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Conserved domains on  [gi|1237938232|ref|NP_001341675|]
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ATP-dependent 6-phosphofructokinase, muscle type isoform 7 [Homo sapiens]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 10092100)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 13-732 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


:

Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1337.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  13 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDF 92
Cdd:cd00764     1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  93 REREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGT 172
Cdd:cd00764    81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 173 DMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 252
Cdd:cd00764   161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 253 RGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL-------------------- 312
Cdd:cd00764   241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILaslmgveavmalleatpdtp 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 313 ----------------------TKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRP-PVSKSGSHTVAVMNVGAP 369
Cdd:cd00764   321 acvvslngnkavrlplmecvqlTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 370 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 449
Cdd:cd00764   401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 450 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 529
Cdd:cd00764   481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 530 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 609
Cdd:cd00764   561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 610 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTd 689
Cdd:cd00764   641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 1237938232 690 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKR 732
Cdd:cd00764   720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 13-732 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1337.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  13 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDF 92
Cdd:cd00764     1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  93 REREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGT 172
Cdd:cd00764    81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 173 DMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 252
Cdd:cd00764   161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 253 RGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL-------------------- 312
Cdd:cd00764   241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILaslmgveavmalleatpdtp 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 313 ----------------------TKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRP-PVSKSGSHTVAVMNVGAP 369
Cdd:cd00764   321 acvvslngnkavrlplmecvqlTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 370 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 449
Cdd:cd00764   401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 450 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 529
Cdd:cd00764   481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 530 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 609
Cdd:cd00764   561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 610 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTd 689
Cdd:cd00764   641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 1237938232 690 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKR 732
Cdd:cd00764   720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 16-713 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1107.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 255
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 256 RLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL----------------------- 312
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILatrqgveavlavlestpetpspv 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 313 -------------------TKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLA---HVRPPVSKSGSH-TVAVMNVGAP 369
Cdd:TIGR02478 321 islrgnkivrkplveavaqTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSipdDDKKLVPSEASRlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 370 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 449
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 450 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 529
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 530 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 609
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 610 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANtPDSGCVLGMRKRALVFQPVA-ELKDQT 688
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVKqLLANET 719

                         730       740
                  ....*....|....*....|....*
gi 1237938232 689 DFEHRIPKEQWWLKLRPILKILAKY 713
Cdd:TIGR02478 720 DFEHRRPKNQWWLQLRPLVRILAGR 744
PFK pfam00365
Phosphofructokinase;
18-312 3.84e-135

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 399.41  E-value: 3.84e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIKEATWESVSMMLQLGGTVIGSARCKDFREREG 97
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  98 RLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSdllsdlqkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMTIG 177
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 178 TDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSEtRTRGSRL 257
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKIKE-LRKGKRF 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1237938232 258 NIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL 312
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRIL 261
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
16-312 9.91e-112

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 341.29  E-value: 9.91e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:PRK03202    2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:PRK03202   80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAK--------RLTEHG---------------IPVIGLPGTIDNDIAGTDYT 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:PRK03202  137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1237938232 256 RLNIIIVAEGAIDKngkpitsEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL 312
Cdd:PRK03202  214 KHAIIVVAEGVMPA-------EELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVL 263
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 16-312 4.47e-111

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 340.51  E-value: 4.47e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:COG0205     2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEAtkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:COG0205    80 EGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAEEYG-----IPVVGIPKTIDNDLPGTDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:COG0205   138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1237938232 256 RLNIIIVAEGAIDKNGKPI---------------TSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL 312
Cdd:COG0205   215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVL 286
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 13-732 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1337.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  13 GIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDF 92
Cdd:cd00764     1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  93 REREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGT 172
Cdd:cd00764    81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 173 DMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRT 252
Cdd:cd00764   161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 253 RGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL-------------------- 312
Cdd:cd00764   241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILaslmgveavmalleatpdtp 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 313 ----------------------TKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRP-PVSKSGSHTVAVMNVGAP 369
Cdd:cd00764   321 acvvslngnkavrlplmecvqlTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPqPLPEKTNLNIAIVNVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 370 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 449
Cdd:cd00764   401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 450 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 529
Cdd:cd00764   481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 530 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 609
Cdd:cd00764   561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 610 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTd 689
Cdd:cd00764   641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTT- 719

