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Conserved domains on  [gi|1187953376|ref|NP_001337957|]
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actin-related protein 3C isoform c [Homo sapiens]

Protein Classification

actin-related protein 3( domain architecture ID 1003867)

actin-related protein 3 (ACTR3) is an ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ASKHA_ATPase-like super family cl49607
ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA ...
 9-107 8.97e-63

ATPase-like domain of the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily; The ASKHA superfamily, also known as actin-like ATPase domain superfamily, includes acetate and sugar kinases, heat-shock cognate 70 (Hsp70) and actin family proteins. They either function as conformational hydrolases (e.g. Hsp70, actin) that perform simple ATP hydrolysis, or as metabolite kinases (e.g. glycerol kinase) that catalyze the transfer of a phosphoryl group from ATP to their cognate substrates. Both activities depend on the presence of specific metal cations. ASKHA superfamily members share a common core fold that includes an actin-like ATPase domain consisting of two subdomains (denoted I _ II) with highly similar ribonuclease (RNase) H-like folds. The fold of each subdomain is characterized by a central five strand beta-sheet and flanking alpha-helices. The two subdomains form an active site cleft in which ATP binds at the bottom. Another common feature of ASKHA superfamily members is the coupling of phosphoryl-group transfer to conformational rearrangement, leading to domain closure. Substrate binding triggers protein motion.


The actual alignment was detected with superfamily member cd10221:

Pssm-ID: 483947  Cd Length: 404  Bit Score: 196.25  E-value: 8.97e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPSCIAIRESAKVVDqAQRRVLRGVDDLDFFIGDEAIDK-PTYATKWPIRHGIIEDWDLMERFME 87
Cdd:cd10221    10 YTKMGYAGNTEPQFIIPTVIAIKESAKVGD-GQRRSKKGIEDLDFYIGDEALANsPTYALKYPIRHGIVEDWDLMERFWE 88

                          90       100
                  ....*....|....*....|
gi 1187953376  88 QVVFKYLRAEPEDHYFLMVE 107
Cdd:cd10221    89 QCIFKYLRCEPEDHYFLLTE 108
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
 9-107 8.97e-63

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 196.25  E-value: 8.97e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPSCIAIRESAKVVDqAQRRVLRGVDDLDFFIGDEAIDK-PTYATKWPIRHGIIEDWDLMERFME 87
Cdd:cd10221    10 YTKMGYAGNTEPQFIIPTVIAIKESAKVGD-GQRRSKKGIEDLDFYIGDEALANsPTYALKYPIRHGIVEDWDLMERFWE 88

                          90       100
                  ....*....|....*....|
gi 1187953376  88 QVVFKYLRAEPEDHYFLMVE 107
Cdd:cd10221    89 QCIFKYLRCEPEDHYFLLTE 108
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
 9-107 2.91e-47

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 156.43  E-value: 2.91e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPSCIAIRESAKVvdqaqRRVLRGVDDLDFFIGDEAIDKP-TYATKWPIRHGIIEDWDLMERFME 87
Cdd:PTZ00280   15 YTKMGYAGNTEPTYIIPTLIADNSKQSR-----RRSKKGFEDLDFYIGDEALAASkSYTLTYPMKHGIVEDWDLMEKFWE 89

                          90       100
                  ....*....|....*....|
gi 1187953376  88 QVVFKYLRAEPEDHYFLMVE 107
Cdd:PTZ00280   90 QCIFKYLRCEPEEHYFILTE 109
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 9-107 3.93e-26

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 99.64  E-value: 3.93e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376    9 YTKLGYAGNTEPQFIIPSCIAiresakvvdQAQRRVLRGVDDLDFFIGDEAIDKPTYAT-KWPIRHGIIEDWDLMERFME 87
Cdd:smart00268  12 TIKAGFAGEDFPQVVFPSIVG---------RPKDGKGMVGDAKDIFVGDEAQEKRGGLElKYPIENGIVENWDDMEKIWD 82

