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Conserved domains on  [gi|1246742805|ref|NP_001342873|]
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WD repeat-containing protein [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
56-311 3.20e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 3.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805  56 KRHKKSCRNISVNESGTEFISVGSDGVLKIADTSTGRVSSKWIVDKNkeiSPYSVV-----QWIendmvfATGDDNGCVS 130
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG---AVRSVAfspdgKLL------ASGSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 131 VWDKRTeGGIIHTHNDHIDYISSI--SPfEERYFVATSGDGVLSVIDARNFKKPILSEEQDEEMTCGAFTRDQhskKKFA 208
Cdd:COG2319   230 LWDLAT-GKLLRTLTGHSGSVRSVafSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG---KLLA 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 209 VGTASGVITLftkgdWGDHTDRILSPIRSHDFSIETIT-RADSDSLYVGGSDGCIRLLHILPNKYERIIGQHSSRstVDA 287
Cdd:COG2319   305 SGSDDGTVRL-----WDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA--VTS 377

                         250       260
                  ....*....|....*....|....*
gi 1246742805 288 VDVTTEGNFLVSCSG-TELAFWPVD 311
Cdd:COG2319   378 VAFSPDGRTLASGSAdGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
56-311 3.20e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 3.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805  56 KRHKKSCRNISVNESGTEFISVGSDGVLKIADTSTGRVSSKWIVDKNkeiSPYSVV-----QWIendmvfATGDDNGCVS 130
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG---AVRSVAfspdgKLL------ASGSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 131 VWDKRTeGGIIHTHNDHIDYISSI--SPfEERYFVATSGDGVLSVIDARNFKKPILSEEQDEEMTCGAFTRDQhskKKFA 208
Cdd:COG2319   230 LWDLAT-GKLLRTLTGHSGSVRSVafSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG---KLLA 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 209 VGTASGVITLftkgdWGDHTDRILSPIRSHDFSIETIT-RADSDSLYVGGSDGCIRLLHILPNKYERIIGQHSSRstVDA 287
Cdd:COG2319   305 SGSDDGTVRL-----WDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA--VTS 377

                         250       260
                  ....*....|....*....|....*
gi 1246742805 288 VDVTTEGNFLVSCSG-TELAFWPVD 311
Cdd:COG2319   378 VAFSPDGRTLASGSAdGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-301 4.50e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 4.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805  58 HKKSCRNISVNESGTEFISVGSDGVLKIADTSTGRVSSKWIVDKNKEISpysvVQWIENDMVFATGDDNGCVSVWDKRTe 137
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSS----VAFSPDGRILSSSSRDKTIKVWDVET- 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 138 GGIIHTHNDHIDYISSISPFEERYFVATSG-DGVLSVIDARNFKKPILSEEQDEEMTCGAFTRDqhsKKKFAVGTASGVI 216
Cdd:cd00200   125 GKCLTTLRGHTDWVNSVAFSPDGTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD---GEKLLSSSSDGTI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 217 TLftkgdWGDHTDRILSPIRSHDFSIETITRADSDSLYVGGS-DGCIRLLHILPNKYERIIGQHSSRstVDAVDVTTEGN 295
Cdd:cd00200   202 KL-----WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNS--VTSLAWSPDGK 274


                  ....*.
gi 1246742805 296 FLVSCS 301
Cdd:cd00200   275 RLASGS 280
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
56-311 3.20e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 3.20e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805  56 KRHKKSCRNISVNESGTEFISVGSDGVLKIADTSTGRVSSKWIVDKNkeiSPYSVV-----QWIendmvfATGDDNGCVS 130
Cdd:COG2319   159 TGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG---AVRSVAfspdgKLL------ASGSADGTVR 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 131 VWDKRTeGGIIHTHNDHIDYISSI--SPfEERYFVATSGDGVLSVIDARNFKKPILSEEQDEEMTCGAFTRDQhskKKFA 208
Cdd:COG2319   230 LWDLAT-GKLLRTLTGHSGSVRSVafSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG---KLLA 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 209 VGTASGVITLftkgdWGDHTDRILSPIRSHDFSIETIT-RADSDSLYVGGSDGCIRLLHILPNKYERIIGQHSSRstVDA 287
Cdd:COG2319   305 SGSDDGTVRL-----WDLATGKLLRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA--VTS 377

                         250       260
                  ....*....|....*....|....*
gi 1246742805 288 VDVTTEGNFLVSCSG-TELAFWPVD 311
Cdd:COG2319   378 VAFSPDGRTLASGSAdGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-301 4.50e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 4.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805  58 HKKSCRNISVNESGTEFISVGSDGVLKIADTSTGRVSSKWIVDKNKEISpysvVQWIENDMVFATGDDNGCVSVWDKRTe 137
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSS----VAFSPDGRILSSSSRDKTIKVWDVET- 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 138 GGIIHTHNDHIDYISSISPFEERYFVATSG-DGVLSVIDARNFKKPILSEEQDEEMTCGAFTRDqhsKKKFAVGTASGVI 216
Cdd:cd00200   125 GKCLTTLRGHTDWVNSVAFSPDGTFVASSSqDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD---GEKLLSSSSDGTI 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 217 TLftkgdWGDHTDRILSPIRSHDFSIETITRADSDSLYVGGS-DGCIRLLHILPNKYERIIGQHSSRstVDAVDVTTEGN 295
Cdd:cd00200   202 KL-----WDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSeDGTIRVWDLRTGECVQTLSGHTNS--VTSLAWSPDGK 274


                  ....*.
gi 1246742805 296 FLVSCS 301
Cdd:cd00200   275 RLASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-264 2.35e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 2.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805  58 HKKSCRNISVNESGTEFISVGSDGVLKIADTSTGRVS------SKWIvdknkeispySVVQWIENDMVFATGDDNGCVSV 131
Cdd:cd00200    92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttlrghTDWV----------NSVAFSPDGTFVASSSQDGTIKL 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 132 WDKRTeGGIIHTHNDHIDYISSISPFEERY-FVATSGDGVLSVIDARNFKKPILSEEQDEEMTCGAFTRDqhsKKKFAVG 210
Cdd:cd00200   162 WDLRT-GKCVATLTGHTGEVNSVAFSPDGEkLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD---GYLLASG 237

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1246742805 211 TASGVITLftkgdWGDHTDRILSPIRSHDFSIETIT-RADSDSLYVGGSDGCIRL 264
Cdd:cd00200   238 SEDGTIRV-----WDLRTGECVQTLSGHTNSVTSLAwSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 56-314 8.55e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 8.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805  56 KRHKKSCRNISVNESGTEFISVGSDGVLKIADTSTGRVSSkwivdKNKE-ISPYSVVQWIENDMVFATGDDNGCVSVWDK 134
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-----TLKGhTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 135 RTeGGIIHTHNDHIDYISSISPFEERYFVATSG-DGVLSVIDARNFKKPILSEEQDEEMTCGAFTRDqhskKKF-AVGTA 212
Cdd:cd00200    81 ET-GECVRTLTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD----GTFvASSSQ 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805 213 SGVITLftkgdWGDHTDRILSPIRSHDFSIETIT-RADSDSLYVGGSDGCIRLLHILPNKYERIIGQHSSRstVDAVDVT 291
Cdd:cd00200   156 DGTIKL-----WDLRTGKCVATLTGHTGEVNSVAfSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG--VNSVAFS 228

                         250       260
                  ....*....|....*....|....*
gi 1246742805 292 TEGNFLVSCS--GTeLAFWPVDQKE 314
Cdd:cd00200   229 PDGYLLASGSedGT-IRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-169 1.23e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805  42 YDVAQISLVEQWSTkrHKKSCRNISVNESGTEFISVGSDGVLKIADTSTGRVsSKWIVDKNKEIspYSVVqWIENDMVFA 121
Cdd:cd00200   162 WDLRTGKCVATLTG--HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC-LGTLRGHENGV--NSVA-FSPDGYLLA 235

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1246742805 122 TGDDNGCVSVWDKRTEG--GIIHTHNDHIdYISSISPfEERYFVATSGDG 169
Cdd:cd00200   236 SGSEDGTIRVWDLRTGEcvQTLSGHTNSV-TSLAWSP-DGKRLASGSADG 283
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
74-180 4.86e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 4.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742805  74 FISVGSDGVLKIADTSTGRVSSKWIVDKNkeisPYSVVQWIENDMVFATGDDNGCVSVWDKRTeGGIIHTHN-----DHI 148
Cdd:COG3391    83 YVANSGSGRVSVIDLATGKVVATIPVGGG----PRGLAVDPDGGRLYVADSGNGRVSVIDTAT-GKVVATIPvgagpHGI 157

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1246742805 149 DyissISPFEERYFVATSGDG----VLSVIDARNFK 180
Cdd:COG3391   158 A----VDPDGKRLYVANSGSNtvsvIVSVIDTATGK 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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