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Conserved domains on  [gi|1179685319|ref|NP_001337332|]
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dyslexia-associated protein KIAA0319 isoform a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
myxo_dep_M36 super family cl45606
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 431-813 6.32e-38

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


The actual alignment was detected with superfamily member NF038112:

Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 154.81  E-value: 6.32e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  431 NLPPVAVVSPQLQELTLplTSALIDGSQSTD-DTEIVSYHWEEINGPFIEeKTSVDSP--------VLRLSNLdpgnySF 501
Cdd:NF038112  1185 NRRPVANAGPDQTVLER--TTVTLNGSGSFDpDGDPLTYAWTQVSGPAVT-LTGADTAtpsftapeVTADTVL-----TF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  502 RLTVTDSDGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDDHQIVLYEWSLGPGSEgkhVVMQGVQ 581
Cdd:NF038112  1257 QLVVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQTSGPA---VTLTGAT 1331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  582 TPYLHLSAMQ---EGDYTFQLKVTDSSrQQSTAVVTVIVQPENnRPPVAVAGPDKElIFPVESATLDGSSSSDDHGIVFY 658
Cdd:NF038112  1332 TATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALTY 1408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  659 HWEHVRGPsAVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTVAVKKENNSPpRARAGGRhVLVLPNNS 735
Cdd:NF038112  1409 AWTQTAGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAGES-ITVDEGST 1485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  736 ITLDGSRSTDDQRIVSYLWIRDGQSPAAgdvIDGSDHSVALQLTNLVEG--VYTFHLRVTDSQGASDTDTATVEVQPDPR 813
Cdd:NF038112  1486 VTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 20-102 1.16e-21

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


:

Pssm-ID: 129004  Cd Length: 93  Bit Score: 90.20  E-value: 1.16e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319    20 CARKQCSEG-RTYSNAVISPNLETTRIMRV----SHTFPVVDCTAACCDLSSCDLAWWF------EGRCYLVSC--PHKE 86
Cdd:smart00765    1 SPGEDCLGRfRVLENAIIRTEESLSAGARFlkspIAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCtyPGKE 80

                            90
                    ....*....|....*.
gi 1179685319    87 NCepkKMGPIRSYLTF 102
Cdd:smart00765   81 VC---KFKPHEGYTSY 93
PARM super family cl37917
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present ...
 202-337 1.11e-03

PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present in most tissues, with high levels in the heart, kidney and placenta. It has been shown to be induced and expressed in prostate after castration and may have a role in cell proliferation and immortalization in prostate cancer.


The actual alignment was detected with superfamily member pfam17061:

Pssm-ID: 465341 [Multi-domain]  Cd Length: 296  Bit Score: 42.15  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  202 SPAVPAE-TQQDPELHYL------NESASTPA---PKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMP 271
Cdd:pfam17061   78 SPASNWEgTSTDPSPPGLsptssgVHLTPTPEehsSGTPETSVPATGSQSPAESPTLTSPQAPASSPSSPSTSPPEVSSA 157

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1179685319  272 SHSLPPASLELSSvtvEKSPVLTvTPGS--TEHSIPTPPTSAAPSESTPSElPISPTTAPRTVKELTV 337
Cdd:pfam17061  158 SVTTNHSSTETST---QPTGAPT-TPESptEEHSSGHTPTSHATSEPVPTE-TTPQTTVPSKVTCELI 220
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 431-813 6.32e-38

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 154.81  E-value: 6.32e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  431 NLPPVAVVSPQLQELTLplTSALIDGSQSTD-DTEIVSYHWEEINGPFIEeKTSVDSP--------VLRLSNLdpgnySF 501
Cdd:NF038112  1185 NRRPVANAGPDQTVLER--TTVTLNGSGSFDpDGDPLTYAWTQVSGPAVT-LTGADTAtpsftapeVTADTVL-----TF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  502 RLTVTDSDGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDDHQIVLYEWSLGPGSEgkhVVMQGVQ 581
Cdd:NF038112  1257 QLVVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQTSGPA---VTLTGAT 1331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  582 TPYLHLSAMQ---EGDYTFQLKVTDSSrQQSTAVVTVIVQPENnRPPVAVAGPDKElIFPVESATLDGSSSSDDHGIVFY 658
Cdd:NF038112  1332 TATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALTY 1408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  659 HWEHVRGPsAVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTVAVKKENNSPpRARAGGRhVLVLPNNS 735
Cdd:NF038112  1409 AWTQTAGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAGES-ITVDEGST 1485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  736 ITLDGSRSTDDQRIVSYLWIRDGQSPAAgdvIDGSDHSVALQLTNLVEG--VYTFHLRVTDSQGASDTDTATVEVQPDPR 813
Cdd:NF038112  1486 VTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-720 9.69e-31

