NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1237937701|ref|NP_001341370|]
View 

sodium-driven chloride bicarbonate exchanger isoform 5 [Homo sapiens]

Protein Classification

anion exchanger family transporter( domain architecture ID 705853)

anion exchanger family transporter similar to human SLC4 proteins which function as bicarbonate transporters

Gene Ontology:  GO:0005452|GO:0022857|GO:0055085
SCOP:  4003612
TCDB:  2.A.31

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Band_3_cyto super family cl26877
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
129-1072 0e+00

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


The actual alignment was detected with superfamily member TIGR00834:

Pssm-ID: 452680 [Multi-domain]  Cd Length: 900  Bit Score: 1123.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  129 FTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 208
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  209 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEpnsmdkNAGQVVSPQSAPACVENKNDVSR 288
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGGLSRARSQSSIGKTLSH------DASEMPNPDNGAPLLPHQPLTEM 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  289 enstvdfskglggqqkghTSPCGMKQRHEKGPPhqqerevDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVL 368
Cdd:TIGR00834  155 ------------------QLLSVPGDIGSREKS-------KLKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVP 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  369 LQGLAEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIR 448
Cdd:TIGR00834  210 LEALLEVPVPVRFLFVLLGPSGPGKDYHEIGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIR 289
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  449 IEPPKNVPSQEKRK----IPAVPNGTAAHGEAEPHGGHSG------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSL 518
Cdd:TIGR00834  290 LEPPAPLQRELLRKryepSTVRPENPTMGGDTEPEDGGSEgphgddDPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNP 369
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  519 QCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYG 598
Cdd:TIGR00834  370 QCLAAVIFIYFAALSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNG 449
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  599 LSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPinmhndleLLTQYSC 678
Cdd:TIGR00834  450 LEYLVGRVWIGLWLVLLVLLLVATEGSFLVRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHP--------LQVFYNT 521
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  679 NCVEPHNPSNGTLKEwresnisasdiiwenLTVSECKSLHGEYVGRACghdhPYVPDVLFWSVILFFSTVTLSATLKQFK 758
Cdd:TIGR00834  522 LFCVPPKPQGPSVSA---------------LLEKDCSKLGGTLGGNNC----RFQPNTALLSLVLMLGTFFLAMFLRKFK 582
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  759 TSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIG-IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPAL 833
Cdd:TIGR00834  583 NSRYFPGKARRLIGDFGVPISILIMVLVDIFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPAL 662
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  834 LCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPK 913
Cdd:TIGR00834  663 LVFILIFMEQQITTLIVSKKERKLKKGSGFHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQ 742
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  914 FLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRK 993
Cdd:TIGR00834  743 IQEVREQRVTGLLVAVLVGLSILMEPILKRIPLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWR 822
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  994 VHLFTIIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMD-LLFTKRELSWLDdlmPESKKKKLEDAEKEEEQSMLAM 1072
Cdd:TIGR00834  823 MHLFTAIQILCLALLWVVKSTPASLAFPFVLILTVPLRRLLLpRLFTERELKCLD---KEDAKVTFDEEDGEDEYNEVPM 899
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
129-1072 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 1123.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  129 FTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 208
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  209 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEpnsmdkNAGQVVSPQSAPACVENKNDVSR 288
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGGLSRARSQSSIGKTLSH------DASEMPNPDNGAPLLPHQPLTEM 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  289 enstvdfskglggqqkghTSPCGMKQRHEKGPPhqqerevDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVL 368
Cdd:TIGR00834  155 ------------------QLLSVPGDIGSREKS-------KLKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVP 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  369 LQGLAEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIR 448
Cdd:TIGR00834  210 LEALLEVPVPVRFLFVLLGPSGPGKDYHEIGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIR 289
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  449 IEPPKNVPSQEKRK----IPAVPNGTAAHGEAEPHGGHSG------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSL 518
Cdd:TIGR00834  290 LEPPAPLQRELLRKryepSTVRPENPTMGGDTEPEDGGSEgphgddDPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNP 369
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  519 QCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYG 598
Cdd:TIGR00834  370 QCLAAVIFIYFAALSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNG 449
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  599 LSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPinmhndleLLTQYSC 678
Cdd:TIGR00834  450 LEYLVGRVWIGLWLVLLVLLLVATEGSFLVRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHP--------LQVFYNT 521
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  679 NCVEPHNPSNGTLKEwresnisasdiiwenLTVSECKSLHGEYVGRACghdhPYVPDVLFWSVILFFSTVTLSATLKQFK 758
Cdd:TIGR00834  522 LFCVPPKPQGPSVSA---------------LLEKDCSKLGGTLGGNNC----RFQPNTALLSLVLMLGTFFLAMFLRKFK 582
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  759 TSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIG-IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPAL 833
Cdd:TIGR00834  583 NSRYFPGKARRLIGDFGVPISILIMVLVDIFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPAL 662
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  834 LCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPK 913
Cdd:TIGR00834  663 LVFILIFMEQQITTLIVSKKERKLKKGSGFHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQ 742
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  914 FLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRK 993
Cdd:TIGR00834  743 IQEVREQRVTGLLVAVLVGLSILMEPILKRIPLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWR 822
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  994 VHLFTIIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMD-LLFTKRELSWLDdlmPESKKKKLEDAEKEEEQSMLAM 1072
Cdd:TIGR00834  823 MHLFTAIQILCLALLWVVKSTPASLAFPFVLILTVPLRRLLLpRLFTERELKCLD---KEDAKVTFDEEDGEDEYNEVPM 899
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
492-1000 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 918.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  492 RIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGG 571
Cdd:pfam00955    1 RLFGGLINDIKRRYPHYLSDFTDALNLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGIIFALFAG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  572 QPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEA 651
Cdd:pfam00955   81 QPLTILGSTGPLLVFEKILFKFCKDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  652 LEKLFELSEAYPINMHndlelltqYSCNCVEP--HNPSNGTLKEWRESNIsasdIIWEN-LTVSECK-SLHGEYVGRACG 727
Cdd:pfam00955  161 FKKLIKIFKKYPLYLN--------YDCTCVPPssNNTTNSTLSLSTESSS----INWSSlLTNSECTeSYGGTLVGSGCG 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  728 hdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTR 807
Cdd:pfam00955  229 ----YVPDTALLSLILFLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTR 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  808 DDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVA 887
Cdd:pfam00955  305 PDRGWIINPFGKNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVA 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  888 ATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFF 967
Cdd:pfam00955  385 ATVRSITHVNSLKVESECVAPGEKPKILGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFF 464
                          490       500       510
                   ....*....|....*....|....*....|...
gi 1237937701  968 DRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTII 1000
Cdd:pfam00955  465 DRILLLFMPQKHQPDTHYLRHVPLRKVHLFTLI 497
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
862-1015 8.01e-04

