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Conserved domains on  [gi|1200005361|ref|NP_001338947|]
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lipase maturation factor 1 isoform 3 [Homo sapiens]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 39-412 9.45e-167

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 474.90  E-value: 9.45e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361  39 GWESQLLETGFLGIFLCPLWTLSRLPqHTPTSRIVLWGFRWLIFRIMLGAGLIKIRGDR-CWRDLTCMDFHYETQPMPNP 117
Cdd:pfam06762   4 QWDSLLLETGFLAIFLAPLGLLRRLP-KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCpTWWDLTALDYHYETQPLPTP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 118 VAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSGNLSFLNWLTMVPSLACFDDATLG 196
Cdd:pfam06762  83 LSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDDAFLY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 197 FLFPSGPG-----------SLKDRVLQMQRDIRGARPEPRF-----GSVVRRAANVSLGV-LLAWLSVPVVLNLLSSR-- 257
Cdd:pfam06762 163 FWTPESRKkpprtrllsviETLLSLLVYGLLIYGTVSLFGLkisenGTFLRRVTLPSIVLgLVSLLSVPVCALLRSNKli 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 258 -----------------------------QVMNTHFNSLHIVNTYGAFGSITKERAEVILQGTASSNASapdamWEDYEF 308
Cdd:pfam06762 243 qsiqlaivtlaavllfalslvpfsvrnllSRMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGSNDGEGP-----WKEYEF 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 309 KCKPGDPSRRPCLISPYHYRLDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLLAHNPFAGRpPPRWVRGEHYRYKF 388
Cdd:pfam06762 318 KYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-PPKYVRAELYRYRF 396

                         410       420
                  ....*....|....*....|....
gi 1200005361 389 SRPgGRHAAEGKWWVRKRIGAYFP 412
Cdd:pfam06762 397 TTP-GERRATGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 39-412 9.45e-167

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 474.90  E-value: 9.45e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361  39 GWESQLLETGFLGIFLCPLWTLSRLPqHTPTSRIVLWGFRWLIFRIMLGAGLIKIRGDR-CWRDLTCMDFHYETQPMPNP 117
Cdd:pfam06762   4 QWDSLLLETGFLAIFLAPLGLLRRLP-KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCpTWWDLTALDYHYETQPLPTP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 118 VAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSGNLSFLNWLTMVPSLACFDDATLG 196
Cdd:pfam06762  83 LSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDDAFLY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 197 FLFPSGPG-----------SLKDRVLQMQRDIRGARPEPRF-----GSVVRRAANVSLGV-LLAWLSVPVVLNLLSSR-- 257
Cdd:pfam06762 163 FWTPESRKkpprtrllsviETLLSLLVYGLLIYGTVSLFGLkisenGTFLRRVTLPSIVLgLVSLLSVPVCALLRSNKli 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 258 -----------------------------QVMNTHFNSLHIVNTYGAFGSITKERAEVILQGTASSNASapdamWEDYEF 308
Cdd:pfam06762 243 qsiqlaivtlaavllfalslvpfsvrnllSRMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGSNDGEGP-----WKEYEF 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 309 KCKPGDPSRRPCLISPYHYRLDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLLAHNPFAGRpPPRWVRGEHYRYKF 388
Cdd:pfam06762 318 KYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-PPKYVRAELYRYRF 396

                         410       420
                  ....*....|....*....|....
gi 1200005361 389 SRPgGRHAAEGKWWVRKRIGAYFP 412
Cdd:pfam06762 397 TTP-GERRATGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 39-412 9.45e-167

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 474.90  E-value: 9.45e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361  39 GWESQLLETGFLGIFLCPLWTLSRLPqHTPTSRIVLWGFRWLIFRIMLGAGLIKIRGDR-CWRDLTCMDFHYETQPMPNP 117
Cdd:pfam06762   4 QWDSLLLETGFLAIFLAPLGLLRRLP-KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCpTWWDLTALDYHYETQPLPTP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 118 VAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSGNLSFLNWLTMVPSLACFDDATLG 196
Cdd:pfam06762  83 LSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDDAFLY 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 197 FLFPSGPG-----------SLKDRVLQMQRDIRGARPEPRF-----GSVVRRAANVSLGV-LLAWLSVPVVLNLLSSR-- 257
Cdd:pfam06762 163 FWTPESRKkpprtrllsviETLLSLLVYGLLIYGTVSLFGLkisenGTFLRRVTLPSIVLgLVSLLSVPVCALLRSNKli 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 258 -----------------------------QVMNTHFNSLHIVNTYGAFGSITKERAEVILQGTASSNASapdamWEDYEF 308
Cdd:pfam06762 243 qsiqlaivtlaavllfalslvpfsvrnllSRMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGSNDGEGP-----WKEYEF 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005361 309 KCKPGDPSRRPCLISPYHYRLDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLLAHNPFAGRpPPRWVRGEHYRYKF 388
Cdd:pfam06762 318 KYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-PPKYVRAELYRYRF 396

                         410       420
                  ....*....|....*....|....
gi 1200005361 389 SRPgGRHAAEGKWWVRKRIGAYFP 412
Cdd:pfam06762 397 TTP-GERRATGAWWKRERVGEYFP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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