NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1229385622|ref|NP_001341167|]
View 

lactosylceramide alpha-2,3-sialyltransferase isoform 4 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 163-373 1.46e-155

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467711  Cd Length: 211  Bit Score: 436.48  E-value: 1.46e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 163 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 242
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 243 FNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 322
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1229385622 323 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 373
Cdd:cd23983   161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 163-373 1.46e-155

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 436.48  E-value: 1.46e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 163 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 242
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 243 FNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 322
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1229385622 323 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 373
Cdd:cd23983   161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 128-378 1.45e-92

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 278.34  E-value: 1.45e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 128 SKYDPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG 207
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 208 NKTTIRMTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKKETLPF-WVRLFFWKQVaeKIPLQPKHFR 279
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 280 ILNPVIIKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQT 359
Cdd:pfam00777 165 FLHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*....
gi 1229385622 360 MHNVTTETKFLLKLVKEGV 378
Cdd:pfam00777 238 VHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 163-373 1.46e-155

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 436.48  E-value: 1.46e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 163 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 242
Cdd:cd23983     1 TCRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 243 FNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGRDKNVPTIGVIAVVLAT 322
Cdd:cd23983    81 FAWLKAMVKKEPLSFWSRLFFWKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQSRLWGWDKNVPTLGVTAVVLAT 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1229385622 323 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 373
Cdd:cd23983   161 HLCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 163-373 1.70e-120

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 347.36  E-value: 1.70e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 163 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 242
Cdd:cd23967     1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 243 FNWLQAMVKKETLPFWVrlFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQsrfwGRDKNVPTIGVIAVVLAT 322
Cdd:cd23967    81 LLWLQAVIKGKKPNGKG--GFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG----KQGKNVPTTGIIAIVMAL 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1229385622 323 HLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 373
Cdd:cd23967   155 HYCDEVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 128-378 1.45e-92

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 278.34  E-value: 1.45e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 128 SKYDPPFgfrkfsSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG 207
Cdd:pfam00777  16 SEWWLPF------TVTEELLELLPK---VSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 208 NKTTIRMTYPEGAPLSDL-------EYYSNDLFVAVLFKSVDFNWLQAMVKKETLPF-WVRLFFWKQVaeKIPLQPKHFR 279
Cdd:pfam00777  87 SKTTLRTMNPESAIDSKYgnlgfshPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRsLRVLYTLKEV--KIPVDPDKVL 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 280 ILNPVIIKETAFDILQYSEPQSRfwgrdknVPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQT 359
Cdd:pfam00777 165 FLHPDFLRYVANFWLRSHGLKGR-------RPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGGFYG 237

                         250
                  ....*....|....*....
gi 1229385622 360 MHNVTTETKFLLKLVKEGV 378
Cdd:pfam00777 238 VHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 163-373 4.43e-70

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 219.02  E-value: 4.43e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 163 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVD 242
Cdd:cd23981     1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 243 FNWLQAMVKKETlpfwVRLF--FWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEpQSRFWGRDkNVPTIGVIAVVL 320
Cdd:cd23981    81 FKWLKYIVYKEK----VSASdgFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPF-NNGLMGRG-NIPTLGSVAITM 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1229385622 321 ATHLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 373
Cdd:cd23981   155 ALHNCDEVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 163-373 1.05e-65

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 207.59  E-value: 1.05e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 163 TCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSND-LFVAVLFKSV 241
Cdd:cd23982     1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPGIENDPDtLLVLVPFKPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 242 DFNWLQAMVKKETLpfwVRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSrfwgrDKNVPTIGVIAVVLA 321
Cdd:cd23982    81 DFYWLYEILSNEKR---VRKGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVPGQRK-----KKQKPTTGLLAITLA 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1229385622 322 THLCDEVSLAGFGYDLNQ-PRTPLHYFDSQCMAAM-NFQtmHNVTTETKFLLKL 373
Cdd:cd23982   153 LHLCDEVHIAGFGYPDNGnSNQPIHYYNQITLKSMaNSG--HNLNAEAQAIQRL 204
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 164-373 2.68e-58

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 188.80  E-value: 2.68e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 164 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPLSDLEYYSNDLFVAVLFKSVDF 243
Cdd:cd23984     2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 244 NWL-QAMVKKETLPFWvrlfFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEpqsRFWGRDKNV-PTIGVIAVVLA 321
Cdd:cd23984    82 RWLlDLLMGKKVSAKG----FWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPK---RFPKEKKPKhPTTGIIAITLA 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1229385622 322 THLCDEVSLAGFGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETKFLLKL 373
Cdd:cd23984   155 LHICNEVHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 128-380 1.46e-38

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 139.70  E-value: 1.46e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 128 SKYDPPFGFRKFS-SKVQTLLELL--PEHDLPEHLKA--KTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGY 202
Cdd:cd23964    41 SHYKLPFGWGGLNrEVVERLLRNLnlTSSRYMFVLRGgrPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 203 SEHVGNKTTIRMTYPEGAPLSDLEYYSND---LFVAVLFKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFR 279
Cdd:cd23964   121 EKDVGTKTSFYTFFPESLHNSLLKHVPQDkdtKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVR 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 280 ILNPviiketafDILQYSEpqsRFWGRDKNV--PTIGVIAVVLATHLCDEVSLAGFGYDlnqPRTPLHYFDSQCMAAMNF 357
Cdd:cd23964   201 LLHP--------DFIRYLF---NRWLNSSTSyrPTTGALMLLTALHTCDQVSVYGFGYD---PRFSLHYYDKTFVKFTVF 266

                         250       260
                  ....*....|....*....|...
gi 1229385622 358 QTMHNVTTETKFLLKLVKEGVVK 380
Cdd:cd23964   267 YANHDFTNERKLWRKLHEEGIIN 289
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 167-373 7.21e-30

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 114.00  E-value: 7.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 167 CVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdlEYYSNDLFVAVLFKSVDFNWL 246
Cdd:cd19952     1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAG----FYLRGPRCGCHPLPLEEEVVL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 247 QAMVKKETLPFWVRLFFWKQVAEKIPLQPKHFRILNpviiketAFDILQYSEpqSRFWGRDKNVPTIGVIAVVLATHLCD 326
Cdd:cd19952    77 ILSRAAAADFKRLKRRKKRHDNAVLLLTDPAPDLLS-------YVRKRLEKL--GLKSFFGGNAPSSGLLAVLLALQLCD 147

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1229385622 327 EVSLAGFGYD-LNQPRTPLHYFDsqCMAAMNFQTMHNVTTETKFLLKL 373
Cdd:cd19952   148 SVDLYGFGVDsGHAPKVPYHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 143-380 6.61e-29

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 113.53  E-value: 6.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 143 VQTLLELLPEHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 222
Cdd:cd23966    56 LEKLFQVVPGENPYRTRDPNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVD 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 223 SDLEYYsndlFVAVLFKSVDFNWLQAMVKKETLpfwvrLFFWKQVAEKIPLQPKHFRILNPVIIKETAFdilQYSEPQSR 302
Cdd:cd23966   136 LDPGVH----LVLVPFKVLDLQWLISALTTGEI-----TRTYTPVKRFIKADKDKVLVINPAFIKYVHD---NWTEHHGR 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 303 FwgrdknvPTIGVIAVVLATHLCDEVSLAGFGYDLNQPRTplHYFDSQcMAAMNFQ--TMHNVTTETKFLLKLVKEGVVK 380
Cdd:cd23966   204 Y-------PSTGFLALIFALHICDEVSVFGFGADSKGNWH--HYWEKN-RSAGAFRktGVHDADFESDIIKKLAKEGKIR 273
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 92-380 2.75e-23