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 43.37  E-value: 8.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  862 GYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNS-LKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSV----- 935
Cdd:cd17484    152 GYLLELLGPRTVFAVTSFFPLLLLIVAFFVKEERVPPhRTKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSsgsam 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  936 --FMTSILKFIPMpvlygvflYMG-------ASSLKGIQFFDRiklfwmpakhqpdfiYLRHVPLRKVHLFTIIQMSCLG 1006
Cdd:cd17484    232 fyFMTNELGFSPE--------FLGrlrvigsIASLLGVLLYNR---------------FLKHVPFRKIFFWTTVLLVLLG 288

                   ....*....
gi 1237937701 1007 LLWIIKVSR 1015
Cdd:cd17484    289 LTDLILVTR 297
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
348-432 6.01e-03

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 38.68  E-value: 6.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  348 GELEFLDRTVVAFVRLSPAVLLQGLAEVPIptRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSG 427
Cdd:COG1762     68 ARPEGVKKPGIAVARLKEPVDFGAMDGEPV--DLVFLLAAPEDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILEL 145

                   ....*
gi 1237937701  428 IDEFL 432
Cdd:COG1762    146 LKEAE 150
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
129-1072 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 1123.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  129 FTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 208
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  209 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGKKQSEpnsmdkNAGQVVSPQSAPACVENKNDVSR 288
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGGLSRARSQSSIGKTLSH------DASEMPNPDNGAPLLPHQPLTEM 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  289 enstvdfskglggqqkghTSPCGMKQRHEKGPPhqqerevDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVL 368
Cdd:TIGR00834  155 ------------------QLLSVPGDIGSREKS-------KLKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVP 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  369 LQGLAEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIR 448
Cdd:TIGR00834  210 LEALLEVPVPVRFLFVLLGPSGPGKDYHEIGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIR 289
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  449 IEPPKNVPSQEKRK----IPAVPNGTAAHGEAEPHGGHSG------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSL 518
Cdd:TIGR00834  290 LEPPAPLQRELLRKryepSTVRPENPTMGGDTEPEDGGSEgphgddDPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNP 369
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  519 QCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYG 598
Cdd:TIGR00834  370 QCLAAVIFIYFAALSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNG 449
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  599 LSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPinmhndleLLTQYSC 678
Cdd:TIGR00834  450 LEYLVGRVWIGLWLVLLVLLLVATEGSFLVRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHP--------LQVFYNT 521
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  679 NCVEPHNPSNGTLKEwresnisasdiiwenLTVSECKSLHGEYVGRACghdhPYVPDVLFWSVILFFSTVTLSATLKQFK 758
Cdd:TIGR00834  522 LFCVPPKPQGPSVSA---------------LLEKDCSKLGGTLGGNNC----RFQPNTALLSLVLMLGTFFLAMFLRKFK 582
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  759 TSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIG-IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPAL 833
Cdd:TIGR00834  583 NSRYFPGKARRLIGDFGVPISILIMVLVDIFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPAL 662
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  834 LCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPK 913
Cdd:TIGR00834  663 LVFILIFMEQQITTLIVSKKERKLKKGSGFHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQ 742
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  914 FLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRK 993
Cdd:TIGR00834  743 IQEVREQRVTGLLVAVLVGLSILMEPILKRIPLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWR 822
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  994 VHLFTIIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMD-LLFTKRELSWLDdlmPESKKKKLEDAEKEEEQSMLAM 1072
