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Conserved domains on  [gi|1242862578|ref|NP_001342335|]
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zinc finger protein 724 isoform 3 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-58 2.14e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.15  E-value: 2.14e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1242862578    2 DVAIEFSVEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQGKEPWN 58
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
137-520 5.14e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 5.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 137 KIFQCDKYVKDFHKFSNSNRHK---TEKNPFKC--KECGKSFCVLSHLTQHKRIHTTVNS----------------YKLE 195
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIrshTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSdlnskslplsnskassSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 196 ECGKAFN-----VSSTLSQHKR---IHTGQKHYKCEECGIAFNKSSHLNTHKIIHTGEKSYKREECGKAFNISSHLTTHK 267
Cdd:COG5048   112 SSSSNSNdnnllSSHSLPPSSRdpqLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 268 IIHTGENAYKCKECGKAFNQSSTLTRHKIIHAgEKPYICEHCGRAFNQSSNLTKHKRIHTGDKPYKCEECGKAF--NVSS 345
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 346 TLTQHKRIHTGE-----KPYKCEECGKAFNVSSTLTQHKR--IHTGE--KPYKCEE--CGKAFNTSSHLTTHKRIHTGEK 414
Cdd:COG5048   271 QSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 415 PYKC--EECGKAFNQFS-----QLTTHKIIHTGEKPYKC--KECGKAFKRSSNLTEHRIIHTGEKP--YKCEECGKAFNL 483
Cdd:COG5048   351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1242862578 484 SSHLTTHKKIHTGEKPYKCkECGKAFNQSSTLARHKI 520
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
542-566 8.14e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.14e-04
                          10        20
                  ....*....|....*....|....*
gi 1242862578 542 NLTQHKIIHTGEKPYKCEECGKAFN 566
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
571-595 2.09e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1242862578 571 LTKHKVIHTGEKPYKCKECGKAFNQ 595
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-539 7.49e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.49e-03
                          10        20
                  ....*....|....*....|....*
gi 1242862578 515 LARHKIIHAGEKPYKCEECGKAFYQ 539
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-58 2.14e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.15  E-value: 2.14e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1242862578    2 DVAIEFSVEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQGKEPWN 58
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-38 1.26e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.26e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1242862578   2 DVAIEFSVEEWQCLDTAQQNLYRNVMLENYRNLVFLG 38
Cdd:pfam01352   6 DVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-37 6.66e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 6.66e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1242862578   2 DVAIEFSVEEWQCLDTAQQNLYRNVMLENYRNLVFL 37
Cdd:cd07765     5 DVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
137-520 5.14e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 5.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 137 KIFQCDKYVKDFHKFSNSNRHK---TEKNPFKC--KECGKSFCVLSHLTQHKRIHTTVNS----------------YKLE 195
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIrshTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSdlnskslplsnskassSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 196 ECGKAFN-----VSSTLSQHKR---IHTGQKHYKCEECGIAFNKSSHLNTHKIIHTGEKSYKREECGKAFNISSHLTTHK 267
Cdd:COG5048   112 SSSSNSNdnnllSSHSLPPSSRdpqLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 268 IIHTGENAYKCKECGKAFNQSSTLTRHKIIHAgEKPYICEHCGRAFNQSSNLTKHKRIHTGDKPYKCEECGKAF--NVSS 345
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 346 TLTQHKRIHTGE-----KPYKCEECGKAFNVSSTLTQHKR--IHTGE--KPYKCEE--CGKAFNTSSHLTTHKRIHTGEK 414
Cdd:COG5048   271 QSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 415 PYKC--EECGKAFNQFS-----QLTTHKIIHTGEKPYKC--KECGKAFKRSSNLTEHRIIHTGEKP--YKCEECGKAFNL 483
Cdd:COG5048   351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1242862578 484 SSHLTTHKKIHTGEKPYKCkECGKAFNQSSTLARHKI 520
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
402-427 2.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 1242862578 402 HLTTHKRIHTGEKPYKCEECGKAFNQ 427
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
542-566 8.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.14e-04