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 98.02  E-value: 2.75e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622  92 CRPKFAKTSMALLFEHRYSVDLLPFVQKAPKDSEAESKY-----DPPFGFRKFSSKVQTLLELLPEHDLPEHLKAKTCRR 166
Cdd:cd23979     3 CRRCVGDPGVSDWFDEHYDPDISPVWTKENMELPPDVQYwwmmlQPQFKPHNTKEVLSKLFQIIPGENPYRSWDPSRCRR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 167 CVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPlsdlEYYSNDLFVAVLFKSVDFNWL 246
Cdd:cd23979    83 CAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAK----NLPANVSFVLVPFKTLDLLWI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 247 QAMVKKETLPfwvrlFFWKQVAEKIPLQPKHFRILNPVIIKetaFDILQYSEPQSRFwgrdknvPTIGVIAVVLATHLCD 326
Cdd:cd23979   159 TSALSTGQIR-----FTYAPVKQFLRVDKDKVQIYNPAFFK---YIHDRWTEHHGRY-------PSTGMLVLFFALHVCD 223

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1229385622 327 EVSLAGFGYDlnqPRTPLHYFDSQCMAAMNFQT--MHNVTTETKFLLKLVKEGVVK 380
Cdd:cd23979   224 EVNVYGFGAD---SRGNWHHYWENNRYAGEFRKtgVHDADFEAHIIDMLAKAGKIK 276
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 144-380 1.57e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 95.79  E-value: 1.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 144 QTLLELLPEHDLPEHlkaKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKT--------TIRMT 215
Cdd:cd23963    46 KSLYELLPKTSPFSH---KRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTnlttlnpsILKRR 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 216 YPEGAP-------LSDLEYYSNDLFVAVLFKsvdFNWLQAMVKKetlpfwvrlffwkqVAEKIPLQPKHFRIlnpviike 288
Cdd:cd23963   123 YNSLKKnrdrdkfLNRLKEYNGSILWYPKFS---FKSSTNLLLK--------------AARALKKNGLNLTV-------- 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 289 tAFDILQYSEPQSRFWGRDKN--VPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDSqcMAAMNFQTMHNV 363
Cdd:cd23963   178 -VYSNPEHFLAVQKFWKRRGLekRPSTGLYLVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYDD--LSPSTKNKVHNM 254

                         250
                  ....*....|....*..
gi 1229385622 364 TTETKFLLKLVKEGVVK 380
Cdd:cd23963   255 PEEFKLLRELHKKGVLK 271
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 143-336 1.28e-21

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 93.41  E-value: 1.28e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 143 VQTLLELLP-EHDLPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEgap 221
Cdd:cd23980    59 IRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPE--- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 222 lSDLEYYSNDLFVAVLFKSVDFNWLQAMVKKETLPfwvrlFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSepqs 301
Cdd:cd23980   136 -SFRELAQNVSMILVPFKTLDLEWVISATTTGTIS-----HTYVPVPRKIKVKKEKILIYHPAFIKYVFDRWLQGH---- 205

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1229385622 302 rfwGRdknVPTIGVIAVVLATHLCDEVSLAGFGYD 336
Cdd:cd23980   206 ---GR---YPSTGILSVIFSLHVCDEVDLYGFGAD 234
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 110-373 2.62e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 89.64  E-value: 2.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 110 SVDLLPFVQKAPKDSEAEsKYDPPFGFRKFSskvqtlLELLPEHDLpehLKAKTCRRCVVIGSGGILHGLELGHTLNQFD 189
Cdd:cd23968     1 SEDLLCRLKKAAPFSTLR-KTTSPFKDLLSL------RYPFPESSL---ENTKRYNTCAVVSSSGALLGSKLGKEIDSHD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 190 VVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLSDLEYYSNDLFV--AVLFKSVDFNWLqamvKKETLPFWVRL 261
Cdd:cd23968    71 AVLRFNDAPTKGFEKDVGSKTTLRlinsqiLSKPEFNFLTDPLYRNVTLLVwdPSSYNVNLEKWY----KKPDFDFFPNY 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 262 FFWKQVaekIPLQPkhFRILNPVIIKEtAFDILQYSEPQSRFwgrdKNVPTIGVIAVVLATHLCDEVSLagFGYDLNQPR 341
Cdd:cd23968   147 IKYRRR---HPEEP--FYLIDPRFLWR-LWDILQEYTPEKIK----PNPPSSGFIGIVLMLHLCDWVDV--YEYVPSVRQ 214