                           90       100
                   ....*....|....*....|
gi 1187953376   88 QVVFKYLRAEPEDHYFLMVE 107
Cdd:smart00268  83 YTFFNELRVEPEEHPVLLTE 102
Actin pfam00022
Actin;
8-107 9.92e-18

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 76.96  E-value: 9.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   8 RYTKLGYAGNTEPQFIIPSCIAIRESAKVVDqaqrrvlrgvdDLDFFIGDEAIDK-PTYATKWPIRHGIIEDWDLMERFM 86
Cdd:pfam00022  11 HTTRAGFAGEDAPKAVIPSCVGKPRGTKVEA-----------ANKYYVGDEALTYrPGMEVRSPVEDGIVVDWDAMEEIW 79

                          90       100
                  ....*....|....*....|.
gi 1187953376  87 EQVVFKYLRAEPEDHYFLMVE 107
Cdd:pfam00022  80 EHVLKEELQVDPEEHPLLLTE 100
 
Name Accession Description Interval E-value
ASKHA_NBD_Arp3-like cd10221
nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, ...
 9-107 8.97e-63

nucleotide-binding domain (NBD) of actin-related protein3 (Arp3) and similar proteins; Arp3, also called actin-like protein 3, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp3 and Arp3B are encoded by the ACTR3 and ACTR3B genes respectively. Arp3B is also known as actin-related protein Arp4.


Pssm-ID: 466822  Cd Length: 404  Bit Score: 196.25  E-value: 8.97e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPSCIAIRESAKVVDqAQRRVLRGVDDLDFFIGDEAIDK-PTYATKWPIRHGIIEDWDLMERFME 87
Cdd:cd10221    10 YTKMGYAGNTEPQFIIPTVIAIKESAKVGD-GQRRSKKGIEDLDFYIGDEALANsPTYALKYPIRHGIVEDWDLMERFWE 88

                          90       100
                  ....*....|....*....|
gi 1187953376  88 QVVFKYLRAEPEDHYFLMVE 107
Cdd:cd10221    89 QCIFKYLRCEPEDHYFLLTE 108
PTZ00280 PTZ00280
Actin-related protein 3; Provisional
 9-107 2.91e-47

Actin-related protein 3; Provisional


Pssm-ID: 240343 [Multi-domain]  Cd Length: 414  Bit Score: 156.43  E-value: 2.91e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPSCIAIRESAKVvdqaqRRVLRGVDDLDFFIGDEAIDKP-TYATKWPIRHGIIEDWDLMERFME 87
Cdd:PTZ00280   15 YTKMGYAGNTEPTYIIPTLIADNSKQSR-----RRSKKGFEDLDFYIGDEALAASkSYTLTYPMKHGIVEDWDLMEKFWE 89

                          90       100
                  ....*....|....*....|
gi 1187953376  88 QVVFKYLRAEPEDHYFLMVE 107
Cdd:PTZ00280   90 QCIFKYLRCEPEEHYFILTE 109
ACTIN smart00268
Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily
 9-107 3.93e-26

Actin; ACTIN subfamily of ACTIN/mreB/sugarkinase/Hsp70 superfamily


Pssm-ID: 214592 [Multi-domain]  Cd Length: 373  Bit Score: 99.64  E-value: 3.93e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376    9 YTKLGYAGNTEPQFIIPSCIAiresakvvdQAQRRVLRGVDDLDFFIGDEAIDKPTYAT-KWPIRHGIIEDWDLMERFME 87
Cdd:smart00268  12 TIKAGFAGEDFPQVVFPSIVG---------RPKDGKGMVGDAKDIFVGDEAQEKRGGLElKYPIENGIVENWDDMEKIWD 82