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 131.70  E-value: 9.69e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  404 VFKVTVSSE-NAFGEGFVNVTVkpaRRVNLPPVAVVS-PQLQELTLPLTsalIDGSQSTDDTEIVSYHWEEINGPFIeek 481
Cdd:NF038112  1255 TFQLVVSDGtKTSAPDTVTVLV---RNVNRAPVAVAGaPATVDERSTVT---LDGSGTDADGDALTYAWTQTSGPAV--- 1325

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  482 TSVDSPVLRLSNLDP-----GNYSFRLTVTDSdGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDD 556
Cdd:NF038112  1326 TLTGATTATATFTAPevtadTQLTFTLTVSDG-TASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPD 1402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  557 HQIVLYEWSlgpGSEGKHVVMQGVQTPYLHLSA---MQEGDYTFQLKVTDSSrqQSTAVVTVIVQPEN-NRPPVAVAGPD 632
Cdd:NF038112  1403 GDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSADG--QASADVTVTVTVRNvNRAPVAHAGES 1477

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  633 KELIfPVESATLDGSSSSDDHGIVFYHWEHVRGPSaVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTV 709
Cdd:NF038112  1478 ITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGPS-VTLTGADSAKLTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTV 1555

                          330
                   ....*....|.
gi 1179685319  710 AVKKENNSPPR 720
Cdd:NF038112  1556 TVKNVNRAPDG 1566
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 20-102 1.16e-21

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 90.20  E-value: 1.16e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319    20 CARKQCSEG-RTYSNAVISPNLETTRIMRV----SHTFPVVDCTAACCDLSSCDLAWWF------EGRCYLVSC--PHKE 86
Cdd:smart00765    1 SPGEDCLGRfRVLENAIIRTEESLSAGARFlkspIAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCtyPGKE 80

                            90
                    ....*....|....*.
gi 1179685319    87 NCepkKMGPIRSYLTF 102
Cdd:smart00765   81 VC---KFKPHEGYTSY 93
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 546-826 3.64e-10

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 63.67  E-value: 3.64e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  546 ITLNGNQSSDDHQIvLYEWSLGPGSEGKHVVMQG----VQTPYLHLS--AMQEGDYTFQLKVTDSSRQ--QSTAVVTVIV 617
Cdd:pfam02010    1 ASVELNGCFSAYTI-DYLWSVFTVSSNLNLQTISspkdLVLPQLTIPsgTLPYGTYVFTLTVSLSSTPslAGTDIITVTV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  618 QPennRPPVAVAGPDKELIFPV-ESATLDGSSSSD------DHGIVFYHWEHVRGPSAVE-MENID-------------- 675
Cdd:pfam02010   80 QP---SPLVAVIDGGSSRVVGYnQDLTLDGSESYDpdvdpgSSSGLTYLWSCRRSSSGDNpLLNNDpvcfsdqnegtllq 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  676 --KAIATVTG--LQVG-TYHFRLTVKDQQGLSSTSTLTVAVKKENnsPPRARAGGRH---VLVLPNNSITLDGSRSTDDQ 747
Cdd:pfam02010  157 stSSSLTIPAstLQANvTYTFKLTVSKGSRNSASTTQTILVVDGN--PPIIILSCISncnRKNNPVDRLVLLASTCLNCS 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  748 R---IVSYLWIRDGQS-------PAAGDVIDGSDHS-VALQLTNLVEGV-YTFHLRVTDSQGASDTDT-ATVEVQPDPRk 814
Cdd:pfam02010  235 SdlsDVTYRWLSLGSEntslvldQLNSQTSTGRSGPyLVIKAGVLQSGVsYRFTLIVTVYPGLVSGLAsISFITNAPPT- 313

                          330
                   ....*....|..
gi 1179685319  815 SGLVELTLQVGV 826
Cdd:pfam02010  314 GGTCSVTPTEGT 325
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 435-521 6.96e-10

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 56.31  E-value: 6.96e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319   435 VAVVSPQLQELTLPLTSALIDgsQSTDDTEIVSYHWEEINGPFIEEKTSVdspvlrLSNLDPGNYSFRLTVTDSDGaTNS 514
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGPTVT------HTYTKPGTYTVTLTVTNAVG-SAS 71


                    ....*..
gi 1179685319   515 TTAALIV 521
Cdd:smart00089   72 ATVTVVV 78
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 626-711 2.18e-08

