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Conserved domains on  [gi|1200005363|ref|NP_001338948|]
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lipase maturation factor 1 isoform 4 [Homo sapiens]

Protein Classification

lipase maturation factor family protein( domain architecture ID 10535984)

lipase maturation factor family protein similar to vertebrate lipase maturation factor, which is involved in the maturation of specific proteins in the endoplasmic reticulum, and may be required for maturation and transport of active lipoprotein lipase through the secretory pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 60-436 9.94e-165

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


:

Pssm-ID: 462004  Cd Length: 419  Bit Score: 470.67  E-value: 9.94e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363  60 YSFGWESQLLETGFLGIFLCPLWTLSRLPqHTPTSRIVLWGFRWLIFRIMLGAGLIKIRGDR-CWRDLTCMDFHYETQPM 138
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLP-KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCpTWWDLTALDYHYETQPL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 139 PNPVAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSGNLSFLNWLTMVPSLACFDDA 217
Cdd:pfam06762  80 PTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDDA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 218 TLGFLFPSGPG-----------SLKDRVLQMQRDIRGARPEPRF-----GSVVRRAANVSLGV-LLAWLSVPVVLNLLSS 280
Cdd:pfam06762 160 FLYFWTPESRKkpprtrllsviETLLSLLVYGLLIYGTVSLFGLkisenGTFLRRVTLPSIVLgLVSLLSVPVCALLRSN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 281 R-------------------------------QVMNTHFNSLHIVNTYGAFGSITKERAEVILQGTASSNASapdamWED 329
Cdd:pfam06762 240 KliqsiqlaivtlaavllfalslvpfsvrnllSRMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGSNDGEGP-----WKE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 330 YEFKCKPGDPSRRPCLISPYHYRLDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLLAHNPFAGRpPPRWVRGEHYR 409
Cdd:pfam06762 315 YEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-PPKYVRAELYR 393

                         410       420
                  ....*....|....*....|....*..
gi 1200005363 410 YKFSRPgGRHAAEGKWWVRKRIGAYFP 436
Cdd:pfam06762 394 YRFTTP-GERRATGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 60-436 9.94e-165

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 470.67  E-value: 9.94e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363  60 YSFGWESQLLETGFLGIFLCPLWTLSRLPqHTPTSRIVLWGFRWLIFRIMLGAGLIKIRGDR-CWRDLTCMDFHYETQPM 138
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLP-KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCpTWWDLTALDYHYETQPL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 139 PNPVAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSGNLSFLNWLTMVPSLACFDDA 217
Cdd:pfam06762  80 PTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDDA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 218 TLGFLFPSGPG-----------SLKDRVLQMQRDIRGARPEPRF-----GSVVRRAANVSLGV-LLAWLSVPVVLNLLSS 280
Cdd:pfam06762 160 FLYFWTPESRKkpprtrllsviETLLSLLVYGLLIYGTVSLFGLkisenGTFLRRVTLPSIVLgLVSLLSVPVCALLRSN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 281 R-------------------------------QVMNTHFNSLHIVNTYGAFGSITKERAEVILQGTASSNASapdamWED 329
Cdd:pfam06762 240 KliqsiqlaivtlaavllfalslvpfsvrnllSRMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGSNDGEGP-----WKE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 330 YEFKCKPGDPSRRPCLISPYHYRLDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLLAHNPFAGRpPPRWVRGEHYR 409
Cdd:pfam06762 315 YEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-PPKYVRAELYR 393

                         410       420
                  ....*....|....*....|....*..
gi 1200005363 410 YKFSRPgGRHAAEGKWWVRKRIGAYFP 436
Cdd:pfam06762 394 YRFTTP-GERRATGAWWKRERVGEYFP 419
 
Name Accession Description Interval E-value
LMF1 pfam06762
Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation ...
 60-436 9.94e-165

Lipase maturation factor; This family of transmembrane proteins includes the lipase maturation factor, LMF1. Lipoprotein lipase and hepatic lipase require LMF1 to fold into their active states. It acts as a chaperone required for maturation and transport of active lipoprotein lipase (LPL), through the secretory pathway.


Pssm-ID: 462004  Cd Length: 419  Bit Score: 470.67  E-value: 9.94e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363  60 YSFGWESQLLETGFLGIFLCPLWTLSRLPqHTPTSRIVLWGFRWLIFRIMLGAGLIKIRGDR-CWRDLTCMDFHYETQPM 138
Cdd:pfam06762   1 YSFQWDSLLLETGFLAIFLAPLGLLRRLP-KSPPPSIVFWLVRWLLFRLMFGAGLVKLRSDCpTWWDLTALDYHYETQPL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 139 PNPVAYYLHHSPWWFHRFETLSNHFIELLVPFFLFLG-RRACIIHGVLQILFQAVLIVSGNLSFLNWLTMVPSLACFDDA 217
Cdd:pfam06762  80 PTPLSWYAHQLPSWFHKLETLGNHVVELVVPFLFFAPiRRLRIVAFFIQVLLQLLIILTGNYGFLNLLTIVLSLSLLDDA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 218 TLGFLFPSGPG-----------SLKDRVLQMQRDIRGARPEPRF-----GSVVRRAANVSLGV-LLAWLSVPVVLNLLSS 280
Cdd:pfam06762 160 FLYFWTPESRKkpprtrllsviETLLSLLVYGLLIYGTVSLFGLkisenGTFLRRVTLPSIVLgLVSLLSVPVCALLRSN 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 281 R-------------------------------QVMNTHFNSLHIVNTYGAFGSITKERAEVILQGTASSNASapdamWED 329
Cdd:pfam06762 240 KliqsiqlaivtlaavllfalslvpfsvrnllSRMNASFNPLHLVNSYGLFGSMTGGRPEVVIEGSNDGEGP-----WKE 314

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1200005363 330 YEFKCKPGDPSRRPCLISPYHYRLDWLMWFAAFQTYEHNDWIIHLAGKLLASDAEALSLLAHNPFAGRpPPRWVRGEHYR 409
Cdd:pfam06762 315 YEFKYKPGDVNRRPPFVAPYHPRLDWQMWFAALGTYQQNPWFLSLLYRLLQNDPEVLGLLDHNPFPDK-PPKYVRAELYR 393

                         410       420
                  ....*....|....*....|....*..
gi 1200005363 410 YKFSRPgGRHAAEGKWWVRKRIGAYFP 436
Cdd:pfam06762 394 YRFTTP-GERRATGAWWKRERVGEYFP 419
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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