|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
1-369 |
2.59e-176 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 507.01 E-value: 2.59e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 1 MISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSP--VVE 78
Cdd:cd01703 14 EIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVYRLLRSYSWndRVE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 79 RLGFDENFVDLTEMvekrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGSQIAAEMREAMYNQLGLTGCAGVAS 158
Cdd:cd01703 94 RLGFDENFMDVTEM------------------------------------RLLVASHIAYEMRERIENELGLTCCAGIAS 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 159 NKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSP------------- 223
Cdd:cd01703 138 NKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsll 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 224 --KILEKELGISVAQRIQKLSFGEDNSPVI-LSGPPQSFSEEDSFKKCSSEV--EAKNKIEELLASLLNRVCQ------- 291
Cdd:cd01703 218 elLLMVKEFGEGIGQRIWKLLFGRDTSPVKpASDFPQQISIEDSYKKCSLEEirEARNKIEELLASLLERMKQdlqevka 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 292 -DGRKPHTVRLIIRRYSSEKH-YGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVK--MPFHLTLLSVCF 367
Cdd:cd01703 298 gDGRRPHTLRLTLRRYTSTKKhYNRESKQAPIPSHVFQKLTGGNEIAARPIEKILMRLFRELVPPKnvKGFNLTLLNVCF 377
|
..
gi 1192732406 368 CN 369
Cdd:cd01703 378 TN 379
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-305 |
1.61e-65 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 219.25 E-value: 1.61e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 1 MISNPELKDKPLGV---QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSYKVTELLEEFSPVV 77
Cdd:COG0389 17 QRDRPELRGKPVAVggdNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRDVSRRVMAILERYTPLV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 78 ERLGFDENFVDLTEMvekrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGS--QIAAEMREAMYNQLGLTGCAG 155
Cdd:COG0389 96 EPLSIDEAFLDVTGS------------------------------------ARLFGSaeAIARRIRRRIRRETGLTVSVG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 156 VASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVA 235
Cdd:COG0389 140 IAPNKFLAKIASDLAKPDGLTVIPPGEVAAFLAPL-PVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFG-KVG 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1192732406 236 QRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKcssEVEAKNKIEELLASLLNRVC----QDGRKPHTVRLIIRR 305
Cdd:COG0389 218 ERLYRLARGIDPRPVEPRRPRKSIGVERTFGE---DLTDLEELEAALRRLAERLAerlrRQGLGARTVTVKLRT 288
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
4-299 |
1.12e-47 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 171.07 E-value: 1.12e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 4 NPELKDKPLGV----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSYKVTELLEEFSPVVER 79
Cdd:PRK02406 13 NPELRGKPVAVggspGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPG-RFDVYKEVSRQIREIFRRYTDLIEP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 80 LGFDENFVDLTEmvEKRLQQlqsdelSAVTvsghvynnqsinlldvlhirllvgsqIAAEMREAMYNQLGLTGCAGVASN 159
Cdd:PRK02406 92 LSLDEAYLDVTD--NKLCIG------SATL--------------------------IAQEIRQDIFEELGLTASAGVAPN 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 160 KLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQ 239
Cdd:PRK02406 138 KFLAKIASDWNKPNGLFVITPEEVDAFLATLP-VEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFG-KFGRRLY 215
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1192732406 240 KLSFGEDNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIEEL---LASLLNRVcQDGRKPHTV 299
Cdd:PRK02406 216 ERARGIDERPVKPDRERKSVGVERTFAEdLYDLEACLAELPRLaekLERRLERA-KPDKRIKTV 278
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
1-167 |
1.68e-37 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 136.55 E-value: 1.68e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 1 MISNPELKDKPLGVQQKY---LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVnGEDLTRYREMSYKVTELLEEFSPV- 76
Cdd:pfam00817 12 LLRDPELKGKPVAVGGGNgrgIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVV-PPDLELYRRASRKIFEILRRFSTPk 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 77 VERLGFDENFVDLTEMVEkrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGSQIAAEMREAMYNQLGLTGCAGV 156
Cdd:pfam00817 91 VEQASIDEAFLDLTGLEK----------------------------------LFGAEEALAKRLRREIAEETGLTCSIGI 136
|
170
....*....|.
gi 1192732406 157 ASNKLLAKLVS 167
Cdd:pfam00817 137 APNKLLAKLAS 147
|
|
| TIGR03491 |
TIGR03491 |
RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family ... |
192-257 |
1.98e-04 |
|
RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family are found broadly but sporadically among bacteria. The N-terminal region is homologous to the Cas4 protein of CRISPR systems, although this protein family shows no signs of association with CRISPR repeats.