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 52.11  E-value: 2.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  626 VAVAGPDKELIFPVESATLDGSSSSDDhGIVFYHWEhvRGPSAVEMENIdkAIATVTGLQVGTYHFRLTVKDQQGLSSTS 705
Cdd:cd00146      1 PTASVSAPPVAELGASVTFSASDSSGG-SIVSYKWD--FGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                   ....*.
gi 1179685319  706 TLTVAV 711
Cdd:cd00146     76 TTTVVV 81
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
481-818 8.09e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.53  E-value: 8.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  481 KTSVDSPVLRLSNLDPGN-YSFRLTVTDSDGATNSTTAALIVNNAVdyPPVANAGPNHTITLPqNSITLNGnQSSDDHQI 559
Cdd:COG3401    186 TVTSTTLVDGGGDIEPGTtYYYRVAATDTGGESAPSNEVSVTTPTT--PPSAPTGLTATADTP-GSVTLSW-DPVTESDA 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  560 VLYEWSLGPGSEGKHVVMQGVQ-TPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNrPPVAVAGPdkelifp 638
Cdd:COG3401    262 TGYRVYRSNSGDGPFTKVATVTtTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGL------- 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  639 veSATLDGSSS-------SDDHGIVFYH---WEHVRGPSAVEMENIDKAIATVTGLQVG-TYHFRLTVKDQQGLSSTSTL 707
Cdd:COG3401    334 --TATAVGSSSitlswtaSSDADVTGYNvyrSTSGGGTYTKIAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSE 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  708 TVAVKKENNsPPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYT 787
Cdd:COG3401    412 EVSATTASA-ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS 490

                          330       340       350
                   ....*....|....*....|....*....|.
gi 1179685319  788 FHLRVTDSQGASDTDTATVEVQPDPRKSGLV 818
Cdd:COG3401    491 VTTGSLVGGSGASSVTNSVSVIGASAAAAVG 521
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 56-87 6.66e-04

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 39.60  E-value: 6.66e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1179685319   56 DCTAACCDLSSCDLAwWFE---------GRCYLVSCPHKEN 87
Cdd:pfam07502   38 DCVRACCSTPRCNLA-VFEerpggedaiPSCYLFNCLYPSR 77
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 398-625 7.83e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 7.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  398 LSVGLYVFKVTVSSENA--FGEGFVNVTVKPARRVnlPPVAVVSPQLQELTLPLtsaLIDGSQSTD------DTEIVSYH 469
Cdd:TIGR00864 2219 LAAGHYCFVFSLSFEDTplKKAACANLGVAAARLM--PIIEGGSYRVWSDTQDL---QLDAEESYDpnldddDQSLLHFH 2293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  470 WEEINGPFIEEKTSV-------DSPVLRL--SNLDPG-NYSFRLTVTDSDGATNSTTAALIVNNA---VDYPPVANAGPN 536
Cdd:TIGR00864 2294 WACQASSKGEAGCCAlnfglggKGPTLGIpgEELAAGiEYTFKLSIGKAGMKEEATNQTVLIQSGhipIVSLECVSCKAQ 2373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  537 HTITLPQNS-ITLNG---NQSSDDHQ------------IVLYEWSLGPGSEGKHVVM-QGVqtpyLHLSamqEGdYTFQL 599
Cdd:TIGR00864 2374 ALYEVSQNSyVYLEGrclNCQSGFHRgrwaartfqndtLVLDESSTSTGSAGMNLVLrQGV----LHDG---EG-YNFTL 2445

                          250       260
                   ....*....|....*....|....*.
gi 1179685319  600 KVTDSSRQQSTAvVTVIVQPenNRPP 625
Cdd:TIGR00864 2446 HVLDDSGDEEGA-ASIRLHH--NMPP 2468
PARM pfam17061
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present ...
 202-337 1.11e-03

PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present in most tissues, with high levels in the heart, kidney and placenta. It has been shown to be induced and expressed in prostate after castration and may have a role in cell proliferation and immortalization in prostate cancer.


