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Conserved domains on  [gi|1234543376|ref|NP_001341658|]
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DNA repair protein complementing XP-C cells isoform 5 [Homo sapiens]

Protein Classification

rad4 family protein( domain architecture ID 11489429)

rad4 family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rad4 TIGR00605
DNA repair protein rad4; All proteins in this family for which functions are known are ...
 141-861 0e+00

DNA repair protein rad4; All proteins in this family for which functions are known are involved in targeting nucleotide excision repair to specific regions of the genome.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


:

Pssm-ID: 273170 [Multi-domain]  Cd Length: 713  Bit Score: 940.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 141 VRESTAFSRSLLpVKPVEIEIETPEQAKTRERseKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQ 220
Cdd:TIGR00605   1 MNEDLAKEYFEL-IRKVENEKEAEKQPKSRRR--KVRRENEPSLRRRKKRFKTGLNELPHEVVLMCNLDSTHSDDRVVSV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 221 PDLHAIGlSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVHIFLLIL 300
Cdd:TIGR00605  78 PDSLSVS-EEIPSREEDYDSREFEDVYLSNLVAEFETISVEIKPSSKAESDDDAETLSRNVCSNEARKDRKYIHILYLLC 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 301 RALQLLTRLVLSLQpIPLKSATAKGKKPSKERLTADPG--GSSETSSQVLENHTKPKTSKGTKQEETFAKGtCRPSAKGK 378
Cdd:TIGR00605 157 LMVHLFTRNEWSLS-APLKSAKLSNLIPEKVRLLLHPSvrKSEELPSRSLRGLRKPLVEKLKKCMETWQKG-LRKTTKGL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 379 R--NKGGRKKRSKpssseedegpGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEP 456
Cdd:TIGR00605 235 LklLNGGRYSRSK----------WEEIEKSSNRKLGGRKYRTLKRGSILENLNVPTRLVFSDFLLSVSKGHNDPEISSEG 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 457 GPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKW 536
Cdd:TIGR00605 305 FVPKLSACNANQRLIMSCESADRTSRFRMKKDPSLPGFSAYSDMDKSPIFTCEEGDKFIDRWITYVDFWVEVFIEQEEKW 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 537 VCVDCVH-GVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAET-LRPYQSPFMDREK- 613
Cdd:TIGR00605 385 VCVDAVHsGVVPKGVTCFEPATLMMTYVFAYDRDGYVKDVTRRYCDQWSTKVRKRRVEKADFGETwFRPIFGALHKRKRt 464

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 614 ---KEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-ETAAILGYCRGEA-VYSRDCVHTLHSRDTWLKKA 688
Cdd:TIGR00605 465 iddIEDQEFLRRHESEGIPKSIQDLKNHPLYVLERHLKKTQALKPgKKACTLGFVNGKAgVYSRKDVHDLKSAEQWYKKG 544

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 689 RVVRLGEVPYKMVKGfsnRARKARLAEPQLREEnDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQL 768
Cdd:TIGR00605 545 RVIKLGEQPYKVVKA---RARTVRLPKGEAEEE-DLGLYSYEQTELYIPPPAVDGIVPKNAYGNIDLFVPSMIPKGAVHL 620

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 769 NLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKG 848
Cdd:TIGR00605 621 RLPGAIKAAKKLNIDYAPAVTGFDFHRGYSKPVLDGIIVCEEFREAIETAWEEIEQIQEEKEQEKHRKRALGNWKTLLKG 700

                         730
                  ....*....|...
gi 1234543376 849 LLIRERLKRRYGP 861
Cdd:TIGR00605 701 LRIRERLKETYGK 713
 
Name Accession Description Interval E-value
rad4 TIGR00605
DNA repair protein rad4; All proteins in this family for which functions are known are ...
 141-861 0e+00

DNA repair protein rad4; All proteins in this family for which functions are known are involved in targeting nucleotide excision repair to specific regions of the genome.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273170 [Multi-domain]  Cd Length: 713  Bit Score: 940.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 141 VRESTAFSRSLLpVKPVEIEIETPEQAKTRERseKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQ 220
Cdd:TIGR00605   1 MNEDLAKEYFEL-IRKVENEKEAEKQPKSRRR--KVRRENEPSLRRRKKRFKTGLNELPHEVVLMCNLDSTHSDDRVVSV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 221 PDLHAIGlSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVHIFLLIL 300
Cdd:TIGR00605  78 PDSLSVS-EEIPSREEDYDSREFEDVYLSNLVAEFETISVEIKPSSKAESDDDAETLSRNVCSNEARKDRKYIHILYLLC 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 301 RALQLLTRLVLSLQpIPLKSATAKGKKPSKERLTADPG--GSSETSSQVLENHTKPKTSKGTKQEETFAKGtCRPSAKGK 378
Cdd:TIGR00605 157 LMVHLFTRNEWSLS-APLKSAKLSNLIPEKVRLLLHPSvrKSEELPSRSLRGLRKPLVEKLKKCMETWQKG-LRKTTKGL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 379 R--NKGGRKKRSKpssseedegpGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEP 456
Cdd:TIGR00605 235 LklLNGGRYSRSK----------WEEIEKSSNRKLGGRKYRTLKRGSILENLNVPTRLVFSDFLLSVSKGHNDPEISSEG 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 457 GPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKW 536
Cdd:TIGR00605 305 FVPKLSACNANQRLIMSCESADRTSRFRMKKDPSLPGFSAYSDMDKSPIFTCEEGDKFIDRWITYVDFWVEVFIEQEEKW 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 537 VCVDCVH-GVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAET-LRPYQSPFMDREK- 613
Cdd:TIGR00605 385 VCVDAVHsGVVPKGVTCFEPATLMMTYVFAYDRDGYVKDVTRRYCDQWSTKVRKRRVEKADFGETwFRPIFGALHKRKRt 464

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 614 ---KEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-ETAAILGYCRGEA-VYSRDCVHTLHSRDTWLKKA 688
Cdd:TIGR00605 465 iddIEDQEFLRRHESEGIPKSIQDLKNHPLYVLERHLKKTQALKPgKKACTLGFVNGKAgVYSRKDVHDLKSAEQWYKKG 544

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 689 RVVRLGEVPYKMVKGfsnRARKARLAEPQLREEnDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQL 768
Cdd:TIGR00605 545 RVIKLGEQPYKVVKA---RARTVRLPKGEAEEE-DLGLYSYEQTELYIPPPAVDGIVPKNAYGNIDLFVPSMIPKGAVHL 620

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 769 NLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKG 848
Cdd:TIGR00605 621 RLPGAIKAAKKLNIDYAPAVTGFDFHRGYSKPVLDGIIVCEEFREAIETAWEEIEQIQEEKEQEKHRKRALGNWKTLLKG 700

                         730
                  ....*....|...
gi 1234543376 849 LLIRERLKRRYGP 861
Cdd:TIGR00605 701 LRIRERLKETYGK 713
RAD4 COG5535
DNA repair protein RAD4 [DNA replication, recombination, and repair];
509-862 2.23e-50

DNA repair protein RAD4 [DNA replication, recombination, and repair];


Pssm-ID: 227822 [Multi-domain]  Cd Length: 650  Bit Score: 188.91  E-value: 2.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 509 SDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCV--HGVVGQPLTCYKYATKP----MTYVVGIDSDGWVRDVTQRY-DP 581
Cdd:COG5535   289 SEGLLEYIDSLEYPGFWGEVVDKFEKKWVFVDPVrlYIVYSELKCKFEPAASIhlniMEYVGAYDACVYVKDVTLRYrDQ 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 582 VWMTVTRKCRVDA--EWWAETLRPYQSP--FMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-- 655
Cdd:COG5535   369 SYSFLKRITKHLFsvQYFVRQFPGLGKCkeASDEEAIEDFDDLDERRSEGIPKSVQDLKRHPKFVLESHLKWNQAIKPga 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 656 ETAAIL--GYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKarLAEPQLREendlgLFGYWQTE 733
Cdd:COG5535   449 KPGFTLtkGKNSVEAVYLRRDVVRLKSAEQWYRMGRVIKPGAQPLKIVKRMRERVRN--LDDKVIRE-----LYSPEQTE 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 734 EYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKD 813
Cdd:COG5535   522 LYGPPLVVAGIIPKNMYGNIDYYVPSMIPRGCVLIPNRNARDIARLLGIDYADAVTGFDFGRSTVKPVLRGIVVPKKNLE 601

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1234543376 814 VLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPK 862
Cdd:COG5535   602 AISNFLAEYERIQEEKERSEVRLGGLKRWKILLRKLRIRLRINEEYGLK 650
BHD_3 smart01032
Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds ...
 745-819 1.05e-41

Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 198100 [Multi-domain]  Cd Length: 75  Bit Score: 146.55  E-value: 1.05e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1234543376  745 VPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAW 819
Cdd:smart01032   1 VPRNEYGNIDLFKPSMLPIGCVHLKLPGLIRVAKRLGIDYAPAVTGFDFKRGSAHPVIDGVVVAEEFAEALLAAW 75
BHD_3 pfam10405
Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds ...
 745-816 2.19e-33

Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 463079 [Multi-domain]  Cd Length: 73  Bit Score: 122.94  E-value: 2.19e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1234543376 745 VPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLL 816
Cdd:pfam10405   1 VPKNAYGNIDIFVPSMLPEGCVHIPLPGAARAAKKLGIDYAPAVTGFDFKGRRGKPVIDGIVVAEEDEEALL 72
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 315-510 1.90e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.18  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376  315 PIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSE 394
Cdd:PHA03307   212 PISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376  395 EDEGPgdkqeKATQRRPHGRERRVASRVSyKEESGSDEAGSGSDfeLSSGEASDPSDedSEPGPPKQRkAPAPQRTKAGS 474
Cdd:PHA03307   292 RERSP-----SPSPSSPGSGPAPSSPRAS-SSSSSSRESSSSST--SSSSESSRGAA--VSPGPSPSR-SPSPSRPPPPA 360

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1234543376  475 KSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSD 510
Cdd:PHA03307   361 DPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAG 396
 
Name Accession Description Interval E-value
rad4 TIGR00605
DNA repair protein rad4; All proteins in this family for which functions are known are ...
 141-861 0e+00

DNA repair protein rad4; All proteins in this family for which functions are known are involved in targeting nucleotide excision repair to specific regions of the genome.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273170 [Multi-domain]  Cd Length: 713  Bit Score: 940.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 141 VRESTAFSRSLLpVKPVEIEIETPEQAKTRERseKIKLEFETYLRRAMKRFNKGVHEDTHKVHLLCLLANGFYRNNICSQ 220
Cdd:TIGR00605   1 MNEDLAKEYFEL-IRKVENEKEAEKQPKSRRR--KVRRENEPSLRRRKKRFKTGLNELPHEVVLMCNLDSTHSDDRVVSV 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 221 PDLHAIGlSIIPARFTRVLPRDVDTYYLSNLVKWFIGTFTVNAELSASEQDNLQTTLERRFAIYSARDDEELVHIFLLIL 300
Cdd:TIGR00605  78 PDSLSVS-EEIPSREEDYDSREFEDVYLSNLVAEFETISVEIKPSSKAESDDDAETLSRNVCSNEARKDRKYIHILYLLC 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 301 RALQLLTRLVLSLQpIPLKSATAKGKKPSKERLTADPG--GSSETSSQVLENHTKPKTSKGTKQEETFAKGtCRPSAKGK 378
Cdd:TIGR00605 157 LMVHLFTRNEWSLS-APLKSAKLSNLIPEKVRLLLHPSvrKSEELPSRSLRGLRKPLVEKLKKCMETWQKG-LRKTTKGL 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 379 R--NKGGRKKRSKpssseedegpGDKQEKATQRRPHGRERRVASRVSYKEESGSDEAGSGSDFELSSGEASDPSDEDSEP 456
Cdd:TIGR00605 235 LklLNGGRYSRSK----------WEEIEKSSNRKLGGRKYRTLKRGSILENLNVPTRLVFSDFLLSVSKGHNDPEISSEG 304

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 457 GPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSDGEKAEKRSIAGIDQWLEVFCEQEEKW 536
Cdd:TIGR00605 305 FVPKLSACNANQRLIMSCESADRTSRFRMKKDPSLPGFSAYSDMDKSPIFTCEEGDKFIDRWITYVDFWVEVFIEQEEKW 384

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 537 VCVDCVH-GVVGQPLTCYKYATKPMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVDAEWWAET-LRPYQSPFMDREK- 613
Cdd:TIGR00605 385 VCVDAVHsGVVPKGVTCFEPATLMMTYVFAYDRDGYVKDVTRRYCDQWSTKVRKRRVEKADFGETwFRPIFGALHKRKRt 464

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 614 ---KEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-ETAAILGYCRGEA-VYSRDCVHTLHSRDTWLKKA 688
Cdd:TIGR00605 465 iddIEDQEFLRRHESEGIPKSIQDLKNHPLYVLERHLKKTQALKPgKKACTLGFVNGKAgVYSRKDVHDLKSAEQWYKKG 544

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 689 RVVRLGEVPYKMVKGfsnRARKARLAEPQLREEnDLGLFGYWQTEEYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQL 768
Cdd:TIGR00605 545 RVIKLGEQPYKVVKA---RARTVRLPKGEAEEE-DLGLYSYEQTELYIPPPAVDGIVPKNAYGNIDLFVPSMIPKGAVHL 620