Pssm-ID: 274603 [Multi-domain] Cd Length: 457 Bit Score: 44.24 E-value: 1.98e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 192 HIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK--ELGISVAQRIQK--LSFGEdNSPVILSGPPQ 257
Cdd:TIGR03491 208 HLSLVPGIGPSRYRLLQELGIHTLEDLAAADPNDLEDfgEQGLGVAEQLVQqaRAQLE-GRPILLAPPKA 276
|
|
| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
637-662 |
4.22e-03 |
|
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 35.28 E-value: 4.22e-03
10 20
....*....|....*....|....*.
gi 1192732406 637 PSDIDPQVFYELPEAVQKELLAEWKR 662
Cdd:cd19318 9 FSQVDPSVLAALPPDLQEELEAAYAQ 34
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
1-369 |
2.59e-176 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 507.01 E-value: 2.59e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 1 MISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSP--VVE 78
Cdd:cd01703 14 EIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVYRLLRSYSWndRVE 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 79 RLGFDENFVDLTEMvekrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGSQIAAEMREAMYNQLGLTGCAGVAS 158
Cdd:cd01703 94 RLGFDENFMDVTEM------------------------------------RLLVASHIAYEMRERIENELGLTCCAGIAS 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 159 NKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSP------------- 223
Cdd:cd01703 138 NKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSNrnrqtvgaapsll 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 224 --KILEKELGISVAQRIQKLSFGEDNSPVI-LSGPPQSFSEEDSFKKCSSEV--EAKNKIEELLASLLNRVCQ------- 291
Cdd:cd01703 218 elLLMVKEFGEGIGQRIWKLLFGRDTSPVKpASDFPQQISIEDSYKKCSLEEirEARNKIEELLASLLERMKQdlqevka 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 292 -DGRKPHTVRLIIRRYSSEKH-YGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVK--MPFHLTLLSVCF 367
Cdd:cd01703 298 gDGRRPHTLRLTLRRYTSTKKhYNRESKQAPIPSHVFQKLTGGNEIAARPIEKILMRLFRELVPPKnvKGFNLTLLNVCF 377
|
..
gi 1192732406 368 CN 369
Cdd:cd01703 378 TN 379
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
1-368 |
2.89e-114 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 346.66 E-value: 2.89e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 1 MISNPELKDKPLGVQQKY----LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMSYKVTELLEEFSPV 76
Cdd:cd00424 14 QLARPELKGRPVVVVPFNsdstCVIACSYEARKYGVKRGMPVREARKMCPNLILVP-ARLDLYRRLSERLLSELEEVAPL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 77 VERLGFDENFVDLTEMVEKrlqqlqsdelsavtvsghvynnqsinlldvlhirLLVGSQIAAEMREAMYNQLG-LTGCAG 155
Cdd:cd00424 93 VEVASIDELFLDLTGSARL----------------------------------LGLGSEVALRIKRHIAEQLGgITASIG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 156 VASNKLLAKLVSGVFKPNQQTVLLPESCQHLIhSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVA 235
Cdd:cd00424 139 IASNKLLAKLAAKYAKPDGLTILDPEDLPGFL-SKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALWGGVSG 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 236 QRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVE-AKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSE--KHY 312
Cdd:cd00424 218 ERLWYALRGIDDEPLSPPRPRKSFSHERVLPRDSRNAEdARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGRwsGHA 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1192732406 313 GRESRQCPIPSHViqklgtgnydVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFC 368
Cdd:cd00424 298 DIPSRSAPRPIST----------EDGELLHALDKLWRALLDDKGPRRLRRLGVRLS 343
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
1-325 |
5.98e-68 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 225.48 E-value: 5.98e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 1 MISNPELKDKPLGV---QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSYKVTELLEEFSPVV 77
Cdd:cd03586 14 QRDNPELKGKPVAVggsSDRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPP-RFDKYREVSRQIMEILREYTPLV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 78 ERLGFDENFVDltemvekrlqqlqsdelsavtVSGHVYNNQSInlldvlhirllvgSQIAAEMREAMYNQLGLTGCAGVA 157
Cdd:cd03586 93 EPLSIDEAYLD---------------------VTDYVRLFGSA-------------TEIAKEIRARIREETGLTASAGIA 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 158 SNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQR 237
Cdd:cd03586 139 PNKFLAKIASDLNKPNGLTVIPPEDVEEFLAPL-PVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFG-KSGRR 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 238 IQKLSFGEDNSPVILSGPPQSFSEEDSF-KKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSEKHygreS 316
Cdd:cd03586 217 LYELARGIDNRPVEPDRERKSIGVERTFsEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTR----T 292
|
....*....
