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Conserved domains on  [gi|1241781262|ref|NP_001341374|]
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sodium-driven chloride bicarbonate exchanger isoform 9 [Homo sapiens]

Protein Classification

anion exchanger family transporter( domain architecture ID 705853)

anion exchanger family transporter similar to human SLC4 proteins which function as bicarbonate transporters

Gene Ontology:  GO:0005452|GO:0022857|GO:0055085
SCOP:  4003612
TCDB:  2.A.31

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Band_3_cyto super family cl26877
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
129-1042 0e+00

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


The actual alignment was detected with superfamily member TIGR00834:

Pssm-ID: 452680 [Multi-domain]  Cd Length: 900  Bit Score: 1133.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  129 FTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 208
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  209 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGK-KQSEPNSMDKNAGQVVSPQSAPACVENKNDVS 287
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGGLSRARSQSSIGKtLSHDASEMPNPDNGAPLLPHQPLTEMQLLSVP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  288 RENSTVDFSKvdLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHE 367
Cdd:TIGR00834  161 GDIGSREKSK--LKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGPSGPGKDYHE 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  368 IGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRK----IPAVPNGTAAH 443
Cdd:TIGR00834  239 IGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQRELLRKryepSTVRPENPTMG 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  444 GEAEPHGGHSG------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATE 517
Cdd:TIGR00834  319 GDTEPEDGGSEgphgddDPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNPQCLAAVIFIYFAALSPAITFGGLLGEKTR 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  518 GRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSL 597
Cdd:TIGR00834  399 NMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIGLWLVLLVLLLVATEGSFL 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  598 VCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPinmhndleLLTQYSCNCVEPHNPSNGTLKEwresnisasdiiwe 677
Cdd:TIGR00834  479 VRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHP--------LQVFYNTLFCVPPKPQGPSVSA-------------- 536
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  678 nLTVSECKSLHGEYVGRACGhdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLID 757
Cdd:TIGR00834  537 -LLEKDCSKLGGTLGGNNCR----FQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVD 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  758 YAIG-IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCG 832
Cdd:TIGR00834  612 IFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSG 691
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  833 YHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILK 912
Cdd:TIGR00834  692 FHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILK 771
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  913 FIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPM 992
Cdd:TIGR00834  772 RIPLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPF 851
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1241781262  993 MVLALVFVRKLMD-LLFTKRELSWLDdlmPESKKKKLEDAEKEEEQSMLAM 1042
Cdd:TIGR00834  852 VLILTVPLRRLLLpRLFTERELKCLD---KEDAKVTFDEEDGEDEYNEVPM 899
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
129-1042 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 1133.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  129 FTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 208
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  209 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGK-KQSEPNSMDKNAGQVVSPQSAPACVENKNDVS 287
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGGLSRARSQSSIGKtLSHDASEMPNPDNGAPLLPHQPLTEMQLLSVP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  288 RENSTVDFSKvdLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHE 367
Cdd:TIGR00834  161 GDIGSREKSK--LKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGPSGPGKDYHE 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  368 IGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRK----IPAVPNGTAAH 443
Cdd:TIGR00834  239 IGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQRELLRKryepSTVRPENPTMG 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  444 GEAEPHGGHSG------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATE 517
Cdd:TIGR00834  319 GDTEPEDGGSEgphgddDPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNPQCLAAVIFIYFAALSPAITFGGLLGEKTR 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  518 GRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSL 597
Cdd:TIGR00834  399 NMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIGLWLVLLVLLLVATEGSFL 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  598 VCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPinmhndleLLTQYSCNCVEPHNPSNGTLKEwresnisasdiiwe 677
Cdd:TIGR00834  479 VRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHP--------LQVFYNTLFCVPPKPQGPSVSA-------------- 536
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  678 nLTVSECKSLHGEYVGRACGhdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLID 757
Cdd:TIGR00834  537 -LLEKDCSKLGGTLGGNNCR----FQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVD 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  758 YAIG-IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCG 832
Cdd:TIGR00834  612 IFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSG 691
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  833 YHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILK 912
Cdd:TIGR00834  692 FHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILK 771
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  913 FIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPM 992
Cdd:TIGR00834  772 RIPLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPF 851
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1241781262  993 MVLALVFVRKLMD-LLFTKRELSWLDdlmPESKKKKLEDAEKEEEQSMLAM 1042
Cdd:TIGR00834  852 VLILTVPLRRLLLpRLFTERELKCLD---KEDAKVTFDEEDGEDEYNEVPM 899
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
462-970 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 916.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  462 RIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGG 541
Cdd:pfam00955    1 RLFGGLINDIKRRYPHYLSDFTDALNLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGIIFALFAG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  542 QPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEA 621
Cdd:pfam00955   81 QPLTILGSTGPLLVFEKILFKFCKDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  622 LEKLFELSEAYPINMHndlelltqYSCNCVEP--HNPSNGTLKEWRESNIsasdIIWEN-LTVSECK-SLHGEYVGRACG 697
Cdd:pfam00955  161 FKKLIKIFKKYPLYLN--------YDCTCVPPssNNTTNSTLSLSTESSS----INWSSlLTNSECTeSYGGTLVGSGCG 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  698 hdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTR 777
Cdd:pfam00955  229 ----YVPDTALLSLILFLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTR 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  778 DDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVA 857
Cdd:pfam00955  305 PDRGWIINPFGKNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVA 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  858 ATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFF 937
Cdd:pfam00955  385 ATVRSITHVNSLKVESECVAPGEKPKILGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFF 464
                          490       500       510
                   ....*....|....*....|....*....|...
gi 1241781262  938 DRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTII 970
Cdd:pfam00955  465 DRILLLFMPQKHQPDTHYLRHVPLRKVHLFTLI 497
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
832-985 9.25e-04

