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Conserved domains on  [gi|1186518022|ref|NP_001337878|]
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WD repeat-containing protein 25 isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-293 1.66e-29

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 1.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  15 ASRSEEDTCTVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDfRITTLKFH 92
Cdd:COG2319   136 ASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLrtLTGHTG-AVRSVAFS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  93 PkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSStdastrdSADRTIIAWDFRTSAKISNQI 172
Cdd:COG2319   214 P-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG-------SADGTVRLWDLATGELLRTLT 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 173 FHERFTCpSLALHPrepvflaqtNGNYLALFS---TVWPYRMSRRRR---YEGHKVEGYSVgcECSPGGDLLVTGSADGR 246
Cdd:COG2319   286 GHSGGVN-SVAFSP---------DGKLLASGSddgTVRLWDLATGKLlrtLTGHTGAVRSV--AFSPDGKTLASGSDDGT 353

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1186518022 247 VLMYSFRTASRACTLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIW 293
Cdd:COG2319   354 VRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-293 1.66e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 1.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  15 ASRSEEDTCTVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDfRITTLKFH 92
Cdd:COG2319   136 ASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLrtLTGHTG-AVRSVAFS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  93 PkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSStdastrdSADRTIIAWDFRTSAKISNQI 172
Cdd:COG2319   214 P-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG-------SADGTVRLWDLATGELLRTLT 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 173 FHERFTCpSLALHPrepvflaqtNGNYLALFS---TVWPYRMSRRRR---YEGHKVEGYSVgcECSPGGDLLVTGSADGR 246
Cdd:COG2319   286 GHSGGVN-SVAFSP---------DGKLLASGSddgTVRLWDLATGKLlrtLTGHTGAVRSV--AFSPDGKTLASGSDDGT 353

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1186518022 247 VLMYSFRTASRACTLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIW 293
Cdd:COG2319   354 VRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-293 1.17e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 1.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  15 ASRSEEDTCTVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDfRITTLKFH 92
Cdd:cd00200    25 ATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVrtLTGHTS-YVSSVAFS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  93 PKDHnIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSeFLSSTdastrdSADRTIIAWDFRTSAKISNQI 172
Cdd:cd00200   103 PDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS------SQDGTIKLWDLRTGKCVATLT 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 173 FHERFtCPSLALHPREPVFLAQTNGNylalFSTVWPYRMSR-RRRYEGHkvEGYSVGCECSPGGDLLVTGSADGRVLMYS 251
Cdd:cd00200   175 GHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1186518022 252 FRTASRACTLQGHTQACVGTTYHPvLPSVLATCSWGGDMKIW 293
Cdd:cd00200   248 LRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 31-70 5.98e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 5.98e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1186518022   31 SGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTD 70
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
15-293 1.66e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.39  E-value: 1.66e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  15 ASRSEEDTCTVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDfRITTLKFH 92
Cdd:COG2319   136 ASGSADGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLrtLTGHTG-AVRSVAFS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  93 PkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSStdastrdSADRTIIAWDFRTSAKISNQI 172
Cdd:COG2319   214 P-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG-------SADGTVRLWDLATGELLRTLT 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 173 FHERFTCpSLALHPrepvflaqtNGNYLALFS---TVWPYRMSRRRR---YEGHKVEGYSVgcECSPGGDLLVTGSADGR 246
Cdd:COG2319   286 GHSGGVN-SVAFSP---------DGKLLASGSddgTVRLWDLATGKLlrtLTGHTGAVRSV--AFSPDGKTLASGSDDGT 353

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1186518022 247 VLMYSFRTASRACTLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIW 293
Cdd:COG2319   354 VRLWDLATGELLRTLTGHTGAVTSVAFSPD-GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
9-294 1.19e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 1.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022   9 PLESFSASRSEEDTCTVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDfRI 86
Cdd:COG2319    88 PDGRLLASASADGTVRLWD-LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLrtLTGHSG-AV 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  87 TTLKFHPkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSStdastrdSADRTIIAWDFRTSA 166
Cdd:COG2319   166 TSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG-------SADGTVRLWDLATGK 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 167 KISNQIFHERFTCpSLALHPrepvflaqtNGNYLALFS---TVWPYRMS---RRRRYEGHKVEGYSVgcECSPGGDLLVT 240
Cdd:COG2319   238 LLRTLTGHSGSVR-SVAFSP---------DGRLLASGSadgTVRLWDLAtgeLLRTLTGHSGGVNSV--AFSPDGKLLAS 305

