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Conserved domains on  [gi|1183596748|ref|NP_001337577|]
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purine nucleoside phosphorylase LACC1 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cu-oxidase_4 super family cl47752
Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able ...
 2-122 2.35e-48

Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.


The actual alignment was detected with superfamily member pfam02578:

Pssm-ID: 460601 [Multi-domain]  Cd Length: 232  Bit Score: 156.49  E-value: 2.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748   2 GRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEYGCSLEDIVVVLGPS 81
Cdd:pfam02578  66 GAAREEDADALVTDEPGVALAVLTADCVPVLLADPVGGVVAAAHAGWRGTVAGILEATVEAMEELGGARPEDILAAIGPS 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1183596748  82 VGPCCFTLPRESAEAFHNLHPACVQLFDSPN-PCIDIRKATR 122
Cdd:pfam02578 146 IGPCCYEVGEEVAEAFAAADPDAAFPATRAGkYLLDLWAANR 187
 
Name Accession Description Interval E-value
Cu-oxidase_4 pfam02578
Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able ...
 2-122 2.35e-48

Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.


Pssm-ID: 460601 [Multi-domain]  Cd Length: 232  Bit Score: 156.49  E-value: 2.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748   2 GRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEYGCSLEDIVVVLGPS 81
Cdd:pfam02578  66 GAAREEDADALVTDEPGVALAVLTADCVPVLLADPVGGVVAAAHAGWRGTVAGILEATVEAMEELGGARPEDILAAIGPS 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1183596748  82 VGPCCFTLPRESAEAFHNLHPACVQLFDSPN-PCIDIRKATR 122
Cdd:pfam02578 146 IGPCCYEVGEEVAEAFAAADPDAAFPATRAGkYLLDLWAANR 187
YfiH cd16833
protein of unknown function YfiH; This subfamily contains YfiH, a protein of unknown function ...
 2-124 1.11e-41

protein of unknown function YfiH; This subfamily contains YfiH, a protein of unknown function from Shigella flexneri, E. coli, and many similar proteins which collectively are often called DUF152. The structure of YfiH reveals a distant homology to Rho-activating toxins cytotoxic necrotizing factor 1 (CNF1) as well as chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs), all having an invariant Cys-His pair forming a catalytic dyad, and is required by the CNF-1 toxins for deamidation activity.


Pssm-ID: 319354  Cd Length: 185  Bit Score: 137.72  E-value: 1.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748   2 GRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEYgCSLEDIVVVLGPS 81
Cdd:cd16833    21 GGTAIPEADALITNEPGVALAVLTADCVPVLLYDPKGGVIAAAHAGWRGTVAGIVEKTVEAMKELG-SDPEDILAAIGPS 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1183596748  82 VGPCCFTLPRESAEAFHNLHPACVQLFDSPNPCIDIRKATRYL 124
Cdd:cd16833   100 IGPCCYEVGEEVAEAFPAAFPEAAAFFKPGKYYLDLWAANRLQ 142
YfiH COG1496
Copper oxidase (laccase) domain [Inorganic ion transport and metabolism];
10-108 7.37e-35

Copper oxidase (laccase) domain [Inorganic ion transport and metabolism];


Pssm-ID: 441105 [Multi-domain]  Cd Length: 246  Bit Score: 122.20  E-value: 7.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748  10 DGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEYgCSLEDIVVVLGPSVGPCCFTL 89
Cdd:COG1496    89 DALVTNEPGVALAVLTADCVPVLFADPEGGVVAAAHAGWRGTVAGILEKTVEAMEALG-ARPEDILAWIGPAIGPCCYEV 167

                          90
                  ....*....|....*....
gi 1183596748  90 PRESAEAFHNLHPACVQLF 108
Cdd:COG1496   168 GEEVAEAFLAADPDAARAF 186
TIGR00726 TIGR00726
YfiH family protein; PSI-BLAST converges on members of this family of uncharacterized ...
 10-97 2.86e-24

