|
Name |
Accession |
Description |
Interval |
E-value |
| AKR_EcYajO-like |
cd19079 |
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ... |
1-313 |
2.11e-160 |
|
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381305 [Multi-domain] Cd Length: 312 Bit Score: 450.11 E-value: 2.11e-160
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKKEyWEDWVLEEEdEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeIPRSSIVIMSKCFSPVRKDlik 80
Cdd:cd19079 20 MSFGDPK-WRPWVLDEE-ESRPIIKRALDLGINFFDTANVYSGGASEEILGRALKEF-APRDEVVIATKVYFPMGDG--- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 81 lymdlssrgvqlhdspelANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGA 159
Cdd:cd19079 94 ------------------PNGRGLSRKHIMAEVDASLKRLGTdYIDLYQIHRWDYETPIEETLEALHDVVKSGKVRYIGA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 160 STMRYYQFIELQNTAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANEETIRSKTDL 239
Cdd:cd19079 156 SSMYAWQFAKALHLAEKNGWTKFVSMQNHYNLLYREEEREMIPLCEEEGIGVIPWSPLARGRLARPWGDTTERRRSTTDT 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 240 -YTRALEFGAGYKAILSRVEELAKKYNVSMATLATAWSLHKG--DYPIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19079 236 aKLKYDYFTEADKEIVDRVEEVAKERGVSMAQVALAWLLSKPgvTAPIVGATKLEHLEDAVAALDIKLSEEEIKYLE 312
|
|
| PdxI |
COG0667 |
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ... |
1-314 |
1.90e-97 |
|
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];
Pssm-ID: 440431 [Multi-domain] Cd Length: 316 Bit Score: 290.54 E-value: 1.90e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKkEYWEDwvleEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeiPRSSIVIMSKCFSPVRKDlik 80
Cdd:COG0667 21 MTFGG-PWGGV----DEAEAIAILDAALDAGINFFDTADVYGPGRSEELLGEALKGR--PRDDVVIATKVGRRMGPG--- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 81 lymdlssrgvqlhdspelANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGA 159
Cdd:COG0667 91 ------------------PNGRGLSREHIRRAVEASLRRLGTdYIDLYQLHRPDPDTPIEETLGALDELVREGKIRYIGV 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 160 STMRYYQFIELQNTAEkhGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANE---ETIRSK 236
Cdd:COG0667 153 SNYSAEQLRRALAIAE--GLPPIVAVQNEYSLLDRSAEEELLPAARELGVGVLAYSPLAGGLLTGKYRRGAtfpEGDRAA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 237 TDLYTRalEFGAGYKAILSRVEELAKKYNVSMATLATAWSLHKG--DYPIVGISKVERLQDALASVTLKLNEEDIKYLEE 314
Cdd:COG0667 231 TNFVQG--YLTERNLALVDALRAIAAEHGVTPAQLALAWLLAQPgvTSVIPGARSPEQLEENLAAADLELSAEDLAALDA 308
|
|
| AKR_AKR12A1_B1_C1 |
cd19087 |
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ... |
1-314 |
6.55e-84 |
|
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.
Pssm-ID: 381313 [Multi-domain] Cd Length: 310 Bit Score: 255.57 E-value: 6.55e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKkeywedwvLEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeipRSSIVIMSKCFSPVRKDLik 80
Cdd:cd19087 21 MNFGG--------RTDEETSFAIMDRALDAGINFFDTADVYGGGRSEEIIGRWIAGR---RDDIVLATKVFGPMGDDP-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 81 lymdlssrgvqlhdspelaNQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGA 159
Cdd:cd19087 88 -------------------NDRGLSRRHIRRAVEASLRRLQTdYIDLYQMHHFDRDTPLEETLRALDDLVRQGKIRYIGV 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 160 STMRYYQFIELQNTAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT---RSIDANEETIRSK 236
Cdd:cd19087 149 SNFAAWQIAKAQGIAARRGLLRFVSEQPMYNLLKRQAELEILPAARAYGLGVIPYSPLAGGLLTgkyGKGKRPESGRLVE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 237 TDLYtRALEFGAGYKAILSRVEELAKKYNVSMATLATAWSL-HKG-DYPIVGISKVERLQDALASVTLKLNEEDIKYLEE 314
Cdd:cd19087 229 RARY-QARYGLEEYRDIAERFEALAAEAGLTPASLALAWVLsHPAvTSPIIGPRTLEQLEDSLAALEITLTPELLAEIDE 307
|
|
| Aldo_ket_red_shaker-like |
cd19074 |
Shaker potassium channel beta subunit family and similar proteins; This family includes ... |
16-307 |
4.26e-80 |
|
Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381300 [Multi-domain] Cd Length: 297 Bit Score: 245.58 E-value: 4.26e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeiPRSSIVIMSKCFSPVRkdliklymdlssrgvqlhDS 95
Cdd:cd19074 20 DDEDAKACVRKAYDLGINFFDTADVYAAGQAEEVLGKALKGW--PRESYVISTKVFWPTG------------------PG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 PelaNQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTA 174
Cdd:cd19074 80 P---NDRGLSRKHIFESIHASLKRLQLdYVDIYYCHRYDPETPLEETVRAMDDLIRQGKILYWGTSEWSAEQIAEAHDLA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 175 EKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT-----------RSIDANEETIRSKTDLYTRA 243
Cdd:cd19074 157 RQFGLIPPVVEQPQYNMLWREIEEEVIPLCEKNGIGLVVWSPLAQGLLTgkyrdgipppsRSRATDEDNRDKKRRLLTDE 236
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246743210 244 LefgagykaiLSRVEEL---AKKYNVSMATLATAWSLHK--GDYPIVGISKVERLQDALASVTLKLNEE 307
Cdd:cd19074 237 N---------LEKVKKLkpiADELGLTLAQLALAWCLRNpaVSSAIIGASRPEQLEENVKASGVKLSPE 296
|
|
| AKR_PsAKR |
cd19091 |
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ... |
1-314 |
3.51e-77 |
|
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.
Pssm-ID: 381317 [Multi-domain] Cd Length: 319 Bit Score: 238.67 E-value: 3.51e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKKEYW-EDWVLEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeipRSSIVIMSKCFSPVRKDLi 79
Cdd:cd19091 21 MTFGGGGGFfGAWGGVDQEEADRLVDIALDAGINFFDTADVYSEGESEEILGKALKGR---RDDVLIATKVRGRMGEGP- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 80 klymdlssrgvqlhdspelaNQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIG 158
Cdd:cd19091 97 --------------------NDVGLSRHHIIRAVEASLKRLGTdYIDLYQLHGFDALTPLEETLRALDDLVRQGKVRYIG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 159 ASTMRYYQFIELQNTAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDaNEETIRSKTD 238
Cdd:cd19091 157 VSNFSAWQIMKALGISERRGLARFVALQAYYSLLGRDLEHELMPLALDQGVGLLVWSPLAGGLLSGKYR-RGQPAPEGSR 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 239 LYTRALEF-----GAGYkAILSRVEELAKKYNVSMATLATAWSLHKgdyP-----IVGISKVERLQDALASVTLKLNEED 308
Cdd:cd19091 236 LRRTGFDFppvdrERGY-DVVDALREIAKETGATPAQVALAWLLSR---PtvssvIIGARNEEQLEDNLGAAGLSLTPEE 311
|
....*.
gi 1246743210 309 IKYLEE 314
Cdd:cd19091 312 IARLDK 317
|
|
| AKR_AKR9C1 |
cd19081 |
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ... |
1-312 |
5.34e-74 |
|
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).
Pssm-ID: 381307 [Multi-domain] Cd Length: 308 Bit Score: 230.18 E-value: 5.34e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGkkeywedWVLEEEDEvFKIMKAAYDAGIRTFDTANIYSA-------GVSEELVGKFIRKyEIPRSSIVIMSKcfsp 73
Cdd:cd19081 17 MVFG-------WTADEETS-FALLDAFVDAGGNFIDTADVYSAwvpgnagGESETIIGRWLKS-RGKRDRVVIATK---- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 74 VRKdliklymdlssrgvqlhdsPELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESG 152
Cdd:cd19081 84 VGF-------------------PMGPNGPGLSRKHIRRAVEASLRRLQTdYIDLYQAHWDDPATPLEETLGALNDLIRQG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 153 KVRYIGASTMRYYQFIELQNTAEKHGWHKFISMQNYHNLLYREE-EREMIPYCQKTGVGLIPWSPLARGLLTRSidanee 231
Cdd:cd19081 145 KVRYIGASNYSAWRLQEALELSRQHGLPRYVSLQPEYNLVDRESfEGELLPLCREEGIGVIPYSPLAGGFLTGK------ 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 232 tIRSKTDL--YTRALEFGAGYK-----AILSRVEELAKKYNVSMATLATAWSLHKG--DYPIVGISKVERLQDALASVTL 302
Cdd:cd19081 219 -YRSEADLpgSTRRGEAAKRYLnerglRILDALDEVAAEHGATPAQVALAWLLARPgvTAPIAGARTVEQLEDLLAAAGL 297
|
330
....*....|
gi 1246743210 303 KLNEEDIKYL 312
Cdd:cd19081 298 RLTDEEVARL 307
|
|
| AKR_AKR11B1-like |
cd19084 |
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ... |
16-313 |
3.14e-73 |
|
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381310 [Multi-domain] Cd Length: 296 Bit Score: 227.79 E-value: 3.14e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeipRSSIVIMSKCfspvrkdliklymdlssrGVQLHDS 95
Cdd:cd19084 23 DDQESIEAIKAAIDLGINFFDTAPVYGFGHSEEILGKALKGR---RDDVVIATKC------------------GLRWDGG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 PELANqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTmryYQFIELQNtA 174
Cdd:cd19084 82 KGVTK--DLSPESIRKEVEQSLRRLQTdYIDLYQIHWPDPNTPIEETAEALEKLKKEGKIRYIGVSN---FSVEQLEE-A 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 175 EKHGwhKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDAN----EETIRSKTDLYTRalEFGAGY 250
Cdd:cd19084 156 RKYG--PIVSLQPPYSMLEREIEEELLPYCRENGIGVLPYGPLAQGLLTGKYKKEptfpPDDRRSRFPFFRG--ENFEKN 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1246743210 251 KAILSRVEELAKKYNVSMATLATAWSLHK--GDYPIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19084 232 LEIVDKLKEIAEKYGKSLAQLAIAWTLAQpgVTSAIVGAKNPEQLEENAGALDWELTEEELKEID 296
|
|
| Aldo_ket_red |
pfam00248 |
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ... |
17-314 |
3.30e-71 |
|
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.
Pssm-ID: 425554 [Multi-domain] Cd Length: 290 Bit Score: 222.57 E-value: 3.30e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKCfspvrKDLIKLYMDlssrgvqlhdsp 96
Cdd:pfam00248 17 KEEALEALRAALEAGINFIDTAEVYGDGKSEELLGEALKDYPVKRDKVVIATKV-----PDGDGPWPS------------ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 elanqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGAStmRYYqfIELQNTAE 175
Cdd:pfam00248 80 ------GGSKENIRKSLEESLKRLGTdYIDLYYLHWPDPDTPIEETWDALEELKKEGKIRAIGVS--NFD--AEQIEKAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 176 KHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDaNEETIRSKTDLYTRALEFGAGYKAILs 255
Cdd:pfam00248 150 TKGKIPIVAVQVEYNLLRRRQEEELLEYCKKNGIPLIAYSPLGGGLLTGKYT-RDPDKGPGERRRLLKKGTPLNLEALE- 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246743210 256 RVEELAKKYNVSMATLATAWSLH--KGDYPIVGISKVERLQDALASVTLKLNEEDIKYLEE 314
Cdd:pfam00248 228 ALEEIAKEHGVSPAQVALRWALSkpGVTIPIPGASNPEQLEDNLGALEFPLSDEEVARIDE 288
|
|
| AKR_SF |
cd06660 |
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ... |
17-298 |
2.01e-69 |
|
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.
