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Conserved domains on  [gi|1212988478|ref|NP_001340077|]
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coiled-coil domain-containing protein 66 isoform 4 [Homo sapiens]

Protein Classification

CCDC66 domain-containing protein( domain architecture ID 12172167)

CCDC66 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 411-558 3.06e-50

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


:

Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 174.21  E-value: 3.06e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212988478 411 TTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEH------QVEEKRRKKQLEEEQRK 484
Cdd:pfam15236   1 TDLKVVSPDDVESLQSSSRMSAMTNSQKTSFLRGQNALLDPAQLEERERKRQKALEHqnaikkQLEEKERQKKLEEERRR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1212988478 485 KEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSR 558
Cdd:pfam15236  81 QEEQEEEERLRREREEEQKQFEEERRKQKEKEEAMTRKTQALLQAMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154
 
Name Accession Description Interval E-value
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 411-558 3.06e-50

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 174.21  E-value: 3.06e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212988478 411 TTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEH------QVEEKRRKKQLEEEQRK 484
Cdd:pfam15236   1 TDLKVVSPDDVESLQSSSRMSAMTNSQKTSFLRGQNALLDPAQLEERERKRQKALEHqnaikkQLEEKERQKKLEEERRR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1212988478 485 KEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSR 558
Cdd:pfam15236  81 QEEQEEEERLRREREEEQKQFEEERRKQKEKEEAMTRKTQALLQAMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154
 
Name Accession Description Interval E-value
CCDC66 pfam15236
Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil ...
 411-558 3.06e-50

Coiled-coil domain-containing protein 66; This protein family, named Coiled-coil domain-containing protein 66 (CCDC) refers to a protein domain found in eukaryotes, and is approximately 160 amino acids in length. CCDC66 protein is detected mainly in the inner segments of photoreceptors in many vertebrates including mice and humans. It has been found in dogs, that a mutation in the CCDC66 gene causes generalized progressive retinal atrophy (gPRA). This shows that the protein encoded for by this gene is vital for healthy vision and guards against photoreceptor cell degeneration. The structure of CCDC66 proteins includes a heptad repeat pattern which contains at least one coiled-coil domain. There are at least two or more alpha-helices which form a cable-like structure.


Pssm-ID: 434558 [Multi-domain]  Cd Length: 154  Bit Score: 174.21  E-value: 3.06e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1212988478 411 TTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEH------QVEEKRRKKQLEEEQRK 484
Cdd:pfam15236   1 TDLKVVSPDDVESLQSSSRMSAMTNSQKTSFLRGQNALLDPAQLEERERKRQKALEHqnaikkQLEEKERQKKLEEERRR 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1212988478 485 KEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSR 558
Cdd:pfam15236  81 QEEQEEEERLRREREEEQKQFEEERRKQKEKEEAMTRKTQALLQAMQKAQELAQRLKQEQRIRELAEKGHDTSQ 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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