                           90       100
                   ....*....|....*....|
gi 1187953376   88 QVVFKYLRAEPEDHYFLMVE 107
Cdd:smart00268  83 YTFFNELRVEPEEHPVLLTE 102
Actin pfam00022
Actin;
8-107 9.92e-18

Actin;


Pssm-ID: 394979 [Multi-domain]  Cd Length: 407  Bit Score: 76.96  E-value: 9.92e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   8 RYTKLGYAGNTEPQFIIPSCIAIRESAKVVDqaqrrvlrgvdDLDFFIGDEAIDK-PTYATKWPIRHGIIEDWDLMERFM 86
Cdd:pfam00022  11 HTTRAGFAGEDAPKAVIPSCVGKPRGTKVEA-----------ANKYYVGDEALTYrPGMEVRSPVEDGIVVDWDAMEEIW 79

                          90       100
                  ....*....|....*....|.
gi 1187953376  87 EQVVFKYLRAEPEDHYFLMVE 107
Cdd:pfam00022  80 EHVLKEELQVDPEEHPLLLTE 100
ASKHA_NBD_Arp4_ACTL6-like cd13395
nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The ...
 10-115 3.58e-15

nucleotide-binding domain (NBD) of the actin-related protein 4 (Arp4)-like subfamily; The Arp4-like subfamily includes Arp4, also called actin-like protein 4, from fungi and plants. Saccharomyces cerevisiae Arp4 acts synergistically with Arp8 to depolymerize F-actin; it binds ATP, but unlike conventional actin, does not form filaments. It is a component of the NuA4 histone acetyltransferase complex, the chromatin-remodeling INO80 complex and the SWR1 chromatin remodeling complex. Arabidopsis thaliana Arp4 is involved in several developmental processes including organization of plant organs, flowering time, anther development, flower senescence and fertility, probably by regulating the chromatin structure. This family also includes human homologs of yeast and plant, which are actin-like protein 6A (encoded by the ACTL6A gene; also known as ArpNbeta, 53 kDa BRG1-associated factor A/BRG1-associated factor 53A/BAF35A, and INO80 complex subunit K/INO80K) and actin-like protein 6B (encoded by the ACTL6B gene; also known as ArpNalpha, 53 kDa BRG1-associated factor B/BRG1-associated factor 53B/BAF35B). ACTL6A and ACTL6B are involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). They are components of numerous complexes with chromatin remodeling and histone acetyltransferase activity. ACTL6A is also a putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Schizosaccharomyces pombe actin-related protein 42 (Arp42) is also included in this family. It is also a component of SWI/SNF and RSC complexes.


Pssm-ID: 466846 [Multi-domain]  Cd Length: 413  Bit Score: 69.90  E-value: 3.58e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376  10 TKLGYAGNTEPQFIIPSCIAIRESAKVVDQAQRRVLRGVddLDFFIGDEAIDKPT--YATKWPIRHGIIEDWDLMERFME 87
Cdd:cd13395    16 TRAGYAGEDTPKAVFPSVVGVVTDDDDAEDYVGGSGEKK--RKYYIGTNSIGVPRpnMEVISPLKDGLIEDWDAFEKLWD 93

                          90       100
                  ....*....|....*....|....*...
gi 1187953376  88 QVVFKYLRAEPEDHYFLMVEfhscrPGW 115
Cdd:cd13395    94 HALKNRLRVDPSEHPLLLTE-----PSW 116
ASKHA_NBD_actin_Arp-T1-3 cd13397
nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar ...
 11-107 7.05e-15

nucleotide-binding domain (NBD) of actin, actin-related proteins T1-T3 (Arp-T1-3), and similar proteins; The family includes actin and human actin-related proteins T1, T2, and T3. Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Arp-T1, encoded by ACTRT1/ARPT1 gene expressed in testis, negatively regulates the Hedgehog (SHH) signaling, binds to the promoter of the SHH signaling mediator, GLI1, and inhibits its expression. Arp-T2 (also called actin-related protein M2; encoded by ACTRT2/ARPM2 gene expressed in testis and various other cell types) and Arp-T3 (also called actin-related protein M1; encoded by ACTRT3/ARPM1 gene expressed in all tested human tissues) play general roles in the organization of the cytoskeleton like other cytoplasmic actin-related proteins.


Pssm-ID: 466848 [Multi-domain]  Cd Length: 359  Bit Score: 68.75  E-value: 7.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376  11 KLGYAGNTEPQFIIPSCIAiRESAKvvdqaqrRVLRGVDDLDFFIGDEAIDKPTYAT-KWPIRHGIIEDWDLMERFMEQV 89
Cdd:cd13397    13 KAGFAGEDLPRAVFPSVVG-RPKYK-------AVMLGAGQKEVYVGDEAQEKRGVLTlSYPIEHGIVTNWDDMEKIWHHT 84

                          90
                  ....*....|....*...
gi 1187953376  90 VFKYLRAEPEDHYFLMVE 107
Cdd:cd13397    85 FENELRVKPEEHPVLLTE 102
ASKHA_NBD_actin cd10224
nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein ...
 11-107 1.47e-13

nucleotide-binding domain (NBD) of actin and similar proteins; Actin is a ubiquitous protein involved in the formation of filaments that are major components of the cytoskeleton. It is a highly dynamic structural protein network involved in processes such as cell contraction, cell motility, vesicle trafficking, intracellular organization, cytokinesis, endocytosis and apoptosis. Actin is a monomeric globular protein (G-actin) that reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. At low salt concentrations, actin exists as a monomer, and as the salt concentration rises F-actin forms, with the consequent hydrolysis of ATP. F-actin assembly is in constant flux with G-actin association occurring at the barbed end (+) and its disassociation at the pointed end (-). Actin monomers that have been released from the pointed end can be reused, if the ADP is exchanged for ATP. F-actin filaments can assemble into higher order structures, for example branched F-actin, and stress fibers. Actin binding proteins regulate actin filament dynamics by a range of functions including actin severing, depolymerizing, capping, stabilizing and de novo actin polymerization. Actins interaction with myosin is the basis of muscular contraction and many aspects of cell motility. In vertebrates there are three main groups of actin isoforms, alpha, beta and gamma. The alpha actins found in muscle tissues are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. In plants there are many isoforms which are probably involved in a variety of functions such as cytoplasmic streaming, cell shape determination, tip growth, graviperception, cell wall deposition, etc.


Pssm-ID: 466823  Cd Length: 365  Bit Score: 65.08  E-value: 1.47e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376  11 KLGYAGNTEPQFIIPSCIAIREsakvvdqaQRRVLRGVDDLDFFIGDEAIDKPTYAT-KWPIRHGIIEDWDLMERFMEQV 89
Cdd:cd10224    13 KAGFAGDDAPRAVFPSIVGRPR--------HQGVMVGMGQKDSYVGDEAQSKRGILTlKYPIEHGIVTNWDDMEKIWHHT 84

                          90
                  ....*....|....*...
gi 1187953376  90 VFKYLRAEPEDHYFLMVE 107
Cdd:cd10224    85 FYNELRVAPEEHPVLLTE 102
PTZ00004 PTZ00004
actin-2; Provisional
 10-107 1.73e-13

actin-2; Provisional


Pssm-ID: 240225 [Multi-domain]  Cd Length: 378  Bit Score: 65.18  E-value: 1.73e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376  10 TKLGYAGNTEPQFIIPSCiairesakVVDQAQRRVLRGVDDLDFFIGDEAIDK-PTYATKWPIRHGIIEDWDLMERFMEQ 88
Cdd:PTZ00004   18 VKAGFAGDDAPRCVFPSI--------VGRPKNPGIMVGMEEKDCYVGDEAQDKrGILTLKYPIEHGIVTNWDDMEKIWHH 89

                          90
                  ....*....|....*....
gi 1187953376  89 VVFKYLRAEPEDHYFLMVE 107
Cdd:PTZ00004   90 TFYNELRVAPEEHPVLLTE 108
PTZ00281 PTZ00281
actin; Provisional
 11-107 2.05e-12

actin; Provisional


Pssm-ID: 173506 [Multi-domain]  Cd Length: 376  Bit Score: 62.02  E-value: 2.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376  11 KLGYAGNTEPQFIIPSCIA-IRESAKVVDQAQRrvlrgvddlDFFIGDEAIDKPTYAT-KWPIRHGIIEDWDLMERFMEQ 88
Cdd:PTZ00281   19 KAGFAGDDAPRAVFPSIVGrPRHTGVMVGMGQK---------DSYVGDEAQSKRGILTlKYPIEHGIVTNWDDMEKIWHH 89

                          90
                  ....*....|....*....
gi 1187953376  89 VVFKYLRAEPEDHYFLMVE 107
Cdd:PTZ00281   90 TFYNELRVAPEEHPVLLTE 108
ASKHA_NBD_Arp1 cd10216
nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, ...
 10-107 2.83e-11

nucleotide-binding domain (NBD) of actin-related protein 1 (Arp1) and similar proteins; Arp1, also called centractin, actin-like protein, alpha-centractin, actin-RPV, or centrosome-associated actin homolog, may be a component of a multi-subunit centrosomal complex involved in microtubule-based vesicle motility. In yeast, actin-related protein is essential for viability and is associated with the centrosome. In vertebrates, Arp1 is a core component of the dynactin complex which assists cytoplasmic dynein by increasing its processivity and by regulation of its cargo binding. The dynactin complex is required for the spindle translocation late in anaphase and is involved in a cell wall synthesis checkpoint. ARP1 forms the backbone filament of the dynactin rod structure and serves as the scaffold for the remaining subunits. It is required for proper orientation of the mitotic spindle. Arp1 is the only actin-related protein known to form actin-like filaments. Human Arp1/centractin is encoded by the ACTR1A gene.


Pssm-ID: 466820 [Multi-domain]  Cd Length: 370  Bit Score: 58.71  E-value: 2.83e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376  10 TKLGYAGNTEPQFIIPSCIAireSAKVVdqaqrRVLRGVDDLDFFIGDEAID-KPTYATKWPIRHGIIEDWDLMERfmeq 88
Cdd:cd10216    13 IKAGFAGDDIPKVVFPSYVG---RPKHV-----RVMAGALEGDVFVGPKAEEhRGLLKIRYPMEHGIVTDWNDMER---- 80

                          90       100
                  ....*....|....*....|....*
gi 1187953376  89 vVFKY------LRAEPEDHYFLMVE 107
Cdd:cd10216    81 -IWQYvysklqLNTFSEEHPVLLTE 104
ASKHA_NBD_ACTL7 cd10214
nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ...
 9-104 1.78e-09

nucleotide-binding domain (NBD) of the actin-like protein 7 (ACTL7)-like family; The ACTL7-like family includes ACTL7A, ACTL7B and ACTL9 (also known as ACTL7C). In mammalian, ACTL7A is expressed in a wide variety of adult tissues, while the ACTL7B is expressed in spermatids through the elongation phase of spermatid development. ACTL7A, also called actin-like-7-alpha, or T-ACTIN-2 in mouse, may play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis. ACTL7B, also called actin-like-7-beta, acts as a key regulator of spermiogenesis that is required for male fertility. ACTL9 is a testis-specific protein that plays an important role in fusion of proacrosomal vesicles and perinuclear theca formation.