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 769 NLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKG 848
Cdd:TIGR00605 621 RLPGAIKAAKKLNIDYAPAVTGFDFHRGYSKPVLDGIIVCEEFREAIETAWEEIEQIQEEKEQEKHRKRALGNWKTLLKG 700

                         730
                  ....*....|...
gi 1234543376 849 LLIRERLKRRYGP 861
Cdd:TIGR00605 701 LRIRERLKETYGK 713
RAD4 COG5535
DNA repair protein RAD4 [DNA replication, recombination, and repair];
509-862 2.23e-50

DNA repair protein RAD4 [DNA replication, recombination, and repair];


Pssm-ID: 227822 [Multi-domain]  Cd Length: 650  Bit Score: 188.91  E-value: 2.23e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 509 SDGEKAEKRSIAGIDQWLEVFCEQEEKWVCVDCV--HGVVGQPLTCYKYATKP----MTYVVGIDSDGWVRDVTQRY-DP 581
Cdd:COG5535   289 SEGLLEYIDSLEYPGFWGEVVDKFEKKWVFVDPVrlYIVYSELKCKFEPAASIhlniMEYVGAYDACVYVKDVTLRYrDQ 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 582 VWMTVTRKCRVDA--EWWAETLRPYQSP--FMDREKKEDLEFQAKHMDQPLPTAIGLYKNHPLYALKRHLLKYEAIYP-- 655
Cdd:COG5535   369 SYSFLKRITKHLFsvQYFVRQFPGLGKCkeASDEEAIEDFDDLDERRSEGIPKSVQDLKRHPKFVLESHLKWNQAIKPga 448

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 656 ETAAIL--GYCRGEAVYSRDCVHTLHSRDTWLKKARVVRLGEVPYKMVKGFSNRARKarLAEPQLREendlgLFGYWQTE 733
Cdd:COG5535   449 KPGFTLtkGKNSVEAVYLRRDVVRLKSAEQWYRMGRVIKPGAQPLKIVKRMRERVRN--LDDKVIRE-----LYSPEQTE 521

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 734 EYQPPVAVDGKVPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKD 813
Cdd:COG5535   522 LYGPPLVVAGIIPKNMYGNIDYYVPSMIPRGCVLIPNRNARDIARLLGIDYADAVTGFDFGRSTVKPVLRGIVVPKKNLE 601

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1234543376 814 VLLTAWENEQAVIERKEKEKKEKRALGNWKLLAKGLLIRERLKRRYGPK 862
Cdd:COG5535   602 AISNFLAEYERIQEEKERSEVRLGGLKRWKILLRKLRIRLRINEEYGLK 650
BHD_3 smart01032
Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds ...
 745-819 1.05e-41

Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 198100 [Multi-domain]  Cd Length: 75  Bit Score: 146.55  E-value: 1.05e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1234543376  745 VPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLLTAW 819
Cdd:smart01032   1 VPRNEYGNIDLFKPSMLPIGCVHLKLPGLIRVAKRLGIDYAPAVTGFDFKRGSAHPVIDGVVVAEEFAEALLAAW 75
BHD_3 pfam10405
Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds ...
 745-816 2.19e-33

Rad4 beta-hairpin domain 3; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 463079 [Multi-domain]  Cd Length: 73  Bit Score: 122.94  E-value: 2.19e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1234543376 745 VPRNEFGNVYLFLPSMMPIGCVQLNLPNLHRVARKLDIDCVQAITGFDFHGGYSHPVTDGYIVCEEFKDVLL 816
Cdd:pfam10405   1 VPKNAYGNIDIFVPSMLPEGCVHIPLPGAARAAKKLGIDYAPAVTGFDFKGRRGKPVIDGIVVAEEDEEALL 72
Rad4 pfam03835
Rad4 transglutaminase-like domain;
525-620 6.79e-21

Rad4 transglutaminase-like domain;


Pssm-ID: 427539 [Multi-domain]  Cd Length: 146  Bit Score: 89.77  E-value: 6.79e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 525 WLEVFCEQEEKWVCVDCVHGVVGQPLTCY--KYATK---PMTYVVGIDSDGWVRDVTQRYDPVWMTVTRKCRVD-----A 594
Cdd:pfam03835  39 WVEVFNPETKKWISVDPLVLKTIELKSKFepRIAEKalnVMTYVVAFDSDGGAKDVTRRYCSTYNAKTRKRRIErtddgK 118