Cdd:TIGR00834  823 MHLFTAIQILCLALLWVVKSTPASLAFPFVLILTVPLRRLLLpRLFTERELKCLD---KEDAKVTFDEEDGEDEYNEVPM 899
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
492-1000 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 918.84  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  492 RIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGG 571
Cdd:pfam00955    1 RLFGGLINDIKRRYPHYLSDFTDALNLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGIIFALFAG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  572 QPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEA 651
Cdd:pfam00955   81 QPLTILGSTGPLLVFEKILFKFCKDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  652 LEKLFELSEAYPINMHndlelltqYSCNCVEP--HNPSNGTLKEWRESNIsasdIIWEN-LTVSECK-SLHGEYVGRACG 727
Cdd:pfam00955  161 FKKLIKIFKKYPLYLN--------YDCTCVPPssNNTTNSTLSLSTESSS----INWSSlLTNSECTeSYGGTLVGSGCG 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  728 hdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTR 807
Cdd:pfam00955  229 ----YVPDTALLSLILFLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTR 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  808 DDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVA 887
Cdd:pfam00955  305 PDRGWIINPFGKNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVA 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  888 ATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFF 967
Cdd:pfam00955  385 ATVRSITHVNSLKVESECVAPGEKPKILGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFF 464
                          490       500       510
                   ....*....|....*....|....*....|...
gi 1237937701  968 DRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTII 1000
Cdd:pfam00955  465 DRILLLFMPQKHQPDTHYLRHVPLRKVHLFTLI 497
Band_3_cyto pfam07565
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
157-439 1.18e-121

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


Pssm-ID: 429542  Cd Length: 255  Bit Score: 374.36  E-value: 1.18e-121
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  157 DVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQN 236
Cdd:pfam07565    1 DVEEEGGRWGKPHVATLSFHSLLELRRCLAKGTVLLDLEATSLPGVAHLVLDQMIYSGQIRPEDREEVLRALLLKHSHQN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  237 -QKKLTNRIPIVRSFADIGKKQSEPNsmdkNAGQVVSPQSAPacvenkndvsrenstvdfskgLGGQQKGHTSPCGMKqr 315
Cdd:pfam07565   81 eLKELGGVKPAVRSLSSIGSSLSHGH----DDSKPLLPQQSS---------------------LEGGLLCEQGEGPNS-- 133
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  316 HEKGPPHqqEREVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQY 395
Cdd:pfam07565  134 DEQLTVS--ESKSPLHFLKKIPEDAEATNVLVGEVDFLERPVLAFVRLKEAVPLEGVTEVPVPVRFLFILLGPSGPGLDY 211
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1237937701  396 HEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLP 439
Cdd:pfam07565  212 HEIGRAIATLMSDEVFHDVAYKADDREDLLAGIDEFLDCSIVLP 255
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
862-1015 8.01e-04

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 43.37  E-value: 8.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  862 GYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNS-LKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSV----- 935
Cdd:cd17484    152 GYLLELLGPRTVFAVTSFFPLLLLIVAFFVKEERVPPhRTKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSsgsam 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  936 --FMTSILKFIPMpvlygvflYMG-------ASSLKGIQFFDRiklfwmpakhqpdfiYLRHVPLRKVHLFTIIQMSCLG 1006
Cdd:cd17484    232 fyFMTNELGFSPE--------FLGrlrvigsIASLLGVLLYNR---------------FLKHVPFRKIFFWTTVLLVLLG 288

                   ....*....
gi 1237937701 1007 LLWIIKVSR 1015
Cdd:cd17484    289 LTDLILVTR 297
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
348-432 6.01e-03

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 38.68  E-value: 6.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237937701  348 GELEFLDRTVVAFVRLSPAVLLQGLAEVPIptRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSG 427
Cdd:COG1762     68 ARPEGVKKPGIAVARLKEPVDFGAMDGEPV--DLVFLLAAPEDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILEL 145

                   ....*
gi 1237937701  428 IDEFL 432
Cdd:COG1762    146 LKEAE 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH