DNA mismatch repair protein Mlh1 isoform 3 [Homo sapiens]
DNA mismatch repair MutL family protein( domain architecture ID 12932958)
DNA mismatch repair MutL family protein is required for DNA mismatch repair (MMR), correcting base-base mismatches and insertion-deletion loops (IDLs) resulting from DNA replication, DNA damage, or recombination events
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
Mlh1_C | pfam16413 | DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch ... |
261-515 | 1.20e-134 | |||||
DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site. : Pssm-ID: 465109 Cd Length: 260 Bit Score: 390.36 E-value: 1.20e-134
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MutL_Trans_MLH1 | cd03483 | MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in ... |
1-94 | 8.15e-60 | |||||
MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. MLH1 forms heterodimers with PMS2, PMS1 and MLH3. These three complexes have distinct functions in meiosis. hMLH1-hPMS2 also participates in the repair of all DNA mismatch repair (MMR) substrates. Roles for hMLH1-hPMS1 or hMLH1-hMLH3 in MMR have not been established. Cells lacking hMLH1 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 causes predisposition to HNPCC, Muir-Torre syndrome and Turcot syndrome (HNPCC variant). Mutation in hMLH1 accounts for a large fraction of HNPCC families. : Pssm-ID: 239565 [Multi-domain] Cd Length: 127 Bit Score: 193.22 E-value: 8.15e-60
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mutL super family | cl35064 | DNA mismatch repair endonuclease MutL; |
19-186 | 8.81e-19 | |||||
DNA mismatch repair endonuclease MutL; The actual alignment was detected with superfamily member PRK00095: Pssm-ID: 234630 [Multi-domain] Cd Length: 617 Bit Score: 89.51 E-value: 8.81e-19
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Name | Accession | Description | Interval | E-value | |||||
Mlh1_C | pfam16413 | DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch ... |
261-515 | 1.20e-134 | |||||
DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site. Pssm-ID: 465109 Cd Length: 260 Bit Score: 390.36 E-value: 1.20e-134
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MutL_Trans_MLH1 | cd03483 | MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in ... |
1-94 | 8.15e-60 | |||||
MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. MLH1 forms heterodimers with PMS2, PMS1 and MLH3. These three complexes have distinct functions in meiosis. hMLH1-hPMS2 also participates in the repair of all DNA mismatch repair (MMR) substrates. Roles for hMLH1-hPMS1 or hMLH1-hMLH3 in MMR have not been established. Cells lacking hMLH1 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 causes predisposition to HNPCC, Muir-Torre syndrome and Turcot syndrome (HNPCC variant). Mutation in hMLH1 accounts for a large fraction of HNPCC families. Pssm-ID: 239565 [Multi-domain] Cd Length: 127 Bit Score: 193.22 E-value: 8.15e-60
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DNA_mis_repair | pfam01119 | DNA mismatch repair protein, C-terminal domain; This family represents the C-terminal domain ... |
1-93 | 9.60e-35 | |||||
DNA mismatch repair protein, C-terminal domain; This family represents the C-terminal domain of the mutL/hexB/PMS1 family. This domain has a ribosomal S5 domain 2-like fold. Pssm-ID: 426060 [Multi-domain] Cd Length: 117 Bit Score: 126.46 E-value: 9.60e-35
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mutl | TIGR00585 | DNA mismatch repair protein MutL; All proteins in this family for which the functions are ... |
2-74 | 1.30e-22 | |||||
DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273155 [Multi-domain] Cd Length: 312 Bit Score: 98.48 E-value: 1.30e-22
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MutL | COG0323 | DNA mismatch repair ATPase MutL [Replication, recombination and repair]; |
3-96 | 9.52e-21 | |||||
DNA mismatch repair ATPase MutL [Replication, recombination and repair]; Pssm-ID: 440092 [Multi-domain] Cd Length: 515 Bit Score: 95.11 E-value: 9.52e-21
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mutL | PRK00095 | DNA mismatch repair endonuclease MutL; |
19-186 | 8.81e-19 | |||||
DNA mismatch repair endonuclease MutL; Pssm-ID: 234630 [Multi-domain] Cd Length: 617 Bit Score: 89.51 E-value: 8.81e-19
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Name | Accession | Description | Interval | E-value | |||||
Mlh1_C | pfam16413 | DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch ... |
261-515 | 1.20e-134 | |||||
DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site. Pssm-ID: 465109 Cd Length: 260 Bit Score: 390.36 E-value: 1.20e-134
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MutL_Trans_MLH1 | cd03483 | MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in ... |
1-94 | 8.15e-60 | |||||
MutL_Trans_MLH1: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH1 (MutL homologue 1). This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. MLH1 forms heterodimers with PMS2, PMS1 and MLH3. These three complexes have distinct functions in meiosis. hMLH1-hPMS2 also participates in the repair of all DNA mismatch repair (MMR) substrates. Roles for hMLH1-hPMS1 or hMLH1-hMLH3 in MMR have not been established. Cells lacking hMLH1 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 causes predisposition to HNPCC, Muir-Torre syndrome and Turcot syndrome (HNPCC variant). Mutation in hMLH1 accounts for a large fraction of HNPCC families. Pssm-ID: 239565 [Multi-domain] Cd Length: 127 Bit Score: 193.22 E-value: 8.15e-60
