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Conserved domains on  [gi|1236589315|ref|NP_001341774|]
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G2/mitotic-specific cyclin-B1 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 247-367 2.59e-82

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410272  Cd Length: 121  Bit Score: 246.73  E-value: 2.59e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPV 326
Cdd:cd20569     1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1236589315 327 MQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS 367
Cdd:cd20569    81 MQHMAKNVVKVNQGLTKHMTVKNKYASSKQMKISTLPQLNS 121
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 167-242 4.31e-41

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20565:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 129  Bit Score: 141.17  E-value: 4.31e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 167 CSEYVKDIYAYLRQLE-----------------------------------------------------NNCVPKKMLQL 193
Cdd:cd20565     1 CSEYVKDIYAYLRQLEeeqavrpkylegqevtgnmrailidwlvqvqmkfrllqetmymtvaiidrflqNNPVPKKMLQL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1236589315 194 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20565    81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
 
Name Accession Description Interval E-value
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 247-367 2.59e-82

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 246.73  E-value: 2.59e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPV 326
Cdd:cd20569     1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1236589315 327 MQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS 367
Cdd:cd20569    81 MQHMAKNVVKVNQGLTKHMTVKNKYASSKQMKISTLPQLNS 121
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 247-365 2.66e-46

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 154.32  E-value: 2.66e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEV--DVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLL 324
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1236589315 325 PVMQHLAKNVVMVNQGltKHMTVKNKYATSKHAKISTLPQL 365
Cdd:pfam02984  81 PCVKLLLELLLNAPSS--KLQAVRRKYSSSKFMKVSTLPPL 119
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
154-360 1.63e-42

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 153.78  E-value: 1.63e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 154 NDVDAEDGADPNLCSEYVKDIYAYLRQLENNCVPK------------KM------------------------------- 190
Cdd:COG5024   164 QDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNpnylikqslyewSMrsilvdwlvevhgkfgllpetlflainiidr 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 191 -----------LQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKI 259
Cdd:COG5024   244 flssrvvslekYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 260 GEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLS-YTEESLLPVMQHLAKNvvmVN 338
Cdd:COG5024   324 SDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSGnYTNPDLKPLNESNKEN---LQ 400

                         250       260
                  ....*....|....*....|..
gi 1236589315 339 QGLTKHMTVKNKYATSKHAKIS 360
Cdd:COG5024   401 NPSVHHDAIFPKYPSPTFGKAS 422
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 167-242 4.31e-41

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 141.17  E-value: 4.31e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 167 CSEYVKDIYAYLRQLE-----------------------------------------------------NNCVPKKMLQL 193
Cdd:cd20565     1 CSEYVKDIYAYLRQLEeeqavrpkylegqevtgnmrailidwlvqvqmkfrllqetmymtvaiidrflqNNPVPKKMLQL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1236589315 194 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20565    81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 179-245 9.58e-28

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 105.68  E-value: 9.58e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1236589315 179 RQLENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLG 245
Cdd:pfam00134  61 RFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 251-332 2.14e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.87  E-value: 2.14e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315  251 HFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSY-TEESLLPVMQH 329
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYfTEEEILRMERL 80


                   ...
gi 1236589315  330 LAK 332
Cdd:smart00385  81 LLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 181-238 1.88e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 56.83  E-value: 1.88e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1236589315  181 LENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDntYTKHQIRQMEMKILR 238
Cdd:smart00385  28 LSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRMERLLLE 83
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 174-308 4.84e-05

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 44.72  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 174 IYAYLR-QLENNCVPKKMLQLVgVTAMFIASKYEEMyPPEIGDFAFVTDNTYT------KHQIRQMEMKILRALNFGLGR 246
Cdd:COG5333    70 ILFFSRfYLKNSVEEISLYSVV-TTCVYLACKVEDT-PRDISIESFEARDLWSeepkssRERILEYEFELLEALDFDLHV 147