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 42.98  E-value: 9.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  832 GYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNS-LKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSV----- 905
Cdd:cd17484    152 GYLLELLGPRTVFAVTSFFPLLLLIVAFFVKEERVPPhRTKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSsgsam 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  906 --FMTSILKFIPMpvlygvflYMG-------ASSLKGIQFFDRiklfwmpakhqpdfiYLRHVPLRKVHLFTIIQMSCLG 976
Cdd:cd17484    232 fyFMTNELGFSPE--------FLGrlrvigsIASLLGVLLYNR---------------FLKHVPFRKIFFWTTVLLVLLG 288

                   ....*....
gi 1241781262  977 LLWIIKVSR 985
Cdd:cd17484    289 LTDLILVTR 297
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
318-402 6.65e-03

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 38.29  E-value: 6.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  318 GELEFLDRTVVAFVRLSPAVLLQGLAEVPIptRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSG 397
Cdd:COG1762     68 ARPEGVKKPGIAVARLKEPVDFGAMDGEPV--DLVFLLAAPEDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILEL 145

                   ....*
gi 1241781262  398 IDEFL 402
Cdd:COG1762    146 LKEAE 150
 
Name Accession Description Interval E-value
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
129-1042 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 1133.72  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  129 FTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLD 208
Cdd:TIGR00834    1 FVELNELMLDRNQEPEWRETARWIKFEEDVEEGGGRWGKPHVATLSFHSLLELRRCFAKGAILLDLAATSLPGVANMVVD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  209 QQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLTNRIPIVRSFADIGK-KQSEPNSMDKNAGQVVSPQSAPACVENKNDVS 287
Cdd:TIGR00834   81 HLIYSGQIRPEDRDEVLRALLLKHSHQSDAKKLGGLSRARSQSSIGKtLSHDASEMPNPDNGAPLLPHQPLTEMQLLSVP 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  288 RENSTVDFSKvdLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHE 367
Cdd:TIGR00834  161 GDIGSREKSK--LKFLKKIPEDAEATNVLVGEVDFLEQPALAFVRLKEAVPLEALLEVPVPVRFLFVLLGPSGPGKDYHE 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  368 IGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRK----IPAVPNGTAAH 443
Cdd:TIGR00834  239 IGRAIATLMSDEVFHDAAYLADDRDDLLAGIDEFLDCSIVLPPGEWDPEIRLEPPAPLQRELLRKryepSTVRPENPTMG 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  444 GEAEPHGGHSG------PELQRTGRIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATE 517
Cdd:TIGR00834  319 GDTEPEDGGSEgphgddDPLQRTGRPFGGLIRDIKRRYPHYLSDFTDALNPQCLAAVIFIYFAALSPAITFGGLLGEKTR 398
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  518 GRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSL 597
Cdd:TIGR00834  399 NMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIGLWLVLLVLLLVATEGSFL 478
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  598 VCYITRFTEEAFASLICIIFIYEALEKLFELSEAYPinmhndleLLTQYSCNCVEPHNPSNGTLKEwresnisasdiiwe 677
Cdd:TIGR00834  479 VRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHP--------LQVFYNTLFCVPPKPQGPSVSA-------------- 536
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  678 nLTVSECKSLHGEYVGRACGhdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLID 757
Cdd:TIGR00834  537 -LLEKDCSKLGGTLGGNNCR----FQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLIGDFGVPISILIMVLVD 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  758 YAIG-IPSPKLQVPSVFKPTR-DDRGWFVTPLG---PNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCG 832
Cdd:TIGR00834  612 IFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPALLVFILIFMEQQITTLIVSKKERKLKKGSG 691
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  833 YHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILK 912
Cdd:TIGR00834  692 FHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLLVAVLVGLSILMEPILK 771
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  913 FIPMPVLYGVFLYMGASSLKGIQFFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTIIQMSCLGLLWIIKVSRAAIVFPM 992
Cdd:TIGR00834  772 RIPLAVLFGIFLYMGVTSLSGIQLFDRLLLLLMPPKYHPDVPYVRRVKTWRMHLFTAIQILCLALLWVVKSTPASLAFPF 851
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1241781262  993 MVLALVFVRKLMD-LLFTKRELSWLDdlmPESKKKKLEDAEKEEEQSMLAM 1042
Cdd:TIGR00834  852 VLILTVPLRRLLLpRLFTERELKCLD---KEDAKVTFDEEDGEDEYNEVPM 899
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
462-970 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 460009  Cd Length: 497  Bit Score: 916.53  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  462 RIFGGLILDIKRKAPYFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGG 541
Cdd:pfam00955    1 RLFGGLINDIKRRYPHYLSDFTDALNLQCLASIIFLYFACLSPAITFGGLLGDATDGYIGVSESILSQAIGGIIFALFAG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  542 QPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEA 621
Cdd:pfam00955   81 QPLTILGSTGPLLVFEKILFKFCKDNGLDYLSFRAWIGLWLAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEA 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  622 LEKLFELSEAYPINMHndlelltqYSCNCVEP--HNPSNGTLKEWRESNIsasdIIWEN-LTVSECK-SLHGEYVGRACG 697
Cdd:pfam00955  161 FKKLIKIFKKYPLYLN--------YDCTCVPPssNNTTNSTLSLSTESSS----INWSSlLTNSECTeSYGGTLVGSGCG 228
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  698 hdhpYVPDVLFWSVILFFSTVTLSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTR 777
Cdd:pfam00955  229 ----YVPDTALLSLILFLGTFWLAYFLKQFKNSPFFPTKVRRLISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTR 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  778 DDRGWFVTPLGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVA 857
Cdd:pfam00955  305 PDRGWIINPFGKNPWWLILAAILPALLVTILIFMDQQITAVIVNRKENKLKKGSGYHLDLFVVAILNGICSLFGLPWMVA 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  858 ATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQFF 937
Cdd:pfam00955  385 ATVRSITHVNSLKVESECVAPGEKPKILGVREQRVTGLLVFILIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLSGIQFF 464
                          490       500       510
                   ....*....|....*....|....*....|...
gi 1241781262  938 DRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTII 970
Cdd:pfam00955  465 DRILLLFMPQKHQPDTHYLRHVPLRKVHLFTLI 497
Band_3_cyto pfam07565
Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion ...
157-409 1.10e-127

