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Conserved domains on  [gi|1212626296|ref|NP_001340021|]
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PCI domain-containing protein 2 isoform 3 [Homo sapiens]

Protein Classification

PCI domain-containing protein( domain architecture ID 2851)

PCI (proteasome-COP9/CSN-initiation factor) domain-containing protein is a component of multiprotein complexes; Similar to Schizosaccharomyces pombe COP9 signalosome complex subunit 7 and Mus musculus PCI domain-containing protein 2

Gene Ontology:  GO:0000338|GO:0003690
PubMed:  9644972

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PINT super family cl02111
motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, ...
78-391 1.90e-55

motif in proteasome subunits, Int-6, Nip-1 and TRIP-15; Also called the PCI (Proteasome, COP9, Initiation factor 3) domain. Unknown function.


The actual alignment was detected with superfamily member COG5600:

Pssm-ID: 470471  Cd Length: 413  Bit Score: 188.08  E-value: 1.90e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296  78 AYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFANNADQQLVKK--------GKSKVG-DMLEKAAELLMSCFR 148
Cdd:COG5600    79 WSKRSSELLQELYKNLTAELSYSSAPHLEVLVKNAVRMLGREIWNLTVVKkqlyglleLKSELNqDNLSKISRLLTRMFN 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 149 VCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKD--DYSTAQRVTYKYYVGRKAMFDSDFKQ 226
Cdd:COG5600   159 SILNDRSPALNPSKKVGLYYIANLLFQIYLRLGRFKLCENFLKASKEVSMPDisEYQKSQVVVFHYYLGIYYLLNENFHE 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 227 AEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHM-PTVELLKKYHLMQ-FAEVTRAVSEGNLLLLHEALAKHEAFFI 304
Cdd:COG5600   239 AFLHLNEAFLQCPWLITRNRKRILPYYIPTSLLVNKFpPTKDLLERFKRCSvYSPLVKAVRSGNIEDFDLALSRNERKFA 318
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 305 RCGIFL-ILEKLKIITYRNLFKKVYLL-LKTHQLSLDAFLVALKFMQVEDV-DIDEVQCILANLIYMGHVKGYISHQHQK 381
Cdd:COG5600   319 KRGLYLtLLAHYPLVCFRNLFRKIWRLhGKQSRLPLSILLIVLQLSAIDNFhSFKEVECILVTLIGLGLLRGYISHSRRT 398
                         330
                  ....*....|
gi 1212626296 382 LVVSKQNPFP 391
Cdd:COG5600   399 VVFSKKDPFP 408
 
Name Accession Description Interval E-value
COG5600 COG5600
Transcription-associated recombination protein [DNA replication, recombination, and repair];
78-391 1.90e-55

Transcription-associated recombination protein [DNA replication, recombination, and repair];


Pssm-ID: 227887  Cd Length: 413  Bit Score: 188.08  E-value: 1.90e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296  78 AYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFANNADQQLVKK--------GKSKVG-DMLEKAAELLMSCFR 148
Cdd:COG5600    79 WSKRSSELLQELYKNLTAELSYSSAPHLEVLVKNAVRMLGREIWNLTVVKkqlyglleLKSELNqDNLSKISRLLTRMFN 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 149 VCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKD--DYSTAQRVTYKYYVGRKAMFDSDFKQ 226
Cdd:COG5600   159 SILNDRSPALNPSKKVGLYYIANLLFQIYLRLGRFKLCENFLKASKEVSMPDisEYQKSQVVVFHYYLGIYYLLNENFHE 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 227 AEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHM-PTVELLKKYHLMQ-FAEVTRAVSEGNLLLLHEALAKHEAFFI 304
Cdd:COG5600   239 AFLHLNEAFLQCPWLITRNRKRILPYYIPTSLLVNKFpPTKDLLERFKRCSvYSPLVKAVRSGNIEDFDLALSRNERKFA 318
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 305 RCGIFL-ILEKLKIITYRNLFKKVYLL-LKTHQLSLDAFLVALKFMQVEDV-DIDEVQCILANLIYMGHVKGYISHQHQK 381
Cdd:COG5600   319 KRGLYLtLLAHYPLVCFRNLFRKIWRLhGKQSRLPLSILLIVLQLSAIDNFhSFKEVECILVTLIGLGLLRGYISHSRRT 398
                         330
                  ....*....|
gi 1212626296 382 LVVSKQNPFP 391
Cdd:COG5600   399 VVFSKKDPFP 408
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
275-386 5.16e-15

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 70.32  E-value: 5.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 275 MQFAEVTRAVSEGNLLLLHEALAKH-EAFFIRCGIFLILEKLKIITYRNLFKKVYLLlkTHQLSLDAFLVALkfmqveDV 353
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYkEELLLDDGLAEHLEDLRRKIREHNLRQLSKP--YSSISLSDLAKLL------GL 72
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1212626296 354 DIDEVQCILANLIYMGHVKGYISHQHQKLVVSK 386
Cdd:pfam01399  73 SVDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Name Accession Description Interval E-value
COG5600 COG5600
Transcription-associated recombination protein [DNA replication, recombination, and repair];
78-391 1.90e-55

Transcription-associated recombination protein [DNA replication, recombination, and repair];


Pssm-ID: 227887  Cd Length: 413  Bit Score: 188.08  E-value: 1.90e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296  78 AYKCQTVIVQSFLRAFQAHKEENWALPVMYAVALDLRVFANNADQQLVKK--------GKSKVG-DMLEKAAELLMSCFR 148
Cdd:COG5600    79 WSKRSSELLQELYKNLTAELSYSSAPHLEVLVKNAVRMLGREIWNLTVVKkqlyglleLKSELNqDNLSKISRLLTRMFN 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 149 VCASDTRAGIEDSKKWGMLFLVNQLFKIYFKINKLHLCKPLIRAIDSSNLKD--DYSTAQRVTYKYYVGRKAMFDSDFKQ 226
Cdd:COG5600   159 SILNDRSPALNPSKKVGLYYIANLLFQIYLRLGRFKLCENFLKASKEVSMPDisEYQKSQVVVFHYYLGIYYLLNENFHE 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 227 AEEYLSFAFEHCHRSSQKNKRMILIYLLPVKMLLGHM-PTVELLKKYHLMQ-FAEVTRAVSEGNLLLLHEALAKHEAFFI 304
Cdd:COG5600   239 AFLHLNEAFLQCPWLITRNRKRILPYYIPTSLLVNKFpPTKDLLERFKRCSvYSPLVKAVRSGNIEDFDLALSRNERKFA 318
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 305 RCGIFL-ILEKLKIITYRNLFKKVYLL-LKTHQLSLDAFLVALKFMQVEDV-DIDEVQCILANLIYMGHVKGYISHQHQK 381
Cdd:COG5600   319 KRGLYLtLLAHYPLVCFRNLFRKIWRLhGKQSRLPLSILLIVLQLSAIDNFhSFKEVECILVTLIGLGLLRGYISHSRRT 398
                         330
                  ....*....|
gi 1212626296 382 LVVSKQNPFP 391
Cdd:COG5600   399 VVFSKKDPFP 408
PCI pfam01399
PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and ...
275-386 5.16e-15

PCI domain; This domain has also been called the PINT motif (Proteasome, Int-6, Nip-1 and TRIP-15).


Pssm-ID: 460195  Cd Length: 105  Bit Score: 70.32  E-value: 5.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212626296 275 MQFAEVTRAVSEGNLLLLHEALAKH-EAFFIRCGIFLILEKLKIITYRNLFKKVYLLlkTHQLSLDAFLVALkfmqveDV 353
Cdd:pfam01399   1 PAYRDLLRAFYSGDLSEFEEILADYkEELLLDDGLAEHLEDLRRKIREHNLRQLSKP--YSSISLSDLAKLL------GL 72
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1212626296 354 DIDEVQCILANLIYMGHVKGYISHQHQKLVVSK 386
Cdd:pfam01399  73 SVDEVEKILAKLIRDGRIRAKIDQVNGIVVFSK 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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