Pssm-ID: 465341 [Multi-domain]  Cd Length: 296  Bit Score: 42.15  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  202 SPAVPAE-TQQDPELHYL------NESASTPA---PKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMP 271
Cdd:pfam17061   78 SPASNWEgTSTDPSPPGLsptssgVHLTPTPEehsSGTPETSVPATGSQSPAESPTLTSPQAPASSPSSPSTSPPEVSSA 157

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1179685319  272 SHSLPPASLELSSvtvEKSPVLTvTPGS--TEHSIPTPPTSAAPSESTPSElPISPTTAPRTVKELTV 337
Cdd:pfam17061  158 SVTTNHSSTETST---QPTGAPT-TPESptEEHSSGHTPTSHATSEPVPTE-TTPQTTVPSKVTCELI 220
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 431-813 6.32e-38

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 154.81  E-value: 6.32e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  431 NLPPVAVVSPQLQELTLplTSALIDGSQSTD-DTEIVSYHWEEINGPFIEeKTSVDSP--------VLRLSNLdpgnySF 501
Cdd:NF038112  1185 NRRPVANAGPDQTVLER--TTVTLNGSGSFDpDGDPLTYAWTQVSGPAVT-LTGADTAtpsftapeVTADTVL-----TF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  502 RLTVTDSDGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDDHQIVLYEWSLGPGSEgkhVVMQGVQ 581
Cdd:NF038112  1257 QLVVSDGTKTSAPDTVTVLVRN-VNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWTQTSGPA---VTLTGAT 1331

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  582 TPYLHLSAMQ---EGDYTFQLKVTDSSrQQSTAVVTVIVQPENnRPPVAVAGPDKElIFPVESATLDGSSSSDDHGIVFY 658
Cdd:NF038112  1332 TATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALTY 1408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  659 HWEHVRGPsAVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTVAVKKENNSPpRARAGGRhVLVLPNNS 735
Cdd:NF038112  1409 AWTQTAGP-TVTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRNVNRAP-VAHAGES-ITVDEGST 1485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  736 ITLDGSRSTDDQRIVSYLWIRDGQSPAAgdvIDGSDHSVALQLTNLVEG--VYTFHLRVTDSQGASDTDTATVEVQPDPR 813
Cdd:NF038112  1486 VTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVNR 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-720 9.69e-31

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 131.70  E-value: 9.69e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  404 VFKVTVSSE-NAFGEGFVNVTVkpaRRVNLPPVAVVS-PQLQELTLPLTsalIDGSQSTDDTEIVSYHWEEINGPFIeek 481
Cdd:NF038112  1255 TFQLVVSDGtKTSAPDTVTVLV---RNVNRAPVAVAGaPATVDERSTVT---LDGSGTDADGDALTYAWTQTSGPAV--- 1325

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  482 TSVDSPVLRLSNLDP-----GNYSFRLTVTDSdGATNSTTAALIVNNaVDYPPVANAGPNHTITlPQNSITLNGNQSSDD 556
Cdd:NF038112  1326 TLTGATTATATFTAPevtadTQLTFTLTVSDG-TASATDTVTVTVRN-VNRAPVANAGADQTVD-ERSTVTLSGSATDPD 1402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  557 HQIVLYEWSlgpGSEGKHVVMQGVQTPYLHLSA---MQEGDYTFQLKVTDSSrqQSTAVVTVIVQPEN-NRPPVAVAGPD 632
Cdd:NF038112  1403 GDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVSADG--QASADVTVTVTVRNvNRAPVAHAGES 1477

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  633 KELIfPVESATLDGSSSSDDHGIVFYHWEHVRGPSaVEMENIDKAIATVTGLQVG---TYHFRLTVKDQQGLSSTSTLTV 709
Cdd:NF038112  1478 ITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGPS-VTLTGADSAKLTFTAPEVSadtTLTFSLTVTDGSGSSGPVVVTV 1555

                          330
                   ....*....|.
gi 1179685319  710 AVKKENNSPPR 720
Cdd:NF038112  1556 TVKNVNRAPDG 1566
MANEC smart00765
The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is ...
 20-102 1.16e-21

The MANEC domain, formerly called MANSC; This domain, comprising 8 conserved cysteines, is found in the N terminus of higher multicellular animal membrane and extracellular proteins. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors. It is possible that some of the cysteine residues in the MANSC domain form structurally important disulfide bridges. All of the MANSC-containing proteins contain predicted transmembrane regions and signal peptides. It has been proposed that the MANSC domain in HAI-1 might function through binding with hepatocyte growth factor activator and matriptase.


