLDQIQ 246
Cdd:COG4886    195 TDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLT 272

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  247 NLRELWMDNNALQVLP----GSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKV 322
Cdd:COG4886    273 NLKTLDLSNNQLTDLKlkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTL 352

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1175460259  323 DDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPEL 376
Cdd:COG4886    353 LLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-447 5.63e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 116.49  E-value: 5.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   75 QVPKEVFNFeRTLEELYLDANQIE-ELPKQLFNCQALRKL---------SIPDN--DLSNL--------------PTTIA 128
Cdd:PLN00113   203 QIPRELGQM-KSLKWIYLGYNNLSgEIPYEIGGLTSLNHLdlvynnltgPIPSSlgNLKNLqylflyqnklsgpiPPSIF 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  129 SLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEASVNPIS-KLPDGFTQL--LNLTQLYLNDaFLEFLPANFGRLVKLRI 204
Cdd:PLN00113   282 SLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLprLQVLQLWSNK-FSGEIPKNLGKHNNLTV 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  205 LELRENHLK-TLPKSMHKLAQLERLDLGNNEF-GELPEVLDQIQNLRELWMDNNALQ-VLPGSIGKLKMLVYLDMSKN-- 279
Cdd:PLN00113   361 LDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNnl 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  280 --RIETVDMDISGCEALEdlLLSSNMLQQLPDSIGLlKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELESlpst 356
Cdd:PLN00113   441 qgRINSRKWDMPSLQMLS--LARNKFFGGLPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSG---- 513

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  357 igylhslrtlavdenflpELPREIGSCKNVTVMSLRSNKLE-FLPEEIGQMQKLRVLNLSDNRLK-NLPFSFTKLKELAA 434
Cdd:PLN00113   514 ------------------EIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQ 575

                          410
                   ....*....|...
gi 1175460259  435 LWLSDNQSKALIP 447
Cdd:PLN00113   576 VNISHNHLHGSLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 87-448 4.52e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 103.77  E-value: 4.52e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   87 LEELYLDANQIE-ELPKQLFNCQALRKLSIPDNDLS-NLPTTIASLVNLKELDISKNG-VQEFPENIKCCKCLTIIEASV 163
Cdd:PLN00113   142 LETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGY 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  164 NPIS-KLPDGFTQLLNLTQLYL--NDAFLEfLPANFGRLVKLRILELRENHLK-TLPKSMHKLAQLERLDLGNNEF-GEL 238
Cdd:PLN00113   222 NNLSgEIPYEIGGLTSLNHLDLvyNNLTGP-IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLsGEI 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  239 PEVLDQIQNLRELWMDNN--------------ALQVL-----------PGSIGKLKMLVYLDMSKNRIeTVDMDISGCEA 293
Cdd:PLN00113   301 PELVIQLQNLEILHLFSNnftgkipvaltslpRLQVLqlwsnkfsgeiPKNLGKHNNLTVLDLSTNNL-TGEIPEGLCSS 379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  294 --LEDLLLSSNMLQ-QLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELESLPSTIGY-LHSLRTLAV 368
Cdd:PLN00113   380 gnLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQGRINSRKWdMPSLQMLSL 459

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  369 DEN-FLPELPREIGScKNVTVMSLRSNKL-EFLPEEIGQMQKLRVLNLSDNRLKN-LPFSFTKLKELAALWLSDNQSKAL 445
Cdd:PLN00113   460 ARNkFFGGLPDSFGS-KRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSGQ 538


                   ...
gi 1175460259  446 IPL 448
Cdd:PLN00113   539 IPA 541
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 133-447 5.85e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 90.29  E-value: 5.85e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  133 LKELDISKNGVQ-EFPENI-KCCKCLTIIEASVNPIS-KLPDGFTQLLNLTQLYlNDAFLEFLPANFGRLVKLRILELRE 209
Cdd:PLN00113    95 IQTINLSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLS-NNMLSGEIPNDIGSFSSLKVLDLGG 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  210 NHLK-TLPKSMHKLAQLERLDLGNNEF-GELPEVLDQIQNLRELWMDNNALQ-VLPGSIGKLKMLVYLDMSKNrietvdm 286
Cdd:PLN00113   174 NVLVgKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYN------- 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  287 disgcealedlllssNMLQQLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELE-SLPSTIGYLHSLR 364
Cdd:PLN00113   247 ---------------NLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLE 311

