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Conserved domains on  [gi|1209857119|ref|NP_001339877|]
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DNA repair-scaffolding protein isoform 18 [Homo sapiens]

Protein Classification

scaffold protein involved in DNA repair( domain architecture ID 10386025)

scaffold protein involved in DNA repair (SPIDR) is a DUF4503 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
271-655 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


:

Pssm-ID: 464397  Cd Length: 385  Bit Score: 739.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 271 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 350
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 351 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 430
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 431 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 510
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 511 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR 590
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGTFSCGDCSRVVTSPVTKMHLEVFLDCP 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1209857119 591 SRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIGLEEIEL 655
Cdd:pfam14951 321 SRPQCTVKVKLLQKSISSLLNSAALEDGSYEVESVLGKEVGPLACYVRSVTTHPTSCIGLEEIEL 385
DUF4502 super family cl20831
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
5-119 3.46e-72

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


The actual alignment was detected with superfamily member pfam14950:

Pssm-ID: 464396  Cd Length: 384  Bit Score: 238.29  E-value: 3.46e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119   5 RSFPRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAP 84
Cdd:pfam14950 270 KKLLRGGLAERLNGLQNRQRSAISLWRHQCVSYQKTLSGRKSGVLVVKILELHEECSMQVAMCEQLAGPGATSPSQGPAP 349
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1209857119  85 RPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKL 119
Cdd:pfam14950 350 RPGASLKVLFTRETAAHLRGHPQDIIHIYPPWQKL 384
 
Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
271-655 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


Pssm-ID: 464397  Cd Length: 385  Bit Score: 739.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 271 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 350
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 351 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 430
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 431 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 510
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 511 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR 590
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGTFSCGDCSRVVTSPVTKMHLEVFLDCP 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1209857119 591 SRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIGLEEIEL 655
Cdd:pfam14951 321 SRPQCTVKVKLLQKSISSLLNSAALEDGSYEVESVLGKEVGPLACYVRSVTTHPTSCIGLEEIEL 385
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
5-119 3.46e-72

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


Pssm-ID: 464396  Cd Length: 384  Bit Score: 238.29  E-value: 3.46e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119   5 RSFPRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAP 84
Cdd:pfam14950 270 KKLLRGGLAERLNGLQNRQRSAISLWRHQCVSYQKTLSGRKSGVLVVKILELHEECSMQVAMCEQLAGPGATSPSQGPAP 349
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1209857119  85 RPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKL 119
Cdd:pfam14950 350 RPGASLKVLFTRETAAHLRGHPQDIIHIYPPWQKL 384
 
Name Accession Description Interval E-value
DUF4503 pfam14951
Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins ...
271-655 0e+00

Domain of unknown function (DUF4503); This family of proteins is found in eukaryotes. Proteins in this family are typically between 313 and 876 amino acids in length.


Pssm-ID: 464397  Cd Length: 385  Bit Score: 739.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 271 QDACGMFGEVHLEFTMSKARQLEGKSCSLVGMKVLQKVTRGRTAGIFSLIDTLWPPAIPLKTPGRDQPCEEIKTHLPPPA 350
Cdd:pfam14951   1 QDAYGMFSEVQLEGLPSKDRQWEGRSCLLAGMKVLQRVTRGRTPGLFSLIDSLWPPVMPLKVPGRSQPSEEIKTHLPPPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 351 LCYILTAHPNLGQIDIIDEDPIYKLYQPPVTRCLRDILQMNDLGTRCSFYATVIYQKPQLKSLLLLEQREIWLLVTDVTL 430
Cdd:pfam14951  81 FCYILSAHPNLGQIEPIEEDPISKLYQPPVVRTLREILQTDGLSTRCSFYARVIYQRPQLKSLLLLEQREIWLLVTDISL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 431 QTKEERDPRLPKTLLVYVAPLCVLGSEVLEALAGAAPHSLFFKDALRDQGRIVCAERTVLLLQKPLLSVVSGASSCELPG 510
Cdd:pfam14951 161 QEKDERDPGLPRTLPVCVAPSCVLDSEVLEALNSAAPCSMLFRDALRDQGRIVCVERTVLLLQKPLLCVASGAESCELPG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119 511 PVMLDSLDSATPVNSICSVQGTVVGVDESTAFSWPVCDMCGNGRLEQRPEDRGAFSCGDCSRVVTSPVLKRHLQVFLDCR 590
Cdd:pfam14951 241 PVRLDELDSETPVNSICSVQGTVVGVDESTAFSWPVCDRCGSGRLEQSPEDRGTFSCGDCSRVVTSPVTKMHLEVFLDCP 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1209857119 591 SRPQCRVKVKLLQRSISSLLRFAAGEDGSYEVKSVLGKEVGLLNCFVQSVTAHPTSCIGLEEIEL 655
Cdd:pfam14951 321 SRPQCTVKVKLLQKSISSLLNSAALEDGSYEVESVLGKEVGPLACYVRSVTTHPTSCIGLEEIEL 385
DUF4502 pfam14950
Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins ...
5-119 3.46e-72

Domain of unknown function (DUF4502); This family of proteins is found in eukaryotes. Proteins in this family are typically between 181 and 876 amino acids in length.


Pssm-ID: 464396  Cd Length: 384  Bit Score: 238.29  E-value: 3.46e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1209857119   5 RSFPRGGLAERLNGLQNRERSAISLWRHQCISYQKTLSGRKSGVLTVKILELHEECAMQVAMCEQLLGSPATSSSQSVAP 84
Cdd:pfam14950 270 KKLLRGGLAERLNGLQNRQRSAISLWRHQCVSYQKTLSGRKSGVLVVKILELHEECSMQVAMCEQLAGPGATSPSQGPAP 349
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1209857119  85 RPGAGLKVLFTKETAGYLRGRPQDTVRIFPPWQKL 119
Cdd:pfam14950 350 RPGASLKVLFTRETAAHLRGHPQDIIHIYPPWQKL 384
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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