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1229385622 342 TPL-HYFDSQCMAAMNFQTMHNVTTETKFLLKL 373
Cdd:cd23968   215 TDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 145-380 1.38e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 87.83  E-value: 1.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 145 TLLELLPEHdlpEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplSD 224
Cdd:cd23970    52 NLRSLLPEV---SPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNP-----SI 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 225 LEYYSNDLFVavlfKSVDFNWLQAMVKKETLPFWVRLFFWKQVAEKiplqpkhFRILNPVIIKETAFDILQYSEPQ---- 300
Cdd:cd23970   124 LEKYYNNLLT----IQDRNNFFLSLKKLDGAILWIPAFFFHTSATV-------TRTLVDFFVEHRGQLKVQLAWPGnimq 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 301 --SRFWGRDKNVP---TIGVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYFDSQ-CMAAMNFQTMHNVTTETKFLL 371
Cdd:cd23970   193 hvNRYWKTKHLSPkrlSTGILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKgTKFTTKWQESHQLPAEFVLLY 272


                  ....*....
gi 1229385622 372 KLVKEGVVK 380
Cdd:cd23970   273 KMHGAGVLK 281
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 130-380 4.92e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 86.73  E-value: 4.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 130 YDPPFGFRKFS-SKVQTLLELLPEHDLPEHLKA-----KTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYS 203
Cdd:cd23973    43 FNPPFGFMGLNyTLVKEVVELIPKPKEQQLLALsppggDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 204 EHVGNKTTIrmtYPEGAP--LSDLEYYSNDLF-----------VAVLFKSVDFNWLQAMVKKETLPfwvRLFFWKQVAEK 270
Cdd:cd23973   123 EDVGTRTSF---YVHTAHsiTSSLMILQKRGFknipqdkdikyILFPEGPRDYQWLEALLKNKTIP---SGAYYGRRPRS 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 271 I---PLQPKHFRILNPviiketafDILQYSepQSRFWgRDKNV---------PTIGVIAVVLATHLCDEVSLAGF---GY 335
Cdd:cd23973   197 YfsgDFTEDKYLVLHP--------DFLRYV--KNRFL-RSKTLkgkywaiyrPTTGAFLLLTALHLCDTVSAYGFiteDY 265

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1229385622 336 DlnqpRTPLHYFDSQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 380
Cdd:cd23973   266 R----KYPDHYYDKK-KTKLVFYINHDFRLEKKLWKRLHDEKIIK 305
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 144-380 8.13e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 79.98  E-value: 8.13e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 144 QTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPegaplS 223
Cdd:cd23987    47 QNLYELLPR---TSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNP-----S 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 224 DLEYYSNDLfvavlfksVDFNWLQAMVKK-ETLP---FWVRLFFWKQVAEKIplqpkhfRILNPVIIK-----ETAFDIL 294
Cdd:cd23987   119 VVQRAFEDL--------VNETWKEKFLQRlQSLNgsiLWIPAFMAKGGEERV-------EWVNDLILKhhinvRTAYPSL 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 295 QYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQTMHNVTTETK 368
Cdd:cd23987   184 RLLHAVRGYWLTNKvhiKRPTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFK 263

                         250
                  ....*....|..
gi 1229385622 369 FLLKLVKEGVVK 380
Cdd:cd23987   264 ALKNLHQQGALK 275
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 137-380 4.73e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 77.69  E-value: 4.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 137 RKFSSKVQTLLELLPEhdlPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVG--------N 208
Cdd:cd23988    40 RRTLNISQNLHSLLPE---VSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGtksdfitmN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 209 KTTIRMTYPEGAPLSDLEYYSNDLfvAVLFKSVdfnwlqamvkketlpFWVRLFFWKQvaekiplQPKHFRILNPVIIK- 287
Cdd:cd23988   117 PSVVQRAFGGFRNESDREKFVHRL--SMLNDSV---------------LWIPAFMVKG-------GEKHVEWVNALILKn 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 288 ----ETAFDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNF 357
Cdd:cd23988   173 klkvRTAYPSLRLIHAVRGYWLTNKvniKRPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSN 252