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  365 TLAV-DENFLPELPREIGSCKNVTVMSLRSNKLEF-LPEEIGQMQKLRVLNLSDNRLK-NLPFSFTKLKELAALWLSDNQ 441
Cdd:PLN00113   312 ILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNS 391


                   ....*.
gi 1175460259  442 SKALIP 447
Cdd:PLN00113   392 LEGEIP 397
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-334 7.01e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 89.76  E-value: 7.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   90 LYLDANQIEELPKqlfNCQA-LRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKccKCLTIIEASVNPISK 168
Cdd:PRK15370   204 LILDNNELKSLPE---NLQGnIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLP--SALQSLDLFHNKISC 276

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  169 LPDGftqllnltqlylndaflefLPAnfgrlvKLRILELRENHLKTLPKsmHKLAQLERLDLGNNEFGELPEVLDqiQNL 248
Cdd:PRK15370   277 LPEN-------------------LPE------ELRYLSVYDNSIRTLPA--HLPSGITHLNVQSNSLTALPETLP--PGL 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  249 RELWMDNNALQVLPGSIGklKMLVYLDMSKNRIETVDMDISgcEALEDLLLSSNMLQQLPDSigLLKKLTTLKVDDNQLT 328
Cdd:PRK15370   328 KTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPEN--LPAALQIMQASRNNLV 401


                   ....*.
gi 1175460259  329 MLPNTI 334
Cdd:PRK15370   402 RLPESL 407
PDZ_densin_erbin-like cd06749
PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95) ...
 1439-1470 1.36e-16

PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of densin, erbin, and related domains. Densin (also known as leucine-rich repeat-containing protein 7, LRRC7, densin-180, protein LAP1) and erbin (also known as densin-180-like protein, Erbb2-interacting protein, protein LAP2) belong to the LAP (leucine-rich repeat and PDZ domain) family of scaffolding proteins that play roles in the maintenance of cell shape and apical-basal polarity. Densin and erbin are components of the excitatory postsynaptic compartment and are regulators of dendritic morphology and postsynaptic structure. The densin PDZ domain binds CaV1.3 alpha1 subunit, delta-catenin, and MAGUIN-1. Binding partners of the erbin PDZ domain include ErbB receptor tyrosine kinase ErbB2, HTLV-1 Tax1, Cav1.3 Ca2+channels, and constituents of the cadherin:catenin cell adhesion complex, in particular delta-catenin, p0071 and ARVCF. The erbin PDZ domain binds Smad3, a transductor of the TGFbeta pathway, possibly by a novel interface of binding. Erbin and two other LAP proteins (scribble and lano) redundantly regulate epithelial polarity and apical adhesion complex. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This densin and erbin-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged as beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467231 [Multi-domain]  Cd Length: 87  Bit Score: 76.21  E-value: 1.36e-16
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1175460259 1439 FCVRIEKNPGLGFSISGGISGQGNPFKPSDKG 1470
Cdd:cd06749      1 IRVRIEKNPGLGFSISGGIGSQGNPFRPDDDG 32
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
16-281 5.68e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 83.59  E-value: 5.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   16 QRSPCKEvrAALRKRPEEELQ-CLEMTTKRKIIGRL----VPCRCfrgEEEIIS-VLDYSHcsLQQVPKevfNFERTLEE 89
Cdd:PRK15370   155 KEAPAKE--AANREEAVQRMRdCLKNNKTELRLKILglttIPACI---PEQITTlILDNNE--LKSLPE---NLQGNIKT 224

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   90 LYLDANQIEELPKQLFNCQALRKLSIpdNDLSNLPTTIASLvnLKELDISKNGVQEFPENIKccKCLTIIEASVNPISKL 169
Cdd:PRK15370   225 LYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLPSA--LQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTL 298

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  170 PDGFTQllNLTQLYLNDAFLEFLPANFGrlVKLRILELRENHLKTLPKSMHklAQLERLDLGNNEFGELPEVLDqiQNLR 249
Cdd:PRK15370   299 PAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTIT 370