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|...
gi 1237938232 690 FEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKR 732
Cdd:cd00764   720 FEHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 16-713 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1107.40  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 255
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 256 RLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL----------------------- 312
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILatrqgveavlavlestpetpspv 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 313 -------------------TKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLA---HVRPPVSKSGSH-TVAVMNVGAP 369
Cdd:TIGR02478 321 islrgnkivrkplveavaqTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSipdDDKKLVPSEASRlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 370 AAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQ 449
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 450 GLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIE 529
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 530 TMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGI 609
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 610 FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANtPDSGCVLGMRKRALVFQPVA-ELKDQT 688
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSAD-DTSAVVIGIRGSNVLFTPVKqLLANET 719

                         730       740
                  ....*....|....*....|....*
gi 1237938232 689 DFEHRIPKEQWWLKLRPILKILAKY 713
Cdd:TIGR02478 720 DFEHRRPKNQWWLQLRPLVRILAGR 744
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 16-341 6.82e-162

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 470.63  E-value: 6.82e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:cd00363     1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDllsdlqkagkitdeeatKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:cd00363    79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGS 255
Cdd:cd00363   142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 256 RLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILT---------------------- 313
Cdd:cd00363   222 RHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILAsrlgaeavelllegtggtpvgi 301

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1237938232 314 ----------KDVTKAMDEKKfDEALKLRGRSFMNNWE 341
Cdd:cd00363   302 qnlnenqvvrHPLTEAVNMTK-RVGVDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
18-312 3.84e-135

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 399.41  E-value: 3.84e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIKEATWESVSMMLQLGGTVIGSARCKDFREREG 97
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGD--IDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  98 RLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSdllsdlqkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMTIG 177
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 178 TDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSEtRTRGSRL 257
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKIKE-LRKGKRF 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1237938232 258 NIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL 312
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRIL 261
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
16-312 9.91e-112

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 341.29  E-value: 9.91e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:PRK03202    2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQkagkitdeeatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:PRK03202   80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAK--------RLTEHG---------------IPVIGLPGTIDNDIAGTDYT 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:PRK03202  137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1237938232 256 RLNIIIVAEGAIDKngkpitsEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL 312
Cdd:PRK03202  214 KHAIIVVAEGVMPA-------EELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVL 263
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 16-312 4.47e-111

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 340.51  E-value: 4.47e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:COG0205     2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEAtkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:COG0205    80 EGREKALENLKKLGIDALVVIGGDGSLDGAA-----------------KLAEEYG-----IPVVGIPKTIDNDLPGTDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:COG0205   138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1237938232 256 RLNIIIVAEGAIDKNGKPI---------------TSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL 312
Cdd:COG0205   215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVL 286
PFK pfam00365
Phosphofructokinase;
361-643 1.10e-104

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 320.83  E-value: 1.10e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 361 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 437
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKTEEgre 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 438 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 517
Cdd:pfam00365  82 KIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRDT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 518 AAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLvQKMKTTVkrgLVLRNEKCNenyTTDF 597
Cdd:pfam00365 156 ASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKEL-RKGKRFS---IIVVAEGAS---DGEF 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1237938232 598 IFNLYsEEGKGIfDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 643
Cdd:pfam00365 228 LAKLI-EEGTGI-ETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 18-312 3.57e-93

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 292.33  E-value: 3.57e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFREREG 97
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  98 RLRAAYNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllSDLQKAGKItdeeatkssylNIVGLVGSIDNDFCGTDMTIG 177
Cdd:TIGR02482  80 REKAVENLKKLGIEGLVVIGGDGSYTGA-----------QKLYEEGGI-----------PVIGLPGTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 178 TDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDweeHLCRRLSETRTRGSRL 257
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDID---ELIQRLKEQHEAGKKH 214

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1237938232 258 NIIIVAEGAIDKNGKpitseDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL 312
Cdd:TIGR02482 215 SIIIVAEGNIVGSAK-----EVAKKIEEKTGIETRVTVLGHTQRGGSPSAFDRVL 264
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 16-312 2.65e-89

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 282.76  E-value: 2.65e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  16 KAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGgdHIKEATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:cd00763     1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:cd00763    79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAM-----------------RLTEHG------FPCVGLPGTIDNDIPGTDYT 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwEEHLCRRLSETRTRGS 255
Cdd:cd00763   136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1237938232 256 RLNIIIVAEGAIDkngkpitSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL 312
Cdd:cd00763   213 KHAIVVVAEGVYD-------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRIL 262
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 18-334 7.75e-75

