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Conserved domains on  [gi|1241781220|ref|NP_001341489|]
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protein NDRG2 isoform h [Homo sapiens]

Protein Classification

NDRG family protein( domain architecture ID 11140417)

N-myc downstream-regulated gene (NDRG) family protein may be involved in cellular differentiation events; similar to Homo sapiens protein NDRG1, which is a stress-responsive protein involved in hormone responses, cell growth, and differentiation; belongs to the alpha/beta hydrolase superfamily

CATH:  3.40.50.1820
PubMed:  12369917|19508187|20667976|37582413|31545554
SCOP:  3000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 26-293 1.44e-158

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


:

Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 445.26  E-value: 1.44e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220  26 THSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYP 105
Cdd:pfam03096   1 EHIIETPCGSVHVTVYGDPEGKKPPILTYHDLGLNHKSCFQGLFNSESMQEILENFCIYHVDAPGQEDGAASFPGGYPYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 106 SLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLT-------GLTSS 178
Cdd:pfam03096  81 SMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTPKAAGWIEWFYNKLSskllyyyGMTDS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 179 IPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITlRCPVMLVVGDQAPHEDAV- 257
Cdd:pfam03096 161 AKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSRRDLTIERPGLET-KCPVLLVVGDNSPHVDAVv 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781220 258 ----------TSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMA 293
Cdd:pfam03096 240 ecntkldptkTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGYYP 285
 
Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 26-293 1.44e-158

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 445.26  E-value: 1.44e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220  26 THSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYP 105
Cdd:pfam03096   1 EHIIETPCGSVHVTVYGDPEGKKPPILTYHDLGLNHKSCFQGLFNSESMQEILENFCIYHVDAPGQEDGAASFPGGYPYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 106 SLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLT-------GLTSS 178
Cdd:pfam03096  81 SMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTPKAAGWIEWFYNKLSskllyyyGMTDS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 179 IPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITlRCPVMLVVGDQAPHEDAV- 257
Cdd:pfam03096 161 AKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSRRDLTIERPGLET-KCPVLLVVGDNSPHVDAVv 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781220 258 ----------TSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMA 293
Cdd:pfam03096 240 ecntkldptkTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGYYP 285
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 84-156 9.68e-06

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 46.15  E-value: 9.68e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1241781220  84 VHVDAPGMeeGA-PVFPLGYqypSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLIN 156
Cdd:COG0596    53 IAPDLRGH--GRsDKPAGGY---TLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD 121
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 122-188 6.20e-05

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 44.52  E-value: 6.20e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 122 NFSTIIGVGVGAGAYILARYALNHPDTVEGLVLI---NIDPNAKGWMDWaahkLTGLTSSIPEMILGHLF 188
Cdd:PLN02894  174 NLSNFILLGHSFGGYVAAKYALKHPEHVQHLILVgpaGFSSESDDKSEW----LTKFRATWKGAVLNHLW 239
 
Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 26-293 1.44e-158

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 445.26  E-value: 1.44e-158
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220  26 THSVETPYGSVTFTVYGTPKPKRPAILTYHDVGLNYKSCFQPLFQFEDMQEIIQNFVRVHVDAPGMEEGAPVFPLGYQYP 105
Cdd:pfam03096   1 EHIIETPCGSVHVTVYGDPEGKKPPILTYHDLGLNHKSCFQGLFNSESMQEILENFCIYHVDAPGQEDGAASFPGGYPYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 106 SLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAKGWMDWAAHKLT-------GLTSS 178
Cdd:pfam03096  81 SMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTPKAAGWIEWFYNKLSskllyyyGMTDS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 179 IPEMILGHLFSQEELSGNSELIQKYRNIITHAPNLDNIELYWNSYNNRRDLNFERGGDITlRCPVMLVVGDQAPHEDAV- 257
Cdd:pfam03096 161 AKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSRRDLTIERPGLET-KCPVLLVVGDNSPHVDAVv 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781220 258 ----------TSFLKMADSGGQPQLTQPGKLTEAFKYFLQGMGYMA 293
Cdd:pfam03096 240 ecntkldptkTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGYYP 285
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 84-156 9.68e-06

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 46.15  E-value: 9.68e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1241781220  84 VHVDAPGMeeGA-PVFPLGYqypSLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLIN 156
Cdd:COG0596    53 IAPDLRGH--GRsDKPAGGY---TLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVD 121
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 122-188 6.20e-05

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 44.52  E-value: 6.20e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 122 NFSTIIGVGVGAGAYILARYALNHPDTVEGLVLI---NIDPNAKGWMDWaahkLTGLTSSIPEMILGHLF 188
Cdd:PLN02894  174 NLSNFILLGHSFGGYVAAKYALKHPEHVQHLILVgpaGFSSESDDKSEW----LTKFRATWKGAVLNHLW 239
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 106-250 8.59e-05

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 43.26  E-value: 8.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 106 SLDQLADMIPCVLQYLNFSTIIGVGVGAGAYILARYALNHPDTVEGLVLINIDPNAK--------------GWMD-WAAH 170
Cdd:pfam00561  51 RTDDLAEDLEYILEALGLEKVNLVGHSMGGLIALAYAAKYPDRVKALVLLGALDPPHeldeadrfilalfpGFFDgFVAD 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781220 171 KLTGLTSSIPEMILGHLFSQEELSGNSEL--IQKYRNIITHAPNLD-NIELYWNSYNNRrdLNFERGGDItlRCPVMLVV 247
Cdd:pfam00561 131 FAPNPLGRLVAKLLALLLLRLRLLKALPLlnKRFPSGDYALAKSLVtGALLFIETWSTE--LRAKFLGRL--DEPTLIIW 206


                  ...
gi 1241781220 248 GDQ 250
Cdd:pfam00561 207 GDQ 209
B12D pfam06522
NADH-ubiquinone reductase complex 1 MLRQ subunit; The MLRQ subunit of mitochondrial ...
 126-171 4.93e-03

NADH-ubiquinone reductase complex 1 MLRQ subunit; The MLRQ subunit of mitochondrial NADH-ubiquinone reductase complex I is nuclear and is found in plants, insects, fungi and higher metazoans. It appears to act within the membrane and, in mammals, is highly expressed in muscle and neural tissue, indicative of a role in ATP generation.


Pssm-ID: 461937  Cd Length: 69  Bit Score: 35.25  E-value: 4.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1241781220 126 IIGVGVGAGAYILARYALNHPDtveglVLINIDPNAKGWMDWAAHK 171
Cdd:pfam06522  11 AIGAAVGGAVFYLLRLLLTNPD-----VRWNKKNNPEPWNVLDNNK 51
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
86-156 6.64e-03

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 37.29  E-value: 6.64e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1241781220  86 VDAPGMeeGAPVFPLGYqYPSLDQLADMIPCVLQYL---NFSTIIGVGVGAGAYILARYALNHPDTVEGLVLIN 156
Cdd:COG2267    61 FDLRGH--GRSDGPRGH-VDSFDDYVDDLRAALDALrarPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLA 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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