Pssm-ID: 381296 [Multi-domain] Cd Length: 232 Bit Score: 215.85 E-value: 2.01e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIpRSSIVIMSKCFspvrkdliklymdlssrgvqlHDSP 96
Cdd:cd06660 16 EEEAFALLDAALEAGGNFFDTADVYGDGRSERLLGRWLKGRGN-RDDVVIATKGG---------------------HPPG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 ELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAE 175
Cdd:cd06660 74 GDPSRSRLSPEHIRRDLEESLRRLGTdYIDLYYLHRDDPSTPVEETLEALNELVREGKIRYIGVSNWSAERLAEALAYAK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 176 KHGWHKFISMQNYHNLLYREE-EREMIPYCQKTGVGLIPWSPLARGLltrsidaneetirsktdlytralefgagykail 254
Cdd:cd06660 154 AHGLPGFAAVQPQYSLLDRSPmEEELLDWAEENGLPLLAYSPLARGP--------------------------------- 200
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1246743210 255 srveelakkynvsmATLATAWSLHK--GDYPIVGISKVERLQDALA 298
Cdd:cd06660 201 --------------AQLALAWLLSQpfVTVPIVGARSPEQLEENLA 232
|
|
| AKR_AKR9A_9B |
cd19080 |
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ... |
1-313 |
2.53e-69 |
|
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381306 [Multi-domain] Cd Length: 307 Bit Score: 218.24 E-value: 2.53e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGkkeywEDWVLE-EEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeipRSSIVIMSKcFSpvrkdli 79
Cdd:cd19080 18 MTFG-----TEWGWGaDREEARAMFDAYVEAGGNFIDTANNYTNGTSERLLGEFIAGN---RDRIVLATK-YT------- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 80 klymdlssrgvqLHDSPELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIG 158
Cdd:cd19080 82 ------------MNRRPGDPNAGGNHRKNLRRSVEASLRRLQTdYIDLLYVHAWDFTTPVEEVMRALDDLVRAGKVLYVG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 159 ASTMRYYQFIELQNTAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANEETIRSKTD 238
Cdd:cd19080 150 ISDTPAWVVARANTLAELRGWSPFVALQIEYSLLERTPERELLPMARALGLGVTPWSPLGGGLLTGKYQRGEEGRAGEAK 229
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743210 239 LYTRAL-EFGAGYKAILSRVEELAKKYNVSMATLATAWSLHKGDY--PIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19080 230 GVTVGFgKLTERNWAIVDVVAAVAEELGRSAAQVALAWVRQKPGVviPIIGARTLEQLKDNLGALDLTLSPEQLARLD 307
|
|
| AKR_AKR11B3 |
cd19085 |
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ... |
1-314 |
9.40e-67 |
|
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.
Pssm-ID: 381311 [Multi-domain] Cd Length: 292 Bit Score: 211.29 E-value: 9.40e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKKEYWEDwvlEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKyeiPRSSIVIMSKCFspvrkdlik 80
Cdd:cd19085 9 WQFGGGYWWGD---QDDEESIATIHAALDAGINFFDTAEAYGDGHSEEVLGKALKG---RRDDVVIATKVS--------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 81 lymdlssrgvqlhdspelanQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGA 159
Cdd:cd19085 74 --------------------PDNLTPEDVRKSCERSLKRLGTdYIDLYQIHWPSSDVPLEETMEALEKLKEEGKIRAIGV 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 160 STmryyqfIELQNTAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT---RSIDANEET-IRS 235
Cdd:cd19085 134 SN------FGPAQLEEALDAGRIDSNQLPYNLLWRAIEYEILPFCREHGIGVLAYSPLAQGLLTgkfSSAEDFPPGdART 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 236 KTDLYTRALEFGAGYKAIlSRVEELAKKYNVSMATLATAWSLHKG--DYPIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19085 208 RLFRHFEPGAEEETFEAL-EKLKEIADELGVTMAQLALAWVLQQPgvTSVIVGARNPEQLEENAAAVDLELSPSVLERLD 286
|
.
gi 1246743210 314 E 314
Cdd:cd19085 287 E 287
|
|
| AKR_AtPLR-like |
cd19093 |
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ... |
1-313 |
3.62e-56 |
|
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.
Pssm-ID: 381319 [Multi-domain] Cd Length: 293 Bit Score: 183.97 E-value: 3.62e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKKEYWeDWVLEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEiPRSSIVIMSKCFS-PVRkdli 79
Cdd:cd19093 10 WQWGDRLWW-GYGEYGDEDLQAAFDAALEAGVNLFDTAEVYGTGRSERLLGRFLKELG-DRDEVVIATKFAPlPWR---- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 80 klymdlssrgvqlhdspelanqcgLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSA-EEVMRALNDVVESGKVRYI 157
Cdd:cd19093 84 ------------------------LTRRSVVKALKASLERLGLdSIDLYQLHWPGPWYSQiEALMDGLADAVEEGLVRAV 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 158 GASTMRYYQFIELQNTAEKHGwHKFISMQNYHNLLYRE-EEREMIPYCQKTGVGLIPWSPLARGLLTRSIdaNEETIRSK 236
Cdd:cd19093 140 GVSNYSADQLRRAHKALKERG-VPLASNQVEYSLLYRDpEQNGLLPACDELGITLIAYSPLAQGLLTGKY--SPENPPPG 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 237 TDLYTRALEFGAGYKAILSRVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19093 217 GRRRLFGRKNLEKVQPLLDALEEIAEKYGKTPAQVALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
|
|
| AKR_AKR6C1_2 |
cd19143 |
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ... |
17-314 |
8.01e-56 |
|
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381369 [Multi-domain] Cd Length: 319 Bit Score: 183.95 E-value: 8.01e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKCFSPVRKDLiklymdlssrgvqlhdsp 96
Cdd:cd19143 30 VDEAKECMKAAYDAGVNFFDNAEVYANGQSEEIMGQAIKELGWPRSDYVVSTKIFWGGGGPP------------------ 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 elANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAE 175
Cdd:cd19143 92 --PNDRGLSRKHIVEGTKASLKRLQLdYVDLVFCHRPDPATPIEETVRAMNDLIDQGKAFYWGTSEWSAQQIEEAHEIAD 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 176 KHGWHKFISMQNYHNLLYREE-EREMIPYCQKTGVGLIPWSPLARGLLT-RSIDANEETIRSKTDLYTR-ALEFGAGYKA 252
Cdd:cd19143 170 RLGLIPPVMEQPQYNLFHRERvEVEYAPLYEKYGLGTTTWSPLASGLLTgKYNNGIPEGSRLALPGYEWlKDRKEELGQE 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246743210 253 ILSRVEEL---AKKYNVSMATLATAWSLHKgdyP-----IVGISKVERLQDALASVTL--KLNEEDIKYLEE 314
Cdd:cd19143 250 KIEKVRKLkpiAEELGCSLAQLAIAWCLKN---PnvstvITGATKVEQLEENLKALEVlpKLTPEVMEKIEA 318
|
|
| AKR_Tas-like |
cd19094 |
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ... |
17-307 |
4.14e-54 |
|
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.
Pssm-ID: 381320 [Multi-domain] Cd Length: 328 Bit Score: 179.68 E-value: 4.14e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYS-------AGVSEELVGKFIRKYEiPRSSIVIMSKCFSPvrkdliklymdlSSRG 89
Cdd:cd19094 17 EAEAHEQLDYAFDEGVNFIDTAEMYPvppspetQGRTEEIIGSWLKKKG-NRDKVVLATKVAGP------------GEGI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 90 VQLHDSPElanqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIH---RYDPH---------------VSAEEVMRALNDVVE 150
Cdd:cd19094 84 TWPRGGGT-----RLDRENIREAVEGSLKRLGTdYIDLYQLHwpdRYTPLfgggyytepseeedsVSFEEQLEALGELVK 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 151 SGKVRYIGAS------TMRYYQfielqnTAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT- 223
Cdd:cd19094 159 AGKIRHIGLSnetpwgVMKFLE------LAEQLGLPRIVSIQNPYSLLNRNFEEGLAEACHRENVGLLAYSPLAGGVLTg 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 224 RSIDANEETIRSKTDLYTRaleFGAGY-----KAILSRVEELAKKYNVSMATLATAWSLHKgdyP-----IVGISKVERL 293
Cdd:cd19094 233 KYLDGAARPEGGRLNLFPG---YMARYrspqaLEAVAEYVKLARKHGLSPAQLALAWVRSR---PfvtstIIGATTLEQL 306
|
330
....*....|....
gi 1246743210 294 QDALASVTLKLNEE 307
Cdd:cd19094 307 KENIDAFDVPLSDE 320
|
|
| YdhF |
COG4989 |
Predicted oxidoreductase YdhF [General function prediction only]; |
9-308 |
7.05e-53 |
|
Predicted oxidoreductase YdhF [General function prediction only];
Pssm-ID: 444013 [Multi-domain] Cd Length: 299 Bit Score: 175.72 E-value: 7.05e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 9 WEDWVLEEEdEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKCfspvrkdliklymdlssr 88
Cdd:COG4989 23 LGEWDLSPA-EAAALIEAALELGITTFDHADIYGGYTCEALFGEALKLSPSLREKIELQTKC------------------ 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 89 GVQLhDSPELANQCG---LSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRY 164
Cdd:COG4989 84 GIRL-PSEARDNRVKhydTSKEHIIASVEGSLRRLGTdYLDLLLLHRPDPLMDPEEVAEAFDELKASGKVRHFGVSNFTP 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 165 YQFIELQntaeKHGWHKFISMQNYHNLLYREE-EREMIPYCQKTGVGLIPWSPLARGLLTRsidaneetirsktdlytra 243
Cdd:COG4989 163 SQFELLQ----SALDQPLVTNQIELSLLHTDAfDDGTLDYCQLNGITPMAWSPLAGGRLFG------------------- 219
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 244 lEFGAGYKAILSRVEELAKKYNVSMATLATAWSL-H-KGDYPIVGISKVERLQDALASVTLKLNEED 308
Cdd:COG4989 220 -GFDEQFPRLRAALDELAEKYGVSPEAIALAWLLrHpAGIQPVIGTTNPERIKAAAAALDIELTREE 285
|
|
| AKR_AKR13A_13D |
cd19076 |
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ... |
15-312 |
9.11e-53 |
|
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381302 [Multi-domain] Cd Length: 303 Bit Score: 175.48 E-value: 9.11e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 15 EEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKyeiPRSSIVIMSKcFSPVRKDliklymdlSSRGVQLHD 94
Cdd:cd19076 29 ADEEESIATLHRALELGVTFLDTADMYGPGTNEELLGKALKD---RRDEVVIATK-FGIVRDP--------GSGFRGVDG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 95 SPElanqcglsrkHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIG-----ASTMRyyqfi 168
Cdd:cd19076 97 RPE----------YVRAACEASLKRLGTdVIDLYYQHRVDPNVPIEETVGAMAELVEEGKVRYIGlseasADTIR----- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 169 elqntaEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANEEtirSKTDLYTRALEFGA 248
Cdd:cd19076 162 ------RAHAVHPITAVQSEYSLWTRDIEDEVLPTCRELGIGFVAYSPLGRGFLTGAIKSPED---LPEDDFRRNNPRFQ 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246743210 249 G-----YKAILSRVEELAKKYNVSMATLATAWSLHKGD--YPIVGISKVERLQDALASVTLKLNEEDIKYL 312
Cdd:cd19076 233 GenfdkNLKLVEKLEAIAAEKGCTPAQLALAWVLAQGDdiVPIPGTKRIKYLEENVGALDVVLTPEELAEI 303
|
|
| AKR_AKR13C1_2 |
cd19078 |
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ... |
1-314 |
2.07e-52 |
|
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.
Pssm-ID: 381304 [Multi-domain] Cd Length: 301 Bit Score: 174.34 E-value: 2.07e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKKEYwedwvlEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeipRSSIVIMSKCFspvrkdlIK 80
Cdd:cd19078 14 MSHGYGPP------PDKEEMIELIRKAVELGITFFDTAEVYGPYTNEELVGEALKPF---RDQVVIATKFG-------FK 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 81 LYMDlSSRGVQLHDSPElanqcglsrkHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGA 159
Cdd:cd19078 78 IDGG-KPGPLGLDSRPE----------HIRKAVEGSLKRLQTdYIDLYYQHRVDPNVPIEEVAGTMKELIKEGKIRHWGL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 160 S-----TMRyyqfielqntaEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDAN----E 230
Cdd:cd19078 147 SeagveTIR-----------RAHAVCPVTAVQSEYSMMWREPEKEVLPTLEELGIGFVPFSPLGKGFLTGKIDENtkfdE 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 231 ETIRSKTDLYTRalEFGAGYKAILSRVEELAKKYNVSMATLATAWSLHKGDY--PIVGISKVERLQDALASVTLKLNEED 308
Cdd:cd19078 216 GDDRASLPRFTP--EALEANQALVDLLKEFAEEKGATPAQIALAWLLAKKPWivPIPGTTKLSRLEENIGAADIELTPEE 293
|
....*.
gi 1246743210 309 IKYLEE 314
Cdd:cd19078 294 LREIED 299
|
|
| AKR_AKR11B2 |
cd19149 |
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ... |
16-314 |
6.01e-52 |
|
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.