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 244.90  E-value: 7.75e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  18 IAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGgDHIKEATWESVSMMLQLGGTVIGSARCKDFR-ER 95
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEG-DTVPLLDLEDVRGILPRGGTILGSSRTNPFKyEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGAdtfrsewsdllSDLQKAGkitdeeatkssyLNIVGLVGSIDNDFCGTDMT 175
Cdd:TIGR02483  81 DGDDKIVANLKELGLDALIAIGGDGTLGIA-----------RRLADKG------------LPVVGVPKTIDNDLEATDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPddDWEEhLCRRLSETRTRGS 255
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPF--DIDS-VCEKVRERFARGK 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 256 RLNIIIVAEGAIDKNGKPITSEDIKN----------------LVVKRLGYDTRVTVLGHVQRGGTPSAFDRIL-TKDVTK 318
Cdd:TIGR02483 215 RFAIVVVAEGAKPKGGEMVVQEGVKDafghvrlggignwlaeEIERRTGIETRATVLGHLQRGGSPSAFDRVLaTRFGVA 294

                         330
                  ....*....|....*....
gi 1237938232 319 AMD---EKKFDEALKLRGR 334
Cdd:TIGR02483 295 AVDlvhEGQFGHMVALRGT 313
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
12-312 7.81e-55

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 192.21  E-value: 7.81e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  12 LGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFT-GARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCK 90
Cdd:PRK14071    1 MGEKKRIGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  91 D----------FREREGRLRAAYNlvKRGITNLCVIGGDGSLTgadtfrsewsdLLSDLQKAGKItdeeatkssylNIVG 160
Cdd:PRK14071   81 DpfafpmpdgsLRDRSQEIIDGYH--SLGLDALIGIGGDGSLA-----------ILRRLAQQGGI-----------NLVG 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 161 LVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDddwE 240
Cdd:PRK14071  137 IPKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYT---L 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 241 EHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSED-------------IKNLVVKRLGYDTRVTVLGHVQRGGTPSA 307
Cdd:PRK14071  214 ENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSP 293


                  ....*
gi 1237938232 308 FDRIL 312
Cdd:PRK14071  294 RDRLL 298
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 15-321 2.53e-52

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 194.10  E-value: 2.53e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  15 GKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGdhIKEATWESVSMMLQLGGTVIGSAR---CKD 91
Cdd:TIGR02478 389 RLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELGTNRslpGDD 466

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  92 FREregrlrAAYNLVKRGITNLCVIGGDGSLTGadtfrsewsdlLSDLQKAgkitdEEATKSSYLNIVGLVGSIDNDFCG 171
Cdd:TIGR02478 467 LGT------IAYYFQQHKIDGLIIIGGFEAFEA-----------LYQLDAA-----REKYPAFRIPMVVIPATISNNVPG 524

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 172 TDMTIGTDSALHRIMEIVDAITTTAQ-SHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPD-DDWEE---HLCRR 246
Cdd:TIGR02478 525 TEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISlKDLQEdieHLKET 604

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1237938232 247 LSETRTRGsrlnIIIVAEGAIdkngKPITSEDIKNLVVK--RLGYDTRVTVLGHVQRGGTPSAFDRIL-TKDVTKAMD 321
Cdd:TIGR02478 605 FAEGRAGK----LILRNEKAS----KVYTTDFIARIISEegKGRFDARTAVLGHMQQGGSPSPFDRVRaTRLAIRAVD 674
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 360-709 2.70e-52

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 184.89  E-value: 2.70e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 360 TVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKS---F 436
Cdd:COG0205     3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKTeegR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 437 EQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 516
Cdd:COG0205    83 EKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG------IPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRLRD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 517 SAAGTkRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLqanVEHLVQKMKTTVKRGLV-----LRNEKCNE 591
Cdd:COG0205   157 TAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIvvaegAGDEDGEA 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 592 NYTTD-FIFNLYSEEGKGI-----------FDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNW-MSGKikesyrngri 658
Cdd:COG0205   233 VLEADtDAFGHVRLGGIGEylakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELlLEGK---------- 302

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1237938232 659 fantpdSGCVLGMRKRALVFQPVAELKDQtdfEHRIPKEQWWLKLRPILKI 709
Cdd:COG0205   303 ------TGVMVGIRRGEIVLVPLEEVANK---EKPVDPDSPLIQLARELGI 344
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 361-641 2.80e-52

