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Conserved domains on  [gi|1194651257|ref|NP_001338604|]
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protein FAM98C isoform 2 [Homo sapiens]

Protein Classification

FAM98 family protein( domain architecture ID 9466)

FAM98 family protein is a DUF2465 domain-containing protein; similar to Homo sapiens proteins FAM98A, FAM98B and FAM98C, which may positively stimulate PRMT1-induced protein arginine methylation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF2465 super family cl10924
Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans ...
 28-252 2.00e-74

Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.


The actual alignment was detected with superfamily member pfam10239:

Pssm-ID: 463016  Cd Length: 302  Bit Score: 229.06  E-value: 2.00e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194651257  28 GAASRGASCPDFRGLCVRLAAELATLGALEqqreagaEVLSAGDGPGAEEDFLRQLGSLLRELHCPDRALCGGDGAAALR 107
Cdd:pfam10239   4 KALEGGLSSPEFTALVAWLTSELKVLCKLE-------ETVNSISGPDDAESFLLELSGFLKELGCPYSALTSGPVTERLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194651257 108 EPGAGLRLLRFLCSELQATRLLCLRslldpSPRPPLGEGVVEGAGMVQELDLTLQALGLPRPAPGTPASQLLQELHAK-- 185
Cdd:pfam10239  77 SKEDRLKLLEFLSSELQAARILLSK-----KPTEPPNELTKKESPTAQELKAICITLGLPKPPANITASQLFSKIETKvn 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194651257 186 -------------------------EALESLSQSLRDQYRCRRCLLLKRLDLTTSAFHWSDRAE---------------- 224
Cdd:pfam10239 152 ellkklppnhvgkpllkkpltpeqwEKLEKINADLSEEYECRRQMLLKRLDVTVQSFQWSDRAKvkedeiarvyqpkrhs 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1194651257 225 ----------------------------------------VLMGNVPDRGGRPNELEPP---MPTWRSRRE 252
Cdd:pfam10239 232 ldpesdvslahllaaredlaiiektssgsvrkntkcainkVLIGRVPDRGGRPSEIEPPppeMPSWQKRQE 302
 
Name Accession Description Interval E-value
DUF2465 pfam10239
Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans ...
 28-252 2.00e-74

Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.


Pssm-ID: 463016  Cd Length: 302  Bit Score: 229.06  E-value: 2.00e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194651257  28 GAASRGASCPDFRGLCVRLAAELATLGALEqqreagaEVLSAGDGPGAEEDFLRQLGSLLRELHCPDRALCGGDGAAALR 107
Cdd:pfam10239   4 KALEGGLSSPEFTALVAWLTSELKVLCKLE-------ETVNSISGPDDAESFLLELSGFLKELGCPYSALTSGPVTERLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194651257 108 EPGAGLRLLRFLCSELQATRLLCLRslldpSPRPPLGEGVVEGAGMVQELDLTLQALGLPRPAPGTPASQLLQELHAK-- 185
Cdd:pfam10239  77 SKEDRLKLLEFLSSELQAARILLSK-----KPTEPPNELTKKESPTAQELKAICITLGLPKPPANITASQLFSKIETKvn 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194651257 186 -------------------------EALESLSQSLRDQYRCRRCLLLKRLDLTTSAFHWSDRAE---------------- 224
Cdd:pfam10239 152 ellkklppnhvgkpllkkpltpeqwEKLEKINADLSEEYECRRQMLLKRLDVTVQSFQWSDRAKvkedeiarvyqpkrhs 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1194651257 225 ----------------------------------------VLMGNVPDRGGRPNELEPP---MPTWRSRRE 252
Cdd:pfam10239 232 ldpesdvslahllaaredlaiiektssgsvrkntkcainkVLIGRVPDRGGRPSEIEPPppeMPSWQKRQE 302
 
Name Accession Description Interval E-value
DUF2465 pfam10239
Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans ...
 28-252 2.00e-74

Protein of unknown function (DUF2465); FAM98A and B proteins are found from worms to humans but their function is unknown. This entry is of a family of proteins that is rich in glycines.


Pssm-ID: 463016  Cd Length: 302  Bit Score: 229.06  E-value: 2.00e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194651257  28 GAASRGASCPDFRGLCVRLAAELATLGALEqqreagaEVLSAGDGPGAEEDFLRQLGSLLRELHCPDRALCGGDGAAALR 107
Cdd:pfam10239   4 KALEGGLSSPEFTALVAWLTSELKVLCKLE-------ETVNSISGPDDAESFLLELSGFLKELGCPYSALTSGPVTERLK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194651257 108 EPGAGLRLLRFLCSELQATRLLCLRslldpSPRPPLGEGVVEGAGMVQELDLTLQALGLPRPAPGTPASQLLQELHAK-- 185
Cdd:pfam10239  77 SKEDRLKLLEFLSSELQAARILLSK-----KPTEPPNELTKKESPTAQELKAICITLGLPKPPANITASQLFSKIETKvn 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1194651257 186 -------------------------EALESLSQSLRDQYRCRRCLLLKRLDLTTSAFHWSDRAE---------------- 224
Cdd:pfam10239 152 ellkklppnhvgkpllkkpltpeqwEKLEKINADLSEEYECRRQMLLKRLDVTVQSFQWSDRAKvkedeiarvyqpkrhs 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1194651257 225 ----------------------------------------VLMGNVPDRGGRPNELEPP---MPTWRSRRE 252
Cdd:pfam10239 232 ldpesdvslahllaaredlaiiektssgsvrkntkcainkVLIGRVPDRGGRPSEIEPPppeMPSWQKRQE 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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