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Conserved domains on  [gi|1219456094|ref|NP_001340704|]
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pejvakin isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gasdermin super family cl20270
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
2-239 1.21e-36

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


The actual alignment was detected with superfamily member pfam04598:

Pssm-ID: 398339  Cd Length: 240  Bit Score: 132.48  E-value: 1.21e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219456094   2 AFAWdaAPLSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLF--PRYKFTStpFTLKDILLGDREISAGIssyq 79
Cdd:pfam04598   1 MFEK--ATRNLVKELDSGGDLIPVDSLNDSTKFQPFCLVTKKKRSSWFwqPRYVPVD--FTLLDVLEPDSPVPEPV---- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219456094  80 llnyedESD-VSLYGRRGNHIVNDVGINVAGSDSIA-----VKASFGIVTKHEVEVSTLLKEITT--RKINFDHSLIRQS 151
Cdd:pfam04598  73 ------ESGfFKFKDKMDGKVQGDVEVAAGGELKIGggaavSQSSFGSLEVQELSVQPLTLESLQerKLLDPEPSFLQQC 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219456094 152 RSSRKaVLCVVMESIRTTRQCSLSVHA--------------GIRGEAmrfhfmdeQNPKGRDKAIVFPAHTTIAFSVFEL 217
Cdd:pfam04598 147 RERGE-NLYVVTEVIETTQEVVLTEHSqvegsgkgmlpgtkTVQGSG--------QGHKDKKVAVTIPKGTVLAYRVIQL 217
                         250       260
                  ....*....|....*....|...
gi 1219456094 218 FIYLDGAFDLCVTSVSK-GGFER 239
Cdd:pfam04598 218 VIKSDGQWEILLLDDDKqGTFEP 240
 
Name Accession Description Interval E-value
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
2-239 1.21e-36

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 132.48  E-value: 1.21e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219456094   2 AFAWdaAPLSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLF--PRYKFTStpFTLKDILLGDREISAGIssyq 79
Cdd:pfam04598   1 MFEK--ATRNLVKELDSGGDLIPVDSLNDSTKFQPFCLVTKKKRSSWFwqPRYVPVD--FTLLDVLEPDSPVPEPV---- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219456094  80 llnyedESD-VSLYGRRGNHIVNDVGINVAGSDSIA-----VKASFGIVTKHEVEVSTLLKEITT--RKINFDHSLIRQS 151
Cdd:pfam04598  73 ------ESGfFKFKDKMDGKVQGDVEVAAGGELKIGggaavSQSSFGSLEVQELSVQPLTLESLQerKLLDPEPSFLQQC 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219456094 152 RSSRKaVLCVVMESIRTTRQCSLSVHA--------------GIRGEAmrfhfmdeQNPKGRDKAIVFPAHTTIAFSVFEL 217
Cdd:pfam04598 147 RERGE-NLYVVTEVIETTQEVVLTEHSqvegsgkgmlpgtkTVQGSG--------QGHKDKKVAVTIPKGTVLAYRVIQL 217
                         250       260
                  ....*....|....*....|...
gi 1219456094 218 FIYLDGAFDLCVTSVSK-GGFER 239
Cdd:pfam04598 218 VIKSDGQWEILLLDDDKqGTFEP 240
 
Name Accession Description Interval E-value
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
2-239 1.21e-36

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 132.48  E-value: 1.21e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219456094   2 AFAWdaAPLSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLF--PRYKFTStpFTLKDILLGDREISAGIssyq 79
Cdd:pfam04598   1 MFEK--ATRNLVKELDSGGDLIPVDSLNDSTKFQPFCLVTKKKRSSWFwqPRYVPVD--FTLLDVLEPDSPVPEPV---- 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219456094  80 llnyedESD-VSLYGRRGNHIVNDVGINVAGSDSIA-----VKASFGIVTKHEVEVSTLLKEITT--RKINFDHSLIRQS 151
Cdd:pfam04598  73 ------ESGfFKFKDKMDGKVQGDVEVAAGGELKIGggaavSQSSFGSLEVQELSVQPLTLESLQerKLLDPEPSFLQQC 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1219456094 152 RSSRKaVLCVVMESIRTTRQCSLSVHA--------------GIRGEAmrfhfmdeQNPKGRDKAIVFPAHTTIAFSVFEL 217
Cdd:pfam04598 147 RERGE-NLYVVTEVIETTQEVVLTEHSqvegsgkgmlpgtkTVQGSG--------QGHKDKKVAVTIPKGTVLAYRVIQL 217
                         250       260
                  ....*....|....*....|...
gi 1219456094 218 FIYLDGAFDLCVTSVSK-GGFER 239
Cdd:pfam04598 218 VIKSDGQWEILLLDDDKqGTFEP 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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