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MutL_Trans | cd00782 | MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
1-93 | 1.25e-36 | |||||
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. Included in this group are proteins similar to human MLH1, hPMS2, hPMS1, hMLH3 and E. coli MutL, MLH1 forms heterodimers with PMS2, PMS1 and MLH3. These three complexes have distinct functions in meiosis. hMLH1-hPMS2 also participates in the repair of all DNA mismatch repair (MMR) substrates. Roles for hMLH1-hPMS1 or hMLH1-hMLH3 in MMR have not been established. Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 causes predisposition to HNPCC, Muir-Torre syndrome and Turcot syndrome (HNPCC variant). Mutation in hPMS2 causes predisposition to HPNCC and Turcot syndrome. Mutation in hMLH1 accounts for a large fraction of HNPCC families. There is no convincing evidence to support hPMS1 having a role in HNPCC predisposition. It has been suggested that hMLH3 may be a low risk gene for colorectal cancer; however there is little evidence to support it having a role in classical HNPCC. It has been suggested that during initiation of DNA mismatch repair in E. coli, the mismatch recognition protein MutS recruits MutL in the presence of ATP. The MutS(ATP)-MutL ternary complex formed, then recruits the latent endonuclease MutH. Pssm-ID: 238405 [Multi-domain] Cd Length: 122 Bit Score: 131.51 E-value: 1.25e-36
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DNA_mis_repair | pfam01119 | DNA mismatch repair protein, C-terminal domain; This family represents the C-terminal domain ... |
1-93 | 9.60e-35 | |||||
DNA mismatch repair protein, C-terminal domain; This family represents the C-terminal domain of the mutL/hexB/PMS1 family. This domain has a ribosomal S5 domain 2-like fold. Pssm-ID: 426060 [Multi-domain] Cd Length: 117 Bit Score: 126.46 E-value: 9.60e-35
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mutl | TIGR00585 | DNA mismatch repair protein MutL; All proteins in this family for which the functions are ... |
2-74 | 1.30e-22 | |||||
DNA mismatch repair protein MutL; All proteins in this family for which the functions are known are involved in the process of generalized mismatch repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273155 [Multi-domain] Cd Length: 312 Bit Score: 98.48 E-value: 1.30e-22
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MutL | COG0323 | DNA mismatch repair ATPase MutL [Replication, recombination and repair]; |
3-96 | 9.52e-21 | |||||
DNA mismatch repair ATPase MutL [Replication, recombination and repair]; Pssm-ID: 440092 [Multi-domain] Cd Length: 515 Bit Score: 95.11 E-value: 9.52e-21
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mutL | PRK00095 | DNA mismatch repair endonuclease MutL; |
19-186 | 8.81e-19 | |||||
DNA mismatch repair endonuclease MutL; Pssm-ID: 234630 [Multi-domain] Cd Length: 617 Bit Score: 89.51 E-value: 8.81e-19
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TopoII_MutL_Trans | cd00329 | MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
3-74 | 1.03e-16 | |||||
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families. Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 75.76 E-value: 1.03e-16
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MutL_Trans_MutL | cd03482 | MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in ... |
19-93 | 6.40e-13 | |||||
MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from the ATP-binding site to the DNA breakage/reunion regions of the enzymes. It has been suggested that during initiation of DNA mismatch repair in E. coli, the mismatch recognition protein MutS recruits MutL in the presence of ATP. The MutS(ATP)-MutL ternary complex formed, then recruits the latent endonuclease MutH. Prokaryotic MutS and MutL are homodimers. Pssm-ID: 239564 [Multi-domain] Cd Length: 123 Bit Score: 65.30 E-value: 6.40e-13
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MutL_Trans_hPMS_2_like | cd03484 | MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in ... |
3-91 | 2.44e-09 | |||||
MutL_Trans_hPMS2_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM2 (hPSM2). hPSM2 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. Included in this group are proteins similar to yeast PMS1. The yeast MLH1-PMS1 and the human MLH1-PMS2 heterodimers play a role in meiosis. hMLH1-hPMS2 also participates in the repair of all DNA mismatch repair (MMR) substrates. Cells lacking hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hPMS2 causes predisposition to HPNCC and Turcot syndrome. Pssm-ID: 239566 [Multi-domain] Cd Length: 142 Bit Score: 55.74 E-value: 2.44e-09
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MutL_Trans_hPMS_1_like | cd03485 | MutL_Trans_hPMS1_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in ... |
19-91 | 9.71e-08 | |||||
MutL_Trans_hPMS1_like: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to human PSM1 (hPSM1) and yeast MLH2. hPSM1 and yMLH2 are members of the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. PMS1 forms a heterodimer with MLH1. The MLH1-PMS1 complex functions in meiosis. Loss of yMLH2 results in a small but significant decrease in spore viability and a significant increase in gene conversion frequencies. A role for hMLH1-hPMS1 in DNA mismatch repair has not been established. Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families, however there is no convincing evidence to support hPMS1 having a role in HNPCC predisposition. Pssm-ID: 239567 [Multi-domain] Cd Length: 132 Bit Score: 50.73 E-value: 9.71e-08
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