Pssm-ID: 381375 [Multi-domain] Cd Length: 315 Bit Score: 173.61 E-value: 6.01e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeipRSSIVIMSKCfsPVRKDLIKLYMDLSSRGVQLHDS 95
Cdd:cd19149 31 DDNESIRTIHAALDLGINLIDTAPAYGFGHSEEIVGKAIKGR---RDKVVLATKC--GLRWDREGGSFFFVRDGVTVYKN 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 pelanqcgLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIElqntA 174
Cdd:cd19149 106 --------LSPESIREEVEQSLKRLGTdYIDLYQTHWQDVETPIEETMEALEELKRQGKIRAIGASNVSVEQIKE----Y 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 175 EKHGwhKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANEE----TIRSKTDLYTRALEfgAGY 250
Cdd:cd19149 174 VKAG--QLDIIQEKYSMLDRGIEKELLPYCKKNNIAFQAYSPLEQGLLTGKITPDREfdagDARSGIPWFSPENR--EKV 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246743210 251 KAILSRVEELAKKYNVSMATLATAWSLHKGDYP--IVGISKVERLQDALASVTLKLNEEDIKYLEE 314
Cdd:cd19149 250 LALLEKWKPLCEKYGCTLAQLVIAWTLAQPGITsaLCGARKPEQAEENAKAGDIRLSAEDIATMRS 315
|
|
| AKR_BsYcsN_EcYdhF-like |
cd19092 |
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ... |
15-308 |
6.66e-51 |
|
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.
Pssm-ID: 381318 [Multi-domain] Cd Length: 287 Bit Score: 170.04 E-value: 6.66e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 15 EEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKCFspvrkdlIKLYMDLSSRGVQLHD 94
Cdd:cd19092 21 ESAEELLSLIEAALELGITTFDHADIYGGGKCEELFGEALALNPGLREKIEIQTKCG-------IRLGDDPRPGRIKHYD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 95 SpelanqcglSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQnt 173
Cdd:cd19092 94 T---------SKEHILASVEGSLKRLGTdYLDLLLLHRPDPLMDPEEVAEAFDELVKSGKVRYFGVSNFTPSQIELLQ-- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 174 aeKHGWHKFISMQNYHNLLYREE-EREMIPYCQKTGVGLIPWSPLARGLLTRSIDANEETIRSKtdlytralefgagyka 252
Cdd:cd19092 163 --SYLDQPLVTNQIELSLLHTEAiDDGTLDYCQLLDITPMAWSPLGGGRLFGGFDERFQRLRAA---------------- 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743210 253 ilsrVEELAKKYNVSMATLATAWSL-HKGD-YPIVGISKVERLQDALASVTLKLNEED 308
Cdd:cd19092 225 ----LEELAEEYGVTIEAIALAWLLrHPARiQPILGTTNPERIRSAVKALDIELTREE 278
|
|
| AKR_AKR3F1-like |
cd19072 |
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ... |
17-313 |
1.64e-50 |
|
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381298 [Multi-domain] Cd Length: 263 Bit Score: 168.56 E-value: 1.64e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeiPRSSIVIMSKcFSPVRkdliklymdlssrgvqlhdsp 96
Cdd:cd19072 25 DKKAIEALRYAIELGINLIDTAEMYGGGHAEELVGKAIKGF--DREDLFITTK-VSPDH--------------------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 elanqcgLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAE 175
Cdd:cd19072 81 -------LKYDDVIKAAKESLKRLGTdYIDLYLIHWPNPSIPIEETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 176 KHgwhKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRsidaneetirsktdlytralefgagyKAILS 255
Cdd:cd19072 154 KG---PIVANQVEYNLFDREEESGLLPYCQKNGIAIIAYSPLEKGKLSN--------------------------AKGSP 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1246743210 256 RVEELAKKYNVSMATLATAWSL-HKGDYPIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19072 205 LLDEIAKKYGKTPAQIALNWLIsKPNVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
|
|
| AKR_AKR10A1_2 |
cd19082 |
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ... |
15-298 |
3.44e-50 |
|
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.
Pssm-ID: 381308 [Multi-domain] Cd Length: 291 Bit Score: 168.50 E-value: 3.44e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 15 EEEDEVFKIMKAAYDAGIRTFDTANIYSA----GVSEELVGKFIRKYEIpRSSIVIMSKCfspvrkdliklymdlssrgv 90
Cdd:cd19082 14 IDEEEAFALLDAFVELGGNFIDTARVYGDwverGASERVIGEWLKSRGN-RDKVVIATKG-------------------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 91 qLHDSPELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIE 169
Cdd:cd19082 73 -GHPDLEDMSRSRLSPEDIRADLEESLERLGTdYIDLYFLHRDDPSVPVGEIVDTLNELVRAGKIRAFGASNWSTERIAE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 170 LQNTAEKHGWHKFISMQNYHNLLYREEER-----------EMIPYCQKTGVGLIPWSPLARGLLTRSIDANEETIRSKTD 238
Cdd:cd19082 152 ANAYAKAHGLPGFAASSPQWSLARPNEPPwpgptlvamdeEMRAWHEENQLPVFAYSSQARGFFSKRAAGGAEDDSELRR 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246743210 239 LYTRALEFgagykAILSRVEELAKKYNVSMATLATAWSLHKG--DYPIVGISKVERLQDALA 298
Cdd:cd19082 232 VYYSEENF-----ERLERAKELAEEKGVSPTQIALAYVLNQPfpTVPIIGPRTPEQLRDSLA 288
|
|
| AKR_AKR11A1_11D1 |
cd19083 |
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ... |
14-313 |
4.15e-50 |
|
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).
Pssm-ID: 381309 [Multi-domain] Cd Length: 307 Bit Score: 168.75 E-value: 4.15e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 14 LEEEDEVfKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEipRSSIVIMSKCfspvrkdliklYMDLSSRGVQLH 93
Cdd:cd19083 30 LDEEEGK-DLVREALDNGVNLLDTAFIYGLGRSEELVGEVLKEYN--RNEVVIATKG-----------AHKFGGDGSVLN 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 94 DSPElanqcglsrkHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIElqn 172
Cdd:cd19083 96 NSPE----------FLRSAVEKSLKRLNTdYIDLYYIHFPDGETPKAEAVGALQELKDEGKIRAIGVSNFSLEQLKE--- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 173 tAEKHGWHKFIsmQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT----RSIDANEETIRSKTDLYTralefGA 248
Cdd:cd19083 163 -ANKDGYVDVL--QGEYNLLQREAEEDILPYCVENNISFIPYFPLASGLLAgkytKDTKFPDNDLRNDKPLFK-----GE 234
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 249 GYKAILSRVEEL---AKKYNVSMATLATAWSLHKG--DYPIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19083 235 RFSENLDKVDKLksiADEKGVTVAHLALAWYLTRPaiDVVIPGAKRAEQVIDNLKALDVTLTEEEIAFID 304
|
|
| AKR_AKR9A1-2 |
cd19146 |
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus ... |
1-316 |
2.85e-49 |
|
Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and similar proteins; Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV and Aspergillus flavus norsolorinic acid reductase (NOR), are founding members of aldo-keto reductase family 9 member A1-2 (AKR9A1-2), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis.
Pssm-ID: 381372 [Multi-domain] Cd Length: 326 Bit Score: 167.22 E-value: 2.85e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKKeyWEDWVLE-EEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIpRSSIVIMSKcfspvrkdli 79
Cdd:cd19146 19 MSFGEA--WKSMMGEcDKETAFKLLDAFYEQGGNFIDTANNYQGEESERWVGEWMASRGN-RDEMVLATK---------- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 80 klymdlSSRGVQLHDS-PELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYI 157
Cdd:cd19146 86 ------YTTGYRRGGPiKIKSNYQGNHAKSLRLSVEASLKKLQTsYIDILYVHWWDYTTSIPELMQSLNHLVAAGKVLYL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 158 GASTMRYYQFIELQNTAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLtRSidANEETIRSKT 237
Cdd:cd19146 160 GVSDTPAWVVSKANAYARAHGLTQFVVYQGHWSAAFRDFERDILPMCEAEGMALAPWGVLGQGQF-RT--EEEFKRRGRS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 238 DLYTRALEfgAGYKAILSRVEELAKKYNVSMATLATAWSLHKGDY--PIVGISKVERLQDALASVTLKLNEEDIKYLEEP 315
Cdd:cd19146 237 GRKGGPQT--EKERKVSEKLEKVAEEKGTAITSVALAYVMHKAPYvfPIVGGRKVEHLKGNIEALGISLSDEEIQEIEDA 314
|
.
gi 1246743210 316 Y 316
Cdd:cd19146 315 Y 315
|
|
| AKR_AKR11C1 |
cd19086 |
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ... |
16-223 |
1.45e-45 |
|
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.
Pssm-ID: 381312 [Multi-domain] Cd Length: 238 Bit Score: 154.94 E-value: 1.45e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKyeiPRSSIVIMSKCfspvrkdliklymdlssrGVQLHDS 95
Cdd:cd19086 22 DDAEAIRALRAALDLGINFFDTADVYGDGHSERLLGKALKG---RRDKVVIATKF------------------GNRFDGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 PELANqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVS-AEEVMRALNDVVESGKVRYIGASTMRYYQFIElqnt 173
Cdd:cd19086 81 PERPQ--DFSPEYIREAVEASLKRLGTdYIDLYQLHNPPDEVLdNDELFEALEKLKQEGKIRAYGVSVGDPEEALA---- 154
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1246743210 174 AEKHGwhKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT 223
Cdd:cd19086 155 ALRRG--GIDVVQVIYNLLDQRPEEELFPLAEEHGVGVIARVPLASGLLT 202
|
|
| AKR_AKR13D1 |
cd19145 |
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ... |
16-312 |
7.62e-43 |
|
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.
Pssm-ID: 381371 [Multi-domain] Cd Length: 304 Bit Score: 149.89 E-value: 7.62e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRkyEIPRSSIVIMSKCFspvrkdliklYMDLSSRGVQLHDS 95
Cdd:cd19145 31 PEEEGIALIHHAFNSGVTFLDTSDIYGPNTNEVLLGKALK--DGPREKVQLATKFG----------IHEIGGSGVEVRGD 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 PElanqcglsrkHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIG-----ASTMRyyqfie 169
Cdd:cd19145 99 PA----------YVRAACEASLKRLDVdYIDLYYQHRIDTTVPIEITMGELKKLVEEGKIKYIGlseasADTIR------ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 170 lqntaEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLtrSIDANEETIRSKTDLYTRALEFGAG 249
Cdd:cd19145 163 -----RAHAVHPITAVQLEWSLWTRDIEEEIIPTCRELGIGIVPYSPLGRGFF--AGKAKLEELLENSDVRKSHPRFQGE 235
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246743210 250 ----YKAILSRVEELAKKYNVSMATLATAWSLHKGD--YPIVGISKVERLQDALASVTLKLNEEDIKYL 312
Cdd:cd19145 236 nlekNKVLYERVEALAKKKGCTPAQLALAWVLHQGEdvVPIPGTTKIKNLNQNIGALSVKLTKEDLKEI 304
|
|
| AKR_unchar |
cd19752 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
1-301 |
1.02e-42 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381391 [Multi-domain] Cd Length: 291 Bit Score: 149.02 E-value: 1.02e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGkkeywedwVLEEEDEVFKIMKAAYDAGIRTFDTANIYS-------AGVSEELVGKFIRKYEIpRSSIVIMSKCFSP 73
Cdd:cd19752 8 MYFG--------TRTDEETSFAILDRYVAAGGNFLDTANNYAfwteggvGGESERLIGRWLKDRGN-RDDVVIATKVGAG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 74 VRkdliklymdlssRGVQLHDSPElanqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESG 152
Cdd:cd19752 79 PR------------DPDGGPESPE-----GLSAETIEQEIDKSLRRLGTdYIDLYYAHVDDRDTPLEETLEAFNELVKAG 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 153 KVRYIGASTMRYYQFIELQNTAEKHGWHKFISMQNYHNLLYREEER----------EMIPYCQKTG-VGLIPWSPLARGL 221
Cdd:cd19752 142 KVRAIGASNFAAWRLERARQIARQQGWAEFSAIQQRHSYLRPRPGAdfgvqrivtdELLDYASSRPdLTLLAYSPLLSGA 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 222 LTRsidaneetirskTDLYTRALEFGAGYKAILSRVEELAKKYNVSMATLATAWSLHK--GDYPIVGISKVERLQDALAS 299
Cdd:cd19752 222 YTR------------PDRPLPEQYDGPDSDARLAVLEEVAGELGATPNQVVLAWLLHRtpAIIPLLGASTVEQLEENLAA 289
|
..
gi 1246743210 300 VT 301
Cdd:cd19752 290 LD 291
|
|
| AKR_AKR13B1 |
cd19088 |
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ... |
17-304 |
2.85e-42 |
|
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.
Pssm-ID: 381314 [Multi-domain] Cd Length: 256 Bit Score: 146.98 E-value: 2.85e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeipRSSIVIMSKcfspvrkdliklymdlssrGVQLHDSP 96
Cdd:cd19088 23 REEAIAVLRRALELGVNFIDTADSYGPDVNERLIAEALHPY---PDDVVIATK-------------------GGLVRTGP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 ELANQCGlSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRyyqfIELQNTAE 175
Cdd:cd19088 81 GWWGPDG-SPEYLRQAVEASLRRLGLdRIDLYQLHRIDPKVPFEEQLGALAELQDEGLIRHIGLSNVT----VAQIEEAR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 176 KHGwhKFISMQNYHNLLYREEErEMIPYCQKTGVGLIPWSPLARGLLTRSidaneetirsktdlytralefgagykaiLS 255
Cdd:cd19088 156 AIV--RIVSVQNRYNLANRDDE-GVLDYCEAAGIAFIPWFPLGGGDLAQP----------------------------GG 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1246743210 256 RVEELAKKYNVSMATLATAWSLHKGDY--PIVGISKVERLQDALASVTLKL 304
Cdd:cd19088 205 LLAEVAARLGATPAQVALAWLLARSPVmlPIPGTSSVEHLEENLAAAGLRL 255
|
|
| AKR_AKR14A1_2 |
cd19089 |
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ... |
18-310 |
2.31e-40 |
|
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.