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 184.81  E-value: 2.80e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 361 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQIS 440
Cdd:cd00363     3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEGRA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 441 A---NITKFNIQGLVIIGGFEAYTGGLELmegRKQFDELCIPFVVI--PATVSNNVPGSDFSVGADTALNTICTTCDRIK 515
Cdd:cd00363    83 KaaeNLKKHGIDALVVIGGDGSYTGADLL---TEEWPSKYQGFNVIglPGTIDNDIKGTDYTIGFDTALKTIVEAIDRIR 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 516 QSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDlqanVEHLVQKMKTTVKRG----LVLRNEKcne 591
Cdd:cd00363   160 DTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG--- 231

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1237938232 592 nyTTDFIFNLYSEEG-------KGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 641
Cdd:cd00363   232 --AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEA 286
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
361-641 9.36e-51

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 179.89  E-value: 9.36e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 361 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFE--- 437
Cdd:PRK03202    4 IGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgra 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 438 QISANITKFNIQGLVIIGGFEAYTGGLELMEGRkqfdelcIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQS 517
Cdd:PRK03202   84 KAIENLKKLGIDALVVIGGDGSYMGAKRLTEHG-------IPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDT 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 518 AAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEK-CNENYTTD 596
Cdd:PRK03202  157 AS-SHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAK 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1237938232 597 FIfnlyseEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 641
Cdd:PRK03202  233 EI------EERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHA 271
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 361-641 4.16e-49

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 175.29  E-value: 4.16e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 361 VAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRtLPKKSFEQIS 440
Cdd:cd00763     3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGQ 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 441 A----NITKFNIQGLVIIGGFEAYTGGLELMEgrkqfdeLCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 516
Cdd:cd00763    82 AkaieQLKKHGIDALVVIGGDGSYMGAMRLTE-------HGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 517 SAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKttvKRGLVLRNEKCnenYTTD 596
Cdd:cd00763   155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1237938232 597 FIFNLYSEEGKgiFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKA 641
Cdd:cd00763   228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYA 270
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 18-278 2.55e-22

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 100.89  E-value: 2.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  18 IAVLTSGGDAQGMNAAVRAVVRVGIFTGA--RVFFVHEGYQGLVDGgDHIKeATWESVSMMLQLGGTVIGSARCKDFRER 95
Cdd:PTZ00286   90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKE-DWIK-LDPKDVKTIHRLGGTILGSSRGGFDPKV 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 egrlrAAYNLVKRGITNLCVIGGDGSLTGADtfrsewsdllsdlqkagKITDEEATKSSYLNIVGLVGSIDNDFCGTDMT 175
Cdd:PTZ00286  168 -----MVDTLIRHGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVVGIPKTIDNDIPIIDES 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 176 IGTDSALHRIMEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPEcppdDDWEEHLCRRLSETRTR 253
Cdd:PTZ00286  226 FGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPE----FDIPLEGVLEYIEQRLQ 301

                         250       260
                  ....*....|....*....|....*..
gi 1237938232 254 GSRLNIIIVAEGAID--KNGKPITSED 278
Cdd:PTZ00286  302 KKGHCVIVVAEGAGQslKDADLDLGTD 328
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
19-266 3.85e-22

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 99.94  E-value: 3.85e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  19 AVLTSGGDAQGMNAAVRAVVRV-----GIftgARVFFVHEGYQGLVDGGDH-IKEATWESVSMMLQLGGTVIGSARckdf 92
Cdd:PRK06830   84 AIVTCGGLCPGLNDVIRAIVLElhhhyGV---RRILGIRYGYQGLIPRYGHdPVELTPEVVADIHEFGGTILGSSR---- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  93 rereGRLRAAY---NLVKRGITNLCVIGGDGSLTGadtfrsewsdllsdlqkAGKITDEEATKSSYLNIVGLVGSIDNDF 169
Cdd:PRK06830  157 ----GPQDPEEivdTLERMNINILFVIGGDGTLRG-----------------ASAIAEEIERRGLKISVIGIPKTIDNDI 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 170 CGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWE----EHL 243
Cdd:PRK06830  216 NFIQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGPngllAAL 295

                         250       260
                  ....*....|....*....|...
gi 1237938232 244 CRRLSEtrtRGSRlnIIIVAEGA 266
Cdd:PRK06830  296 EKRLAE---RGHA--VIVVAEGA 313
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
361-643 1.44e-17