                          90       100
                  ....*....|....*....|....*...
gi 1234543376 595 EWWAETLRPYQSPFMDR--EKKEDLEFQ 620
Cdd:pfam03835 119 DWWESVLRPYNKPNREAsrDDYEDAELL 146
BHD_2 smart01031
Rad4 beta-hairpin domain 2; This short domain is found in the Rad4 protein. This domain binds ...
 678-737 3.18e-19

Rad4 beta-hairpin domain 2; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 214985 [Multi-domain]  Cd Length: 56  Bit Score: 81.96  E-value: 3.18e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376  678 LHSRDTWLKKARVVRLGEVPYKMVKgfsnRARKARLAEPQLREENDLGLFGYWQTEEYQP 737
Cdd:smart01031   1 LKSAEHWLRQGRVVKPGEQPYKVVK----RKRKKDRIPNDTGEEEELELYGEWQTELYIP 56
BHD_1 smart01030
Rad4 beta-hairpin domain 1; This short domain is found in the Rad4 protein. This domain binds ...
 624-675 4.56e-18

Rad4 beta-hairpin domain 1; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 214984 [Multi-domain]  Cd Length: 54  Bit Score: 78.42  E-value: 4.56e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1234543376  624 MDQPLPTAIGLYKNHPLYALKRHLLKYEAIYPETAAI--LGYCRGEAVYSRDCV 675
Cdd:smart01030   1 LNEPIPTSIQDFKNHPLYVLERHLKKNEAIYPKAKPVgtFGYGKGEPVYLRSDV 54
BHD_2 pfam10404
Rad4 beta-hairpin domain 2; This short domain is found in the Rad4 protein. This domain binds ...
 679-738 1.85e-15

Rad4 beta-hairpin domain 2; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 463078 [Multi-domain]  Cd Length: 63  Bit Score: 71.47  E-value: 1.85e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1234543376 679 HSRDTWLKKARVVRLGEVPYKMVKGFSNRARKARLAEPQL---REENDLGLFGYWQTEEYQPP 738
Cdd:pfam10404   1 KSAEKWYREGREVKPGEQPLKRVKARAVTKNRKREEEDAReedGEEGGVGLYAEWQTELYIPP 63
BHD_1 pfam10403
Rad4 beta-hairpin domain 1; This short domain is found in the Rad4 protein. This domain binds ...
 627-675 2.00e-14

Rad4 beta-hairpin domain 1; This short domain is found in the Rad4 protein. This domain binds to DNA.


Pssm-ID: 463077  Cd Length: 54  Bit Score: 68.34  E-value: 2.00e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1234543376 627 PLPTAIGLYKNHPLYALKRHLLKYEAIYPeTAAILGYCR----GEAVYSRDCV 675
Cdd:pfam10403   3 PMPTNIQDFKNHPLYVLERHLKRNEVIYP-GAKPVGTFRykkkGEPVYRRSDV 54
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 315-510 1.90e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 55.18  E-value: 1.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376  315 PIPLKSATAKGKKPSKERLTADPGGSSETSSQVLENHTKPKTSKGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSSSE 394
Cdd:PHA03307   212 PISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376  395 EDEGPgdkqeKATQRRPHGRERRVASRVSyKEESGSDEAGSGSDfeLSSGEASDPSDedSEPGPPKQRkAPAPQRTKAGS 474
Cdd:PHA03307   292 RERSP-----SPSPSSPGSGPAPSSPRAS-SSSSSSRESSSSST--SSSSESSRGAA--VSPGPSPSR-SPSPSRPPPPA 360

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1234543376  475 KSASRTHRGSHRKDPSLPAASSSSSSSKRGKKMCSD 510
Cdd:PHA03307   361 DPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAG 396
recX PRK14136
recombination regulator RecX; Provisional
 349-493 2.43e-03

recombination regulator RecX; Provisional


Pssm-ID: 237620 [Multi-domain]  Cd Length: 309  Bit Score: 41.14  E-value: 2.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1234543376 349 ENHTKPKTSkGTKQEETFAKGTCRPSAKGKRNKGGRKKRSKPSS--SEEDEGPGDKQEKATQRRPHGRERRVASRVSYKE 426
Cdd:PRK14136   11 QEADHPARA-ARAGRPHASRETDRTVSGEGRPAGRTATRASDDAlvSFEIAAPDEPFDDDESFDAHDRARRRVSGVGVRD 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1234543376 427 E-SGSDEAGSGSDFELSSGEASDPSDED----SEPGPPKQRKAPAPQRTKAGSKSASRTHRGSHRKDPSLPA 493
Cdd:PRK14136   90 AgAPGGRAADARAANLSSAAKRAEAAGDvytrTSQHPRRTRRAAGPFHSDSSPSASSEDDGAARSRASSRPA 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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