Pssm-ID: 381315 [Multi-domain] Cd Length: 308 Bit Score: 143.17 E-value: 2.31e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 18 DEVFKIMKAAYDAGIRTFDTANIY--SAGVSEELVGKfirkyeiprssivIMSKCFSPVRKDLIklymdLSSR-GVQLHD 94
Cdd:cd19089 29 EEARELLRTAFDLGITHFDLANNYgpPPGSAEENFGR-------------ILKRDLRPYRDELV-----ISTKaGYGMWP 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 95 SPelaNQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGAStmRY-----YQFI 168
Cdd:cd19089 91 GP---YGDGGSRKYLLASLDQSLKRMGLdYVDIFYHHRYDPDTPLEETMTALADAVRSGKALYVGIS--NYpgakaRRAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 169 ELQNtaeKHGwHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT-RSIDANEETIRSKTDLYTRALEFG 247
Cdd:cd19089 166 ALLR---ELG-VPLIIHQPRYSLLDRWAEDGLLEVLEEAGIGFIAFSPLAQGLLTdKYLNGIPPDSRRAAESKFLTEEAL 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 248 AGYKA-ILSRVEELAKKYNVSMATLATAWSL-HKG-DYPIVGISKVERLQDALASV-TLKLNEEDIK 310
Cdd:cd19089 242 TPEKLeQLRKLNKIAAKRGQSLAQLALSWVLrDPRvTSVLIGASSPSQLEDNVAALkNLDFSEEELA 308
|
|
| AKR_unchar |
cd19102 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
7-314 |
4.81e-40 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381328 [Multi-domain] Cd Length: 302 Bit Score: 142.43 E-value: 4.81e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 7 EYWedWVLEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeipRSSIVIMSKCfSPVRKDliklymdlS 86
Cdd:cd19102 17 GGG--WGPQDDRDSIAAIRAALDLGINWIDTAAVYGLGHSEEVVGRALKGL---RDRPIVATKC-GLLWDE--------E 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 87 SRGVQlhdspelanqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGAST---- 161
Cdd:cd19102 83 GRIRR-----------SLKPASIRAECEASLRRLGVdVIDLYQIHWPDPDEPIEEAWGALAELKEEGKVRAIGVSNfsvd 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 162 -MRYYQFIelqntaekhgwHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDAneETIRS--KTD 238
Cdd:cd19102 152 qMKRCQAI-----------HPIASLQPPYSLLRRGIEAEILPFCAEHGIGVIVYSPMQSGLLTGKMTP--ERVASlpADD 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 239 LYTRALEF-GAGYKAILSRVEEL---AKKYNVSMATLATAWSLHKgdyP-----IVGISKVERLQDALASVTLKLNEEDI 309
Cdd:cd19102 219 WRRRSPFFqEPNLARNLALVDALrpiAERHGRTVAQLAIAWVLRR---PevtsaIVGARRPDQIDETVGAADLRLTPEEL 295
|
....*
gi 1246743210 310 KYLEE 314
Cdd:cd19102 296 AEIEA 300
|
|
| AKR_AKR13A1 |
cd19144 |
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ... |
15-324 |
2.46e-39 |
|
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.
Pssm-ID: 381370 [Multi-domain] Cd Length: 323 Bit Score: 141.04 E-value: 2.46e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 15 EEEDEVFKIMKAAYDAGIRTFDTANIYsaGVSEELVGKFIRKYEIPRSSIVIMSKcfspvrkdlIKLYMDLSSRGVQLHD 94
Cdd:cd19144 31 KPDEERFAVLDAAFELGCTFWDTADIY--GDSEELIGRWFKQNPGKREKIFLATK---------FGIEKNVETGEYSVDG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 95 SPELANQcglsrkhifdAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIG-----ASTMRyyqfi 168
Cdd:cd19144 100 SPEYVKK----------ACETSLKRLGVdYIDLYYQHRVDGKTPIEKTVAAMAELVQEGKIKHIGlsecsAETLR----- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 169 elqntaEKHGWHKFISMQ-NYH--NLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT---RSIDANEEtirskTDLYTR 242
Cdd:cd19144 165 ------RAHAVHPIAAVQiEYSpfSLDIERPEIGVLDTCRELGVAIVAYSPLGRGFLTgaiRSPDDFEE-----GDFRRM 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 243 ALEFGA-GYKAILS---RVEELAKKYNVSMATLATAWSLHKGD--YPIVGISKVERLQDALASVTLKLNEEDIKYLEEPY 316
Cdd:cd19144 234 APRFQAeNFPKNLElvdKIKAIAKKKNVTAGQLTLAWLLAQGDdiIPIPGTTKLKRLEENLGALKVKLTEEEEKEIREIA 313
|
....*...
gi 1246743210 317 CPVPIQGE 324
Cdd:cd19144 314 EEAEVVGE 321
|
|
| AKR_AKR11B1 |
cd19148 |
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ... |
11-310 |
6.41e-39 |
|
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381374 [Multi-domain] Cd Length: 302 Bit Score: 139.36 E-value: 6.41e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 11 DWVLEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEiPRSSIVIMSKCfspvrkdliklYMDLSSRGV 90
Cdd:cd19148 18 MWGGTDEKEAIETIHKALDLGINLIDTAPVYGFGLSEEIVGKALKEYG-KRDRVVIATKV-----------GLEWDEGGE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 91 QLHDSpelanqcglSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIE 169
Cdd:cd19148 86 VVRNS---------SPARIRKEVEDSLRRLQTdYIDLYQVHWPDPLVPIEETAEALKELLDEGKIRAIGVSNFSPEQMET 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 170 LQNTAEKHgwhkfiSMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIdaNEETIRSKTDLYTRALEF-GA 248
Cdd:cd19148 157 FRKVAPLH------TVQPPYNLFEREIEKDVLPYARKHNIVTLAYGALCRGLLSGKM--TKDTKFEGDDLRRTDPKFqEP 228
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743210 249 GYKAILSRVEEL----AKKYNVSMATLATAWSLHKGDYPIV--GISKVERLQDALASVTLKLNEEDIK 310
Cdd:cd19148 229 RFSQYLAAVEELdklaQERYGKSVIHLAVRWLLDQPGVSIAlwGARKPEQLDAVDEVFGWSLNDEDMK 296
|
|
| AKR_unchar |
cd19101 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-314 |
2.38e-37 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381327 [Multi-domain] Cd Length: 304 Bit Score: 135.41 E-value: 2.38e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYsaGVSEELVGKFIRKY---EIPRSSIVIMSKcFSPVRKDLiklymdlssrgvql 92
Cdd:cd19101 21 DEDAAVRAMAAYVDAGLTTFDCADIY--GPAEELIGEFRKRLrreRDAADDVQIHTK-WVPDPGEL-------------- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 93 hdspelanqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSA-EEVMRALNDVVESGKVRYIGA---STMRyyqf 167
Cdd:cd19101 84 ----------TMTRAYVEAAIDRSLKRLGVdRLDLVQFHWWDYSDPGyLDAAKHLAELQEEGKIRHLGLtnfDTER---- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 168 ieLQNTAEKHGwhKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT------RSIDANEETIRSKTdLYT 241
Cdd:cd19101 150 --LREILDAGV--PIVSNQVQYSLLDRRPENGMAALCEDHGIKLLAYGTLAGGLLSekylgvPEPTGPALETRSLQ-KYK 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 242 RAL-EFG--AGYKAILSRVEELAKKYNVSMATLATAWSLhkgDYP-----IVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19101 225 LMIdEWGgwDLFQELLRTLKAIADKHGVSIANVAVRWVL---DQPgvagvIVGARNSEHIDDNVRAFSFRLDDEDRAAID 301
|
.
gi 1246743210 314 E 314
Cdd:cd19101 302 A 302
|
|
| AKR_AKR9A3_9B1-4 |
cd19147 |
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; ... |
1-313 |
4.60e-37 |
|
Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD) and similar proteins; Phanerochaete chrysosporium ADD (EC1.1.1.91) is a founding member of aldo-keto reductase family 9 member A3. It is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). This family also includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Pssm-ID: 381373 [Multi-domain] Cd Length: 319 Bit Score: 134.95 E-value: 4.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGkkEYWEDWV-LEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIpRSSIVIMSKCFSPVRKDLI 79
Cdd:cd19147 18 MSIG--DAWSGFMgSMDKEQAFELLDAFYEAGGNFIDTANNYQDEQSETWIGEWMKSRKN-RDQIVIATKFTTDYKAYEV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 80 KlymdlssrgvqlhdSPELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIG 158
Cdd:cd19147 95 G--------------KGKAVNYCGNHKRSLHVSVRDSLRKLQTdWIDILYVHWWDYTTSIEEVMDSLHILVQQGKVLYLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 159 ASTMRYYQFIELQNTAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLtRSIDANEETIRSKTD 238
Cdd:cd19147 161 VSDTPAWVVSAANYYATAHGKTPFSVYQGRWNVLNRDFERDIIPMARHFGMALAPWDVLGGGKF-QSKKAVEERKKNGEG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 239 LYT--RALEFGAGYKAILSRVEELAKKYNV-SMATLATAWSLHKGDY--PIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19147 240 LRSfvGGTEQTPEEVKISEALEKVAEEHGTeSVTAIALAYVRSKAPNvfPLVGGRKIEHLKDNIEALSIKLTPEEIEYLE 319
|
|
| AKR_AKR6B1 |
cd19142 |
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ... |
23-305 |
7.60e-37 |
|
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.
Pssm-ID: 381368 [Multi-domain] Cd Length: 325 Bit Score: 134.51 E-value: 7.60e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 23 IMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKcfspvrkdlikLYMDLSSRGvqlhdspelanqC 102
Cdd:cd19142 36 IVTLAYENGINYFDTSDAFTSGQAETELGRILKKKGWKRSSYIVSTK-----------IYWSYGSEE------------R 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 103 GLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAEKHGWHK 181
Cdd:cd19142 93 GLSRKHIIESVRASLRRLQLdYIDIVIIHKADPMCPMEEVVRAMSYLIDNGLIMYWGTSRWSPVEIMEAFSIARQFNCPT 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 182 FISMQNYHNLLYREE-EREMIPYCQKTGVGLIPWSPLARGLltrSIDANEETIRSKTDLYTRALEFGAGYKA-------- 252
Cdd:cd19142 173 PICEQSEYHMFCREKmELYMPELYNKVGVGLITWSPLSLGL---DPGISEETRRLVTKLSFKSSKYKVGSDGngiheetr 249
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246743210 253 ----ILSRVEELAKKYNVSMATLATAWSLHKGDYP--IVGISKVERLQDALASVTL--KLN 305
Cdd:cd19142 250 rashKLRELSLIAERLGCDLTQLLIAWSLKNENVQcvLIGASSLEQLYSQLNSLQLlpKLN 310
|
|
| Aldo_ket_red_shaker |
cd19141 |
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family ... |
18-300 |
1.26e-34 |
|
Shaker potassium channel beta subunit (AKR6A) family of aldo-keto reductase (AKR); This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.