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1186518022 241 GSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIWH 294
Cdd:COG2319   306 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWD 358
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-293 1.17e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.49  E-value: 1.17e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  15 ASRSEEDTCTVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDfRITTLKFH 92
Cdd:cd00200    25 ATGSGDGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVrtLTGHTS-YVSSVAFS 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  93 PKDHnIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSeFLSSTdastrdSADRTIIAWDFRTSAKISNQI 172
Cdd:cd00200   103 PDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASS------SQDGTIKLWDLRTGKCVATLT 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 173 FHERFtCPSLALHPREPVFLAQTNGNylalFSTVWPYRMSR-RRRYEGHkvEGYSVGCECSPGGDLLVTGSADGRVLMYS 251
Cdd:cd00200   175 GHTGE-VNSVAFSPDGEKLLSSSSDG----TIKLWDLSTGKcLGTLRGH--ENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1186518022 252 FRTASRACTLQGHTQACVGTTYHPvLPSVLATCSWGGDMKIW 293
Cdd:cd00200   248 LRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 34-293 5.18e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 5.18e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  34 CLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFrITTLKFHPkDHNIFLCGGFSSEMKAW 111
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLrtLKGHTGP-VRDVAASA-DGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 112 DIRTGKVMRSYKATIQQTLDILFLREGSEFLSStdastrdSADRTIIAWDFRTSAKISNQIFHERFTCpSLALHPrepvf 191
Cdd:cd00200    79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSS-------SRDKTIKVWDVETGKCLTTLRGHTDWVN-SVAFSP----- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 192 laqtNGNYLALFST-----VWPYR-MSRRRRYEGHKVEGYSVgcECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHT 265
Cdd:cd00200   146 ----DGTFVASSSQdgtikLWDLRtGKCVATLTGHTGEVNSV--AFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                         250       260
                  ....*....|....*....|....*...
gi 1186518022 266 QACVGTTYHPVlPSVLATCSWGGDMKIW 293
Cdd:cd00200   220 NGVNSVAFSPD-GYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
15-164 1.10e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  15 ASRSEEDTCTVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDfRITTLKFH 92
Cdd:COG2319   262 ASGSADGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLrtLTGHTG-AVRSVAFS 339

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1186518022  93 PkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSStdastrdSADRTIIAWDFRT 164
Cdd:COG2319   340 P-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASG-------SADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
26-293 7.20e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 7.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022  26 WNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQLFSGRSDFRITTLKFHPKDHNIFLCGGFS 105
Cdd:COG2319    20 LLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 106 SEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSStdastrdSADRTIIAWDFRTSAKISNQIFHERfTCPSLALH 185
Cdd:COG2319   100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASG-------SADGTVRLWDLATGKLLRTLTGHSG-AVTSVAFS 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 186 PrepvflaqtNGNYLALFST-----VW-PYRMSRRRRYEGHKVEGYSVgcECSPGGDLLVTGSADGRVLMYSFRTASRAC 259
Cdd:COG2319   172 P---------DGKLLASGSDdgtvrLWdLATGKLLRTLTGHTGAVRSV--AFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1186518022 260 TLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIW 293
Cdd:COG2319   241 TLTGHSGSVRSVAFSPD-GRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-161 3.31e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 3.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022   9 PLESFSASRSEEDTCTVWNaVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLETGTQL--FSGRSDFrI 86
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgtLRGHENG-V 222

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1186518022  87 TTLKFHPkDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQTLDILFLREGSEFLSStdastrdSADRTIIAWD 161
Cdd:cd00200   223 NSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG-------SADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 215-294 2.16e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 2.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 215 RRYEGHKVEGysVGCECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPvLPSVLATCSWGGDMKIWH 294
Cdd:cd00200    45 RTLKGHTGPV--RDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWD 121
WD40 COG2319
WD40 repeat [General function prediction only];
141-294 4.73e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1186518022 141 FLSSTDASTRDSADRTIIAWDFRTSAKISNQIFHERFTCPSLALHPREPVFLAQTNGNYLALfstvWPYRMSRRRRYEGH 220
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL----DAAAGALLATLLGH 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1186518022 221 KVEGYSVgcECSPGGDLLVTGSADGRVLMYSFRTASRACTLQGHTQACVGTTYHPVlPSVLATCSWGGDMKIWH 294
Cdd:COG2319    78 TAAVLSV--AFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWD 148
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 31-70 5.98e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 5.98e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1186518022   31 SGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTD 70
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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