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Conserved domains on  [gi|1182946083|ref|NP_001337516|]
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tRNA (guanine(10)-N2)-methyltransferase homolog isoform e [Homo sapiens]

Protein Classification

TRM11 family methyltransferase( domain architecture ID 1004176)

TRM11 family SAM-dependent methyltransferase containing a THUMP domain, similar to Homo sapiens tRNA (guanine(10)-N2)-methyltransferase, the catalytic subunit of a tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs

EC:  2.1.1.-
Gene Ontology:  GO:0003676|GO:0008168
PubMed:  2690010

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Trm11 super family cl34076
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 38-153 9.62e-09

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG1041:

Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 53.03  E-value: 9.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182946083  38 RANLRQYGLEKYylDVLVSDASKPSWRKGTyFDAIITDPPYGIRESTRRTGsqkeipkgiekwekcpeshvpvslsyhLS 117
Cdd:COG1041    65 RENLEHYGYEDA--DVIRGDARDLPLADES-VDAIVTDPPYGRSSKISGEE---------------------------LL 114

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1182946083 118 DMFLDLLNFAAETLVLGGRLVywlpVYTPEYTEEMV 153
Cdd:COG1041   115 ELYEKALEEAARVLKPGGRVV----IVTPRDIDELL 146
 
Name Accession Description Interval E-value
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 38-153 9.62e-09

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 53.03  E-value: 9.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182946083  38 RANLRQYGLEKYylDVLVSDASKPSWRKGTyFDAIITDPPYGIRESTRRTGsqkeipkgiekwekcpeshvpvslsyhLS 117
Cdd:COG1041    65 RENLEHYGYEDA--DVIRGDARDLPLADES-VDAIVTDPPYGRSSKISGEE---------------------------LL 114

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1182946083 118 DMFLDLLNFAAETLVLGGRLVywlpVYTPEYTEEMV 153
Cdd:COG1041   115 ELYEKALEEAARVLKPGGRVV----IVTPRDIDELL 146
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
 38-99 3.10e-05

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 43.97  E-value: 3.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1182946083  38 RANLRQYGLEKYYldVLVSDASKPSWRKGTyFDAIITDPPYGIRESTRRTGSQKEIPKGIEK 99
Cdd:TIGR01177 221 RINLEHYGIEDFF--VKRGDATKLPLSSES-VDAIATDPPYGRSTTAAGDGLESLYERSLEE 279
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 38-88 4.01e-03

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 36.95  E-value: 4.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1182946083  38 RANLRQYGLEKYyLDVLVSDASKPSWRKGTYfDAIITDPPYGIRESTRRTG 88
Cdd:pfam01170  80 RLNAENAGVGDL-IEFVQADAADLPLLEGSV-DVIVTNPPYGIRLGSKGAL 128
 
Name Accession Description Interval E-value
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 38-153 9.62e-09

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 53.03  E-value: 9.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182946083  38 RANLRQYGLEKYylDVLVSDASKPSWRKGTyFDAIITDPPYGIRESTRRTGsqkeipkgiekwekcpeshvpvslsyhLS 117
Cdd:COG1041    65 RENLEHYGYEDA--DVIRGDARDLPLADES-VDAIVTDPPYGRSSKISGEE---------------------------LL 114

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1182946083 118 DMFLDLLNFAAETLVLGGRLVywlpVYTPEYTEEMV 153
Cdd:COG1041   115 ELYEKALEEAARVLKPGGRVV----IVTPRDIDELL 146
TIGR01177 TIGR01177
putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is ...
 38-99 3.10e-05

putative methyltransferase, TIGR01177 family; This family of probable methyltransferases is found exclusively in the Archaea. [Hypothetical proteins, Conserved]


Pssm-ID: 273486 [Multi-domain]  Cd Length: 329  Bit Score: 43.97  E-value: 3.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1182946083  38 RANLRQYGLEKYYldVLVSDASKPSWRKGTyFDAIITDPPYGIRESTRRTGSQKEIPKGIEK 99
Cdd:TIGR01177 221 RINLEHYGIEDFF--VKRGDATKLPLSSES-VDAIATDPPYGRSTTAAGDGLESLYERSLEE 279
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 38-88 4.01e-03

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 36.95  E-value: 4.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1182946083  38 RANLRQYGLEKYyLDVLVSDASKPSWRKGTYfDAIITDPPYGIRESTRRTG 88
Cdd:pfam01170  80 RLNAENAGVGDL-IEFVQADAADLPLLEGSV-DVIVTNPPYGIRLGSKGAL 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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