                          250       260       270
                   ....*....|....*....|....*....|..
gi 1175460259  250 ELWMDNNALQVLPGSIGklKMLVYLDMSKNRI 281
Cdd:PRK15370   371 TLDVSRNALTNLPENLP--AALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 148-344 3.21e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 76.36  E-value: 3.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  148 ENIKCCKCLTIIEASVNPISKLPdGFTQLLNLTQLYLNDAFLEFLPaNFGRLVKLrilelrenhlktlpksmhklaqlER 227
Cdd:cd21340     18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNL-----------------------KK 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  228 LDLGNNEFGELpEVLDQIQNLRELWMDNNALQ------VLPGSIGKLKM-LVYLDMSKNRIETVDmDISGCEALEDLLLS 300
Cdd:cd21340     73 LYLGGNRISVV-EGLENLTNLEELHIENQRLPpgekltFDPRSLAALSNsLRVLNISGNNIDSLE-PLAPLRNLEQLDAS 150

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1175460259  301 SNMLQQLPDSIGLLKK---LTTLKVDDNQLTMLP----NTIGNLSLLEEFD 344
Cdd:cd21340    151 NNQISDLEELLDLLSSwpsLRELDLTGNPVCKKPkyrdKIILASKSLEVLD 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 176-366 7.78e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 7.78e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  176 LLNLTQLYLNDAFLEFLPaNFGRLVKLRILELRENHLKTLPKsmhklaqlerldlgnnefgelpevLDQIQNLRELWMDN 255
Cdd:cd21340      1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN------------------------LEFLTNLTHLYLQN 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  256 NALQVLPGsIGKLKMLVYLDMSKNRIETVDmDISGCEALEDLLLSSnmlQQL---------PDSI-GLLKKLTTLKVDDN 325
Cdd:cd21340     56 NQIEKIEN-LENLVNLKKLYLGGNRISVVE-GLENLTNLEELHIEN---QRLppgekltfdPRSLaALSNSLRVLNISGN 130

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1175460259  326 QLTMLpNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTL 366
Cdd:cd21340    131 NIDSL-EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSL 170
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 90-252 1.86e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 71.36  E-value: 1.86e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   90 LYLDANQIEELPKqLFNCQALRKLSIPDNDLSNLPTtIASLVNLKELDISKNGVQEFpENIKCCKCLTIIEASVNPISKL 169
Cdd:cd21340      7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  170 pDGFTQLLNLTQLYL------NDAFLEFLPANFGRLVK-LRILELRENHLKTLpKSMHKLAQLERLDLGNNEFGELPEVL 242
Cdd:cd21340     84 -EGLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                          170
                   ....*....|
gi 1175460259  243 DQIQNLRELW 252
Cdd:cd21340    162 DLLSSWPSLR 171
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
246-458 8.09e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.19  E-value: 8.09e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  246 QNLRELWMDNNALQVLPGSIGKLKMLVYLDmsKNRIETVDMDISGceALEDLLLSSNMLQQLPDSigLLKKLTTLKVDDN 325
Cdd:PRK15370   178 NNKTELRLKILGLTTIPACIPEQITTLILD--NNELKSLPENLQG--NIKTLYANSNQLTSIPAT--LPDTIQEMELSIN 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  326 QLTMLPNTIGnlSLLEEFDCSCNELESLPSTIGylHSLRTLAVDENFLPELPREIGSckNVTVMSLRSNKLEFLPEEIGq 405
Cdd:PRK15370   252 RITELPERLP--SALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP- 324

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1175460259  406 mQKLRVLNLSDNRLKNLPFSFTklKELAALWLSDNQskalIPLQTEAHPETKQ 458
Cdd:PRK15370   325 -PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQ----ITVLPETLPPTIT 370
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
113-338 1.62e-11

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 69.04  E-value: 1.62e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  113 LSIPDNDLSNLPttiASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL--------------N 178
Cdd:PRK15387   227 LVIPDNNLTSLP---ALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWifgnqltslpvlppG 303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  179 LTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSmhklaqLERLDLGNNEFGELPEVLDQiqnLRELWMDNNAL 258
Cdd:PRK15387   304 LQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSG------LQELSVSDNQLASLPTLPSE---LYKLWAYNNRL 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  259 QVLPGSIGKLKMLVyldMSKNRIETVDMDISgceALEDLLLSSNMLQQLPdsiGLLKKLTTLKVDDNQLTMLPNTIGNLS 338
Cdd:PRK15387   375 TSLPALPSGLKELI---VSGNRLTSLPVLPS---ELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLS 445
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 200-440 1.24e-09