Pssm-ID: 381367 [Multi-domain] Cd Length: 310 Bit Score: 128.33 E-value: 1.26e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 18 DEVFK-IMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKCFSPVRKDliklymdlssrgvqlhdsp 96
Cdd:cd19141 29 DEVAEeLVTLAYENGINLFDTAEVYAAGKAEIVLGKILKKKGWRRSSYVITTKIFWGGKAE------------------- 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 elaNQCGLSRKHIFDAVQDSVKRLG-TYIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAE 175
Cdd:cd19141 90 ---TERGLSRKHIIEGLKASLERLQlEYVDIVFANRPDPNTPMEEIVRAFTHVINQGMAMYWGTSRWSAMEIMEAYSVAR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 176 KHGWHKFISMQNYHNLLYREEEREMIPYC-QKTGVGLIPWSPLARGLLTRSIDAN-EETIRSKTDLYTRAL-----EFGA 248
Cdd:cd19141 167 QFNLIPPIVEQAEYHLFQREKVEMQLPELfHKIGVGAMTWSPLACGILSGKYDDGvPEYSRASLKGYQWLKekilsEEGR 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1246743210 249 GYKAILSRVEELAKKYNVSMATLATAWSLhKGDYP---IVGISKVERLQDALASV 300
Cdd:cd19141 247 RQQAKLKELQIIADRLGCTLPQLAIAWCL-KNEGVssvLLGASSTEQLYENLQAI 300
|
|
| AKR_unchar |
cd19103 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-314 |
1.44e-34 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381329 [Multi-domain] Cd Length: 299 Bit Score: 127.84 E-value: 1.44e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeiPRSSIVIMSKcFSPvrkdliklymdlssrgvQLHDS 95
Cdd:cd19103 30 DEDTLKAVFDKAMAAGLNLWDTAAVYGMGASEKILGEFLKRY--PREDYIISTK-FTP-----------------QIAGQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 PElanqcglsrkhifDAVQD----SVKRLGT-YIDVLQIH------RYDPHvsaeevmraLNDVVESGKVRYIGASTMRY 164
Cdd:cd19103 90 SA-------------DPVADmlegSLARLGTdYIDIYWIHnpadveRWTPE---------LIPLLKSGKVKHVGVSNHNL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 165 YQFIELQNTAEKHGWHkfIS-MQNYHNLLYREEEREMI-PYCQKTGVGLIPWSPLARGLLTRSIDAN----EETIRSKTd 238
Cdd:cd19103 148 AEIKRANEILAKAGVS--LSaVQNHYSLLYRSSEEAGIlDYCKENGITFFAYMVLEQGALSGKYDTKhplpEGSGRAET- 224
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246743210 239 lYTRALEfgaGYKAILSRVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYLEE 314
Cdd:cd19103 225 -YNPLLP---QLEELTAVMAEIGAKHGASIAQVAIAWAIAKGTTPIIGVTKPHHVEDAARAASITLTDDEIKELEQ 296
|
|
| AKR_AKR8A1-2 |
cd19077 |
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ... |
15-313 |
5.45e-34 |
|
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).
Pssm-ID: 381303 [Multi-domain] Cd Length: 302 Bit Score: 126.20 E-value: 5.45e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 15 EEEDEVFKIMKAAYDAGIRTFDTANIYSAGV---SEELVGKFIRKYEIPRSSIVIMSK-CFspvrkDLIKLYMDLSSRGV 90
Cdd:cd19077 22 TPDEEAFETMKAALDAGSNLWNGGEFYGPPDphaNLKLLARFFRKYPEYADKVVLSVKgGL-----DPDTLRPDGSPEAV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 91 qlhdspelanqcglsRKHIfdavQDSVKRLGT--YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMryyqfi 168
Cdd:cd19077 97 ---------------RKSI----ENILRALGGtkKIDIFEPARVDPNVPIEETIKALKELVKEGKIRGIGLSEV------ 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 169 ELQNTAEKHGWHKFISMQNYHNLLYRE-EEREMIPYCQKTGVGLIPWSPLARGLLTRSI----DANEETIRSKTDLYTRa 243
Cdd:cd19077 152 SAETIRRAHAVHPIAAVEVEYSLFSREiEENGVLETCAELGIPIIAYSPLGRGLLTGRIkslaDIPEGDFRRHLDRFNG- 230
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246743210 244 lEFGAGYKAILSRVEELAKKYNVSMATLATAWSLHKGD---YPIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19077 231 -ENFEKNLKLVDALQELAEKKGCTPAQLALAWILAQSGpkiIPIPGSTTLERVEENLKAANVELTDEELKEIN 302
|
|
| AKR_AKR3F1 |
cd19137 |
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ... |
16-313 |
1.91e-33 |
|
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381363 [Multi-domain] Cd Length: 260 Bit Score: 123.83 E-value: 1.91e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeiPRSSIVIMSKCFspvrkdliklymdlssrgvqlhds 95
Cdd:cd19137 24 RDEEMVELLKTAIELGYTHIDTAEMYGGGHTEELVGKAIKDF--PREDLFIVTKVW------------------------ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 PElanqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRyyqfIELQNTA 174
Cdd:cd19137 78 PT-----NLRYDDLLRSLQNSLRRLDTdYIDLYLIHWPNPNIPLEETLSAMAEGVRQGLIRYIGVSNFN----RRLLEEA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 175 EKHGWHKFISMQNYHNLLYRE-EEREMIPYCQKTGVGLIPWSPLARGLLTRsidaNEEtirsktdlytralefgagykai 253
Cdd:cd19137 149 ISKSQTPIVCNQVKYNLEDRDpERDGLLEYCQKNGITVVAYSPLRRGLEKT----NRT---------------------- 202
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246743210 254 lsrVEELAKKYNVSMATLATAWSLHKGDypIVGISK---VERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19137 203 ---LEEIAKNYGKTIAQIALAWLIQKPN--VVAIPKagrVEHLKENLKATEIKLSEEEMKLLD 260
|
|
| ARA1 |
COG0656 |
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ... |
12-310 |
2.81e-33 |
|
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440421 [Multi-domain] Cd Length: 259 Bit Score: 123.24 E-value: 2.81e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 12 WVLEEEDEVfKIMKAAYDAGIRTFDTANIYSAgvsEELVGKFIRKYEIPRSSIVIMSKcfspvrkdliklymdlssrgvq 91
Cdd:COG0656 13 WQLPGEEAA-AAVRTALEAGYRHIDTAAMYGN---EEGVGEAIAASGVPREELFVTTK---------------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 92 lhdspeLANQcGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRydP-HVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIE 169
Cdd:COG0656 67 ------VWND-NHGYDDTLAAFEESLERLGLdYLDLYLIHW--PgPGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEE 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 170 LQNTAEKHgwhkfISM-QNYHNLLYREeeREMIPYCQKTGVGLIPWSPLARGLLtrsidANEETIRsktdlytralefga 248
Cdd:COG0656 138 LLAETGVK-----PAVnQVELHPYLQQ--RELLAFCREHGIVVEAYSPLGRGKL-----LDDPVLA-------------- 191
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246743210 249 gykailsrveELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIK 310
Cdd:COG0656 192 ----------EIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMA 243
|
|
| AKR_KCAB3B_AKR6A9-like |
cd19160 |
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo ... |
18-300 |
2.33e-32 |
|
voltage-gated potassium channel subunit beta-3 (KCAB3B) and similar proteins; KCAB3B from Homo sapiens, Rattus norvegicus, and Mus musculus, are founding members of aldo-keto reductase family 6 member A9 (AKR6A9), A12 (AKR6A12), A14 (AKR6A14), respectively. KCAB3B, also called Shaker channel b-subunit 3 (Kvb3), K(+) channel subunit beta-3, or Kv-beta-3, is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. It alters the functional properties of Kv1.5.
Pssm-ID: 381386 [Multi-domain] Cd Length: 325 Bit Score: 122.79 E-value: 2.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 18 DEVFK-IMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKCFspvrkdliklymdlssRGVQLHdsp 96
Cdd:cd19160 32 DETAEdLLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVVTTKIY----------------WGGQAE--- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 elaNQCGLSRKHIFDAVQDSVKRLG-TYIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAE 175
Cdd:cd19160 93 ---TERGLSRKHIIEGLRGSLDRLQlEYVDIVFANRSDPNSPMEEIVRAMTYVINQGMAMYWGTSRWSAMEIMEAYSVAR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 176 KHGWHKFISMQNYHNLLYREEEREMIP-YCQKTGVGLIPWSPLARGLLT-----RSIDANEETIRSKTDLYTRAL-EFGA 248
Cdd:cd19160 170 QFNLIPPVCEQAEYHLFQREKVEMQLPeLYHKIGVGSVTWSPLACGLITgkydgRVPDTCRAAVKGYQWLKEKVQsEEGK 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1246743210 249 GYKAILSRVEELAKKYNVSMATLATAWSLHKGDYPIV--GISKVERLQDALASV 300
Cdd:cd19160 250 KQQAKVKELHPIADRLGCTVAQLAIAWCLRSEGVSSVllGVSSAEQLIENLGSI 303
|
|
| AKR_AKR15A-like |
cd19090 |
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ... |
11-307 |
2.61e-32 |
|
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381316 [Multi-domain] Cd Length: 278 Bit Score: 121.12 E-value: 2.61e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 11 DWVLEEEDEVFKIMKAAYDAGIRTFDTANIYsaGVSEELVGKFIRkyEIPRSSIVIMSKCfsPVRKDLIKLYmdlssrgv 90
Cdd:cd19090 13 VFGGVDDDEAVATIRAALDLGINYIDTAPAY--GDSEERLGLALA--ELPREPLVLSTKV--GRLPEDTADY-------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 91 qlhdspelanqcglSRKHIFDAVQDSVKRLGT-YIDVLQIHryDPH-------VSAEEVMRALNDVVESGKVRYIGASTM 162
Cdd:cd19090 79 --------------SADRVRRSVEESLERLGRdRIDLLMIH--DPErvpwvdiLAPGGALEALLELKEEGLIKHIGLGGG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 163 RYY---QFIElqntaekHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDAneetiRSKTDL 239
Cdd:cd19090 143 PPDllrRAIE-------TGDFDVVLTANRYTLLDQSAADELLPAAARHGVGVINASPLGMGLLAGRPPE-----RVRYTY 210
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 240 YTRALEFGAGYKailsRVEELAKKYNVSMATLATAWSL-HKG-DYPIVGISKVERLQDALASVTLKLNEE 307
Cdd:cd19090 211 RWLSPELLDRAK----RLYELCDEHGVPLPALALRFLLrDPRiSTVLVGASSPEELEQNVAAAEGPLPEE 276
|
|
| AKR_PA4992-like |
cd19095 |
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ... |
3-299 |
1.73e-31 |
|
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381321 [Multi-domain] Cd Length: 253 Bit Score: 118.49 E-value: 1.73e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 3 FGKKEYWEDWVLEEEDEVFKIMKAAYDAGIRTFDTANIYsaGVSEELVGKFIRkyEIPRSSIVIMSKCFSPVRKdlikly 82
Cdd:cd19095 5 LGTSGIGRVWGVPSEAEAARLLNTALDLGINLIDTAPAY--GRSEERLGRALA--GLRRDDLFIATKVGTHGEG------ 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 83 mdlssrGVQLHDSpelanqcglSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGAST 161
Cdd:cd19095 75 ------GRDRKDF---------SPAAIRASIERSLRRLGTdYIDLLQLHGPSDDELTGEVLETLEDLKAAGKVRYIGVSG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 162 MryyqfielQNTAEKH-GWHKFISMQNYHNLLYREEErEMIPYCQKTGVGLIPWSPLARGLLTRsidanEETIRSKTDLY 240
Cdd:cd19095 140 D--------GEELEAAiASGVFDVVQLPYNVLDREEE-ELLPLAAEAGLGVIVNRPLANGRLRR-----RVRRRPLYADY 205
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246743210 241 TRALEFGAGYKAilsrveelakkynVSMATLATAWSL-HKG-DYPIVGISKVERLQDALAS 299
Cdd:cd19095 206 ARRPEFAAEIGG-------------ATWAQAALRFVLsHPGvSSAIVGTTNPEHLEENLAA 253
|
|
| AKR_AKR7A1-5 |
cd19075 |
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ... |
1-301 |
4.43e-31 |
|
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.
Pssm-ID: 381301 [Multi-domain] Cd Length: 304 Bit Score: 118.43 E-value: 4.43e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKKEywEDWVLEEEDEVFKIMKaayDAGIRTFDTANIYSAGVSEELVGKfirkyeiprssivimskcfspvrkdlik 80
Cdd:cd19075 8 MTFGSQG--RFTTAEAAAELLDAFL---ERGHTEIDTARVYPDGTSEELLGE---------------------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 81 lyMDLSSRGVQLHDSPELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGA 159
Cdd:cd19075 55 --LGLGERGFKIDTKANPGVGGGLSPENVRKQLETSLKRLKVdKVDVFYLHAPDRSTPLEETLAAIDELYKEGKFKEFGL 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 160 STMRYYQFIELQNTAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANEEtiRSKTDL 239
Cdd:cd19075 133 SNYSAWEVAEIVEICKENGWVLPTVYQGMYNAITRQVETELFPCLRKLGIRFYAYSPLAGGFLTGKYKYSED--KAGGGR 210
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743210 240 YTRALEFGAGYKAI---------LSRVEELAKKYNVSMATLATAWSLH-------KGDYPIVGISKVERLQDALASVT 301
Cdd:cd19075 211 FDPNNALGKLYRDRywkpsyfeaLEKVEEAAEKEGISLAEAALRWLYHhsaldgeKGDGVILGASSLEQLEENLAALE 288
|
|
| AKR_AKR3F2_3 |
cd19073 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ... |
16-310 |
7.78e-31 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381299 [Multi-domain] Cd Length: 243 Bit Score: 116.60 E-value: 7.78e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSPvrkdliklymdlssrgvqlhds 95
Cdd:cd19073 12 RGDDCANAVKEALELGYRHIDTAEIYN---NEAEVGEAIAESGVPREDLFITTKVWRD---------------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 pelanqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRyyqfIELQNTA 174
Cdd:cd19073 67 -------HLRPEDLKKSVDRSLEKLGTdYVDLLLIHWPNPTVPLEETLGALKELKEAGKVKSIGVSNFT----IELLEEA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 175 EKHGWHKFISMQ-NYHNLLYReeeREMIPYCQKTGVGLIPWSPLARGLLTRsidaneetirsktdlytralefgagykai 253
Cdd:cd19073 136 LDISPLPIAVNQvEFHPFLYQ---AELLEYCRENDIVITAYSPLARGEVLR----------------------------- 183
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 254 LSRVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIK 310
Cdd:cd19073 184 DPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVA 240
|
|
| tas |
PRK10625 |
putative aldo-keto reductase; Provisional |
1-314 |
9.59e-31 |
|
putative aldo-keto reductase; Provisional
Pssm-ID: 236727 [Multi-domain] Cd Length: 346 Bit Score: 118.80 E-value: 9.59e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 1 MSFGKKEywedwvleEEDEVFKIMKAAYDAGIRTFDTANIY-------SAGVSEELVGKFIRKYEiPRSSIVIMSKCFSP 73
Cdd:PRK10625 21 MTFGEQN--------SEADAHAQLDYAVAQGINLIDVAEMYpvpprpeTQGLTETYIGNWLAKRG-SREKLIIASKVSGP 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 74 VRKDliklymdlssrgvqlhDSPELANQcGLSRKHIFDAVQDSVKRLGT-YIDVLQIH--------------RYD---PH 135
Cdd:PRK10625 92 SRNN----------------DKGIRPNQ-ALDRKNIREALHDSLKRLQTdYLDLYQVHwpqrptncfgklgySWTdsaPA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 136 VSAEEVMRALNDVVESGKVRYIGAS------TMRYYQFielqntAEKHGWHKFISMQNYHNLLYREEEREMIPYCQKTGV 209
Cdd:PRK10625 155 VSLLETLDALAEQQRAGKIRYIGVSnetafgVMRYLHL------AEKHDLPRIVTIQNPYSLLNRSFEVGLAEVSQYEGV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 210 GLIPWSPLARGLLTRSIDANEETIRSKTDLYTRALEFGA--GYKAILSRVeELAKKYNVSMATLATAWSLHKgdyPIV-- 285
Cdd:PRK10625 229 ELLAYSCLAFGTLTGKYLNGAKPAGARNTLFSRFTRYSGeqTQKAVAAYV-DIAKRHGLDPAQMALAFVRRQ---PFVas 304
|
330 340 350
....*....|....*....|....*....|..
gi 1246743210 286 ---GISKVERLQDALASVTLKLNEEDIKYLEE 314
Cdd:PRK10625 305 tllGATTMEQLKTNIESLHLTLSEEVLAEIEA 336
|
|
| AKR_AKR1-5-like |
cd19071 |
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ... |
17-313 |
3.48e-30 |
|
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.
Pssm-ID: 381297 [Multi-domain] Cd Length: 251 Bit Score: 114.89 E-value: 3.48e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSPvrkdliklymdlssrgvqlHDSP 96
Cdd:cd19071 13 PEETAEAVLAALEAGYRHIDTAAAYG---NEAEVGEAIRESGVPREELFITTKLWPT-------------------DHGY 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 ELANQcglsrkhifdAVQDSVKRLGT-YIDVLQIH------RYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIE 169
Cdd:cd19071 71 ERVRE----------ALEESLKDLGLdYLDLYLIHwpvpgkEGGSKEARLETWRALEELVDEGLVRSIGVSNFNVEHLEE 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 170 LqntaEKHGWHKFISMQN-YHNLLYREEEREmipYCQKTGVGLIPWSPLARGllTRSIDANEEtirsktdlytralefga 248
Cdd:cd19071 141 L----LAAARIKPAVNQIeLHPYLQQKELVE---FCKEHGIVVQAYSPLGRG--RRPLLDDPV----------------- 194
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1246743210 249 gykailsrVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19071 195 --------LKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAID 251
|
|
| AKR_KCAB1B_AKR6A3-like |
cd19159 |
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo ... |
18-300 |
4.08e-30 |
|
voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins; KCAB1B from Homo sapiens, Mus musculus, Mustela putorius, Rattus norvegicus, and Kvb1.1, Kvb1.2 from Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A3 (AKR6A3), A8 (AKR6A8), A10a (AKR6A10a), A13 (AKR6A13), A7 (AKR6A7) and A10b (AKR6A10b), respectively. KCAB1B, also called Shaker channel b-subunit 1(Kvb1), K(+) channel subunit beta-1, or Kv-beta-1, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It modulates action potentials via its effect on the pore-forming alpha subunits.
Pssm-ID: 381385 [Multi-domain] Cd Length: 323 Bit Score: 116.68 E-value: 4.08e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 18 DEVF-KIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKcfspvrkdliklymdlssrgvqLHDSP 96
Cdd:cd19159 30 DEVAeRLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTK----------------------LYWGG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 ELANQCGLSRKHIFDAVQDSVKRLG-TYIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAE 175
Cdd:cd19159 88 KAETERGLSRKHIIEGLKGSLQRLQlEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVAR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 176 KHGWHKFISMQNYHNLLYREEEREMIPYC-QKTGVGLIPWSPLARGLLTRSI-----DANEETIRSKTDLYTRAL-EFGA 248
Cdd:cd19159 168 QFNMIPPVCEQAEYHLFQREKVEVQLPELyHKIGVGAMTWSPLACGIISGKYgngvpESSRASLKCYQWLKERIVsEEGR 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1246743210 249 GYKAILSRVEELAKKYNVSMATLATAWSLHKGDYP--IVGISKVERLQDALASV 300
Cdd:cd19159 248 KQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSsvLLGSSTPEQLIENLGAI 301
|
|
| AKR_KCAB2B_AKR6A1-like |
cd19158 |
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos ... |
22-302 |
4.33e-30 |
|
voltage-gated potassium channel subunit beta-2 (KCAB2B) and similar proteins; KCAB2B from Bos taurus, Rattus norvegicus, Mus musculus, Homo sapiens, and Oryctolagus cuniculus, are founding members of aldo-keto reductase family 6 member A1 (AKR6A1), A2 (AKR6A2), A4 (AKR6A4), A5 (AKR6A5), and A6 (AKR6A6), respectively. KCAB2B, also called Shaker channel b-subunit 2 (Kvb2), or K(+) channel subunit beta-2, or Kv-beta-2, or Kvbeta2, is a cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits. It may be involved in the regulation of nerve signaling, and prevents neuronal hyperexcitability.
Pssm-ID: 381384 [Multi-domain] Cd Length: 324 Bit Score: 116.34 E-value: 4.33e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 22 KIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKCFSPVRKDliklymdlssrgvqlhdspelaNQ 101
Cdd:cd19158 35 HLMTLAYDNGINLFDTAEVYAAGKAEVVLGNIIKKKGWRRSSLVITTKIFWGGKAE----------------------TE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 102 CGLSRKHIFDAVQDSVKRLG-TYIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAEKHGWH 180
Cdd:cd19158 93 RGLSRKHIIEGLKASLERLQlEYVDVVFANRPDPNTPMEETVRAMTHVINQGMAMYWGTSRWSSMEIMEAYSVARQFNLI 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 181 KFISMQNYHNLLYREEEREMIPYC-QKTGVGLIPWSPLARGLLTRSIDA-----NEETIRSKTDLYTRAL-EFGAGYKAI 253
Cdd:cd19158 173 PPICEQAEYHMFQREKVEVQLPELfHKIGVGAMTWSPLACGIVSGKYDSgippySRASLKGYQWLKDKILsEEGRRQQAK 252
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1246743210 254 LSRVEELAKKYNVSMATLATAWSLHKGDYP--IVGISKVERLQDALASVTL 302
Cdd:cd19158 253 LKELQAIAERLGCTLPQLAIAWCLRNEGVSsvLLGASNAEQLMENIGAIQV 303
|
|
| AKR_AKR14A2 |
cd19151 |
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is ... |
22-310 |
1.06e-28 |
|
Salmonella enterica aldo-keto reductase (AKR) and similar protein; Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Pssm-ID: 381377 [Multi-domain] Cd Length: 309 Bit Score: 112.50 E-value: 1.06e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 22 KIMKAAYDAGIRTFDTANIYS--AGVSEELVGKfirkyeiprssivIMSKCFSPVRKDLIklymdLSSR-GVQLHDSPel 98
Cdd:cd19151 34 AMLRRAFDLGITHFDLANNYGppPGSAEENFGR-------------ILKEDLKPYRDELI-----ISTKaGYTMWPGP-- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 99 ANQCGlSRKHIFDAVQDSVKRLG-TYIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAEKH 177
Cdd:cd19151 94 YGDWG-SKKYLIASLDQSLKRMGlDYVDIFYHHRPDPETPLEETMGALDQIVRQGKALYVGISNYPPEEAREAAAILKDL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 178 GWHKFISMQNYhNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT-RSIDANEETIR-SKTDLYTRALEFGAGYKAILS 255
Cdd:cd19151 173 GTPCLIHQPKY-SMFNRWVEEGLLDVLEEEGIGCIAFSPLAQGLLTdRYLNGIPEDSRaAKGSSFLKPEQITEEKLAKVR 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743210 256 RVEELAKKYNVSMATLATAWSLHKGDYP--IVGISKVERLQDALASVT-LKLNEEDIK 310
Cdd:cd19151 252 RLNEIAQARGQKLAQMALAWVLRNKRVTsvLIGASKPSQIEDAVGALDnREFSEEELA 309
|
|
| AKR_galDH |
cd19163 |
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ... |
17-301 |
1.26e-28 |
|
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).
Pssm-ID: 381389 [Multi-domain] Cd Length: 293 Bit Score: 111.87 E-value: 1.26e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKyeIPRSSIVIMSKCfspVRKDLIKLYM-DLSsrgvqlhds 95
Cdd:cd19163 32 EEEAIRTVHEALDSGINYIDTAPWYGQGRSETVLGKALKG--IPRDSYYLATKV---GRYGLDPDKMfDFS--------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 pelanqcglsRKHIFDAVQDSVKRLGT-YIDVLQIH------RYDPHVsaEEVMRALNDVVESGKVRYIGASTmryYQfI 168
Cdd:cd19163 98 ----------AERITKSVEESLKRLGLdYIDIIQVHdiefapSLDQIL--NETLPALQKLKEEGKVRFIGITG---YP-L 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 169 ELQNTAEKHGWHKFISMQNY-HNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT-RSI----DANEETirsktdlytr 242
Cdd:cd19163 162 DVLKEVLERSPVKIDTVLSYcHYTLNDTSLLELLPFFKEKGVGVINASPLSMGLLTeRGPpdwhPASPEI---------- 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246743210 243 alefgagyKAILSRVEELAKKYNVSMATLATAWSLHKGDYP--IVGISKVERLQDALASVT 301
Cdd:cd19163 232 --------KEACAKAAAYCKSRGVDISKLALQFALSNPDIAttLVGTASPENLRKNLEAAE 284
|
|
| AKR_YeaE |
cd19138 |
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ... |
12-313 |
2.24e-27 |
|
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381364 [Multi-domain] Cd Length: 266 Bit Score: 107.72 E-value: 2.24e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 12 WVLEE-----EDEVfKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeipRSSIVIMSKcfspvrkdliklymdls 86
Cdd:cd19138 19 WYMGEdpakrAQEI-EALRAGIDLGMTLIDTAEMYGDGGSEELVGEAIRGR---RDKVFLVSK----------------- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 87 srgVQLHDSpelanqcglSRKHIFDAVQDSVKRLGT-YIDVLQIHrYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYY 165
Cdd:cd19138 78 ---VLPSNA---------SRQGTVRACERSLRRLGTdYLDLYLLH-WRGGVPLAETVAAMEELKKEGKIRAWGVSNFDTD 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 166 QFIELQNTAekhGWHKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANEETIRsktdlytrale 245
Cdd:cd19138 145 DMEELWAVP---GGGNCAANQVLYNLGSRGIEYDLLPWCREHGVPVMAYSPLAQGGLLRRGLLENPTLK----------- 210
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246743210 246 fgagykailsrveELAKKYNVSMATLATAWSLHKGDypIVGI---SKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19138 211 -------------EIAARHGATPAQVALAWVLRDGN--VIAIpksGSPEHARENAAAADLELTEEDLAELD 266
|
|
| AKR_unchar |
cd19105 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
18-255 |
1.65e-26 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381331 [Multi-domain] Cd Length: 250 Bit Score: 104.97 E-value: 1.65e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 18 DEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeiPRSSIVIMSKCFSPVRKDliklymdlssrgvqlhdspe 97
Cdd:cd19105 25 RESPELLRRALDLGINYFDTAEGYGNGNSEEIIGEALKGL--RRDKVFLATKASPRLDKK-------------------- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 98 lanqcglSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDP---HVSAEEVMRALNDVVESGKVRYIGASTMRYYQfiELQNT 173
Cdd:cd19105 83 -------DKAELLKSVEESLKRLQTdYIDIYQLHGVDTpeeRLLNEELLEALEKLKKEGKVRFIGFSTHDNMA--EVLQA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 174 AEKHGWHKFIsMQNYhNLLYREEER-EMIPYCQKTGVGLIPWSPLARGLLtrsIDANEETIRSKTDLYtraleFGAGYKA 252
Cdd:cd19105 154 AIESGWFDVI-MVAY-NFLNQPAELeEALAAAAEKGIGVVAMKTLAGGYL---QPALLSVLKAKGFSL-----PQAALKW 223
|
...
gi 1246743210 253 ILS 255
Cdd:cd19105 224 VLS 226
|
|
| AKR_AKR14A1 |
cd19150 |
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar ... |
23-300 |
3.78e-26 |
|
Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ/AKR14A1) and similar proteins; Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo.