Pssm-ID: 129004  Cd Length: 93  Bit Score: 90.20  E-value: 1.16e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319    20 CARKQCSEG-RTYSNAVISPNLETTRIMRV----SHTFPVVDCTAACCDLSSCDLAWWF------EGRCYLVSC--PHKE 86
Cdd:smart00765    1 SPGEDCLGRfRVLENAIIRTEESLSAGARFlkspIAVNTWEDCVRACCSTPNCNLAVFElrredaEGNCYLFNCtyPGKE 80

                            90
                    ....*....|....*.
gi 1179685319    87 NCepkKMGPIRSYLTF 102
Cdd:smart00765   81 VC---KFKPHEGYTSY 93
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 546-826 3.64e-10

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 63.67  E-value: 3.64e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  546 ITLNGNQSSDDHQIvLYEWSLGPGSEGKHVVMQG----VQTPYLHLS--AMQEGDYTFQLKVTDSSRQ--QSTAVVTVIV 617
Cdd:pfam02010    1 ASVELNGCFSAYTI-DYLWSVFTVSSNLNLQTISspkdLVLPQLTIPsgTLPYGTYVFTLTVSLSSTPslAGTDIITVTV 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  618 QPennRPPVAVAGPDKELIFPV-ESATLDGSSSSD------DHGIVFYHWEHVRGPSAVE-MENID-------------- 675
Cdd:pfam02010   80 QP---SPLVAVIDGGSSRVVGYnQDLTLDGSESYDpdvdpgSSSGLTYLWSCRRSSSGDNpLLNNDpvcfsdqnegtllq 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  676 --KAIATVTG--LQVG-TYHFRLTVKDQQGLSSTSTLTVAVKKENnsPPRARAGGRH---VLVLPNNSITLDGSRSTDDQ 747
Cdd:pfam02010  157 stSSSLTIPAstLQANvTYTFKLTVSKGSRNSASTTQTILVVDGN--PPIIILSCISncnRKNNPVDRLVLLASTCLNCS 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  748 R---IVSYLWIRDGQS-------PAAGDVIDGSDHS-VALQLTNLVEGV-YTFHLRVTDSQGASDTDT-ATVEVQPDPRk 814
Cdd:pfam02010  235 SdlsDVTYRWLSLGSEntslvldQLNSQTSTGRSGPyLVIKAGVLQSGVsYRFTLIVTVYPGLVSGLAsISFITNAPPT- 313

                          330
                   ....*....|..
gi 1179685319  815 SGLVELTLQVGV 826
Cdd:pfam02010  314 GGTCSVTPTEGT 325
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 435-521 6.96e-10

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 56.31  E-value: 6.96e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319   435 VAVVSPQLQELTLPLTSALIDgsQSTDDTEIVSYHWEEINGPFIEEKTSVdspvlrLSNLDPGNYSFRLTVTDSDGaTNS 514
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGPTVT------HTYTKPGTYTVTLTVTNAVG-SAS 71


                    ....*..
gi 1179685319   515 TTAALIV 521
Cdd:smart00089   72 ATVTVVV 78
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 392-717 3.13e-09

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 60.59  E-value: 3.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  392 TLNLSQLSVGLYVFKVTVSSE---NAFGEGFVNVTVKPArrvnlPPVAV-------VSPQLQELTLpltsaliDGSQSTD 461
Cdd:pfam02010   44 TIPSGTLPYGTYVFTLTVSLSstpSLAGTDIITVTVQPS-----PLVAVidggssrVVGYNQDLTL-------DGSESYD 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  462 ------DTEIVSYHWEEINGPFIEEKTSVDSPV-----LRLSNLDPGN---------------YSFRLTVTDSDGATNST 515
Cdd:pfam02010  112 pdvdpgSSSGLTYLWSCRRSSSGDNPLLNNDPVcfsdqNEGTLLQSTSssltipastlqanvtYTFKLTVSKGSRNSAST 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  516 TAALIVNNavDYPP------VANAGpnhTITLPQNS---ITLNGNQSSDDHQIVLYEWsLGPGSEGKHVV--------MQ 578
Cdd:pfam02010  192 TQTILVVD--GNPPiiilscISNCN---RKNNPVDRlvlLASTCLNCSSDLSDVTYRW-LSLGSENTSLVldqlnsqtST 265

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  579 GVQTPYLHLSA--MQEG-DYTFQLKVTDSSRQQS-TAVVTVIvqpeNNRPPVAVA-------GPDKELIFPVESatldgS 647
Cdd:pfam02010  266 GRSGPYLVIKAgvLQSGvSYRFTLIVTVYPGLVSgLASISFI----TNAPPTGGTcsvtpteGTALETKFTVTC-----Q 336

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  648 SSSDDHGIVFYHWEHVRGPSAVEMENI------DKAIATVTGLQVGTYHFRLT----VKDQQGLSSTSTLTVAVKKENNS 717
Cdd:pfam02010  337 GWTDDDLPLTYQFGDISFREASEEWFLlyegssQISISTFLPPGLPANDYQVTvvvvVYDSLGAATSVSLTITVTPPSSS 416
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 530-618 7.41e-09