gi 1192732406 317 RQCPIPSHV 325
Cdd:cd03586 293 RSRTLPEPT 301
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-305 |
1.61e-65 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 219.25 E-value: 1.61e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 1 MISNPELKDKPLGV---QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSYKVTELLEEFSPVV 77
Cdd:COG0389 17 QRDRPELRGKPVAVggdNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRDVSRRVMAILERYTPLV 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 78 ERLGFDENFVDLTEMvekrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGS--QIAAEMREAMYNQLGLTGCAG 155
Cdd:COG0389 96 EPLSIDEAFLDVTGS------------------------------------ARLFGSaeAIARRIRRRIRRETGLTVSVG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 156 VASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVA 235
Cdd:COG0389 140 IAPNKFLAKIASDLAKPDGLTVIPPGEVAAFLAPL-PVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFG-KVG 217
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1192732406 236 QRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKcssEVEAKNKIEELLASLLNRVC----QDGRKPHTVRLIIRR 305
Cdd:COG0389 218 ERLYRLARGIDPRPVEPRRPRKSIGVERTFGE---DLTDLEELEAALRRLAERLAerlrRQGLGARTVTVKLRT 288
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
4-299 |
1.12e-47 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 171.07 E-value: 1.12e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 4 NPELKDKPLGV----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSYKVTELLEEFSPVVER 79
Cdd:PRK02406 13 NPELRGKPVAVggspGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPG-RFDVYKEVSRQIREIFRRYTDLIEP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 80 LGFDENFVDLTEmvEKRLQQlqsdelSAVTvsghvynnqsinlldvlhirllvgsqIAAEMREAMYNQLGLTGCAGVASN 159
Cdd:PRK02406 92 LSLDEAYLDVTD--NKLCIG------SATL--------------------------IAQEIRQDIFEELGLTASAGVAPN 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 160 KLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQ 239
Cdd:PRK02406 138 KFLAKIASDWNKPNGLFVITPEEVDAFLATLP-VEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHFG-KFGRRLY 215
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1192732406 240 KLSFGEDNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIEEL---LASLLNRVcQDGRKPHTV 299
Cdd:PRK02406 216 ERARGIDERPVKPDRERKSVGVERTFAEdLYDLEACLAELPRLaekLERRLERA-KPDKRIKTV 278
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
4-369 |
4.81e-46 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 167.11 E-value: 4.81e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 4 NPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLV------NGED----------------LTRYRE 61
Cdd:cd01702 17 LGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILAhvatykKGEDeadyhenpsparhkvsLDPYRR 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 62 MSYKVTELLEEFSPVVERLGFDENFVDLtemvekrlqqlqsdelsavtvsghvynnqsinlldvlhirllvGSQIAAEMR 141
Cdd:cd01702 97 ASRKILNILKRFGDVVEKASIDEAYLDL-------------------------------------------GSRIVEEIR 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 142 EAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCL-EALGINSVRDLQT 220
Cdd:cd01702 134 QQVYDELGYTCSAGIAHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLP-ITSIRGLGGKLGEEIiDLLGLPTEGDVAG 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 221 F--SPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSF--KKCSSEVEAKNKIEELLASLLNRVCQD---- 292
Cdd:cd01702 213 FrsSESDLQEHFGEKLGEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFpgKTALSTEDVQHWLLVLASELNSRLEDDryen 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1192732406 293 GRKPHTVRLiirRYSSEKHYGRESRQCPIPSHVIQKLgtgnydvMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCN 369
Cdd:cd01702 293 NRRPKTLVL---SLRQRGDGVRRSRSCALPRYDAQKI-------VKDAFKLIKAINEEGLGLAWNYPLTLLSLSFTK 359
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
1-314 |
2.69e-40 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 152.49 E-value: 2.69e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 1 MISNPELKDKPLGV-----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMSYKVTELLEEFSP 75
Cdd:PRK01810 21 IAYDPSLQGKPLAVagnekERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRR-PNFDRYREASRQMFQILSEFTP 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 76 VVERLGFDENFVDLTEMVEKrlqqlqsdelsavtvsGHVYnnqsinlldvlhirllvgsQIAAEMREAMYNQLGLTGCAG 155
Cdd:PRK01810 100 LVQPVSIDEGYLDITDCYAL----------------GSPL-------------------EIAKMIQQRLLTELQLPCSIG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 156 VASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISvA 235
Cdd:PRK01810 145 IAPNKFLAKMASDMKKPLGITVLRKRDVPEMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGIN-G 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 236 QRIQKLSFGEDNSPVilsgPPQSFSEEDS------FKKCSSEV-EAKNKIEELLASLLNRVCQDGRKPHTVRLIIrRYSS 308
Cdd:PRK01810 223 VRLQRRANGIDDRPV----DPEAIYQFKSvgnsttLSHDMDEEkELLDVLRRLSKSVSKRLQKKTVVSYNVQIMI-RYHD 297
|
....*.