Band 3 cytoplasmic domain; This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).


Pssm-ID: 429542  Cd Length: 255  Bit Score: 389.77  E-value: 1.10e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  157 DVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQN 236
Cdd:pfam07565    1 DVEEEGGRWGKPHVATLSFHSLLELRRCLAKGTVLLDLEATSLPGVAHLVLDQMIYSGQIRPEDREEVLRALLLKHSHQN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  237 -QKKLTNRIPIVRSFADIGKKQSEPNSMDKNAGQVVSP-QSAPACVENKNDVSRENSTVDFSKVDLHFMKKIPPGAEASN 314
Cdd:pfam07565   81 eLKELGGVKPAVRSLSSIGSSLSHGHDDSKPLLPQQSSlEGGLLCEQGEGPNSDEQLTVSESKSPLHFLKKIPEDAEATN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  315 ILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPTRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDL 394
Cdd:pfam07565  161 VLVGEVDFLERPVLAFVRLKEAVPLEGVTEVPVPVRFLFILLGPSGPGLDYHEIGRAIATLMSDEVFHDVAYKADDREDL 240
                          250
                   ....*....|....*
gi 1241781262  395 VSGIDEFLDQVTVLP 409
Cdd:pfam07565  241 LAGIDEFLDCSIVLP 255
MFS_FBT cd17484
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ...
832-985 9.25e-04

Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341037 [Multi-domain]  Cd Length: 399  Bit Score: 42.98  E-value: 9.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  832 GYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNS-LKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSV----- 905
Cdd:cd17484    152 GYLLELLGPRTVFAVTSFFPLLLLIVAFFVKEERVPPhRTKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSsgsam 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  906 --FMTSILKFIPMpvlygvflYMG-------ASSLKGIQFFDRiklfwmpakhqpdfiYLRHVPLRKVHLFTIIQMSCLG 976
Cdd:cd17484    232 fyFMTNELGFSPE--------FLGrlrvigsIASLLGVLLYNR---------------FLKHVPFRKIFFWTTVLLVLLG 288

                   ....*....
gi 1241781262  977 LLWIIKVSR 985
Cdd:cd17484    289 LTDLILVTR 297
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
318-402 6.65e-03

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 38.29  E-value: 6.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781262  318 GELEFLDRTVVAFVRLSPAVLLQGLAEVPIptRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSG 397
Cdd:COG1762     68 ARPEGVKKPGIAVARLKEPVDFGAMDGEPV--DLVFLLAAPEDDSEEHLKLLAELARLLSDEEFREKLLNAKSPEEILEL 145

                   ....*
gi 1241781262  398 IDEFL 402
Cdd:COG1762    146 LKEAE 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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