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 53.61  E-value: 7.41e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319   530 VANAGPNHTITLPQNSITLNGnQSSDDHQIVLYEWSLGPG--SEGKHVVMQgvqtpYLHlsamqEGDYTFQLKVTDSSRq 607
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTA-TSSDDGSIVSYTWDFGDGtsSTGPTVTHT-----YTK-----PGTYTVTLTVTNAVG- 68

                            90
                    ....*....|.
gi 1179685319   608 QSTAVVTVIVQ 618
Cdd:smart00089   69 SASATVTVVVQ 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 626-712 8.50e-09

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 53.22  E-value: 8.50e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319   626 VAVAGPDKELIFPVESATLDGSSSsDDHGIVFYHWEHVRGPSAVEmenidkAIATVTGLQVGTYHFRLTVKDQQGlSSTS 705
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTATSS-DDGSIVSYTWDFGDGTSSTG------PTVTHTYTKPGTYTVTLTVTNAVG-SASA 72


                    ....*..
gi 1179685319   706 TLTVAVK 712
Cdd:smart00089   73 TVTVVVQ 79
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 489-810 1.06e-08

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 58.67  E-value: 1.06e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  489 LRLSNLDPGNYSFRLTVTDSDgaTNSTTAALIVNNAVDYPP-VANAGPNHTITLPQNS-ITLNGNQSSD------DHQIV 560
Cdd:pfam02010   45 IPSGTLPYGTYVFTLTVSLSS--TPSLAGTDIITVTVQPSPlVAVIDGGSSRVVGYNQdLTLDGSESYDpdvdpgSSSGL 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  561 LYEWSLGPGSEGKHVVM--QGVQTPYLH-LSAMQEGD---------------YTFQLKVTDSSRQQSTAVVTVIVQPENn 622
Cdd:pfam02010  123 TYLWSCRRSSSGDNPLLnnDPVCFSDQNeGTLLQSTSssltipastlqanvtYTFKLTVSKGSRNSASTTQTILVVDGN- 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  623 rPP---VAVAGPDKELIFPVES---ATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENI--DKAIATVTG---------LQ 685
Cdd:pfam02010  202 -PPiiiLSCISNCNRKNNPVDRlvlLASTCLNCSSDLSDVTYRWLSLGSENTSLVLDQlnSQTSTGRSGpylvikagvLQ 280

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  686 VGT-YHFRLTVKDQQGLSSTSTlTVAVKkeNNSPPRaraGGRhVLVLPNN------SITLDGSRSTDD------------ 746
Cdd:pfam02010  281 SGVsYRFTLIVTVYPGLVSGLA-SISFI--TNAPPT---GGT-CSVTPTEgtaletKFTVTCQGWTDDdlpltyqfgdis 353

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1179685319  747 --QRIVSYLWIRDGQSPaagdvidgSDHSVALQLTNLVEG-VYTFHLRVTDSQGASDTDTATVEVQP 810
Cdd:pfam02010  354 frEASEEWFLLYEGSSQ--------ISISTFLPPGLPANDyQVTVVVVVYDSLGAATSVSLTITVTP 412
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 626-711 2.18e-08

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 52.11  E-value: 2.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  626 VAVAGPDKELIFPVESATLDGSSSSDDhGIVFYHWEhvRGPSAVEMENIdkAIATVTGLQVGTYHFRLTVKDQQGLSSTS 705
Cdd:cd00146      1 PTASVSAPPVAELGASVTFSASDSSGG-SIVSYKWD--FGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTK 75


                   ....*.
gi 1179685319  706 TLTVAV 711
Cdd:cd00146     76 TTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 720-809 8.54e-08

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 50.53  E-value: 8.54e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319   720 RARAGGRHVLVLPNNSITLDGSrSTDDQRIVSYLWirdgqspaagDVIDGSD-HSVALQLTNLVEGVYTFHLRVTDSQGa 798
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTW----------DFGDGTSsTGPTVTHTYTKPGTYTVTLTVTNAVG- 68

                            90
                    ....*....|.
gi 1179685319   799 SDTDTATVEVQ 809
Cdd:smart00089   69 SASATVTVVVQ 79
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 622-711 2.14e-07

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 49.58  E-value: 2.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  622 NRPPVAVAGPDKElIFPVESATLDGSSSSD-DHGIVFYHWEHVRGpSAVEMENIDKAIATvtglqVGTYHFRLTVKDQQG 700
Cdd:pfam18911    1 NAAPVADAGGDRI-VAEGETVTFDASASDDpDGDILSYRWDFGDG-TTATGANVSHTYAA-----PGTYTVTLTVTDDSG 73