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1236589315 247 PLPLHFLRRASKIGEVD--VEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEW 308
Cdd:COG5333   148 HHPYKYLEGFLKDLQEKdkYKLLQIAWKIINDALRTDLCLLYPPHIIALAALLIACEVLGMPII 211
 
Name Accession Description Interval E-value
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 247-367 2.59e-82

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 246.73  E-value: 2.59e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPV 326
Cdd:cd20569     1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLLPV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1236589315 327 MQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNS 367
Cdd:cd20569    81 MQHMAKNVVKVNQGLTKHMTVKNKYASSKQMKISTLPQLNS 121
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 247-365 4.76e-63

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 197.41  E-value: 4.76e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPV 326
Cdd:cd20570     1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYTGYTEDDLKPI 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1236589315 327 MQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQL 365
Cdd:cd20570    81 MQHMAKNVVKVNEGLTKHVAVKNKYASSKLMKISTIPQL 119
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 247-359 1.64e-61

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 193.21  E-value: 1.64e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPV 326
Cdd:cd20509     1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPI 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1236589315 327 MQHLAKNVVMVNQglTKHMTVKNKYATSKHAKI 359
Cdd:cd20509    81 VQKMAKLVVKSQT--SKYQAVKNKYSSSKFMRI 111
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 247-365 2.66e-46

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 154.32  E-value: 2.66e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEV--DVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLL 324
Cdd:pfam02984   1 PTPLSFLRRFSKAADYlhDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1236589315 325 PVMQHLAKNVVMVNQGltKHMTVKNKYATSKHAKISTLPQL 365
Cdd:pfam02984  81 PCVKLLLELLLNAPSS--KLQAVRRKYSSSKFMKVSTLPPL 119
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
154-360 1.63e-42

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 153.78  E-value: 1.63e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 154 NDVDAEDGADPNLCSEYVKDIYAYLRQLENNCVPK------------KM------------------------------- 190
Cdd:COG5024   164 QDLDATDQEDPLMVPEYASDIFEYLLKLELIDLPNpnylikqslyewSMrsilvdwlvevhgkfgllpetlflainiidr 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 191 -----------LQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKI 259
Cdd:COG5024   244 flssrvvslekYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKA 323

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 260 GEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLS-YTEESLLPVMQHLAKNvvmVN 338
Cdd:COG5024   324 SDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSGnYTNPDLKPLNESNKEN---LQ 400

                         250       260
                  ....*....|....*....|..
gi 1236589315 339 QGLTKHMTVKNKYATSKHAKIS 360
Cdd:COG5024   401 NPSVHHDAIFPKYPSPTFGKAS 422
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 167-242 4.31e-41

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 141.17  E-value: 4.31e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 167 CSEYVKDIYAYLRQLE-----------------------------------------------------NNCVPKKMLQL 193
Cdd:cd20565     1 CSEYVKDIYAYLRQLEeeqavrpkylegqevtgnmrailidwlvqvqmkfrllqetmymtvaiidrflqNNPVPKKMLQL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1236589315 194 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20565    81 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 167-242 1.74e-38

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 134.19  E-value: 1.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 167 CSEYVKDIYAYLRQLENNC------------------------------------------------------VPKKMLQ 192
Cdd:cd20507     1 VSEYVKDIYKYLRQLEKKYaidpdylsgqpeitermrailvdwlvevhlkfkllpetlyltvniidrylskkqVPRKKLQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1236589315 193 LVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20507    81 LVGVTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 249-362 1.09e-31

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 115.79  E-value: 1.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 249 PLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQ 328
Cdd:cd20512     2 PMNFLRRISKADDYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRGDWNDNLVHYSGYTESQLIPCAD 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1236589315 329 HLAKNVVMvnqGLTKHMTVKNKYATSKHAKISTL 362
Cdd:cd20512    82 IMLEYLVK---PIKHHDAFFKKYSSKKFLKASIF 112
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 247-352 2.05e-31

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 115.07  E-value: 2.05e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPV 326
Cdd:cd20510     1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                          90       100
                  ....*....|....*....|....*.
gi 1236589315 327 MQHLakNVVMVNQGLTKHMTVKNKYA 352
Cdd:cd20510    81 VRKL--NAMLTKPPNKKLKTVRSKYS 104
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 163-242 3.93e-31