Pssm-ID: 381376 [Multi-domain] Cd Length: 309 Bit Score: 105.61 E-value: 3.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 23 IMKAAYDAGIRTFDTANIYS--AGVSEELVGKfirkyeiprssivIMSKCFSPVRKDLIklymdLSSR-GVQLHDSPELA 99
Cdd:cd19150 35 ILRTAFDLGITHFDLANNYGppPGSAEENFGR-------------ILREDFAGYRDELI-----ISTKaGYDMWPGPYGE 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 100 nqcGLSRKHIFDAVQDSVKRLG-TYIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAEKHG 178
Cdd:cd19150 97 ---WGSRKYLLASLDQSLKRMGlDYVDIFYSHRFDPDTPLEETMGALDHAVRSGKALYVGISSYSPERTREAAAILRELG 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 179 WHKFISMQNYhNLLYR-EEEREMIPYCQKTGVGLIPWSPLARGLLT-RSID-------ANEETIRSKTDLYTRALEFgag 249
Cdd:cd19150 174 TPLLIHQPSY-NMLNRwVEESGLLDTLQELGVGCIAFTPLAQGLLTdKYLNgipegsrASKERSLSPKMLTEANLNS--- 249
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1246743210 250 ykaiLSRVEELAKKYNVSMATLATAWSLHKGDYP--IVGISKVERLQDALASV 300
Cdd:cd19150 250 ----IRALNEIAQKRGQSLAQMALAWVLRDGRVTsaLIGASRPEQLEENVGAL 298
|
|
| AKR_unchar |
cd19104 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
12-300 |
8.55e-25 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381330 [Multi-domain] Cd Length: 321 Bit Score: 101.96 E-value: 8.55e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 12 WVLEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRkyEIPrSSIVIMSKCfspvrkdliklymdlssrGVQ 91
Cdd:cd19104 26 MGRTTREEQIAAVRRALDLGINFFDTAPSYGDGKSEENLGRALK--GLP-AGPYITTKV------------------RLD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 92 LHDSPELANQcgLSRKhifdaVQDSVKRLGT-YIDVLQIH---------RYDPHVSAEEVMR------ALNDVVESGKVR 155
Cdd:cd19104 85 PDDLGDIGGQ--IERS-----VEKSLKRLKRdSVDLLQLHnrigderdkPVGGTLSTTDVLGlggvadAFERLRSEGKIR 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 156 YIGASTMRYYQFIelqNTAEKHGwhKFISMQNYHNLL--------YREEE----REMIPYCQKTGVGLIPWSPLARGLLT 223
Cdd:cd19104 158 FIGITGLGNPPAI---RELLDSG--KFDAVQVYYNLLnpsaaearPRGWSaqdyGGIIDAAAEHGVGVMGIRVLAAGALT 232
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246743210 224 RSIDANEETIRSKTDLYTRALEFGAgykailsRVEELAKKYNVSMATLATAWSLHKGDYP--IVGISKVERLQDALASV 300
Cdd:cd19104 233 TSLDRGREAPPTSDSDVAIDFRRAA-------AFRALAREWGETLAQLAHRFALSNPGVStvLVGVKNREELEEAVAAE 304
|
|
| PRK09912 |
PRK09912 |
L-glyceraldehyde 3-phosphate reductase; Provisional |
23-314 |
1.25e-24 |
|
L-glyceraldehyde 3-phosphate reductase; Provisional
Pssm-ID: 182140 [Multi-domain] Cd Length: 346 Bit Score: 101.99 E-value: 1.25e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 23 IMKAAYDAGIRTFDTANIYS--AGVSEELVGKFIRKYeiprssivimskcFSPVRKDLIklymdLSSR-GVQLHDSPEla 99
Cdd:PRK09912 48 ILRKAFDLGITHFDLANNYGppPGSAEENFGRLLRED-------------FAAYRDELI-----ISTKaGYDMWPGPY-- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 100 nQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTmryYQFIELQNTAE-KH 177
Cdd:PRK09912 108 -GSGGSRKYLLASLDQSLKRMGLeYVDIFYSHRVDENTPMEETASALAHAVQSGKALYVGISS---YSPERTQKMVElLR 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 178 GWH-KFISMQNYHNLLYREEERE-MIPYCQKTGVGLIPWSPLARGLLT-RSIDANEETIR-----SKTDLYTRALEFGAG 249
Cdd:PRK09912 184 EWKiPLLIHQPSYNLLNRWVDKSgLLDTLQNNGVGCIAFTPLAQGLLTgKYLNGIPQDSRmhregNKVRGLTPKMLTEAN 263
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743210 250 YKAiLSRVEELAKKYNVSMATLATAWSL--HKGDYPIVGISKVERLQDALASVT-LKLNEEDIKYLEE 314
Cdd:PRK09912 264 LNS-LRLLNEMAQQRGQSMAQMALSWLLkdERVTSVLIGASRAEQLEENVQALNnLTFSTEELAQIDQ 330
|
|
| AKR_unchar |
cd19100 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
16-298 |
1.75e-24 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381326 [Multi-domain] Cd Length: 238 Bit Score: 99.09 E-value: 1.75e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYsaGVSEELVGKFIRKYeipRSSIVIMSKCFSPVRKDliklymdlssrgvqlhds 95
Cdd:cd19100 25 SQEEAAAIIRRALDLGINYFDTAPSY--GDSEEKIGKALKGR---RDKVFLATKTGARDYEG------------------ 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 pelanqcglSRKHIfdavQDSVKRLGT-YIDVLQIH------RYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFI 168
Cdd:cd19100 82 ---------AKRDL----ERSLKRLGTdYIDLYQLHavdteeDLDQVFGPGGALEALLEAKEEGKIRFIGISGHSPEVLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 169 ELQNTAEkhgwhkFISMQ---NYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTrsiDANEETIRsktdlytRALE 245
Cdd:cd19100 149 RALETGE------FDVVLfpiNPAGDHIDSFREELLPLAREKGVGVIAMKVLAGGRLL---SGDPLDPE-------QALR 212
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1246743210 246 FgagykailsrveelakkynvsmatlatAWSLHKGDYPIVGISKVERLQDALA 298
Cdd:cd19100 213 Y---------------------------ALSLPPVDVVIVGMDSPEELDENLA 238
|
|
| AKR_FDH |
cd19162 |
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ... |
17-298 |
1.41e-23 |
|
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381388 [Multi-domain] Cd Length: 290 Bit Score: 98.20 E-value: 1.41e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeiPRSSIVIMSKcfspvrkdlIKLYMDLSSRGVQlhdsP 96
Cdd:cd19162 18 EDEAAATLDAAWDAGIRYFDTAPLYGLGLSERRLGAALARH--PRAEYVVSTK---------VGRLLEPGAAGRP----A 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 ELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSA--EEVMRALNDVVESGKVRYIGASTMRYYQFIELqnt 173
Cdd:cd19162 83 GADRRFDFSADGIRRSIEASLERLGLdRLDLVFLHDPDRHLLQalTDAFPALEELRAEGVVGAIGVGVTDWAALLRA--- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 174 AEKHGWHKFIsMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTrsidaneeTIRSKTDLYtralEFGAGYKAI 253
Cdd:cd19162 160 ARRADVDVVM-VAGRYTLLDRRAATELLPLCAAKGVAVVAAGVFNSGILA--------TDDPAGDRY----DYRPATPEV 226
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1246743210 254 LSRVEELA---KKYNVSMATLATAWSLHkgdYP-----IVGISKVERLQDALA 298
Cdd:cd19162 227 LARARRLAavcRRYGVPLPAAALQFPLR---HPavasvVVGAASPAELRDNLA 276
|
|
| AKR_AKR3C2-3 |
cd19120 |
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ... |
24-310 |
2.43e-23 |
|
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.
Pssm-ID: 381346 [Multi-domain] Cd Length: 269 Bit Score: 96.92 E-value: 2.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 24 MKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSPVrkdliklymdlssrgvqlhdspelanqcg 103
Cdd:cd19120 31 VKLALKAGFRHIDTAEMYG---NEKEVGEALKESGVPREDLFITTKVSPGI----------------------------- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 104 lsrKHIFDAVQDSVKRLGT-YIDVLQIH----RYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAekhg 178
Cdd:cd19120 79 ---KDPREALRKSLAKLGVdYVDLYLIHspffAKEGGPTLAEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTA---- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 179 whKFISMQN---YHNLLYREEErEMIPYCQKTGVGLIPWSPLARglLTRSIDaneetirsktdlytralefgagyKAILS 255
Cdd:cd19120 152 --KIKPAVNqieFHPYLYPQQP-ALLEYCREHGIVVSAYSPLSP--LTRDAG-----------------------GPLDP 203
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 1246743210 256 RVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIK 310
Cdd:cd19120 204 VLEKIAEKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVE 258
|
|
| AKR_unchar |
cd19097 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
17-300 |
4.63e-23 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381323 [Multi-domain] Cd Length: 267 Bit Score: 96.06 E-value: 4.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYsaGVSEELVGKFIRKYeiprSSIVIMSKCfspvrkdliklymdlssrgvqlhdsP 96
Cdd:cd19097 25 EKEAKKILEYALKAGINTLDTAPAY--GDSEKVLGKFLKRL----DKFKIITKL-------------------------P 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 ELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRY-DPHVSAEEVMRALNDVVESGKVRYIGASTmryYQFIELQNTA 174
Cdd:cd19097 74 PLKEDKKEDEAAIEASVEASLKRLKVdSLDGLLLHNPdDLLKHGGKLVEALLELKKEGLIRKIGVSV---YSPEELEKAL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 175 EKhgwHKFISMQ-NYhNLL-YREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDaneetirsktdlytRALEFGAGYKA 252
Cdd:cd19097 151 ES---FKIDIIQlPF-NILdQRFLKSGLLAKLKKKGIEIHARSVFLQGLLLMEPD--------------KLPAKFAPAKP 212
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1246743210 253 ILSRVEELAKKYNVSMATLATAW--SLHKGDYPIVGISKVERLQDALASV 300
Cdd:cd19097 213 LLKKLHELAKKLGLSPLELALGFvlSLPEIDKIVVGVDSLEQLKEIIAAF 262
|
|
| AKR_AKR15A1 |
cd19161 |
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium ... |
17-278 |
2.25e-22 |
|
Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD) and similar proteins; Microbacterium luteolum PLD (EC1.1.1.107) is a founding member of aldo-keto reductase family 15 member A1 (AKR15A1). It catalyzes irreversible oxidation of pyridoxal.
Pssm-ID: 381387 [Multi-domain] Cd Length: 310 Bit Score: 95.09 E-value: 2.25e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeiPRSSIVIMSKC---FSPVRKDLIKLYMDlssrgvqLH 93
Cdd:cd19161 19 NADADATLDAAWDSGIRYFDTAPMYGHGLAEHRLGDFLREK--PRDEFVLSTKVgrlLKPAREGSVPDPNG-------FV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 94 DSPELANQCGLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEV------------MRALNDVVESGKVRYIG-- 158
Cdd:cd19161 90 DPLPFEIVYDYSYDGIMRSFEDSLQRLGLnRIDILYVHDIGVYTHGDRKerhhfaqlmsggFKALEELKKAGVIKAFGlg 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 159 -------ASTMRYYQFielqntaekhgwhKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANee 231
Cdd:cd19161 170 vnevqicLEALDEADL-------------DCFLLAGRYSLLDQSAEEEFLPRCEQRGTSLVIGGVFNSGILATGTKSG-- 234
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1246743210 232 tirsktdlytRALEFGAGYKAILSRVEELAK---KYNVSMATLATAWSLH 278
Cdd:cd19161 235 ----------AKFNYGDAPAEIISRVMEIEKicdAYNVPLAAAALQFPLR 274
|
|
| AKR_AKR3F3 |
cd19140 |
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ... |
18-310 |
2.58e-22 |
|
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.