YfiH family protein; PSI-BLAST converges on members of this family of uncharacterized bacterial proteins and shows no significant similarity to any characterized protein. No completed genome to date has two members. Members of the family have been crystallized but the function is unknown. [Unknown function, General]


Pssm-ID: 273235 [Multi-domain]  Cd Length: 221  Bit Score: 93.99  E-value: 2.86e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748  10 DGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEyGCSLEDIVVVLGPSVGPCCFTL 89
Cdd:TIGR00726  65 DGLITNTPNLVLAVYTADCVPVLFYDRVGKIVAAVHAGWRGLKNGIIAKTVKMFKKF-GSKPKDLIAVIGPAIGGCCYEV 143


                  ....*...
gi 1183596748  90 PRESAEAF 97
Cdd:TIGR00726 144 DKEVYEAF 151
PRK10723 PRK10723
polyphenol oxidase;
10-108 8.65e-13

polyphenol oxidase;


Pssm-ID: 182677  Cd Length: 243  Bit Score: 63.88  E-value: 8.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748  10 DGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEygcsLEDIVVVLGPSVGPCCFTL 89
Cdd:PRK10723   89 DASYSNTPGTVCAVMTADCLPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVACFAAK----PENILAWLGPAIGPQAFEV 164

                          90
                  ....*....|....*....
gi 1183596748  90 PRESAEAFHNLHPACVQLF 108
Cdd:PRK10723  165 GPEVREAFMAKDAKASAAF 183
 
Name Accession Description Interval E-value
Cu-oxidase_4 pfam02578
Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able ...
 2-122 2.35e-48

Multi-copper polyphenol oxidoreductase laccase; Laccases are multi-copper oxidoreductases able to oxidize a wide variety of phenolic and non-phenolic compounds and are widely distributed among both prokaryotes and eukaryotes. There are two main active catalytic sites with conserved histidines that are capable of binding four copper atoms.


Pssm-ID: 460601 [Multi-domain]  Cd Length: 232  Bit Score: 156.49  E-value: 2.35e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748   2 GRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEYGCSLEDIVVVLGPS 81
Cdd:pfam02578  66 GAAREEDADALVTDEPGVALAVLTADCVPVLLADPVGGVVAAAHAGWRGTVAGILEATVEAMEELGGARPEDILAAIGPS 145

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1183596748  82 VGPCCFTLPRESAEAFHNLHPACVQLFDSPN-PCIDIRKATR 122
Cdd:pfam02578 146 IGPCCYEVGEEVAEAFAAADPDAAFPATRAGkYLLDLWAANR 187
YfiH cd16833
protein of unknown function YfiH; This subfamily contains YfiH, a protein of unknown function ...
 2-124 1.11e-41

protein of unknown function YfiH; This subfamily contains YfiH, a protein of unknown function from Shigella flexneri, E. coli, and many similar proteins which collectively are often called DUF152. The structure of YfiH reveals a distant homology to Rho-activating toxins cytotoxic necrotizing factor 1 (CNF1) as well as chemotaxis protein CheD that stimulates methylation of methyl-accepting chemotaxis proteins (MCPs), all having an invariant Cys-His pair forming a catalytic dyad, and is required by the CNF-1 toxins for deamidation activity.


Pssm-ID: 319354  Cd Length: 185  Bit Score: 137.72  E-value: 1.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748   2 GRKEPDSYDGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEYgCSLEDIVVVLGPS 81
Cdd:cd16833    21 GGTAIPEADALITNEPGVALAVLTADCVPVLLYDPKGGVIAAAHAGWRGTVAGIVEKTVEAMKELG-SDPEDILAAIGPS 99

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1183596748  82 VGPCCFTLPRESAEAFHNLHPACVQLFDSPNPCIDIRKATRYL 124
Cdd:cd16833   100 IGPCCYEVGEEVAEAFPAAFPEAAAFFKPGKYYLDLWAANRLQ 142
YfiH COG1496
Copper oxidase (laccase) domain [Inorganic ion transport and metabolism];
10-108 7.37e-35

Copper oxidase (laccase) domain [Inorganic ion transport and metabolism];