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 114.96  E-value: 3.93e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 163 DPNLCSEYVKDIYAYLRQLE-----------------------------------------------------NNCVPKK 189
Cdd:cd20566     1 NPQLCSDYVKDIYQYLRQLEvqqsirphyldgkeinermrailvdwlvqvhsrfqllqetlymcvaimdrflqVQPVSRK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1236589315 190 MLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20566    81 KLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 179-245 9.58e-28

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 105.68  E-value: 9.58e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1236589315 179 RQLENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLG 245
Cdd:pfam00134  61 RFLSKKSVPKNKLQLVGVTCLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 179-242 3.46e-27

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 104.25  E-value: 3.46e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1236589315 179 RQLENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20504    65 RFLSQMSVLRSKLQLVGTACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 247-334 6.51e-24

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 94.30  E-value: 6.51e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTP-TLQHYLSYTEESLLP 325
Cdd:cd20537     1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPqLLQLVTGYSENDLQE 80


                  ....*....
gi 1236589315 326 VMQHLAKNV 334
Cdd:cd20537    81 CAKELLELL 89
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 177-242 8.77e-24

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 95.46  E-value: 8.77e-24
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1236589315 177 YLRQLENncVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20519    68 YLSTQTN--VPKTQLQLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 163-242 2.92e-22

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 91.32  E-value: 2.92e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 163 DPNLCSEYVKDIYAYLRQLE-------------------------------------------------------NNCVP 187
Cdd:cd20562     1 DPQMCSLYATDIYLNLRVAElkrrplpdymekiqrditpsmrgilvdwlvevaeeyklvpdtlyltvsyidrflsGNYVN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1236589315 188 KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20562    81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQF 135
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 155-242 5.74e-22

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 90.78  E-value: 5.74e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 155 DVDAEDGADPNLCSEYVKDIYAYLRQ-----------------------------------------------------L 181
Cdd:cd20508     1 DIDEENSDDPFQVSEYAKDIFDYMKEreekfvvpdylekqteltpsmrailvdwlvevqenfelnhetlylavklvdlyL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1236589315 182 ENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20508    81 SKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDF 141
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 163-242 4.69e-21

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 88.12  E-value: 4.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 163 DPNLCSEYVKDIYAYLRQLENNCVPK------------KM---------------------------------------- 190
Cdd:cd20568     1 DPLMVAEYVPEIFEYLRELELKTLPNpnymddqkelrwKMrgilvdwlvevhekfrllpetlflavniidrflskrvvsl 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1236589315 191 --LQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20568    81 nkLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 252-330 2.95e-20

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 84.99  E-value: 2.95e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 252 FLRR---ASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQ 328
Cdd:cd20506     6 FLRRflrAAQASVPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPHPWNPTLEHYTGYKAADLKPCVQ 85


                  ..
gi 1236589315 329 HL 330
Cdd:cd20506    86 AL 87
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 179-242 5.47e-20

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 85.47  E-value: 5.47e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1236589315 179 RQLENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20567    84 RFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 251-332 2.14e-19

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 81.87  E-value: 2.14e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315  251 HFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSY-TEESLLPVMQH 329
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYfTEEEILRMERL 80


                   ...
gi 1236589315  330 LAK 332
Cdd:smart00385  81 LLE 83
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 168-242 2.74e-18

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 80.49  E-value: 2.74e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 168 SEYVKDIYAYLRQLENNCVPKK------------------------------------------------------MLQL 193
Cdd:cd20561     2 PDYHEDIHTYLREMEVKCKPKVgymkkqpditnsmrailvdwlvevgeeyklqnetlhlavnyidrflssmsvlrgKLQL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1236589315 194 VGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20561    82 VGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTF 130
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 186-244 9.10e-18

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 77.75  E-value: 9.10e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1236589315 186 VPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGL 244
Cdd:cd20542    38 ISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQVLRMERRVLRRLRFDL 96
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 159-242 3.33e-17