gi 1192732406 309 EKHYGR 314
Cdd:PRK01810 298 RRTITR 303
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
1-167 |
1.68e-37 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 136.55 E-value: 1.68e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 1 MISNPELKDKPLGVQQKY---LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVnGEDLTRYREMSYKVTELLEEFSPV- 76
Cdd:pfam00817 12 LLRDPELKGKPVAVGGGNgrgIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVV-PPDLELYRRASRKIFEILRRFSTPk 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 77 VERLGFDENFVDLTEMVEkrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGSQIAAEMREAMYNQLGLTGCAGV 156
Cdd:pfam00817 91 VEQASIDEAFLDLTGLEK----------------------------------LFGAEEALAKRLRREIAEETGLTCSIGI 136
|
170
....*....|.
gi 1192732406 157 ASNKLLAKLVS 167
Cdd:pfam00817 137 APNKLLAKLAS 147
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
5-305 |
1.37e-32 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 130.13 E-value: 1.37e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 5 PELKDKPLGV-QQKYL---VVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVnGEDLTRYREMSYKVTELLEEFSPVVERL 80
Cdd:cd01701 67 PDLKGKPVAVcHGKGPnseIASCNYEARSYGIKNGMWVGQAKKLCPQLVTL-PYDFEAYEEVSLTFYEILASYTDNIEAV 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 81 GFDENFVDLTEMVEkrlqqlqsdelsavtvsghvynnQSINLLDVLhirllvGSQIAAEMREAmynqlglTGC---AGVA 157
Cdd:cd01701 146 SCDEALIDITSLLE-----------------------ETYELPEEL------AEAIRNEIRET-------TGCsasVGIG 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 158 SNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTA-KCLEALG-INSVRDLQTFSPKILEKELGISVA 235
Cdd:cd01701 190 PNILLARLATRKAKPDGQYHLSAEKVEEFLSQLK-VGDLPGVGSSLAeKLVKLFGdTCGGLELRSKTKEKLQKVLGPKTG 268
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1192732406 236 QRIQKLSFGEDNSPVILSGPPQSFSEEDS----FKKcssEVEAKNKIEELLASLLNRVCQDGRKPHTVRL-IIRR 305
Cdd:cd01701 269 EKLYDYCRGIDDRPVTGEKERKSVSAEINygirFTN---VDDVEQFLQRLSEELSKRLEESNVTGRQITLkLMKR 340
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
5-306 |
2.97e-32 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 130.44 E-value: 2.97e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 5 PELKDKPL---GVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLG 81
Cdd:PRK03348 25 PTLRGRPVlvgGLGGRGVVAGASYEARVFGARSAMPMHQARRLVGNGAVVLPPRFVVYRAASRRVFDTLRELSPVVEQLS 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 82 FDENFVDLTEmvekrlqqLQSDELSAVTvsghvynnqsinlldvlhirllvgsQIAAEMREAMYNQLGLTGCAGVASNKL 161
Cdd:PRK03348 105 FDEAFVEPAE--------LAGASAEEVE-------------------------AFAERLRARVREETGLPASVGAGSGKQ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 162 LAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKL 241
Cdd:PRK03348 152 IAKIASGLAKPDGIRVVPPGEERELLAPLP-VRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVANLLGATVGPALHRL 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1192732406 242 SFGEDNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRY 306
Cdd:PRK03348 231 ARGIDDRPVAERAEAKQISAESTFAVdLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKS 296
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
4-329 |
5.57e-30 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 121.50 E-value: 5.57e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 4 NPELKDKPLGVqqkyL------VVTCNYEARKLGVKKLMNVRDAKEKCPQL-VLVNGEDLTRYREMSYKVTELLEEFSPV 76
Cdd:cd01700 17 RPLLLGRPLVV----LsnndgcVIARSPEAKALGIKMGSPYFKVPDLLERHgVAVFSSNYALYGDMSRRIMSILERFSPD 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 77 VERLGFDENFVDLTemvekrlqqlqsdelsavtvsgHVYNNQSINlldvlhirllvgsQIAAEMREAMYNQLGLTGCAGV 156
Cdd:cd01700 93 VEVYSIDESFLDLT----------------------GSLRFGDLE-------------ELARKIRRRILQETGIPVTVGI 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 157 ASNKLLAKLVSGVFKPNQQT----VLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI 232
Cdd:cd01700 138 GPTKTLAKLANDLAKKKNPYggvvDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 233 sVAQRIQKLSFGEDNSPVILSGPP-QSFSEEDSFKKcssEVEAKNKIEELLASLLNRVC----QDGRKPHTVRLIIR--R 305
Cdd:cd01700 218 -VGERLVRELNGIDCLPLEEYPPPkKSIGSSRSFGR---DVTDLDELKQALAEYAERAAeklrRQKSVARTISVFIGtsG 293
|
330 340
....*....|....*....|....
gi 1192732406 306 YSSEKHYGRESRQCPIPSHVIQKL 329
Cdd:cd01700 294 FSRQPKYYSATNTLPYPTNDTREI 317
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
4-311 |
4.22e-29 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 119.05 E-value: 4.22e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 4 NPELKDKPL---GVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEdLTRYREMSYKVTELLEEFSPVVERL 80
Cdd:PRK14133 22 NPKLKGKPVivgGISERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVR-HERYKEVSKNIFKILYEVTPIVEPV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 81 GFDENFVDLTEMVEKrlqqlqsdelsavtvsghvynnqsinlldvlhirllvGSQIAAEMREAMYNQLGLTGCAGVASNK 160
Cdd:PRK14133 101 SIDEAYLDITNIKEE-------------------------------------PIKIAKYIKKKVKKETGLTLSVGISYNK 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 161 LLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK---ELGISVAQR 237
Cdd:PRK14133 144 FLAKLASDWNKPDGIKIITEDMIPDILKPLP-ISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEyfgKFGVEIYER 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1192732406 238 IQklsfGEDNSPVILSGPPQSFSEEDSFKKcssEVEAKNKIEELLASLLNRVCQDGRKPH----TVRLIIRRYSSEKH 311
Cdd:PRK14133 223 IR----GIDYREVEVSRERKSIGKETTLKK---DTKDKEELKKYLKDFSNIISEELKKRNlygkTVTVKIKTSDFQTH 293
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
4-265 |
1.72e-27 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 115.41 E-value: 1.72e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 4 NPELKDKPL--GVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSYKVTELLEEFSPVVERLG 81
Cdd:PRK02794 55 NPELRDKPViiGGGKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKP-DMEKYVRVGREVRAMMQALTPLVEPLS 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 82 FDENFVDL--TEmvekRLQqlqsDELSAVTVSghvynnqsinlldvlhiRLlvgsqiAAEMREamynQLGLTGCAGVASN 159
Cdd:PRK02794 134 IDEAFLDLsgTE----RLH----GAPPAVVLA-----------------RF------ARRVER----EIGITVSVGLSYN 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 160 KLLAKLVSGVFKPNQQTVLLPESCQHLIHSlNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGiSVAQRIQ 239
Cdd:PRK02794 179 KFLAKIASDLDKPRGFSVIGRAEALAFLAP-KPVGIIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFG-SMGLRLW 256
|
250 260
....*....|....*....|....*.
gi 1192732406 240 KLSFGEDNSPVILSGPPQSFSEEDSF 265
Cdd:PRK02794 257 RLARGIDDRKVSPDREAKSVSAETTF 282
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
4-324 |
2.34e-27 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 115.10 E-value: 2.34e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 4 NPELKDKPLGV-----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEdLTRYREMSYKVTELLEEFSPVVE 78
Cdd:PRK03103 22 NPELKGRPVIVsgdpeRRSGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPR-MQRYIDVSLQITRILEDFTDLVE 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 79 RLGFDENFVDLTemvekrlqqlqsdelsavtvsghvynnqsinlldvlHIRLLVGS--QIAAEMREAMYNQLGLTGCAGV 156
Cdd:PRK03103 101 PFSIDEQFLDVT------------------------------------GSQKLFGSplEIAQKIQQRIMRETGVYARVGI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 157 ASNKLLAKLVSGVF---KPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIs 233
Cdd:PRK03103 145 GPNKLLAKMACDNFakkNPDGLFTLDKEDVPADLWPLP-VRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGI- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 234 VAQRIQKLSFGEDNSPVilsgPPQSFSEEDSFKKCSS---EVEAKNKIEELLASLLNRVCQDGRKPH----TVRLIIRry 306
Cdd:PRK03103 223 NGEVLWRTANGIDYSPV----TPHSLDRQKAIGHQMTlprDYRGFEEIKVVLLELCEEVCRRARAKGymgrTVSVSLR-- 296
|
330
....*....|....*....