Pssm-ID: 466819 [Multi-domain]  Cd Length: 368  Bit Score: 53.58  E-value: 1.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPSCIAIR--ESAKVVDQAQRRvlrgvddldfFIGDEAID-KPTYATKWPIRHGIIEDWDLMERF 85
Cdd:cd10214    14 YCKAGFAGQPRPSYVISSTVGKPpqESAKTGDNRKET----------FVGKELANvEPPLKLVNPLRHGIVVDWDCVQDI 83

                          90
                  ....*....|....*....
gi 1187953376  86 MEQVVFKYLRAEPEDHYFL 104
Cdd:cd10214    84 WEYIFEKEMKILPEEHAVL 102
PTZ00466 PTZ00466
actin-like protein; Provisional
 9-107 6.07e-09

actin-like protein; Provisional


Pssm-ID: 240426 [Multi-domain]  Cd Length: 380  Bit Score: 52.25  E-value: 6.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPSCIAiRESAKvvdqaqrRVLRGVDDLDFFIGDEA-----IDKPTYatkwPIRHGIIEDWDLME 83
Cdd:PTZ00466   23 YIKAGFAGEDVPNLVFPSYVG-RPKYK-------RVMAGAVEGNIFVGNKAeeyrgLLKVTY----PINHGIIENWNDME 90

                          90       100
                  ....*....|....*....|....
gi 1187953376  84 RFMEQvVFKYLRAEPEDHYFLMVE 107
Cdd:PTZ00466   91 NIWIH-VYNSMKINSEEHPVLLTE 113
ASKHA_NBD_Arp2 cd10220
nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, ...
 9-107 6.42e-09

nucleotide-binding domain (NBD) of actin-related protein2 (Arp2) and similar proteins; Arp2, also called actin-like protein 2, is the ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex is comprised of 7 proteins (Arp2, Arp3, and five conserved proteins, ARPC1-5). It generates cytoplasmic branched filaments networks, by promoting nucleation of actin filaments as 70 degrees branches on the side of older filaments. It is activated, by simultaneously binding to a pre-existing filament and a nucleation promoting factor plus an actin monomer. Daughter branches subsequently detach/debranch from the mother filament. Its Arp2 and Arp3 subunits must be loaded with ATP for it to initiate the assembly of branched actin filaments. ATP hydrolysis may be required for branch initiation or debranching. The Arp2/3 complex is also found in the nucleus where it plays a role in promoting de novo actin polymerization and in RNA polymerase II-dependent transcription. This may in part be through regulating nuclear actin polymerization in a way like its function in the cytoplasm. Human Arp2 is encoded by the ACTR2 gene.


Pssm-ID: 466821  Cd Length: 381  Bit Score: 52.18  E-value: 6.42e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPSCIA---IRESAKVVDQAqrrvlrgVDDLdfFIGDEAIDKPTY-ATKWPIRHGIIEDWDLMER 84
Cdd:cd10220    11 FVKCGFAGSNFPEHVFPSLVGrpiLRAEEKVGDIE-------IKDI--MVGDEASELRSMlEVTYPMENGIVRNWDDMEH 81

                          90       100
                  ....*....|....*....|...
gi 1187953376  85 FMEQVVFKYLRAEPEDHYFLMVE 107
Cdd:cd10220    82 LWDYTFGEKLKIDPRECKILLTE 104
PTZ00452 PTZ00452
actin; Provisional
 9-107 5.44e-07

actin; Provisional


Pssm-ID: 185631  Cd Length: 375  Bit Score: 46.67  E-value: 5.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPSCIAiresakvvDQAQRRVLRGVDDLDFFIGDEA-IDKPTYATKWPIRHGIIEDWDLMERFME 87
Cdd:PTZ00452   16 YCKIGIAGDDAPTSCFPAIVG--------RSKQNDGIFSTFNKEYYVGEEAqAKRGVLAIKEPIQNGIINSWDDIEIIWH 87

