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Conserved domains on  [gi|1384072046|ref|NP_001339820|]
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DENN domain-containing protein 3 isoform 3 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 17456)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

Gene Ontology:  GO:0005085|GO:0032483
PubMed:  11563850|21330364
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
uDENN super family cl04085
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
122-158 9.57e-05

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


The actual alignment was detected with superfamily member pfam03456:

Pssm-ID: 470944  Cd Length: 59  Bit Score: 39.13  E-value: 9.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1384072046 122 LPQLCFPGGVCVATEPKEDCVHFlVLTDVCGNRTYGV 158
Cdd:pfam03456  21 IPMFCFPEGLETLSSREPTFFSF-VLTDEDGSRLYGA 56
 
Name Accession Description Interval E-value
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
122-158 9.57e-05

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 39.13  E-value: 9.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1384072046 122 LPQLCFPGGVCVATEPKEDCVHFlVLTDVCGNRTYGV 158
Cdd:pfam03456  21 IPMFCFPEGLETLSSREPTFFSF-VLTDEDGSRLYGA 56
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
118-163 7.04e-03

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 34.62  E-value: 7.04e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1384072046  118 DLLTLPQLCFP-GGVCVATEPKEDCVHF-LVLTDVCGNRTYGVVAQYY 163
Cdd:smart00800  42 LPDSIPLFCFPeGLDFVTQTSSKDPQFFsFVLTDIDGSRRYGFCLRFY 89
 
Name Accession Description Interval E-value
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
122-158 9.57e-05

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 39.13  E-value: 9.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1384072046 122 LPQLCFPGGVCVATEPKEDCVHFlVLTDVCGNRTYGV 158
Cdd:pfam03456  21 IPMFCFPEGLETLSSREPTFFSF-VLTDEDGSRLYGA 56
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
118-163 7.04e-03

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 34.62  E-value: 7.04e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1384072046  118 DLLTLPQLCFP-GGVCVATEPKEDCVHF-LVLTDVCGNRTYGVVAQYY 163
Cdd:smart00800  42 LPDSIPLFCFPeGLDFVTQTSSKDPQFFsFVLTDIDGSRRYGFCLRFY 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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