                           90
                   ....*....|..
gi 1179685319  701 LS-STSTLTVAV 711
Cdd:pfam18911   74 ASnSTATDTVTV 85
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 719-808 3.02e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 49.03  E-value: 3.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  719 PRARAGGRHVlVLPNNSITLDGSrSTDDQRIVSYLWIRDGqspaaGDVIDGSDHSValQLTNLVEGVYTFHLRVTDSQGA 798
Cdd:cd00146      1 PTASVSAPPV-AELGASVTFSAS-DSSGGSIVSYKWDFGD-----GEVSSSGEPTV--THTYTKPGTYTVTLTVTNAVGS 71

                           90
                   ....*....|
gi 1179685319  799 SDTDTATVEV 808
Cdd:cd00146     72 SSTKTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 529-617 6.05e-07

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 48.26  E-value: 6.05e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  529 PVANAGPNHTITLPQnSITLNGNqSSDDHQIVLYEWSLGPGSegkhVVMQGVQTPylHLSAMQEGDYTFQLKVTDSSRQQ 608
Cdd:cd00146      1 PTASVSAPPVAELGA-SVTFSAS-DSSGGSIVSYKWDFGDGE----VSSSGEPTV--THTYTKPGTYTVTLTVTNAVGSS 72


                   ....*....
gi 1179685319  609 STAVVTVIV 617
Cdd:cd00146     73 STKTTTVVV 81
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 433-521 1.28e-06

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 47.11  E-value: 1.28e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  433 PPVAVVSPQLQELTLPLT-SAlidgsQSTDDTEIVSYHWEEINGPFIeektSVDSPVLRLSNLDPGNYSFRLTVTDSDGA 511
Cdd:cd00146      1 PTASVSAPPVAELGASVTfSA-----SDSSGGSIVSYKWDFGDGEVS----SSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                           90
                   ....*....|
gi 1179685319  512 TNSTTAALIV 521
Cdd:cd00146     72 SSTKTTTVVV 81
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 528-617 2.07e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 46.88  E-value: 2.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  528 PPVANAGPNHTITLPQnSITLNGNQSSD-DHQIVLYEWSLGPGSEG-----KHVvmqgvqtpYlhlsaMQEGDYTFQLKV 601
Cdd:pfam18911    3 APVADAGGDRIVAEGE-TVTFDASASDDpDGDILSYRWDFGDGTTAtganvSHT--------Y-----AAPGTYTVTLTV 68

                           90
                   ....*....|....*..
gi 1179685319  602 TDSS-RQQSTAVVTVIV 617
Cdd:pfam18911   69 TDDSgASNSTATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 716-808 2.59e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 46.49  E-value: 2.59e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  716 NSPPRARAGGRhVLVLPNNSITLDGSRSTD-DQRIVSYLWirdgqspaagDVIDGSdhsvALQLTNLV-----EGVYTFH 789
Cdd:pfam18911    1 NAAPVADAGGD-RIVAEGETVTFDASASDDpDGDILSYRW----------DFGDGT----TATGANVShtyaaPGTYTVT 65

                           90       100
                   ....*....|....*....|
gi 1179685319  790 LRVTDSQGASD-TDTATVEV 808
Cdd:pfam18911   66 LTVTDDSGASNsTATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 431-521 3.05e-06

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 46.11  E-value: 3.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  431 NLPPVAVVSPQlQELTLPLTSALiDGSQSTD-DTEIVSYHWEEINGpfieekTSVDSPVLRLSNLDPGNYSFRLTVTDSD 509
Cdd:pfam18911    1 NAAPVADAGGD-RIVAEGETVTF-DASASDDpDGDILSYRWDFGDG------TTATGANVSHTYAAPGTYTVTLTVTDDS 72

                           90
                   ....*....|...
gi 1179685319  510 GATNST-TAALIV 521
Cdd:pfam18911   73 GASNSTaTDTVTV 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
481-818 8.09e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.53  E-value: 8.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  481 KTSVDSPVLRLSNLDPGN-YSFRLTVTDSDGATNSTTAALIVNNAVdyPPVANAGPNHTITLPqNSITLNGnQSSDDHQI 559
Cdd:COG3401    186 TVTSTTLVDGGGDIEPGTtYYYRVAATDTGGESAPSNEVSVTTPTT--PPSAPTGLTATADTP-GSVTLSW-DPVTESDA 261