                         250       260
                  ....*....|....*....|...
gi 1229385622 358 QTMHNVTTETKFLLKLVKEGVVK 380
Cdd:cd23988   253 AGPHRMPLEFKTLNVLHNRGALK 275
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 144-380 8.64e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 76.68  E-value: 8.64e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 144 QTLLELLPEHDlPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPls 223
Cdd:cd23969    47 QDLYQLLPEVS-P--LKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIP-- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 224 dlEYYSNDLFVAVLFKSVDfnwlqamvkketlpfwvRLffwKQVAEKIPLQP--------KHFRILNPVIIKE-----TA 290
Cdd:cd23969   122 --HAYGDLVNATDKEKFVE-----------------RL---RQLGDSILWIPafvskggeEHVQWTNEIILKHklnvkTA 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 291 FDILQYSEPQSRFWGRDK---NVPTIGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQCMAAMNFQtmHNVT 364
Cdd:cd23969   180 YPPLRLNHAIRGYWLTTKfriKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLTTARP--HKMP 257

                         250
                  ....*....|....*.
gi 1229385622 365 TETKFLLKLVKEGVVK 380
Cdd:cd23969   258 EEFRALRSLHQRGALR 273
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 150-351 1.18e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 76.28  E-value: 1.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 150 LPEHDLPEhlKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIR------MTYPEGAPLS 223
Cdd:cd23985    33 LPKKSLRE--EVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRlinsqlVTTEKHKFLK 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 224 DLEYYSNDLFVavlfksvdfnWLQAMVKKEtLPFWVR----LFF--WKQVAEKIPLQPkhFRILNPVIIKETaFDILQYS 297
Cdd:cd23985   111 DSLYNEGILIV----------WDPAPYHSD-IPEWYKnpdyNFFenYKTYRRLNPNQP--FYILHPQMQWEL-WDIIQEN 176

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 298 EPQSrfwgRDKNVPTIGVIAVVLATHLCDEVSLAGFgydL-NQPRTPL-----HYFDSQC 351
Cdd:cd23985   177 SPEE----IQPNPPSSGMLGIILMMTLCDQVDVYEF---LpSKRKTDVchyyqKFFDRAC 229
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 165-382 2.08e-13

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 69.87  E-value: 2.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 165 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEgaPLSDLEYYSNDlfvAVLFKSVdfn 244
Cdd:cd23986    50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ--ILTNPNHHFID---SSLYKDV--- 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 245 wlqAMVKKETLPFWVRLFFW------------KQVAEKIPLQPkhFRILNPVIIKETaFDILQYSEPQSrfwgRDKNVPT 312
Cdd:cd23986   122 ---ILVAWDPAPYSANLHKWykkpdynlftpyVQYRKRNPNQP--FYILHPKFIWQL-WDIIQENTQEK----IQPNPPS 191

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1229385622 313 IGVIAVVLATHLCDEVSLAGFGYDLNQprTPL-HYFDSQCMAAMNFQTMHNVTTEtKFLLKLVKEGVVKDL 382
Cdd:cd23986   192 SGFIGILIMMSMCREVHVYEYIPSVRQ--TDLcHYHERYYDAACTLGAYHPLLYE-KLLIQRMNKGTEDDL 259
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 128-380 2.12e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 70.24  E-value: 2.12e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 128 SKYDPPFGFRKFSSK-VQTLLELLPEHD----LPEHLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGY 202
Cdd:cd23972    41 SQRKVPYGWKGLSHQvVASTLSLLNDSAnaklFFPRDTPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 203 SEHVGNKTTIR-----------MTY--------PEGaplSDLEYysndLFVAVLFKsvDFNWLQAMVKKETLPF------ 257
Cdd:cd23972   121 EEDVGTKTSFYgftvntmknslISYwnlgftrtPQG---QDLQY----IFIPSDIR--DYVMLRSAILGVPVPEgldkgd 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 258 -WVRLFFWKQVAEKiplqpkhFRILNPVIIKETAFDILQySEPQSRFWGrDKNVPTIGVIAVVLATHLCDEVSLAGFGYD 336
Cdd:cd23972   192 rPHKYFGPEASAKK-------FKLLHPDFISYLTDRFLK-SKLLNTHYG-HLYMPSTGALMLLTALHTCDQVSAYGFITS 262

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1229385622 337 lNQPRTPLHYFDSQcMAAMNFQTMHNVTTETKFLLKLVKEGVVK 380
Cdd:cd23972   263 -NYWKFSDHYYERK-KKPLVFYANHDMLLEAALWRRLHKAGILQ 304
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 129-380 4.14e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 68.82  E-value: 4.14e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 129 KYDppfGFRKFSSKV-QTLLELLPEhDLPehLKAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEgYSEHVG 207
Cdd:cd23971    34 HYE---GERKKTITVnEKLFSMLPK-ESP--FSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVG 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 208 NKT----------TIRMTYPEGAPLS---DLEYYSNDLFvavlfksvdfnWLQAMVKKETLPFWVRLFFwkqVAEKIPLQ 274
Cdd:cd23971   107 SKTnlvtanpsilREKFHNLKKRRRPfveRMKVYGNALL-----------LLPAFSYTSNTEPSLRALY---TLEDFGSP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 275 PKHFrILNPviiketafdilQYSEPQSRFWgRDKNVPTI----GVIAVVLATHLCDEVSLAGF---GYDLNQPRTPLHYF 347
Cdd:cd23971   173 QKVL-FFNP-----------EYLRNLSRYW-KSKGLKARrlstGLMLVSAALELCENVHLYGFwpfSTDLDGNPISHHYY 239

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1229385622 348 DsQCMAAMNFqtmHNVTTETKFLLKLVKEGVVK 380
Cdd:cd23971   240 D-NVLPKKGV---HAMPEEFLRYLKLHSQGVLR 268
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 164-215 3.42e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 65.34  E-value: 3.42e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1229385622 164 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMT 215
Cdd:cd23965     1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVV 52
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 164-380 2.24e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 64.00  E-value: 2.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 164 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMtypegaplsdleYYSNDLFVAVL-FKSVD 242
Cdd:cd23974    84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYT------------FSTNTLMNSLRaYAGVG 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 243 FNWLQamVKKET----LPFWVRLFFWKQVA------EKIP-------------LQPKHFRILNPviiketafDILQYSep 299
Cdd:cd23974   152 FNGPP--QSKETryifLPDHDRDYLLVKAAlthtpiDRGRdkskrpskyfgkdVTAEKFKIYHP--------DFIRYL-- 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 300 QSRF-WG-------RDKNVPTIGVIAVVLATHLCDEVSLAGF---GYDLNQPrtplHYFDSQcMAAMNFQTMHNVTTETK 368
Cdd:cd23974   220 RNRFlWSpilntkqRDIYRPSTGAVMLLAALHTCDQVSAYGFmtpDYGKYSD----HYYDKT-YHKVVFYANHDLRLEMQ 294