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 85.12  E-value: 1.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 361 VAVMNVGAPAAGMNAAVRSTVRIGLIQ-GNRVLVVHDGFEGLAKG--QIEEAGWSYVGGWTGQGGSKLGTKR-------- 429
Cdd:PRK14071    7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgdpfafp 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 430 ----TLPKKSfEQISANITKFNIQGLVIIGGfeayTGGLELMegRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALN 505
Cdd:PRK14071   87 mpdgSLRDRS-QEIIDGYHSLGLDALIGIGG----DGSLAIL--RRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVN 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 506 TICTTCDRIKQSAAgTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIrdlqanvEHLVQKMKTTVKRG---- 581
Cdd:PRK14071  160 IATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknfc 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1237938232 582 LVLRNEKC----NENYTTDFIF--NLYSEEGKGIFD---------SRKNVLGHMQQGGSPTPFDRNFATKMGAKAMN 643
Cdd:PRK14071  232 LVVVSEAVrteeGEQVTKTQALgeDRYGGIGQYLAEqiaertgaeTRVTVLGHIQRGGIPSPRDRLLASAFGVAAVD 308
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
116-302 2.80e-15

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 78.75  E-value: 2.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 116 IGGDGSltgADTfrsewsdllsdlqkAGKITdEEATKSSY-LNIVGLVGSIDNDFCGTDMTIGTDSALHRI----MEI-- 188
Cdd:PRK14072  110 NGGNDS---MDT--------------ALKVS-QLAKKMGYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIatsvLEAal 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 189 -VDAITTTaqshQRTFVLEVMGRHCGYLALVTSLSC-----GADWVFIPECPPDDDweehlcRRLSETRTRGSRLN--II 260
Cdd:PRK14072  172 dVAAMANT----SKVFILEVMGRHAGWLAAAAALAKqnpddAPHLIYLPERPFDEE------KFLADVRAIVKRYGycVV 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1237938232 261 IVAEGAIDKNGKPI----TSED-------------IKNLVVKRLGYDTRVTVLGHVQRG 302
Cdd:PRK14072  242 VVSEGIRDADGKFIaeagLAEDafghaqlggvapvLANLIKEKLGKKVHWAVLDYLQRA 300
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 16-266 1.78e-13

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 73.12  E-value: 1.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  16 KAIAVLTSGGDAQGMNAAVRAVVR--VGIFTGARVFFVHEGYQGLVdGGDHIK--EATWESVSMMLQLGGTVIGSARCK- 90
Cdd:PRK06555    4 KKVALLTAGGLAPCLSSAVGGLIEryTEIAPEVEIIAYRSGYQGLL-LGDSIEitPAVRANAGLLHRYGGSPIGNSRVKl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  91 ----D------FREREGRLR-AAYNLVKRGITNLCVIGGDGSLTGAdtfrsewSDLLSDLQKAGkitdeeatkssY-LNI 158
Cdd:PRK06555   83 tnvaDcvkrglVKEGENPLKvAAERLAADGVDILHTIGGDDTNTTA-------ADLAAYLAENG-----------YdLTV 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 159 VGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVL-EVMGRHCGYLALVTS----------------- 220
Cdd:PRK06555  145 VGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATArayrewldrqeyvpgfg 224

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1237938232 221 LSCGA---DWVFIPECPPDDDWEehlCRRLSETRTRGSRLNiIIVAEGA 266
Cdd:PRK06555  225 LSAERwdiHAVYLPEMAFDLEAE---AERLKAVMDEVGNVN-IFLSEGA 269
PLN02884 PLN02884
6-phosphofructokinase
 19-306 2.37e-13

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 72.54  E-value: 2.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  19 AVLTSGGDAQGMNAAVRAVV-RVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARckdfrereG 97
Cdd:PLN02884   57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSR--------G 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  98 RLRAAY---NLVKRGITNLCVIGGDGSLTGADTfrsewsdllsdlqkagkITDEEATKSSYLNIVGLVGSIDNDFCGTDM 174
Cdd:PLN02884  129 GAKTSDivdSIEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDK 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 175 TIGTDSALHRIMEIVDAITTTAQSHQRTF-VLEVMGRHCGYLALVTSLSCG-ADWVFIPECPPDDDWEEHLCRRLSE-TR 251
Cdd:PLN02884  192 TFGFDTAVEEAQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHLEHlIE 271

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1237938232 252 TRGSRlnIIIVAEGAIDKNGKPITSEDIK-NLVVKRLGYDTRVTVLGHVQRGGTPS 306
Cdd:PLN02884  272 TKGSA--VVCVAEGAGQDLLQKTNATDASgNPVLGDIGVHLQQEIKKHFKDIGVPA 325
PLN02564 PLN02564
6-phosphofructokinase
 19-266 1.26e-10