gi 1192732406 307 SSEKHYGRE-SRQCPIPSH 324
Cdd:PRK03103 297 GADFDWPTGfSRQMTLPEP 315
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
2-250 |
2.51e-26 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 110.65 E-value: 2.51e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 2 ISNPELKDKPLGV-------QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTrYREMSYKVTELLEEFS 74
Cdd:PRK01216 18 VLNPSLKGKPVVVcvysgrfEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEV-YQQVSNRIMKLLREYS 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 75 PVVERLGFDENFVDLTEMVEKrlqqlqsdelsavtvsghvyNNQSINLldvlhirllvgsqiAAEMREAMYNQLGLTGCA 154
Cdd:PRK01216 97 EKIEIASIDEAYLDISDKVKN--------------------YQDAYNL--------------GLEIKNKILEKEKITVTV 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 155 GVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISV 234
Cdd:PRK01216 143 GISKNKVFAKIAADMAKPNGIKVIDDEEVKRFINELD-IADIPGIGDITAEKLKKLGVNKLVDTLRIEFDELKGIIGEAK 221
|
250
....*....|....*.
gi 1192732406 235 AQRIQKLSFGEDNSPV 250
Cdd:PRK01216 222 AKYLFSLARNEYNEPV 237
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
4-370 |
1.48e-25 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 109.31 E-value: 1.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 4 NPELKDKPL----GVqqkylVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEdLTRYREMSYKVTELLEEFSPVVER 79
Cdd:PRK03858 23 DPALRGRPVivggGV-----VLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPR-MSAYSRASKAVFEVFRDTTPLVEG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 80 LGFDENFVDltemvekrlqqlqsdelsavtVSGhvynnqsinlldvlhIRLLVG--SQIAAEMREAMYNQLGLTGCAGVA 157
Cdd:PRK03858 97 LSIDEAFLD---------------------VGG---------------LRRISGtpVQIAARLRRRVREEVGLPITVGVA 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 158 SNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQR 237
Cdd:PRK03858 141 RTKFLAKVASQVAKPDGLLVVPPDRELAFLHPLP-VRRLWGVGPVTAAKLRAHGITTVGDVAELPESALVSLLGPAAGRH 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 238 IQKLSFGEDNSPVILSGPPQSFSEEDSF-KKCSSEVEaknkIEELLASLLNRVCQDGRKPH------TVRLiirRYSSek 310
Cdd:PRK03858 220 LHALAHNRDPRRVETGRRRRSVGAQRALgRGPNSPAE----VDAVVVALVDRVARRMRAAGrtgrtvVLRL---RFDD-- 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1192732406 311 hYGRESRqcpipSHVIqklgtgnyDVMTPMVDILMKLFRNMVNVKMPFH----LTLLSVCFCNL 370
Cdd:PRK03858 291 -FTRATR-----SHTL--------PRPTASTATLLAAARDLVAAAAPLIaergLTLVGFAVSNL 340
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
5-304 |
1.13e-24 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 105.87 E-value: 1.13e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 5 PELKDKPLGV------QQKYLVVTC-NYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMSYKVTELLEEFSPVV 77
Cdd:PRK03352 25 PELAGLPVIVggngdpTEPRKVVTCaSYEARAFGVRAGMPLRTAARRCPDAVFLP-SDPAAYDAASEEVMATLRDLGVPV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 78 ERLGFDENFVdltemvekrlqqlqsdelsAVTVSGHVynnqsinlldvlhirllvgsQIAAEMREAMYNQLGLTGCAGVA 157
Cdd:PRK03352 104 EVWGWDEAFL-------------------GVDTDDPE--------------------ALAEEIRAAVLERTGLSCSVGIG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 158 SNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQR 237
Cdd:PRK03352 145 DNKLRAKIATGFAKPAGVFRLTDANWMAVMGDRP-TDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGPTTGPW 223
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1192732406 238 IQKLSFGEDNSPVIlSGP--PQSFSEEDSFKK---CSSEVEAknKIEELLASLLNRVCQDGRKPHTVRLIIR 304
Cdd:PRK03352 224 LLLLARGGGDTEVS-AEPwvPRSRSREVTFPQdltDRAEVES--AVRELARRVLDEVVAEGRPVTRVAVKVR 292
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
4-311 |
