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Conserved domains on  [gi|1241781240|ref|NP_001341555|]
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DNA mismatch repair protein Mlh1 isoform 6 [Homo sapiens]

Protein Classification

Mlh1_C domain-containing protein( domain architecture ID 11242692)

Mlh1_C domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mlh1_C pfam16413
DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch ...
144-398 2.51e-136

DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site.


:

Pssm-ID: 465109  Cd Length: 260  Bit Score: 389.98  E-value: 2.51e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781240 144 NLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQ--WALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEP 221
Cdd:pfam16413   1 RLTSIKELRAEVEESMHKELTEIFANHTFVGCVDERrrLALIQHGTKLYLVDYGALSEELFYQIGLTDFGNFGRIRLSPP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781240 222 APLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILR 301
Cdd:pfam16413  81 LSLYELLELALESEESGWTEEDGPKEELAEKIVELLIEKAEMLEEYFSIEIDEDGNLESLPLLLKGYTPNLDKLPLFLLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781240 302 LATEVNWDEEKECFESLSKECAMFYSIRKQY----ISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFT 377
Cdd:pfam16413 161 LATEVDWDDEKECFETFLRELALFYSPEPLPppsnDESNDDEDEEEDEEIEARREEWKWVIEHVLFPAIKRRLLPPKSLL 240
                         250       260
                  ....*....|....*....|.
gi 1241781240 378 EDGnILQLANLPDLYKVFERC 398
Cdd:pfam16413 241 KDT-VVQVANLPDLYKVFERC 260
 
Name Accession Description Interval E-value
Mlh1_C pfam16413
DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch ...
144-398 2.51e-136

DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site.


Pssm-ID: 465109  Cd Length: 260  Bit Score: 389.98  E-value: 2.51e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781240 144 NLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQ--WALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEP 221
Cdd:pfam16413   1 RLTSIKELRAEVEESMHKELTEIFANHTFVGCVDERrrLALIQHGTKLYLVDYGALSEELFYQIGLTDFGNFGRIRLSPP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781240 222 APLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILR 301
Cdd:pfam16413  81 LSLYELLELALESEESGWTEEDGPKEELAEKIVELLIEKAEMLEEYFSIEIDEDGNLESLPLLLKGYTPNLDKLPLFLLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781240 302 LATEVNWDEEKECFESLSKECAMFYSIRKQY----ISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFT 377
Cdd:pfam16413 161 LATEVDWDDEKECFETFLRELALFYSPEPLPppsnDESNDDEDEEEDEEIEARREEWKWVIEHVLFPAIKRRLLPPKSLL 240
                         250       260
                  ....*....|....*....|.
gi 1241781240 378 EDGnILQLANLPDLYKVFERC 398
Cdd:pfam16413 241 KDT-VVQVANLPDLYKVFERC 260
 
Name Accession Description Interval E-value
Mlh1_C pfam16413
DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch ...
144-398 2.51e-136

DNA mismatch repair protein Mlh1 C-terminus; This is the C-terminal domain of DNA mismatch repair protein Mlh1, these proteins belong to the MutL family. This domain forms part of the endonuclease active site.


Pssm-ID: 465109  Cd Length: 260  Bit Score: 389.98  E-value: 2.51e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781240 144 NLTSVLSLQEEINEQGHEVLREMLHNHSFVGCVNPQ--WALAQHQTKLYLLNTTKLSEELFYQILIYDFANFGVLRLSEP 221
Cdd:pfam16413   1 RLTSIKELRAEVEESMHKELTEIFANHTFVGCVDERrrLALIQHGTKLYLVDYGALSEELFYQIGLTDFGNFGRIRLSPP 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781240 222 APLFDLAMLALDSPESGWTEEDGPKEGLAEYIVEFLKKKAEMLADYFSLEIDEEGNLIGLPLLIDNYVPPLEGLPIFILR 301
Cdd:pfam16413  81 LSLYELLELALESEESGWTEEDGPKEELAEKIVELLIEKAEMLEEYFSIEIDEDGNLESLPLLLKGYTPNLDKLPLFLLR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1241781240 302 LATEVNWDEEKECFESLSKECAMFYSIRKQY----ISEESTLSGQQSEVPGSIPNSWKWTVEHIVYKALRSHILPPKHFT 377
Cdd:pfam16413 161 LATEVDWDDEKECFETFLRELALFYSPEPLPppsnDESNDDEDEEEDEEIEARREEWKWVIEHVLFPAIKRRLLPPKSLL 240
                         250       260
                  ....*....|....*....|.
gi 1241781240 378 EDGnILQLANLPDLYKVFERC 398
Cdd:pfam16413 241 KDT-VVQVANLPDLYKVFERC 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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