Pssm-ID: 441105 [Multi-domain]  Cd Length: 246  Bit Score: 122.20  E-value: 7.37e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748  10 DGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEYgCSLEDIVVVLGPSVGPCCFTL 89
Cdd:COG1496    89 DALVTNEPGVALAVLTADCVPVLFADPEGGVVAAAHAGWRGTVAGILEKTVEAMEALG-ARPEDILAWIGPAIGPCCYEV 167

                          90
                  ....*....|....*....
gi 1183596748  90 PRESAEAFHNLHPACVQLF 108
Cdd:COG1496   168 GEEVAEAFLAADPDAARAF 186
TIGR00726 TIGR00726
YfiH family protein; PSI-BLAST converges on members of this family of uncharacterized ...
 10-97 2.86e-24

YfiH family protein; PSI-BLAST converges on members of this family of uncharacterized bacterial proteins and shows no significant similarity to any characterized protein. No completed genome to date has two members. Members of the family have been crystallized but the function is unknown. [Unknown function, General]


Pssm-ID: 273235 [Multi-domain]  Cd Length: 221  Bit Score: 93.99  E-value: 2.86e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748  10 DGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEyGCSLEDIVVVLGPSVGPCCFTL 89
Cdd:TIGR00726  65 DGLITNTPNLVLAVYTADCVPVLFYDRVGKIVAAVHAGWRGLKNGIIAKTVKMFKKF-GSKPKDLIAVIGPAIGGCCYEV 143


                  ....*...
gi 1183596748  90 PRESAEAF 97
Cdd:TIGR00726 144 DKEVYEAF 151
PRK10723 PRK10723
polyphenol oxidase;
10-108 8.65e-13

polyphenol oxidase;


Pssm-ID: 182677  Cd Length: 243  Bit Score: 63.88  E-value: 8.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748  10 DGITTNQRGVTIAALGADCIPIVFADPVKKACGVAHAGWKGTLLGVAMATVNAMIAEygcsLEDIVVVLGPSVGPCCFTL 89
Cdd:PRK10723   89 DASYSNTPGTVCAVMTADCLPVLFCNRAGTEVAAAHAGWRGLCAGVLEETVACFAAK----PENILAWLGPAIGPQAFEV 164

                          90
                  ....*....|....*....
gi 1183596748  90 PRESAEAFHNLHPACVQLF 108
Cdd:PRK10723  165 GPEVREAFMAKDAKASAAF 183
CNF1_CheD_YfiH-like cd16832
cytotoxic necrotizing factor 1 (CNF1), chemotaxis protein CheD and YfiH (DUF152) are distant ...
 10-84 5.16e-06

cytotoxic necrotizing factor 1 (CNF1), chemotaxis protein CheD and YfiH (DUF152) are distant homologs; This family contains distant homologs that include cytotoxic necrotizing factor 1 (CNF1), chemotaxis protein CheD and a protein of unknown function YfiH. CNF-1 along with dermonecrotic toxin (DNT) from Bordetella species, and Burkholderia Lethal Factor 1 (BLF1, also known as BPSL1549) are Rho-activating toxins. The bacterial chemotaxis protein CheD stimulates methylation of methyl-accepting chemotaxis proteins (MCPs). YfiH, a domain of unknown function, also included in this family reveals a structure with a distant homology between to the CNF1, and CheD, all having an invariant Cys-His pair forming a catalytic dyad that is required by the CNF-1 toxins for deamidation activity.


Pssm-ID: 319353  Cd Length: 145  Bit Score: 43.92  E-value: 5.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1183596748  10 DGITTNQRGVTIAALG-ADCIPIVFADPVKKACGVAHAGWKGTLLGV--------AMATVNAMIAEYGCSLEDIVVVLGP 80
Cdd:cd16832    12 NGIVIKLKPVIITSGNlSGCTTVVARDPGAKYIAKAHTGTTKSLAGFtsttgvdkAVEVLVLLTKEPGASENFEDSLITY 91


                  ....
gi 1183596748  81 SVGP 84
Cdd:cd16832    92 SSSE 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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