                          10        20
                  ....*....|....*....|....*
gi 1242862578 542 NLTQHKIIHTGEKPYKCEECGKAFN 566
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
571-595 2.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1242862578 571 LTKHKVIHTGEKPYKCKECGKAFNQ 595
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-539 7.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.49e-03
                          10        20
                  ....*....|....*....|....*
gi 1242862578 515 LARHKIIHAGEKPYKCEECGKAFYQ 539
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 524-604 7.53e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 524 GEKPYKCE--ECGKAFYQYSNLTQHKiihtgekpyKCEECGKAFNWSSTLTKHKVIHTGEKPYKCKECGKAFNQCSNLTT 601
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1242862578 602 HKK 604
Cdd:COG5189   417 HRK 419
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 358-406 9.73e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 9.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1242862578 358 KPYkCEECGKAFNVSSTLTQHKRIHTgekpYKCEECGKAFNTSSHLTTH 406
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
2-58 2.14e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 116.15  E-value: 2.14e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1242862578    2 DVAIEFSVEEWQCLDTAQQNLYRNVMLENYRNLVFLGIAVSKPDLITCLEQGKEPWN 58
Cdd:smart00349   5 DVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 2-38 1.26e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.44  E-value: 1.26e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1242862578   2 DVAIEFSVEEWQCLDTAQQNLYRNVMLENYRNLVFLG 38
Cdd:pfam01352   6 DVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 2-37 6.66e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 6.66e-17
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1242862578   2 DVAIEFSVEEWQCLDTAQQNLYRNVMLENYRNLVFL 37
Cdd:cd07765     5 DVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
137-520 5.14e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 5.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 137 KIFQCDKYVKDFHKFSNSNRHK---TEKNPFKC--KECGKSFCVLSHLTQHKRIHTTVNS----------------YKLE 195
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIrshTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSdlnskslplsnskassSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 196 ECGKAFN-----VSSTLSQHKR---IHTGQKHYKCEECGIAFNKSSHLNTHKIIHTGEKSYKREECGKAFNISSHLTTHK 267
Cdd:COG5048   112 SSSSNSNdnnllSSHSLPPSSRdpqLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 268 IIHTGENAYKCKECGKAFNQSSTLTRHKIIHAgEKPYICEHCGRAFNQSSNLTKHKRIHTGDKPYKCEECGKAF--NVSS 345
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASS 270

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 346 TLTQHKRIHTGE-----KPYKCEECGKAFNVSSTLTQHKR--IHTGE--KPYKCEE--CGKAFNTSSHLTTHKRIHTGEK 414
Cdd:COG5048   271 QSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 415 PYKC--EECGKAFNQFS-----QLTTHKIIHTGEKPYKC--KECGKAFKRSSNLTEHRIIHTGEKP--YKCEECGKAFNL 483
Cdd:COG5048   351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNR 430

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1242862578 484 SSHLTTHKKIHTGEKPYKCkECGKAFNQSSTLARHKI 520
Cdd:COG5048   431 HYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
246-606 6.98e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 6.98e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 246 KSYKREECGKAFNISSHLTTHKIIHTGENAYKC--KECGKAFNQSSTLTRHKIIHAGEKPYICEHCGRAFNQSSNLTKHK 323
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 324 R-IHTGDKPYKCEECGKAFNVSSTLTQHKRIHTGEKPYKCEECGKAFNV----SSTLTQHKRIHTGEKPYKCEECGKAFN 398
Cdd:COG5048   112 SsSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 399 TSSHLTTHKRIHTGEKPYKCEECGKAFNQFSQLT---THKIIHTGEKPYK---------------CKECGKAFKRSSNLT 460
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSslpLTTNSQLSPKSLLsqspsslsssdssssASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 461 EHRIIHTGE-------KPYKCEECGKAFNLSSHLTTHK--KIHTGE--KPYKCKE--CGKAFNQSSTLARHKIIHAGEKP 527
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 528 YKC--EECGKAFYQYSN-----LTQHKIIHTGEKPYKCE--ECGKAFNWSSTLTKHKVIHTGEKP--YKCKECGKAFNQC 596
Cdd:COG5048   352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410
                  ....*....|
gi 1242862578 597 SNLTTHKKIH 606
Cdd:COG5048   432 YNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-613 1.87e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.87e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 276 YKCKECGKAFNQSSTLTRHKIIHAGEKPYICEHCGRAFNQS--SNLTKHKRIHTGDKPYKCEECGKAFNVSSTLTQHKRI 353