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 78.35  E-value: 3.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 159 EDGADPNLCSEYVKDIYAYL-RQLENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKIL 237
Cdd:cd20560    78 EVGEEYKLQTETLYLAVNYLdRFLSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLL 157


                  ....*
gi 1236589315 238 RALNF 242
Cdd:cd20560   158 KVLAF 162
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 247-363 7.71e-17

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 75.80  E-value: 7.71e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILD-NGEWTPTLQHYLSYTEESLLP 325
Cdd:cd20511     1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNkTPEWTSTLEFHTGYSESQLME 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1236589315 326 VMQHLAKnvVMVNQGLTKHMTVKNKYATSKHAKISTLP 363
Cdd:cd20511    81 CARLMVR--LHSKAGTGKLTAVYKKYSSSKFGAVALLP 116
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 179-240 3.60e-16

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 73.13  E-value: 3.60e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1236589315 179 RQLENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRAL 240
Cdd:cd20536    32 RFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTREQICNLECIILTKL 93
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 186-242 4.73e-16

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 74.11  E-value: 4.73e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1236589315 186 VPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20580    81 INKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 247-355 5.99e-15

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 70.40  E-value: 5.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLP 325
Cdd:cd20505     1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADpYLKYLPSVIAAAAVCLANHTLGNEVWPQKLARSTGYSLEDLLP 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1236589315 326 VMQHLAKnvVMVNQGLTKHMTVKNKYATSK 355
Cdd:cd20505    81 CLRDLHR--TFLNAPSSPQQAIREKYKSSK 108
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 186-242 1.61e-14

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 69.91  E-value: 1.61e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1236589315 186 VPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20579    81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 247-356 1.95e-11

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 60.22  E-value: 1.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 247 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLP 325
Cdd:cd20564     1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDADpYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLESLKP 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1236589315 326 VMQHLAKNVVMVNQglTKHMTVKNKYATSKH 356
Cdd:cd20564    81 CLMDLHQTYLKAPQ--HAQQSIREKYKNSKY 109
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 181-238 1.88e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 56.83  E-value: 1.88e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1236589315  181 LENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDntYTKHQIRQMEMKILR 238
Cdd:smart00385  28 LSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRMERLLLE 83
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 252-362 3.00e-09

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 54.43  E-value: 3.00e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 252 FLRRASKIGEVDVEQHTLAKYLMELTMLDYD-MVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHL 330
Cdd:cd20563     6 FLLQYLKRHEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVPCLSDL 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1236589315 331 AKnvVMVNQGLTKHMTVKNKYATSKHAKISTL 362
Cdd:cd20563    86 HK--ACLGAPHRPQQAIREKYKGSKYMQVSLL 115
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 249-330 1.29e-08

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 51.98  E-value: 1.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 249 PLHFLRRASKIGEVDVEQHTL----------------AKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGE-WTPT 311
Cdd:cd20529     3 PAHFLEYYLSQGVLFVDDHDGlpsellekvkeyvrkyADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPtWPEE 82

                          90
                  ....*....|....*....
gi 1236589315 312 LQHYLSYTEESLLPVMQHL 330
Cdd:cd20529    83 LEKLTGYSEDELEPCVELL 101
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 179-240 3.03e-08

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 50.78  E-value: 3.03e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1236589315 179 RQLENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRAL 240
Cdd:cd20521    34 RYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYKYEDVVRMMGEIVAAL 95
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 186-240 1.89e-07

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 49.99  E-value: 1.89e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1236589315 186 VPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRAL 240
Cdd:cd20515    93 IRKSQLQLLGAVCLFLASKLKETIPLTAEKLCIYTDNSITLQELLDWELLVLTKL 147
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 269-366 2.87e-07

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 48.39  E-value: 2.87e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 269 LAKYLMELTMLDYDMVHFPPSQIAAGAFCLAlKILDNGE--WTPTLQHYLSYTEESLLPVMQHL-----AKNVVMVNQGl 341
Cdd:cd20522     2 LASYICELSLLHTELGRYSPAVIAASCLLLA-RVLLNQAlpWPSQLEEFTGFSLEDLLSCVLHLhkkcfHEDSPKDYRN- 79