                         250
                  ....*....|..
gi 1229385622 369 FLLKLVKEGVVK 380
Cdd:cd23974   295 LWQKLHKAGLIK 306
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 157-348 2.10e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 60.65  E-value: 2.10e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 157 EHLKAKT-CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTypegaPLSDLEYysndlfva 235
Cdd:cd23976     7 DHKPLKMhCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-----AHSSIQR-------- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 236 VLFKSvdfNWLQAMVKKETLPFWVRLFFWKQVAEKipLQPKHFRILNPVIIKETAFDI-----LQYSEPQSRFWGRDKNV 310
Cdd:cd23976    74 ILRNR---NELLNVSQGTVFIFWGPSNYMRRDGKG--LVYNNLQLMNQILPKLKVYTItrhkmLQFDELFKRETGKDRKI 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1229385622 311 P----TIGVIAVVLATHLCDEVSLAG-----FGYDLNQPRTPLHYFD 348
Cdd:cd23976   149 SntwlSTGWFTMIIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 164-214 4.95e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 59.10  E-value: 4.95e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1229385622 164 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRM 214
Cdd:cd23978     1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 164-222 8.24e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 58.33  E-value: 8.24e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1229385622 164 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 222
Cdd:cd23977     1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPL 59
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 164-222 2.23e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 51.09  E-value: 2.23e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1229385622 164 CRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEGYSEHVGNKTTIRMTYPEGAPL 222
Cdd:cd23975     1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPL 59
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 165-380 2.59e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 51.68  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 165 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPVEG-YSEHVGNKTT--------IRMTYPE----GAP-LSDLEYYSN 230
Cdd:cd23991    65 KQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNlvtanpsiISIKYAKlnerRKPfLETVSVYGD 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 231 DLFvavLFKSVDFNWLQAMVKK--ETLpfwvRLFFWKQvaekiplQPKHFrilNPVIIKETAfdilqysepqsRFWgRDK 308
Cdd:cd23991   145 AFL---LLPAFSYRSNTALSFKvyYTL----EDFKAKQ-------KVIFF---HPIYLKHLA-----------QFW-RSK 195

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1229385622 309 NVP----TIGVIAVVLATHLCDEVSLAGF-GYDLNQPRTPL--HYFDSQcMAAMNFqtmHNVTTETKFLLKLVKEGVVK 380
Cdd:cd23991   196 GVQvyrlSTGLMITSAALELCEEVKLYGFwPFSKNTEGKPIshHYYDNQ-LPKPGF---HSMPKEFYQLLQLHSKGILK 270
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 144-361 2.28e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 48.68  E-value: 2.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 144 QTLLELLPEhDLPEHlkAKTCRRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV-EGYSEHVGNKTTIRMTYPEgapl 222
Cdd:cd23990    47 SEIFKMFPK-DMPYS--RSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPS---- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 223 sdleyysndlFVAVLFKSVDfnwlqamvkKETLPFWVRLffwkQVAEKIP-LQPKHFRILNPVIIKETAFDILQYSEPQ- 300
Cdd:cd23990   120 ----------IITERFHKLE---------KWRRPFYEVL----QVYENASvVLPAFYNTRNTDVSIRVKYVLDDFESQQa 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 301 ------------SRFWGRD---KNVPTIGVIAVVLATHLCDEVSLAGFG---------------YDLNQPRTPLHYFDSQ 350
Cdd:cd23990   177 vyyfhpqyllnvSRFWLRQgvrAKRISSGLMLVTAALELCEEVHLYGFWafpmnpsgifithhyYDNVKPRPGFHAMPSE 256

                         250
                  ....*....|.
gi 1229385622 351 CmaaMNFQTMH 361
Cdd:cd23990   257 I---FNFLHMH 264
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 165-380 5.75e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 44.44  E-value: 5.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 165 RRCVVIGSGGILHGLELGHTLNQFDVVIRLNSAPV-EGYSEHVGNKTTIRMTYPEgapLSDLEYYSNDLFVAVLFKSV-- 241
Cdd:cd23989    64 KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPS---IIDKRFQNLLWSRKSFVESMkv 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1229385622 242 ---DFNWLQAM-VKKETLP-FWVrlffWKQVAEKIPLQPKHFRilNPVIIKETafdilqysepqSRFW-GRD---KNVPT 312
Cdd:cd23989   141 ygrSYIYMPAFsMKTGTDPsLRV----YYTLADVGANQTVLFA--NPNFLRNV-----------GKFWkSKGvhaKRLST 203

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1229385622 313 iGVIAVVLATHLCDEVSLAG---FGYDLNQPRTPLHYFDSQcmaaMNFQTMHNVTTETKFLLKLVKEGVVK 380
Cdd:cd23989   204 -GLFLVSAALGLCEEVTIYGfwpFSVDLDERTISHHYYDNV----LPDSGFHAMPEEFLQLWHLHKSGVLR 269
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH