NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1217328820|ref|NP_001340560|]
View 

NEDD4-binding protein 2-like 1 isoform 9 [Homo sapiens]

Protein Classification

ATP-binding protein( domain architecture ID 1004283)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AAA_33 super family cl38431
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 87-173 4.60e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


The actual alignment was detected with superfamily member pfam13671:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 50.00  E-value: 4.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1217328820  87 STDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYE---VIFREP 159
Cdd:pfam13671  29 SSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDATNLRRDERARLLALAREYGVPvriVVFEAP 107

                          90
                  ....*....|....
gi 1217328820 160 DTRWKFNVQELARQ 173
Cdd:pfam13671 108 EEVLRERLAARARA 121
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 87-173 4.60e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 50.00  E-value: 4.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1217328820  87 STDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYE---VIFREP 159
Cdd:pfam13671  29 SSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDATNLRRDERARLLALAREYGVPvriVVFEAP 107

                          90
                  ....*....|....
gi 1217328820 160 DTRWKFNVQELARQ 173
Cdd:pfam13671 108 EEVLRERLAARARA 121
COG4639 COG4639
Predicted kinase [General function prediction only];
80-155 4.41e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 39.04  E-value: 4.41e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1217328820  80 FPRALIFSTDDF---FFREDGAYEFNPDFLEEAHEwnqkRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYEVI 155
Cdd:COG4639    23 FAPTEVVSSDDIralLGGDENDQSAWGDVFQLAHE----IARARLRAGR-LTVVDATNLQREARRRLLALARAYGALVV 96
 
Name Accession Description Interval E-value
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 87-173 4.60e-08

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 50.00  E-value: 4.60e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1217328820  87 STDDFFFR----EDGAYEFNPDFLEEAHEWNQKRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYE---VIFREP 159
Cdd:pfam13671  29 SSDDERKRlfgeGRPSISYYTDATDRTYERLHELARIALRAGR-PVILDATNLRRDERARLLALAREYGVPvriVVFEAP 107

                          90
                  ....*....|....
gi 1217328820 160 DTRWKFNVQELARQ 173
Cdd:pfam13671 108 EEVLRERLAARARA 121
COG4639 COG4639
Predicted kinase [General function prediction only];
80-155 4.41e-04

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 39.04  E-value: 4.41e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1217328820  80 FPRALIFSTDDF---FFREDGAYEFNPDFLEEAHEwnqkRARKAMRNGIsPIIIDNTNLHAWEMKPYAVMALENNYEVI 155
Cdd:COG4639    23 FAPTEVVSSDDIralLGGDENDQSAWGDVFQLAHE----IARARLRAGR-LTVVDATNLQREARRRLLALARAYGALVV 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH