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focal adhesion kinase 1 isoform 44 [Homo sapiens]
Focal_AT domain-containing protein( domain architecture ID 10508098)
Focal_AT domain-containing protein
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
Focal_AT | pfam03623 | Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in ... |
208-337 | 1.35e-78 | |||
Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localising FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not. : Pssm-ID: 460992 Cd Length: 130 Bit Score: 236.39 E-value: 1.35e-78
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Name | Accession | Description | Interval | E-value | |||
Focal_AT | pfam03623 | Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in ... |
208-337 | 1.35e-78 | |||
Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localising FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not. Pssm-ID: 460992 Cd Length: 130 Bit Score: 236.39 E-value: 1.35e-78
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Name | Accession | Description | Interval | E-value | |||
Focal_AT | pfam03623 | Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in ... |
208-337 | 1.35e-78 | |||
Focal adhesion targeting region; Focal adhesion kinase (FAK) is a tyrosine kinase found in focal adhesions, intracellular signaling complexes that are formed following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localising FAK to focal adhesions. The crystal structure of FAT shows it forms a four-helix bundle that resembles those found in two other proteins involved in cell adhesion, alpha-catenin and vinculin. The binding of FAT to the focal adhesion protein, paxillin, requires the integrity of the helical bundle, whereas binding to another focal adhesion protein, talin, does not. Pssm-ID: 460992 Cd Length: 130 Bit Score: 236.39 E-value: 1.35e-78
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