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 64.38  E-value: 1.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  19 AVLTSGGDAQGMNAAVRAVVrVGIFTG---ARVFFVHEGYQGLVdgGDHIKEATWESVSMMLQLGGTVIGSARCKdfrer 95
Cdd:PLN02564   91 CIVTCGGLCPGLNTVIREIV-CGLSYMygvTRILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSRGG----- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  96 EGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEwsdllsdLQKAG-KITdeeatkssylnIVGLVGSIDNDFCGTDM 174
Cdd:PLN02564  163 HDTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEE-------IRRRGlKVA-----------VAGIPKTIDNDIPVIDK 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 175 TIGTDSALHRIMEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSL-SCGADWVFIPECPPDDDWE----EHLCRRLS 248
Cdd:PLN02564  225 SFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLaSRDVDCCLIPESPFYLEGKgglfEFIEKRLK 304

                         250
                  ....*....|....*...
gi 1237938232 249 EtrtrgSRLNIIIVAEGA 266
Cdd:PLN02564  305 E-----NGHMVIVVAEGA 317
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 360-539 5.91e-08

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 55.82  E-value: 5.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 360 TVAVMNVGAPAAGMNAAVRSTVRIGLI--QGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTlpKKSFE 437
Cdd:PTZ00286   89 KAGIVTCGGLCPGLNVVIRELVMNLINnyGVKTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRG--GFDPK 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232 438 QISANITKFNIQGLVIIGGFEAYTGGLELM-EGRKQfdELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQ 516
Cdd:PTZ00286  167 VMVDTLIRHGINILFTLGGDGTHRGALAIYkELRRR--KLNISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYV 244

                         170       180
                  ....*....|....*....|...
gi 1237938232 517 SAAGTKRRVFIIETMGGYCGYLA 539
Cdd:PTZ00286  245 EAKSAKNGVGIVKLMGRDSGFIA 267
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 3-268 6.04e-06

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 50.04  E-value: 6.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232    3 HEEHHAAKTLGIGkaiaVLTSGGDAQGMNAAVRavvrvGIFTGARVFFVHEGYQGLVDGGDHIKEATWESV--SMM---L 77
Cdd:PTZ00287   169 HESFKGGNVLKIG----IILSGGPAPGGHNVIS-----GIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTItdSLMnrfR 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232   78 QLGG-TVIGSARCKdFREREGrLRAAYNLV-KRGITNLCVIGGDGSLTgadtfrsewsdllsdlqKAGKITDEEATKSSY 155
Cdd:PTZ00287   240 NLGGfNMLWSGRGK-VRNKDD-LIAIENIVaKLKLNGLVIIGGDGSNS-----------------NAALISEYFAERQIP 300

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  156 LNIVGLVGSIDNDFC--GTDMTIGTDSALHRIMEIVDAITTTAQS-HQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPE 232
Cdd:PTZ00287   301 ISIIGIPKTIDGDLKseAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGE 380

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1237938232  233 CPPDD-----DWEEHLCRRLSETRTRGSRLNIIIVAEGAID 268
Cdd:PTZ00287   381 EVEKEnlslkDIVSNIVNTILKRRSLNKNYGVILIPEGLIE 421
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 16-268 8.14e-04

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 43.04  E-value: 8.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232   16 KAIAVLTSGGDAQGMNAAVRAVVR-VGIFTGARVFFvheGYQGLVDG--GDHIKEATWESVSMMLQLGG-TVIGSARCKd 91
Cdd:PTZ00468   103 RRIGVVLSGGQASGGHNVIAGLMSyIKLCNQSSQLF---GFLGGPEGvySERYRELTEDDINGILNQGGfNIICSGRHK- 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232   92 fREREGRLRAAYNLV-KRGITNLCVIGGDGSLTGADtfrsewsdLLSDLQKagkitdeeaTKSSYLNIVGLVGSIDNDFC 170
Cdd:PTZ00468   179 -IETEEQMRASLEICeKLKLHGLVVIGGDDSNTNAA--------VLAEYFK---------RNSSSTVVVGCPKTIDGDLK 240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1237938232  171 G--TDMTIGTDSAL----HRIMEIVDAITTtaqSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPD-------- 236
Cdd:PTZ00468   241 NevIETSFGYDTAVktysEQIGSIMDAIKT---EGYGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEenrslmsi 317

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1237938232  237 -DDWEEHLCRRLSetrtRGSRLNIIIVAEGAID 268
Cdd:PTZ00468   318 vDEIVEMILKRDS----LGKKHGIVLLPEGLIE 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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