                          90       100
                  ....*....|....*....|....*
gi 1236589315 342 TKHMTVKNKYATSKHAKISTLPQLN 366
Cdd:cd20522    80 VSLTAVKQRYEDERFLSISKIKVMS 104
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 186-241 5.24e-07

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 47.38  E-value: 5.24e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1236589315 186 VPKKMLQLVGVTAMFIASKYEEMYP--PEIGDFAFVTDNTYTKHQIRQMEMKILRALN 241
Cdd:cd20559    36 VLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELFIQMEMHILNTLN 93
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 249-328 9.84e-07

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 46.25  E-value: 9.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 249 PLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQ 328
Cdd:cd00043     2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSGVSEKELRKAEK 81
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 184-242 5.89e-06

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 45.75  E-value: 5.89e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1236589315 184 NCVP--KKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20575    89 SCVPtrKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKW 149
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 186-242 1.76e-05

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 43.36  E-value: 1.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 186 VPKKMLQLVGVTAMFIASKYEE--MYPPEIGDF-AFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20528    44 ISEDQLHLVALTCLLLAAKFEEldDNIPKISDLnRYLCNSVYSKQEYLQMELLILEFFQW 103
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 177-242 4.21e-05

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 43.43  E-value: 4.21e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1236589315 177 YL-RQLENNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20573    82 YLdRFLSVEPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKW 148
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 174-308 4.84e-05

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 44.72  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1236589315 174 IYAYLR-QLENNCVPKKMLQLVgVTAMFIASKYEEMyPPEIGDFAFVTDNTYT------KHQIRQMEMKILRALNFGLGR 246
Cdd:COG5333    70 ILFFSRfYLKNSVEEISLYSVV-TTCVYLACKVEDT-PRDISIESFEARDLWSeepkssRERILEYEFELLEALDFDLHV 147

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1236589315 247 PLPLHFLRRASKIGEVD--VEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEW 308
Cdd:COG5333   148 HHPYKYLEGFLKDLQEKdkYKLLQIAWKIINDALRTDLCLLYPPHIIALAALLIACEVLGMPII 211
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 165-235 6.55e-05

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 40.86  E-value: 6.55e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1236589315 165 NLCSEYVKDIYAYLRQ-LENNCVPKKMLQLVGVTAMFIASKYEEmYPPEIGDFAFVTDntYTKHQIRQMEMK 235
Cdd:cd00043    14 GLPEEVLELAIELLDRfLSKGLLLGRSPELIAAACLYLACKLEE-LPRTLKEIAKVSG--VSEKELRKAEKE 82
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 272-298 2.04e-04

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 40.34  E-value: 2.04e-04
                          10        20
                  ....*....|....*....|....*..
gi 1236589315 272 YLMELTMLDYDMVHFPPSQIAAGAFCL 298
Cdd:cd20520    43 QLLDLCILDIGSLQFSYSVLAASALYL 69
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 187-242 1.32e-03

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 38.82  E-value: 1.32e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1236589315 187 PKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNF 242
Cdd:cd20574    94 RKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 177-244 1.66e-03

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 38.73  E-value: 1.66e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1236589315 177 YLrqleNNCV----PKKMLqlvgVTAMFIASKYEEMYPPeIGDFA-FVTDNTYTKHQIRQMEMKILRALNFGL 244
Cdd:cd20524    87 YL----KNSVmeyhPKEIM----LTCLYLACKVEEFNIS-IDQFVgNIKESEKTAEIILEYELLLLQGLNFHL 150
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 268-330 2.05e-03

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 37.33  E-value: 2.05e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1236589315 268 TLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDngEWTPTLQHYLSYTEESLLPVMQHL 330
Cdd:cd20722    31 ALARYLAELSLADYAFNQYPPSLLAICSLELADRMLQ--HRSPITERLSGYPQSALEDCVGKL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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