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Conserved domains on  [gi|1205914832|ref|NP_001339360|]
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RCC1 and BTB domain-containing protein 2 isoform 7 [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-258 2.54e-44

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 153.59  E-value: 2.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832  71 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNL 149
Cdd:COG5184    73 GNNSYGQLGDGTTTDRTTPVKVPGLTGvVAVAA---GYY-HSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832 150 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVW 229
Cdd:COG5184   149 SG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCW 223

                         170       180
                  ....*....|....*....|....*....
gi 1205914832 230 GYNGNGQLGLGNSGNQPTPCRVAALQGIR 258
Cdd:COG5184   224 GSNSSGQLGDGTTTDRATPVQVAGLTGVV 252
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-258 2.54e-44

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 153.59  E-value: 2.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832  71 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNL 149
Cdd:COG5184    73 GNNSYGQLGDGTTTDRTTPVKVPGLTGvVAVAA---GYY-HSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832 150 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVW 229
Cdd:COG5184   149 SG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCW 223

                         170       180
                  ....*....|....*....|....*....
gi 1205914832 230 GYNGNGQLGLGNSGNQPTPCRVAALQGIR 258
Cdd:COG5184   224 GSNSSGQLGDGTTTDRATPVQVAGLTGVV 252
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
170-220 3.85e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.53  E-value: 3.85e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1205914832 170 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKvVVTIACGQMCCMAV 220
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK-VVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-258 2.54e-44

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 153.59  E-value: 2.54e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832  71 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNL 149
Cdd:COG5184    73 GNNSYGQLGDGTTTDRTTPVKVPGLTGvVAVAA---GYY-HSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGL 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832 150 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVW 229
Cdd:COG5184   149 SG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCW 223

                         170       180
                  ....*....|....*....|....*....
gi 1205914832 230 GYNGNGQLGLGNSGNQPTPCRVAALQGIR 258
Cdd:COG5184   224 GSNSSGQLGDGTTTDRATPVQVAGLTGVV 252
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-248 2.29e-41

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 145.89  E-value: 2.29e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832  71 GTNCCGCLGLGDVQSTIEPRRLDSLNGkkIACLSYGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTnLS 150
Cdd:COG5184   174 GANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGD-HSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG-LT 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832 151 NkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVWG 230
Cdd:COG5184   250 G--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPG-LSG--VVAVAAGSSHTCALLTDGTVWCWG 324

                         170
                  ....*....|....*...
gi 1205914832 231 YNGNGQLGLGNSGNQPTP 248
Cdd:COG5184   325 DNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-258 7.28e-40

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 142.04  E-value: 7.28e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832  71 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIStNL 149
Cdd:COG5184    23 GDNSYGQLGDGTTTDRSTPVRVPGLSNvVAVAA---GGD-HTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP-GL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832 150 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNkvVVTIACGQMCCMAVVDTGEVYVW 229
Cdd:COG5184    98 TG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG--VVAIAAGGYHTCALKSDGTVWCW 173

                         170       180
                  ....*....|....*....|....*....
gi 1205914832 230 GYNGNGQLGLGNSGNQPTPCRVAALQGIR 258
Cdd:COG5184   174 GANSYGQLGDGTTTDRPTPVQVGGLSGVV 202
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-258 5.21e-39

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 139.73  E-value: 5.21e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832  71 GTNCCGCLGLGDVQSTIEPRRLDsLNGKKIACLSYGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTnLS 150
Cdd:COG5184   123 GDNSSGQLGDGTTTNRLTPVQVD-AGLSGVVAIAAGGY-HTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LS 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832 151 NkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVWG 230
Cdd:COG5184   200 G--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG-LTG--VVAIAAGGSHTCALKSDGTVWCWG 274

                         170       180
                  ....*....|....*....|....*...
gi 1205914832 231 YNGNGQLGLGNSGNQPTPCRVAALQGIR 258
Cdd:COG5184   275 DNSYGQLGDGTTTDRSTPVKVPGLSGVV 302
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 110-253 5.24e-37

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 134.33  E-value: 5.24e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIStNLSNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGST 189
Cdd:COG5184     9 HSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVP-GLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTT 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1205914832 190 VNQPIPRRVTGclqNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAA 253
Cdd:COG5184    86 TDRTTPVKVPG---LTGVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDA 146
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 155-258 8.05e-26

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 104.29  E-value: 8.05e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1205914832 155 IEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVWGYNGN 234
Cdd:COG5184     1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG-LSN--VVAVAAGGDHTCALKADGTVWCWGNNSY 77

                          90       100
                  ....*....|....*....|....
gi 1205914832 235 GQLGLGNSGNQPTPCRVAALQGIR 258
Cdd:COG5184    78 GQLGDGTTTDRTTPVKVPGLTGVV 101
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
170-220 3.85e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.53  E-value: 3.85e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1205914832 170 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKvVVTIACGQMCCMAV 220
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK-VVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
117-167 4.27e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 59.84  E-value: 4.27e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1205914832 117 EGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKqVIEVACGSYHSLVL 167
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK-VVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
154-183 5.77e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 53.58  E-value: 5.77e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 1205914832 154 VIEVACGSYHSLVLTSDGEVFAWGYNNSGQ 183
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
224-262 6.46e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 50.98  E-value: 6.46e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1205914832 224 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRV 262
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQV 40
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
207-236 2.43e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 34.71  E-value: 2.43e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1205914832 207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQ 236
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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