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Conserved domains on  [gi|1206271452|ref|NP_001339332|]
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arginine-hydroxylase NDUFAF5, mitochondrial isoform 4 [Homo sapiens]

Protein Classification

methyltransferase domain-containing protein( domain architecture ID 1002315)

methyltransferase domain-containing protein similar to vertebrate mitochondrial arginine-hydroxylase NDUFAF5 and bacterial malonyl-[acyl-carrier protein] O-methyltransferase

EC:  2.1.1.-
Gene Ontology:  GO:0032259|GO:0008168

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BioC super family cl37044
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 2-153 8.83e-19

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


The actual alignment was detected with superfamily member TIGR02072:

Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 80.41  E-value: 8.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1206271452   2 LCLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSlqlaetereggFSPHISPFTAVNDLGHLLGRAgFNTLT 81
Cdd:TIGR02072 106 LALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQS-----------FGQHGLRYLSLDELKALLKNS-FELLT 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1206271452  82 VDTDEIQVNYPGMFELMEDLQGMGESNCA---WNRKALLHrdtMLAAaavYREMYRNEdgSVPATYQIYYMIGWK 153
Cdd:TIGR02072 174 LEEELITLSFDDPLDVLRHLKKTGANGLSsgrTSRKQLKA---FLER---YEQEFQPD--GLPLTYHVVYGIAKK 240
 
Name Accession Description Interval E-value
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 2-153 8.83e-19

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 80.41  E-value: 8.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1206271452   2 LCLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSlqlaetereggFSPHISPFTAVNDLGHLLGRAgFNTLT 81
Cdd:TIGR02072 106 LALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQS-----------FGQHGLRYLSLDELKALLKNS-FELLT 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1206271452  82 VDTDEIQVNYPGMFELMEDLQGMGESNCA---WNRKALLHrdtMLAAaavYREMYRNEdgSVPATYQIYYMIGWK 153
Cdd:TIGR02072 174 LEEELITLSFDDPLDVLRHLKKTGANGLSsgrTSRKQLKA---FLER---YEQEFQPD--GLPLTYHVVYGIAKK 240
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 3-78 5.18e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 41.64  E-value: 5.18e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1206271452   3 CLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRcsLQLAETEREggFSPHISPFTAvNDLGHLLGRAGFN 78
Cdd:pfam13489  89 VLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRL--LLEWPYLRP--RNGHISLFSA-RSLKRLLEEAGFE 159
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 2-56 2.62e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 39.59  E-value: 2.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1206271452   2 LCLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSLQLAeteregGFS 56
Cdd:COG2226    95 FVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA------GFE 143
 
Name Accession Description Interval E-value
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 2-153 8.83e-19

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 80.41  E-value: 8.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1206271452   2 LCLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSlqlaetereggFSPHISPFTAVNDLGHLLGRAgFNTLT 81
Cdd:TIGR02072 106 LALQWCDDLSQALSELARVLKPGGLLAFSTFGPGTLHELRQS-----------FGQHGLRYLSLDELKALLKNS-FELLT 173

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1206271452  82 VDTDEIQVNYPGMFELMEDLQGMGESNCA---WNRKALLHrdtMLAAaavYREMYRNEdgSVPATYQIYYMIGWK 153
Cdd:TIGR02072 174 LEEELITLSFDDPLDVLRHLKKTGANGLSsgrTSRKQLKA---FLER---YEQEFQPD--GLPLTYHVVYGIAKK 240
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 3-78 5.18e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 41.64  E-value: 5.18e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1206271452   3 CLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRcsLQLAETEREggFSPHISPFTAvNDLGHLLGRAGFN 78
Cdd:pfam13489  89 VLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRL--LLEWPYLRP--RNGHISLFSA-RSLKRLLEEAGFE 159
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 2-56 2.62e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 39.59  E-value: 2.62e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1206271452   2 LCLHWVNDLPRALEQIHYILKPDGVFIGAMFGGDTLYELRCSLQLAeteregGFS 56
Cdd:COG2226    95 FVLHHLPDPERALAEIARVLKPGGRLVVVDFSPPDLAELEELLAEA------GFE 143
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 1-28 2.73e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.41  E-value: 2.73e-04
                          10        20
                  ....*....|....*....|....*...
gi 1206271452   1 MLCLHWVNDLPRALEQIHYILKPDGVFI 28
Cdd:pfam08241  66 SEVLHHVEDPERALREIARVLKPGGILI 93
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
3-31 4.33e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 35.18  E-value: 4.33e-03
                          10        20
                  ....*....|....*....|....*....
gi 1206271452   3 CLHWVNDLPRALEQIHYILKPDGVFIGAM 31
Cdd:COG4106    72 ALHWLPDHAALLARLAAALAPGGVLAVQV 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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