1.09e-13 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 74.28 E-value: 1.09e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 4 NPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMSYKVTELLEEFSPVVERLGFD 83
Cdd:PTZ00205 152 HPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP-PDFDAYNEESNTVRRIVAEYDPNYISFGLD 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 84 ENFVDLTEMVEkRLQQLQSDElsavtvsghvynnqsinlldvlhirllvgsQIAAEMREAMYNQLGLTGCAGVASNKLLA 163
Cdd:PTZ00205 231 ELTLEVSAYIE-RFEGTKTAE------------------------------DVASELRVRVFGETKLTASAGIGPTAALA 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 164 KLVSGVFKPNQQTVL---LPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQT--------FSPKILEKELGI 232
Cdd:PTZ00205 280 KIASNINKPNGQHDLnlhTRGDVMTYVRDLG-LRSVPGVGKVTEALLKGLGITTLSDIYNrrvelcyiLHNNLFRFLLGA 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 233 SVAqrIQKL-----SFGEDNSPVILSGPPQSFSEEDSFKKcsseVEAKNKIEELLASLLNRVCQDGRKPH----TVRLII 303
Cdd:PTZ00205 359 SIG--IMQWpdaatAANTENCEGATGGQRKAISSERSFTT----PRTKEGLQEMVDTVFNGAYEEMRKSElmcrQISLTI 432
|
....*...
gi 1192732406 304 rRYSSEKH 311
Cdd:PTZ00205 433 -RWASYRY 439
|
|
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
5-245 |
5.53e-13 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 71.33 E-value: 5.53e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 5 PELKDKPLGV--QQKYLVVTCNYEARKLGVK---KLMNVRDAKEKCPQLVLVNGEDLtrYREMSYKVTELLEEFSPVVER 79
Cdd:PRK03609 20 PDLRGKPVVVlsNNDGCVIARSAEAKALGIKmgdPWFKQKDLFRRCGVVCFSSNYEL--YADMSNRVMSTLEELSPRVEI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 80 LGFDENFVDLTemvekrlqqlqsdelsavtvsghvynnqsinllDVLHIRLLvgSQIAAEMREAMYNQLGLTGCAGVASN 159
Cdd:PRK03609 98 YSIDEAFCDLT---------------------------------GVRNCRDL--TDFGREIRATVLQRTHLTVGVGIAQT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 160 KLLAKLVSGVFKP-NQQT---VLL--PESCQHLIhSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS 233
Cdd:PRK03609 143 KTLAKLANHAAKKwQRQTggvVDLsnLERQRKLL-SLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVV 221
|
250
....*....|..
gi 1192732406 234 VAQRIQKLSfGE 245
Cdd:PRK03609 222 LERTVRELR-GE 232
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
5-260 |
1.10e-07 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 54.31 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 5 PELKDKPLGV--QQKYLVVT-CNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMSYKVTELLEEFSPVVERLG 81
Cdd:cd03468 18 PADDEAPLAVveRKKAGRILaCNAAARAAGVRPGMPLAEALALCPNLQVVE-YDPEADARALQELALWLLRFTPLVALDG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 82 FDENFVDltemvekrlqqlqsdelsaVTVSGHVYNNQsINLLDVLHIRLLVgsqiaaemreamynqLGLTGCAGVASNKL 161
Cdd:cd03468 97 PDGLLLD-------------------VTGCLHLFGGE-DALAASLRAALAT---------------LGLSARAGIADTPG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 162 LAKLVSgvFKPNQQTVLLPESCQHLIHSLNH-IKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQK 240
Cdd:cd03468 142 AAWLLA--RAGGGRGVLRREALAAALVLLAPlPVAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQ 219
|
250 260
....*....|....*....|
gi 1192732406 241 LsFGEDNSPVILSGPPQSFS 260
Cdd:cd03468 220 A-YGRDPEPLLFSPPPPAFD 238
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
256-370 |
1.39e-06 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 47.17 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 256 PQSFSEEDSF-KKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYssekHYGRESRQCPIPSHviqklgTGNY 334
Cdd:pfam11799 1 RKSIGAERTFgRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYS----DFRTITRSVTLPSP------TDDT 70
|
90 100 110
....*....|....*....|....*....|....*.