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 354 HTGE-KPYKCEECGKAFNVSSTLTQHKRIHTGEKPYKCEEC-GKAFNTSSHLTTHKRIHTGEKpykceeCGKAFNQFSQL 431
Cdd:COG5048   114 SSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 432 TTHKIIHTGEKPYKCKECGKAFKRSSNLTEHRIIHTgEKPYKCEECGKAF----NLSSHLTTHKKIHTGEkpykCKECGK 507
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSS----ASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 508 AFNQSSTLARHKIIHAGE-------KPYKCEECGKAFYQYSNLTQHK--IIHTGE--KPYKCEE--CGKAFNWSSTLTKH 574
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1242862578 575 KVIHTGEKPYKCK--ECGKAFNQCSNLTTHKKIHAVEKSDK 613
Cdd:COG5048   343 ILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKN 383
zf-H2C2_2 pfam13465
Zinc-finger double domain;
402-427 2.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 1242862578 402 HLTTHKRIHTGEKPYKCEECGKAFNQ 427
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 384-463 2.69e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 384 GEKPYKCE--ECGKAFNTSSHLTTHKrihtgekpyKCEECGKAFNQFSQLTTHKIIHTGEKPYKCKECGKAFKRSSNLTE 461
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1242862578 462 HR 463
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
375-399 3.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.05e-04
                          10        20
                  ....*....|....*....|....*
gi 1242862578 375 LTQHKRIHTGEKPYKCEECGKAFNT 399
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
486-511 3.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 1242862578 486 HLTTHKKIHTGEKPYKCKECGKAFNQ 511
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
318-342 4.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.26e-04
                          10        20
                  ....*....|....*....|....*
gi 1242862578 318 NLTKHKRIHTGDKPYKCEECGKAFN 342
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-370 5.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.23e-04
                          10        20
                  ....*....|....*....|....
gi 1242862578 347 LTQHKRIHTGEKPYKCEECGKAFN 370
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
542-566 8.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.14e-04
                          10        20
                  ....*....|....*....|....*
gi 1242862578 542 NLTQHKIIHTGEKPYKCEECGKAFN 566
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 468-547 8.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 8.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 468 GEKPYKCE--ECGKAFNLSSHLTTHKKiHtgekpykcKECGKAFNQSSTLARHKIIHAGEKPYKCEECGKAFYQYSNLTQ 545
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1242862578 546 HK 547
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
431-455 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*
gi 1242862578 431 LTTHKIIHTGEKPYKCKECGKAFKR 455
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
571-595 2.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1242862578 571 LTKHKVIHTGEKPYKCKECGKAFNQ 595
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
458-482 2.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|....*
gi 1242862578 458 NLTEHRIIHTGEKPYKCEECGKAFN 482
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 440-492 6.78e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 6.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1242862578 440 GEKPYKCK--ECGKAFKRSSNLTEHR-------------------IIHTGEKPYKCEECGKAFNLSSHLTTHKK 492
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-539 7.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.49e-03
                          10        20
                  ....*....|....*....|....*
gi 1242862578 515 LARHKIIHAGEKPYKCEECGKAFYQ 539
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 524-604 7.53e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.93  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242862578 524 GEKPYKCE--ECGKAFYQYSNLTQHKiihtgekpyKCEECGKAFNWSSTLTKHKVIHTGEKPYKCKECGKAFNQCSNLTT 601
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1242862578 602 HKK 604
Cdd:COG5189   417 HRK 419
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 358-406 9.73e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 9.73e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1242862578 358 KPYkCEECGKAFNVSSTLTQHKRIHTgekpYKCEECGKAFNTSSHLTTH 406
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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