                          90       100
                  ....*....|....*....|
gi 1187953376  88 QVVFKYLRAEPEDHYFLMVE 107
Cdd:PTZ00452   88 HAFYNELCMSPEDQPVFMTD 107
ASKHA_NBD_actin-like cd10169
nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ...
 9-107 2.03e-05

nucleotide-binding domain (NBD) of actin and actin-related proteins (ARPs); Actin is ubiquitous in eukaryotes, and the major component of the actin cytoskeleton; monomeric globular protein (G-actin) reversibly polymerizes to form filaments (F-actin). Each actin protomer binds one molecule of ATP and either calcium or magnesium ions. F-actin filaments form with the consequent hydrolysis of ATP. Some actin-related proteins (Arps) have roles in cytoskeletal functions, such as actin polymerization (Arp2/3) and dynein motor activity (Arp1). Both conventional actin and specific Arps have been implicated in chromatin remodeling and/or transcription regulation. The actin/ARP family belongs to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466810 [Multi-domain]  Cd Length: 258  Bit Score: 41.71  E-value: 2.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   9 YTKLGYAGNTEPQFIIPsciairesakvvdqaqrrvlrgvddldffigdeaidkptyatkwpirhgiiedWDLMERFMEQ 88
Cdd:cd10169     9 TIKAGFAGEDAPRLIFP-----------------------------------------------------WDDMEKIWEH 35

                          90
                  ....*....|....*....
gi 1187953376  89 VVFKYLRAEPEDHYFLMVE 107
Cdd:cd10169    36 VFYNLLRVDPEEHPVLLTE 54
ASKHA_NBD_Arp10 cd10207
nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; ...
 8-107 1.36e-04

nucleotide-binding domain (NBD) of actin-related protein 10 (Arp10) and similar proteins; Arp10, also known as actin-related protein 11 (Arp11), is a subunit of the cargo-binding portion of the dynein activator, dynactin. It, together with dynactin4 (p62), -5(p25), and -6(p27), forms a heterotetrameric complex located at the pointed end of Arp1. Arp1 forms a mini-filament of uniform size, with proteins bound along its length and at both ends. Human Arp10 is encoded by the ACTR10 gene.


Pssm-ID: 466813 [Multi-domain]  Cd Length: 375  Bit Score: 39.54  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   8 RYTKLGYAGNTEPQFIIPSciairesaKVVDQAQRRVLRGvddldffigdeaidkptyatkWPIRHGIIEDW-DLMERFM 86
Cdd:cd10207     8 AYTKCGFAGESAPRCIIPS--------EVKLPGGKKVIRV---------------------VDQRSGNEEELyEALKEFL 58

                          90       100
                  ....*....|....*....|.
gi 1187953376  87 EQVVFKYLRAEPEDHYFLMVE 107
Cdd:cd10207    59 HELYFKHLLVNPKDRRVVVVE 79
ASKHA_NBD_AtARP7-like cd10209
nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar ...
 8-100 1.03e-03

nucleotide-binding domain (NBD) of Arabidopsis thaliana actin-related protein 7 and similar proteins; Arabidopsis thaliana ARP7 is an essential nuclear protein, ubiquitously expressed in all cell types. It is needed for normal embryogenesis, plant architecture, and floral organ abscission. It may play a role in regulating various phases of plant development through chromatin-mediated gene regulation.


Pssm-ID: 466815 [Multi-domain]  Cd Length: 354  Bit Score: 36.98  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1187953376   8 RYTKLGYAGNT-EPQFIIPSciairesakvvdqAQRRVLRGVDDLDFFIGDEAIDkptyatkwPIRHGIIEDWDLMERFM 86
Cdd:cd10209     8 RLLKAGYAYPDrEPSVVEPT-------------RVTPAVEDGEESDTVVEGNTVS--------PIRRGRIEDWDALEALL 66

                          90
                  ....*....|....
gi 1187953376  87 EQVVFKYLRAEPED 100
Cdd:cd10209    67 RYVFYTGLGWEEGN 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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