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  560 VLYEWSLGPGSEGKHVVMQGVQ-TPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTVIVQPENNrPPVAVAGPdkelifp 638
Cdd:COG3401    262 TGYRVYRSNSGDGPFTKVATVTtTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGL------- 333

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  639 veSATLDGSSS-------SDDHGIVFYH---WEHVRGPSAVEMENIDKAIATVTGLQVG-TYHFRLTVKDQQGLSSTSTL 707
Cdd:COG3401    334 --TATAVGSSSitlswtaSSDADVTGYNvyrSTSGGGTYTKIAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSE 411

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  708 TVAVKKENNsPPRARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYT 787
Cdd:COG3401    412 EVSATTASA-ASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLS 490

                          330       340       350
                   ....*....|....*....|....*....|.
gi 1179685319  788 FHLRVTDSQGASDTDTATVEVQPDPRKSGLV 818
Cdd:COG3401    491 VTTGSLVGGSGASSVTNSVSVIGASAAAAVG 521
MANEC pfam07502
MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the ...
 56-87 6.66e-04

MANEC domain; This region of similarity, comprising 8 conserved cysteines, is found in the N-terminal region of several membrane-associated and extracellular proteins. Although formerly called MANSC (for motif at N terminus with seven cysteines) it has now been renamed by MANEC (motif at N terminus with eight cysteines) by Richard Mitter and Stephen Fitzgerald after the discovery of an eighth conserved cysteine. It is postulated that this domain may play a role in the formation of protein complexes involving various protease activators and inhibitors.


Pssm-ID: 462186  Cd Length: 90  Bit Score: 39.60  E-value: 6.66e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1179685319   56 DCTAACCDLSSCDLAwWFE---------GRCYLVSCPHKEN 87
Cdd:pfam07502   38 DCVRACCSTPRCNLA-VFEerpggedaiPSCYLFNCLYPSR 77
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 398-625 7.83e-04

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 43.92  E-value: 7.83e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  398 LSVGLYVFKVTVSSENA--FGEGFVNVTVKPARRVnlPPVAVVSPQLQELTLPLtsaLIDGSQSTD------DTEIVSYH 469
Cdd:TIGR00864 2219 LAAGHYCFVFSLSFEDTplKKAACANLGVAAARLM--PIIEGGSYRVWSDTQDL---QLDAEESYDpnldddDQSLLHFH 2293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  470 WEEINGPFIEEKTSV-------DSPVLRL--SNLDPG-NYSFRLTVTDSDGATNSTTAALIVNNA---VDYPPVANAGPN 536
Cdd:TIGR00864 2294 WACQASSKGEAGCCAlnfglggKGPTLGIpgEELAAGiEYTFKLSIGKAGMKEEATNQTVLIQSGhipIVSLECVSCKAQ 2373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  537 HTITLPQNS-ITLNG---NQSSDDHQ------------IVLYEWSLGPGSEGKHVVM-QGVqtpyLHLSamqEGdYTFQL 599
Cdd:TIGR00864 2374 ALYEVSQNSyVYLEGrclNCQSGFHRgrwaartfqndtLVLDESSTSTGSAGMNLVLrQGV----LHDG---EG-YNFTL 2445

                          250       260
                   ....*....|....*....|....*.
gi 1179685319  600 KVTDSSRQQSTAvVTVIVQPenNRPP 625
Cdd:TIGR00864 2446 HVLDDSGDEEGA-ASIRLHH--NMPP 2468
PARM pfam17061
PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present ...
 202-337 1.11e-03

PARM; Human PARM-1 is a mucin-like, androgen-regulated transmembrane protein that is present in most tissues, with high levels in the heart, kidney and placenta. It has been shown to be induced and expressed in prostate after castration and may have a role in cell proliferation and immortalization in prostate cancer.


Pssm-ID: 465341 [Multi-domain]  Cd Length: 296  Bit Score: 42.15  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1179685319  202 SPAVPAE-TQQDPELHYL------NESASTPA---PKLPERSVLLPLPTTPSSGEVLEKEKASQLQEQSSNSSGKEVLMP 271
Cdd:pfam17061   78 SPASNWEgTSTDPSPPGLsptssgVHLTPTPEehsSGTPETSVPATGSQSPAESPTLTSPQAPASSPSSPSTSPPEVSSA 157

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1179685319  272 SHSLPPASLELSSvtvEKSPVLTvTPGS--TEHSIPTPPTSAAPSESTPSElPISPTTAPRTVKELTV 337
Cdd:pfam17061  158 SVTTNHSSTETST---QPTGAPT-TPESptEEHSSGHTPTSHATSEPVPTE-TTPQTTVPSKVTCELI 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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