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Conserved domains on  [gi|1239469489|ref|NP_001341960|]
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calcyphosin-2 isoform 3 [Homo sapiens]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 1000101)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FRQ1 super family cl34916
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
218-305 4.62e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5126:

Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 48.63  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239469489 218 LGKYFQQLDKEGNGLLDKADFKQALkvfhlevsEKDFESAWLILNDNGNGKVDYGEFKRGIIGEMNEYRKSYVRKAFMKL 297
Cdd:COG5126     7 LDRRFDLLDADGDGVLERDDFEALF--------RRLWATLFSEADTDGDGRISREEFVAGMESLFEATVEPFARAAFDLL 78


                  ....*...
gi 1239469489 298 DFNKSGSV 305
Cdd:COG5126    79 DTDGDGKI 86
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
218-305 4.62e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 48.63  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239469489 218 LGKYFQQLDKEGNGLLDKADFKQALkvfhlevsEKDFESAWLILNDNGNGKVDYGEFKRGIIGEMNEYRKSYVRKAFMKL 297
Cdd:COG5126     7 LDRRFDLLDADGDGVLERDDFEALF--------RRLWATLFSEADTDGDGRISREEFVAGMESLFEATVEPFARAAFDLL 78


                  ....*...
gi 1239469489 298 DFNKSGSV 305
Cdd:COG5126    79 DTDGDGKI 86
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 222-278 8.70e-07

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 45.62  E-value: 8.70e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1239469489 222 FQQLDKEGNGLLDKADFKQALKVFHLEVSEKDFESAWLILNDNGNGKVDYGEFKRGI 278
Cdd:cd00051     6 FRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELM 62
PTZ00183 PTZ00183
centrin; Provisional
 222-377 8.29e-06

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 45.45  E-value: 8.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239469489 222 FQQLDKEGNGLLDKADFKQALKVFHLEVSEKDFESAWLILNDNGNGKVDYGEFKRGIIGEMNE-YRKSYVRKAFMKLDFN 300
Cdd:PTZ00183   23 FDLFDTDGSGTIDPKELKVAMRSLGFEPKKEEIKQMIADVDKDGSGKIDFEEFLDIMTKKLGErDPREEILKAFRLFDDD 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1239469489 301 KSGSVPIINIRKCycakkhSQVISGHSTEEEIKssflETLKVACSKSDevsygefedyyeglsiGIVDDEDFVNILR 377
Cdd:PTZ00183  103 KTGKISLKNLKRV------AKELGETITDEELQ----EMIDEADRNGD----------------GEISEEEFYRIMK 153
EF-hand_7 pfam13499
EF-hand domain pair;
218-278 2.36e-05

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 41.86  E-value: 2.36e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1239469489 218 LGKYFQQLDKEGNGLLDKADFKQALKVFHL--EVSEKDFESAWLILNDNGNGKVDYGEFKRGI 278
Cdd:pfam13499   4 LKEAFKLLDSDGDGYLDVEELKKLLRKLEEgePLSDEEVEELFKEFDLDKDGRISFEEFLELY 66
 
Name Accession Description Interval E-value
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
218-305 4.62e-07

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 48.63  E-value: 4.62e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239469489 218 LGKYFQQLDKEGNGLLDKADFKQALkvfhlevsEKDFESAWLILNDNGNGKVDYGEFKRGIIGEMNEYRKSYVRKAFMKL 297
Cdd:COG5126     7 LDRRFDLLDADGDGVLERDDFEALF--------RRLWATLFSEADTDGDGRISREEFVAGMESLFEATVEPFARAAFDLL 78


                  ....*...
gi 1239469489 298 DFNKSGSV 305
Cdd:COG5126    79 DTDGDGKI 86
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 222-278 8.70e-07

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 45.62  E-value: 8.70e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1239469489 222 FQQLDKEGNGLLDKADFKQALKVFHLEVSEKDFESAWLILNDNGNGKVDYGEFKRGI 278
Cdd:cd00051     6 FRLFDKDGDGTISADELKAALKSLGEGLSEEEIDEMIREVDKDGDGKIDFEEFLELM 62
PTZ00183 PTZ00183
centrin; Provisional
 222-377 8.29e-06

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 45.45  E-value: 8.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1239469489 222 FQQLDKEGNGLLDKADFKQALKVFHLEVSEKDFESAWLILNDNGNGKVDYGEFKRGIIGEMNE-YRKSYVRKAFMKLDFN 300
Cdd:PTZ00183   23 FDLFDTDGSGTIDPKELKVAMRSLGFEPKKEEIKQMIADVDKDGSGKIDFEEFLDIMTKKLGErDPREEILKAFRLFDDD 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1239469489 301 KSGSVPIINIRKCycakkhSQVISGHSTEEEIKssflETLKVACSKSDevsygefedyyeglsiGIVDDEDFVNILR 377
Cdd:PTZ00183  103 KTGKISLKNLKRV------AKELGETITDEELQ----EMIDEADRNGD----------------GEISEEEFYRIMK 153
EF-hand_7 pfam13499
EF-hand domain pair;
218-278 2.36e-05

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 41.86  E-value: 2.36e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1239469489 218 LGKYFQQLDKEGNGLLDKADFKQALKVFHL--EVSEKDFESAWLILNDNGNGKVDYGEFKRGI 278
Cdd:pfam13499   4 LKEAFKLLDSDGDGYLDVEELKKLLRKLEEgePLSDEEVEELFKEFDLDKDGRISFEEFLELY 66
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
222-278 7.40e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 42.47  E-value: 7.40e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1239469489 222 FQQLDKEGNGLLDKADFKQALKVfhLEVSEKDFESAWLILNDNGNGKVDYGEFKRGI 278
Cdd:COG5126    75 FDLLDTDGDGKISADEFRRLLTA--LGVSEEEADELFARLDTDGDGKISFEEFVAAV 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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