gi 1192732406 335 DVMTpmvDILMKLFRNMVNvkmPFHLTLLSVCFCNL 370
Cdd:pfam11799 71 DEIY---RAALRLLRRLYR---GRPVRLLGVSLSNL 100
|
|
| TIGR03491 |
TIGR03491 |
RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family ... |
192-257 |
1.98e-04 |
|
RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family are found broadly but sporadically among bacteria. The N-terminal region is homologous to the Cas4 protein of CRISPR systems, although this protein family shows no signs of association with CRISPR repeats.
Pssm-ID: 274603 [Multi-domain] Cd Length: 457 Bit Score: 44.24 E-value: 1.98e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1192732406 192 HIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK--ELGISVAQRIQK--LSFGEdNSPVILSGPPQ 257
Cdd:TIGR03491 208 HLSLVPGIGPSRYRLLQELGIHTLEDLAAADPNDLEDfgEQGLGVAEQLVQqaRAQLE-GRPILLAPPKA 276
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
180-212 |
2.43e-04 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 38.53 E-value: 2.43e-04
10 20 30
....*....|....*....|....*....|...
gi 1192732406 180 PESCQHLIHSLNhIKEIPGIGYKTAKCLEALGI 212
Cdd:pfam11798 1 PDDVPEFLWPLP-ISKIPGIGKKLAEKLKALGI 32
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
195-238 |
1.53e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 37.08 E-value: 1.53e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 1192732406 195 EIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK--ELGISVAQRI 238
Cdd:pfam14520 6 SISGIGPKTALALLSAGIGTVEDLAEADVDELAEipGIGEKTAQRI 51
|
|
| radA |
PRK04301 |
DNA repair and recombination protein RadA; Validated |
193-240 |
3.66e-03 |
|
DNA repair and recombination protein RadA; Validated
Pssm-ID: 235273 [Multi-domain] Cd Length: 317 Bit Score: 39.86 E-value: 3.66e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1192732406 193 IKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS--VAQRIQK 240
Cdd:PRK04301 8 LEDLPGVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGesTAAKIIE 57
|
|
| Rev1_UBM2 |
cd19318 |
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, ... |
637-662 |
4.22e-03 |
|
Ubiquitin-Binding Motif 2 (UBM2) of Y-family polymerase Rev1; This model characterizes UBM2, the second ubiquitin-binding motif of Rev1, a DNA damage tolerance protein. Rev1 acts as a translesion synthesis (TLS) DNA polymerase and may also recruit other TLS polymerases to the site of DNA damage; in that process the UBMs are essential for Rev1 function, triggering TLS activation via recognition of ubiquitin moieties in PCNA, the proliferating cell nuclear antigen.
Pssm-ID: 412037 Cd Length: 36 Bit Score: 35.28 E-value: 4.22e-03
10 20
....*....|....*....|....*.
gi 1192732406 637 PSDIDPQVFYELPEAVQKELLAEWKR 662
Cdd:cd19318 9 FSQVDPSVLAALPPDLQEELEAAYAQ 34
|
|
| RecG |
COG1200 |
RecG-like helicase [Replication, recombination and repair]; |
193-218 |
7.55e-03 |
|
RecG-like helicase [Replication, recombination and repair];
Pssm-ID: 440813 [Multi-domain] Cd Length: 684 Bit Score: 39.65 E-value: 7.55e-03
10 20
....*....|....*....|....*.
gi 1192732406 193 IKEIPGIGYKTAKCLEALGINSVRDL 218
Cdd:COG1200 8 LTYLKGVGPKRAKLLAKLGIRTVGDL 33
|
|
| PRK10917 |
PRK10917 |
ATP-dependent DNA helicase RecG; Provisional |
193-218 |
7.60e-03 |
|
ATP-dependent DNA helicase RecG; Provisional
Pssm-ID: 236794 [Multi-domain] Cd Length: 681 Bit Score: 39.36 E-value: 7.60e-03
10 20
....*....|....*....|....*.
gi 1192732406 193 IKEIPGIGYKTAKCLEALGINSVRDL 218
Cdd:PRK10917 11 LTSLKGVGPKTAEKLAKLGIHTVQDL 36
|
|
| |
