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Conserved domains on  [gi|1231293770|ref|NP_001341512|]
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interleukin-12 subunit alpha isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IL12 super family cl03854
Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer ...
 51-215 1.43e-90

Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus and HIV. IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit. On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses.


The actual alignment was detected with superfamily member pfam03039:

Pssm-ID: 460785  Cd Length: 214  Bit Score: 264.81  E-value: 1.43e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293770  51 DHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQK--------------------------------------NESC 92
Cdd:pfam03039  12 QHLSLARNLPIQSPPPMHQYCLGHSQNLLTATETLLQKarklleyyscteeeidheditkdktstvkaclplelkkNESC 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293770  93 LNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSET 172
Cdd:pfam03039  92 LASRETSFITNGSCLSSEKTSVMMTLCLSSIYEDLKMYQEEFKAINALLKMDPRQQILLDQNLLAAIEELMQALNSNSET 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1231293770 173 VPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS 215
Cdd:pfam03039 172 VPQPSSKEEDDFYKTKKKLCILLHAFRIRAVTIDRVMSYLNSS 214
 
Name Accession Description Interval E-value
IL12 pfam03039
Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer ...
 51-215 1.43e-90

Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus and HIV. IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit. On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses.


Pssm-ID: 460785  Cd Length: 214  Bit Score: 264.81  E-value: 1.43e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293770  51 DHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQK--------------------------------------NESC 92
Cdd:pfam03039  12 QHLSLARNLPIQSPPPMHQYCLGHSQNLLTATETLLQKarklleyyscteeeidheditkdktstvkaclplelkkNESC 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293770  93 LNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSET 172
Cdd:pfam03039  92 LASRETSFITNGSCLSSEKTSVMMTLCLSSIYEDLKMYQEEFKAINALLKMDPRQQILLDQNLLAAIEELMQALNSNSET 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1231293770 173 VPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS 215
Cdd:pfam03039 172 VPQPSSKEEDDFYKTKKKLCILLHAFRIRAVTIDRVMSYLNSS 214
 
Name Accession Description Interval E-value
IL12 pfam03039
Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer ...
 51-215 1.43e-90

Interleukin-12 alpha subunit; Interleukin 12 (IL-12) is a disulphide-bonded heterodimer consisting of a 35kDa alpha subunit and a 40kDa beta subunit. It is involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus and HIV. IL-12 also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis. Suppression of IL-12 activity in such diseases may have therapeutic benefit. On the other hand, administration of recombinant IL-12 may have therapeutic benefit in conditions associated with pathological Th2 responses.


Pssm-ID: 460785  Cd Length: 214  Bit Score: 264.81  E-value: 1.43e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293770  51 DHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQK--------------------------------------NESC 92
Cdd:pfam03039  12 QHLSLARNLPIQSPPPMHQYCLGHSQNLLTATETLLQKarklleyyscteeeidheditkdktstvkaclplelkkNESC 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1231293770  93 LNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSET 172
Cdd:pfam03039  92 LASRETSFITNGSCLSSEKTSVMMTLCLSSIYEDLKMYQEEFKAINALLKMDPRQQILLDQNLLAAIEELMQALNSNSET 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1231293770 173 VPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS 215
Cdd:pfam03039 172 VPQPSSKEEDDFYKTKKKLCILLHAFRIRAVTIDRVMSYLNSS 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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