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 61.60  E-value: 1.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  200 VKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEvldqiqnlrelwmdnnALQVLPGSIGKLKMLVYLDMSKN 279
Cdd:cd00116     28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPR----------------GLQSLLQGLTKGCGLQELDLSDN 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  280 RIEtvdmdISGCEALEDLLLSSNmLQQLpdsigllkKLTTLKVDDNQLTMLPNTIGNLSL-LEEFDCSCNEL-----ESL 353
Cdd:cd00116     92 ALG-----PDGCGVLESLLRSSS-LQEL--------KLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLegascEAL 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  354 PSTIGYLHSLRTLAVDENFL-----PELPREIGSCKNVTVMSLRSNKLE-----FLPEEIGQMQKLRVLNLSDNRLKNLP 423
Cdd:cd00116    158 AKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAG 237

                          250       260
                   ....*....|....*....|...
gi 1175460259  424 FS------FTKLKELAALWLSDN 440
Cdd:cd00116    238 AAalasalLSPNISLLTLSLSCN 260
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 66-334 9.97e-09

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 60.27  E-value: 9.97e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   66 LDYSHCS-LQQVPKEVFNFERtLEELYLD-ANQIEELPKQLfNCQALRKLSIpdNDLSNLPTTIASLVNLKELDISKNGV 143
Cdd:PLN03210   662 LKLSDCSsLVELPSSIQYLNK-LEDLDMSrCENLEILPTGI-NLKSLYRLNL--SGCSRLKSFPDISTNISWLDLDETAI 737

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  144 QEFPENIKCCKCLTII--EASVNPISKLPDGFTQLL-----NLTQLYLND--AFLEfLPANFGRLVKLRILELRE-NHLK 213
Cdd:PLN03210   738 EEFPSNLRLENLDELIlcEMKSEKLWERVQPLTPLMtmlspSLTRLFLSDipSLVE-LPSSIQNLHKLEHLEIENcINLE 816

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  214 TLPKSMHkLAQLERLDL-GNNEFGELPEVldqIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSK-NRIETVDMDISGC 291
Cdd:PLN03210   817 TLPTGIN-LESLESLDLsGCSRLRTFPDI---STNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKL 892

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 1175460259  292 EALEDLLLSSnmLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 334
Cdd:PLN03210   893 KHLETVDFSD--CGALTEASWNGSPSEVAMATDNIHSKLPSTV 933
LRR_8 pfam13855
Leucine rich repeat;
178-235 4.89e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 4.89e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  178 NLTQLYLNDAFLEFL-PANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEF 235
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
166-440 1.91e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.47  E-value: 1.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  166 ISKLPDGFTQllNLTQLYLNDAFLEFLPAnfgRLVKLRILELRENHLKTLPKSMHKLAQLErldLGNNEFGELPEVldqI 245
Cdd:PRK15387   213 LTTLPDCLPA--HITTLVIPDNNLTSLPA---LPPELRTLEVSGNQLTSLPVLPPGLLELS---IFSNPLTHLPAL---P 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  246 QNLRELWMDNNALQVLPGSIGKLKMLvylDMSKNRIETVDMDISgceALEDLLLSSNMLQQLPDsigLLKKLTTLKVDDN 325
Cdd:PRK15387   282 SGLCKLWIFGNQLTSLPVLPPGLQEL---SVSDNQLASLPALPS---ELCKLWAYNNQLTSLPT---LPSGLQELSVSDN 352

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  326 QLTMLPNTIGNLSLLEEFDCSCNELESLPStigylhSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPeeigq 405
Cdd:PRK15387   353 QLASLPTLPSELYKLWAYNNRLTSLPALPS------GLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLP----- 421

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1175460259  406 mQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 440
Cdd:PRK15387   422 -SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGN 455
PLN03150 PLN03150
hypothetical protein; Provisional
 306-381 2.00e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.51  E-value: 2.00e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175460259  306 QLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELE-SLPSTIGYLHSLRTLAVDENFLP-ELPREIG 381
Cdd:PLN03150   433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 63-251 2.05e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.59  E-value: 2.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   63 ISVLDYSHCSLQQVPKEVF-NFER--TLEELYLDANQIEELP-----KQLFNCQ-ALRKLSIPDNDLSNLPTTIASLV-- 131
Cdd:cd00116     83 LQELDLSDNALGPDGCGVLeSLLRssSLQELKLNNNGLGDRGlrllaKGLKDLPpALEKLVLGRNRLEGASCEALAKAlr 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  132 ---NLKELDISKNGVQEFpenikcckcltiieasvnPISKLPDGFTQLLNLTQLYLNDAFLE-----FLPANFGRLVKLR 203
Cdd:cd00116    163 anrDLKELNLANNGIGDA------------------GIRALAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLE 224

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1175460259  204 ILELRENHLK-----TLPKSMHKLAQ-LERLDLGNNEFGE-----LPEVLDQIQNLREL 251
Cdd:cd00116    225 VLNLGDNNLTdagaaALASALLSPNIsLLTLSLSCNDITDdgakdLAEVLAEKESLLEL 283
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
87-177 2.36e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.39  E-value: 2.36e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   87 LEELYLDANQIEELPKQLfnCQALRKLSIPDNDLSNLPTTIASlvNLKELDISKNGVQEFPENIKCCkcLTIIEASVNPI 166
Cdd:PRK15370   327 LKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLPAA--LQIMQASRNNL 400

                           90
                   ....*....|.
gi 1175460259  167 SKLPDGFTQLL 177
Cdd:PRK15370   401 VRLPESLPHFR 411
PLN03150 PLN03150
hypothetical protein; Provisional
 353-419 2.37e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 52.13  E-value: 2.37e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1175460259  353 LPSTIGYLHSLRTLAVDENFLP-ELPREIGSCKNVTVMSLRSNKLE-FLPEEIGQMQKLRVLNLSDNRL 419
Cdd:PLN03150   434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 174-420 3.37e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 3.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  174 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMH-------KLAQLERLDLGNNEFGELP----EVL 242
Cdd:cd00116     25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQsllqgltKGCGLQELDLSDNALGPDGcgvlESL 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  243 DQIQNLRELWMDNNALQVLPG--SIGKLKM----LVYLDMSKNRIETvdmdiSGCEALEDLLLSsnmlqqlpdsiglLKK 316
Cdd:cd00116    105 LRSSSLQELKLNNNGLGDRGLrlLAKGLKDlppaLEKLVLGRNRLEG-----ASCEALAKALRA-------------NRD 166

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  317 LTTLKVDDNQLtmlpNTIGNLSLLEEFDCSCNeleslpstigylhsLRTLAVDENFLpelpREIG---------SCKNVT 387
Cdd:cd00116    167 LKELNLANNGI----GDAGIRALAEGLKANCN--------------LEVLDLNNNGL----TDEGasalaetlaSLKSLE 224

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1175460259  388 VMSLRSNKL------EFLPEEIGQMQKLRVLNLSDNRLK 420
Cdd:cd00116    225 VLNLGDNNLtdagaaALASALLSPNISLLTLSLSCNDIT 263
LRR_8 pfam13855
Leucine rich repeat;
246-304 3.44e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 3.44e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1175460259  246 QNLRELWMDNNALQVL-PGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEALEDLLLSSNML 304
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
385-441 5.30e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 5.30e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1175460259  385 NVTVMSLRSNKLEFLPEEI-GQMQKLRVLNLSDNRLKNL-PFSFTKLKELAALWLSDNQ 441
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
271-327 4.05e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 4.05e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1175460259  271 LVYLDMSKNRIETVDMDI-SGCEALEDLLLSSNMLQQL-PDSIGLLKKLTTLKVDDNQL 327
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
362-419 4.25e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 4.25e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  362 SLRTLAVDENFLPELPREI-GSCKNVTVMSLRSNKLEFL-PEEIGQMQKLRVLNLSDNRL 419
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
85-141 9.60e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 9.60e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1175460259   85 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSNL-PTTIASLVNLKELDISKN 141
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 337-447 1.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  337 LSLLEEFDCSCNELE-SLPSTIGYL-HSLRTLAV-DENFLPELPReiGSCKNVTVMSLRSNKLEF-LPEEIGQMQKLRVL 412
Cdd:PLN00113    92 LPYIQTINLSNNQLSgPIPDDIFTTsSSLRYLNLsNNNFTGSIPR--GSIPNLETLDLSNNMLSGeIPNDIGSFSSLKVL 169

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1175460259  413 NLSDNRLK-NLPFSFTKLKELAALWLSDNQSKALIP 447
Cdd:PLN00113   170 DLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGQIP 205
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 69-328 3.59e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.78  E-value: 3.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259   69 SHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFnCQALRKlsipdndlsnlPTTIASLVnLKELDISKNGVQEFPE 148
Cdd:COG5238    164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEEL-AEALTQ-----------NTTVTTLW-LKRNPIGDEGAEILAE 230

