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Conserved domains on  [gi|1182949991|ref|NP_001337553|]
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WD repeat-containing protein 27 isoform 4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-199 1.68e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991  48 DGTeLCIWNTkDPSHQLLILRGHHQPITAMAF---GNkvnplLICSASLDYVI-MWNLDEcrEKVLQGLVPRGtvmgsll 123
Cdd:COG2319   267 DGT-VRLWDL-ATGELLRTLTGHSGGVNSVAFspdGK-----LLASGSDDGTVrLWDLAT--GKLLRTLTGHT------- 330

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1182949991 124 GKVLCLQLSLDDHVVAVCAGNKIfmldIEVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSL 199
Cdd:COG2319   331 GAVRSVAFSPDGKTLASGSDDGT----VRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-199 1.68e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991  48 DGTeLCIWNTkDPSHQLLILRGHHQPITAMAF---GNkvnplLICSASLDYVI-MWNLDEcrEKVLQGLVPRGtvmgsll 123
Cdd:COG2319   267 DGT-VRLWDL-ATGELLRTLTGHSGGVNSVAFspdGK-----LLASGSDDGTVrLWDLAT--GKLLRTLTGHT------- 330

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1182949991 124 GKVLCLQLSLDDHVVAVCAGNKIfmldIEVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSL 199
Cdd:COG2319   331 GAVRSVAFSPDGKTLASGSDDGT----VRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-198 1.11e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991  54 IWNTKDPSHQLLiLRGHHQPITAMAFGNKVNPLliCSASLDYVI-MWNLDEcrekvlqglvprGTVMGSLLGK---VLCL 129
Cdd:cd00200   161 LWDLRTGKCVAT-LTGHTGEVNSVAFSPDGEKL--LSSSSDGTIkLWDLST------------GKCLGTLRGHengVNSV 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1182949991 130 QLSLDDHVVAVCAGNKIfmldIEVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 198
Cdd:cd00200   226 AFSPDGYLLASGSEDGT----IRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-199 1.68e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.99  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991  48 DGTeLCIWNTkDPSHQLLILRGHHQPITAMAF---GNkvnplLICSASLDYVI-MWNLDEcrEKVLQGLVPRGtvmgsll 123
Cdd:COG2319   267 DGT-VRLWDL-ATGELLRTLTGHSGGVNSVAFspdGK-----LLASGSDDGTVrLWDLAT--GKLLRTLTGHT------- 330

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1182949991 124 GKVLCLQLSLDDHVVAVCAGNKIfmldIEVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSL 199
Cdd:COG2319   331 GAVRSVAFSPDGKTLASGSDDGT----VRLWDLATGELLRTLTGHTG-AVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-198 1.11e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.03  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991  54 IWNTKDPSHQLLiLRGHHQPITAMAFGNKVNPLliCSASLDYVI-MWNLDEcrekvlqglvprGTVMGSLLGK---VLCL 129
Cdd:cd00200   161 LWDLRTGKCVAT-LTGHTGEVNSVAFSPDGEKL--LSSSSDGTIkLWDLST------------GKCLGTLRGHengVNSV 225

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1182949991 130 QLSLDDHVVAVCAGNKIfmldIEVWDHCTGSLIYsssVLSAY--PLLSLFIDAESRQLVTGCADGQLWIFS 198
Cdd:cd00200   226 AFSPDGYLLASGSEDGT----IRVWDLRTGECVQ---TLSGHtnSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
48-211 2.33e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnpLLIcSASLDYVI-MWNLDECRE-KVLQGLVprgtvmgsl 122
Cdd:COG2319   141 DGT-VRLWDLATGK-LLRTLTGHSGAVTSVAFspdGK----LLA-SGSDDGTVrLWDLATGKLlRTLTGHT--------- 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991 123 lGKVLCLQLSLDDHVVAVCAGNKIfmldIEVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSLMDG 202
Cdd:COG2319   205 -GAVRSVAFSPDGKLLASGSADGT----VRLWDLATGKLLRTLTGHSG-SVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                         170
                  ....*....|....*.
gi 1182949991 203 -------HHYRRVARV 211
Cdd:COG2319   279 ellrtltGHSGGVNSV 294
WD40 COG2319
WD40 repeat [General function prediction only];
48-202 4.84e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 4.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991  48 DGTeLCIWNTKDPShQLLILRGHHQPITAMAF---GNkvnplLICSASLD-YVIMWNLDECRE-KVLQGLVPRgtvmgsl 122
Cdd:COG2319   183 DGT-VRLWDLATGK-LLRTLTGHTGAVRSVAFspdGK-----LLASGSADgTVRLWDLATGKLlRTLTGHSGS------- 248

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991 123 lgkVLCLQLSLDDHVVAVCAGNKIfmldIEVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSLMDG 202
Cdd:COG2319   249 ---VRSVAFSPDGRLLASGSADGT----VRLWDLATGELLRTLTGHSG-GVNSVAFSPDGKLLASGSDDGTVRLWDLATG 320
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-202 3.10e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.32  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991  67 LRGHHQPITAMAFGNKVNplLICSASLD-YVIMWNLDECR-EKVLQGlvprgtvmgsLLGKVLCLQLSLDDHVVAVCAGN 144
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGK--LLATGSGDgTIKVWDLETGElLRTLKG----------HTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1182949991 145 KifmlDIEVWD----HCTGSLI-YSSSVlsayplLSLFIDAESRQLVTGCADGQLWIFSLMDG 202
Cdd:cd00200    73 K----TIRLWDletgECVRTLTgHTSYV------SSVAFSPDGRILSSSSRDKTIKVWDVETG 125
WD40 COG2319
WD40 repeat [General function prediction only];
54-202 4.23e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 4.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1182949991  54 IWNTkDPSHQLLILRGHHQPITAMAFgnkvNP---LLIcSASLDYVI-MWNLDecrekvlqglvpRGTVMGSLLG---KV 126
Cdd:COG2319   104 LWDL-ATGLLLRTLTGHTGAVRSVAF----SPdgkTLA-SGSADGTVrLWDLA------------TGKLLRTLTGhsgAV 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1182949991 127 LCLQLSLDDHVVAVCAGNKIfmldIEVWDHCTGSLIYSSSVLSAyPLLSLFIDAESRQLVTGCADGQLWIFSLMDG 202
Cdd:COG2319   166 TSVAFSPDGKLLASGSDDGT----VRLWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATG 236
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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