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  149 NIKCCKCLTIIEASVNPISKlpDGFTQLL-------NLTQLYLNdafleflpanfGRlvklrilELRENHLKTLPKSMHK 221
Cdd:COG5238    231 ALKGNKSLTTLDLSNNQIGD--EGVIALAealknntTVETLYLS-----------GN-------QIGAEGAIALAKALQG 290

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  222 LAQLERLDLGNNEFGE-----LPEVLDQIQNLRELWMDNNALQV-----LPGSIGKLKMLVYLDMSKNRIETVDMD---- 287
Cdd:COG5238    291 NTTLTSLDLSVNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTTLHSLDLSDNQIGDEGAIalak 370

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1175460259  288 -ISGCEALEDLLLSSNML-----QQLPDSIgLLKKLTTLKVDDNQLT 328
Cdd:COG5238    371 yLEGNTTLRELNLGKNNIgkqgaEALIDAL-QTNRLHTLILDGNLIG 416
PLN03150 PLN03150
hypothetical protein; Provisional
 398-447 1.04e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 1.04e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1175460259  398 FLPEEIGQMQKLRVLNLSDNRLK-NLPFSFTKLKELAALWLSDNQSKALIP 447
Cdd:PLN03150   433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIP 483
PDZ4_Scribble-like cd06701
PDZ domain 4 of Drosophila Scribble, human Scribble homolog, and related domains; PDZ (PSD-95 ...
 1441-1470 1.47e-03

PDZ domain 4 of Drosophila Scribble, human Scribble homolog, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 4 of Drosophila Scribble (also known as LAP4), human Scribble homolog (also known as hScrib, LAP4, CriB1, ScrB1 and Vartul), and related domains. They belong to the LAP family, which describes proteins that contain either one or four PDZ domains and 16 LRRs (leucine-rich repeats) and function in controlling cell shape, size and subcellular protein localization. In Drosophila, the Scribble complex, comprising Scribble, discs large, and lethal giant larvae, plays a role in apico-basal cell polarity, in other forms of polarity, including regulation of the actin cytoskeleton, cell signaling and vesicular trafficking, and in tumor development. Mammalian Scribble is important in many aspects of cancer development. Scribble and its homologs can be downregulated or overexpressed in cancer; they have a role in cancer beyond their function in loss of cell polarity. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This Scribble-like family PDZ4 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467185 [Multi-domain]  Cd Length: 98  Bit Score: 39.52  E-value: 1.47e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1175460259 1441 VRIEKNPG--LGFSISGGISGQ-GNPFKPSDKG 1470
Cdd:cd06701      7 LTIVKEPGekLGISIRGGAKGHaGNPLDPTDEG 39
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 407-440 1.73e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1175460259  407 QKLRVLNLSDNRLKNLPFsFTKLKELAALWLSDN 440
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGN 33
PLN03150 PLN03150
hypothetical protein; Provisional
 169-242 1.82e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 1.82e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1175460259  169 LPDGFTQLLNLTQLYLNDAFLE-FLPANFGRLVKLRILELRENHLK-TLPKSMHKLAQLERLDL-GNNEFGELPEVL 242
Cdd:PLN03150   434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLnGNSLSGRVPAAL 510
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 200-432 5.39e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.40  E-value: 5.39e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  200 VKLRILELRENHL-KTLPKSMHKLAQL----ERLDLGNNEFGELPEVLDQI-QNLRELWMDNNALQVLPGSIgKLKMLVY 273
Cdd:PLN03210   537 ITLDIDEIDELHIhENAFKGMRNLLFLkfytKKWDQKKEVRWHLPEGFDYLpPKLRLLRWDKYPLRCMPSNF-RPENLVK 615

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  274 LDMSKNRIETVDMDISGCEALEDL-LLSSNMLQQLPDsigllkklttlkvddnqLTMLPNtignlslLEEFD-CSCNELE 351
Cdd:PLN03210   616 LQMQGSKLEKLWDGVHSLTGLRNIdLRGSKNLKEIPD-----------------LSMATN-------LETLKlSDCSSLV 671

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1175460259  352 SLPSTIGYLHSLRTLavdenflpelprEIGSCKNvtvmslrsnkLEFLPEEIgQMQKLRVLNLSD-NRLKNLPFSFTKLK 430
Cdd:PLN03210   672 ELPSSIQYLNKLEDL------------DMSRCEN----------LEILPTGI-NLKSLYRLNLSGcSRLKSFPDISTNIS 728


                   ..
gi 1175460259  431 EL 432
Cdd:PLN03210   729 WL 730
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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