Pssm-ID: 381366 [Multi-domain] Cd Length: 253 Bit Score: 93.86 E-value: 2.58e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 18 DEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCfspvrkdliklymdlssrgvqLHDSpe 97
Cdd:cd19140 21 EECTRAVEHALELGYRHIDTAQMYG---NEAQVGEAIAASGVPRDELFLTTKV---------------------WPDN-- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 98 lanqcgLSRKHIFDAVQDSVKRLGT-YIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIElqntAEK 176
Cdd:cd19140 75 ------YSPDDFLASVEESLRKLRTdYVDLLLLHWPNKDVPLAETLGALNEAQEAGLARHIGVSNFTVALLRE----AVE 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 177 HGWHKFISMQ-NYHNLLyreEEREMIPYCQKTGVGLIPWSPLARGLLtrsidANEETIRsktdlytralefgagykails 255
Cdd:cd19140 145 LSEAPLFTNQvEYHPYL---DQRKLLDAAREHGIALTAYSPLARGEV-----LKDPVLQ--------------------- 195
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743210 256 rveELAKKYNVSMATLATAWSLHKGDypIVGISK---VERLQDALASVTLKLNEEDIK 310
Cdd:cd19140 196 ---EIGRKHGKTPAQVALRWLLQQEG--VAAIPKatnPERLEENLDIFDFTLSDEEMA 248
|
|
| COG1453 |
COG1453 |
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only]; |
16-314 |
4.34e-22 |
|
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
Pssm-ID: 441062 [Multi-domain] Cd Length: 365 Bit Score: 95.27 E-value: 4.34e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYsaGVSEELVGKFIRKYeipRSSIVIMSKcfSPVRKDliklymdlssrgvqlhdS 95
Cdd:COG1453 27 DEEEAEALIRRAIDNGINYIDTARGY--GDSEEFLGKALKGP---RDKVILATK--LPPWVR-----------------D 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 PELAnqcglsrKHIFDavqDSVKRLGT-YIDVLQIH------RYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFI 168
Cdd:COG1453 83 PEDM-------RKDLE---ESLKRLQTdYIDLYLIHglnteeDLEKVLKPGGALEALEKAKAEGKIRHIGFSTHGSLEVI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 169 elQNTAEKHGWhKFISMQnyHNLLYRE--EEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANEETIRSKTDLYTRALEF 246
Cdd:COG1453 153 --KEAIDTGDF-DFVQLQ--YNYLDQDnqAGEEALEAAAEKGIGVIIMKPLKGGRLANPPEKLVELLCPPLSPAEWALRF 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 247 gagykaILSRVEelakkynVSMatlatawslhkgdyPIVGISKVERLQDALASVTL--KLNEEDIKYLEE 314
Cdd:COG1453 228 ------LLSHPE-------VTT--------------VLSGMSTPEQLDENLKTADNlePLTEEELAILER 270
|
|
| AKR_unchar |
cd19099 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
19-298 |
4.50e-21 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381325 [Multi-domain] Cd Length: 316 Bit Score: 91.61 E-value: 4.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 19 EVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIR----KYEIPRSSIVIMSK-------CFSPVRKDLIKLYMDLSS 87
Cdd:cd19099 22 EYREALKAALDSGINVIDTAINYRGGRSERLIGKALRelieKGGIKRDEVVIVTKagyipgdGDEPLRPLKYLEEKLGRG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 88 RGVQlHDSPELAnQCgLSRKHIFDAVQDSVKRLGT-YIDVLQIH---RYDPHVSAEEVMRALNDV-------VESGKVRY 156
Cdd:cd19099 102 LIDV-ADSAGLR-HC-ISPAYLEDQIERSLKRLGLdTIDLYLLHnpeEQLLELGEEEFYDRLEEAfealeeaVAEGKIRY 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 157 IGAST-------MRYYQFIELQNTA--------EKHGWhKFI------SMQNYHNLLYREEEREM--IPYCQKTGVGLIP 213
Cdd:cd19099 179 YGISTwdgfrapPALPGHLSLEKLVaaaeevggDNHHF-KVIqlplnlLEPEALTEKNTVKGEALslLEAAKELGLGVIA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 214 WSPLARGLLTRSI-DANEETIRSKTDLYTRALEFGAGYKAILSrveelakkynvsmatlatawslhkgdyPIVGISKVER 292
Cdd:cd19099 258 SRPLNQGQLLGELrLADLLALPGGATLAQRALQFARSTPGVDS---------------------------ALVGMRRPEH 310
|
....*.
gi 1246743210 293 LQDALA 298
Cdd:cd19099 311 VDENLA 316
|
|
| AKR_AKR15A |
cd19152 |
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ... |
12-300 |
8.19e-21 |
|
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.
Pssm-ID: 381378 [Multi-domain] Cd Length: 308 Bit Score: 90.75 E-value: 8.19e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 12 WVLEEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRkyEIPRSSIVIMSKC---FSPVRKDliklymDLSSR 88
Cdd:cd19152 14 YEAVSDEEAKATLVAAWDLGIRYFDTAPWYGAGLSEERLGAALR--ELGREDYVISTKVgrlLVPLQEV------EPTFE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 89 GVQLHDSPELANQCgLSRKHIFDAVQDSVKRLGTY-IDVLQIHRYDPHVSAEEV-----------MRALNDVVESGKVRY 156
Cdd:cd19152 86 PGFWNPLPFDAVFD-YSYDGILRSIEDSLQRLGLSrIDLLSIHDPDEDLAGAESdehfaqaikgaFRALEELREEGVIKA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 157 IGASTMRYY---QFIELQNTaekhgwhKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLARGLLT--------RS 225
Cdd:cd19152 165 IGLGVNDWEvilRILEEADL-------DWVMLAGRYTLLDHSAARELLPECEKRGVKVVNAGPFNSGFLAggdnfdyyEY 237
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 226 IDANEETIRsKTDlytralefgagykailsRVEELAKKYNVSMATLATAWSL-HKG-DYPIVGISKVERLQDALASV 300
Cdd:cd19152 238 GPAPPELIA-RRD-----------------RIEALCEQHGVSLAAAALQFALaPPAvASVAPGASSPERVEENVALL 296
|
|
| AKR_AKR5G1-3 |
cd19157 |
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ... |
12-314 |
1.89e-19 |
|
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381383 [Multi-domain] Cd Length: 265 Bit Score: 86.29 E-value: 1.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 12 WVLEEEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSpvrkdliklymdlssrGVQ 91
Cdd:cd19157 18 FKVEEGSEVVNAVKTALKNGYRSIDTAAIYG---NEEGVGKGIKESGIPREELFITSKVWN----------------ADQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 92 LHDSpelanqcglsrkhIFDAVQDSVKRLGT-YIDVLQIHrYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIEL 170
Cdd:cd19157 79 GYDS-------------TLKAFEASLERLGLdYLDLYLIH-WPVKGKYKETWKALEKLYKDGRVRAIGVSNFQVHHLEDL 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 171 QNTAEkhgwhkFISMQN---YHNLLYREEEREmipYCQKTGVGLIPWSPLARGLLTrsidaNEETIRsktdlytralefg 247
Cdd:cd19157 145 LADAE------IVPMVNqveFHPRLTQKELRD---YCKKQGIQLEAWSPLMQGQLL-----DNPVLK------------- 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 248 agykailsrveELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYLEE 314
Cdd:cd19157 198 -----------EIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDA 253
|
|
| PLN02587 |
PLN02587 |
L-galactose dehydrogenase |
17-319 |
3.06e-17 |
|
L-galactose dehydrogenase
Pssm-ID: 178198 [Multi-domain] Cd Length: 314 Bit Score: 80.59 E-value: 3.06e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKCfspvrkdliklymdlsSRGVQLHDsp 96
Cdd:PLN02587 30 EEDAIASVREAFRLGINFFDTSPYYGGTLSEKVLGKALKALGIPREKYVVSTKC----------------GRYGEGFD-- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 elanqcgLSRKHIFDAVQDSVKRLG-TYIDVLQIH-----RYDPHVSaeEVMRALNDVVESGKVRYIGASTMRYYQFIEL 170
Cdd:PLN02587 92 -------FSAERVTKSVDESLARLQlDYVDILHCHdiefgSLDQIVN--ETIPALQKLKESGKVRFIGITGLPLAIFTYV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 171 QNTAEKHGWHKFISMQNYHnlLYREEEREMIPYCQKTGVGLIPWSPLARGLLTRSidaneetirSKTDLYTRALEFgagy 250
Cdd:PLN02587 163 LDRVPPGTVDVILSYCHYS--LNDSSLEDLLPYLKSKGVGVISASPLAMGLLTEN---------GPPEWHPAPPEL---- 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1246743210 251 KAILSRVEELAKKYNVSMATLATAWSLHKGDYP--IVGISKVERLQDALASV----TLKLNEEDIKYLEEPYCPV 319
Cdd:PLN02587 228 KSACAAAATHCKEKGKNISKLALQYSLSNKDISttLVGMNSVQQVEENVAAAteleTSGIDEELLSEVEAILAPV 302
|
|
| AKR_AKR3F2 |
cd19139 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ... |
18-310 |
5.17e-17 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381365 [Multi-domain] Cd Length: 248 Bit Score: 78.93 E-value: 5.17e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 18 DEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKcfspvrkdlikLYMDlssrgvqlhdspe 97
Cdd:cd19139 14 DVVIDSVRTALELGYRHIDTAQIYD---NEAAVGQAIAESGVPRDELFITTK-----------IWID------------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 98 lanqcGLSRKHIFDAVQDSVKRLGT-YIDVLQIH---RYDPhVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIE---- 169
Cdd:cd19139 67 -----NLSKDKLLPSLEESLEKLRTdYVDLTLIHwpsPNDE-VPVEEYIGALAEAKEQGLTRHIGVSNFTIALLDEaiav 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 170 ------LQNTAEKHGWhkfisMQNyhnllyreeeREMIPYCQKTGVGLIPWSPLARGLLTRsidanEETIRsktdlytra 243
Cdd:cd19139 141 vgagaiATNQIELSPY-----LQN----------RKLVAHCKQHGIHVTSYMTLAYGKVLD-----DPVLA--------- 191
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 244 lefgagykailsrveELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIK 310
Cdd:cd19139 192 ---------------AIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMA 243
|
|
| AKR_galDH-like |
cd19153 |
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ... |
15-309 |
7.62e-17 |
|
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381379 [Multi-domain] Cd Length: 294 Bit Score: 79.50 E-value: 7.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 15 EEEDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYEIPRSSIVIMSKCfspvrkdliklymdlSSRGVQLHD 94
Cdd:cd19153 30 LEQDEAVAIVAEAFAAGINHFDTSPYYGAESSEAVLGKALAALQVPRSSYTVATKV---------------GRYRDSEFD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 95 SpelanqcglSRKHIFDAVQDSVKRLG-TYIDVLQIH-----RYDPHVSaeEVMRALNDVVESGKVRYIGASTmryYQFI 168
Cdd:cd19153 95 Y---------SAERVRASVATSLERLHtTYLDVVYLHdiefvDYDTLVD--EALPALRTLKDEGVIKRIGIAG---YPLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 169 ELQNTAEKHGWHKFISMQNYHNL-LYREEEREMIPYC-QKTGVGLIPWSPLARGLLTrsidanEETIRSKTDLYTRALEF 246
Cdd:cd19153 161 TLTRATRRCSPGSLDAVLSYCHLtLQDARLESDAPGLvRGAGPHVINASPLSMGLLT------SQGPPPWHPASGELRHY 234
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 247 GAGYKAILSRVEelakkynVSMATLATAWSL--HKGDYP-IVGISKVERLQDALASVT-LKLNEEDI 309
Cdd:cd19153 235 AAAADAVCASVE-------ASLPDLALQYSLaaHAGVGTvLLGPSSLAQLRSMLAAVDaVASLGAAI 294
|
|
| AKR_Fe-S_oxidoreductase |
cd19096 |
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ... |
17-299 |
2.02e-16 |
|
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381322 [Multi-domain] Cd Length: 255 Bit Score: 77.60 E-value: 2.02e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSAGVSEELVGKFIRKYeiPRSSIVIMSKCFSpvrkdliklYMDLSSRGVqlhdsp 96
Cdd:cd19096 20 EEKAIEMIRYAIDAGINYFDTAYGYGGGKSEEILGEALKEG--PREKFYLATKLPP---------WSVKSAEDF------ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 elanqcglsRKHIfdavQDSVKRLGT-YIDVLQIH-----RYDPHVSAEEVMRALNDVVESGKVRYIGAST-MRYYQFIE 169
Cdd:cd19096 83 ---------RRIL----EESLKRLGVdYIDFYLLHglnspEWLEKARKGGLLEFLEKAKKEGLIRHIGFSFhDSPELLKE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 170 LQNTaekhgwHKFISMQNYHNLLYREEE--REMIPYCQKTGVGLIPWSPLARGLLTRsidaneetirsktdlytralefg 247
Cdd:cd19096 150 ILDS------YDFDFVQLQYNYLDQENQagRPGIEYAAKKGMGVIIMEPLKGGGLAN----------------------- 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1246743210 248 agykaILSRVEELAKKYNVSMATLATAWSLHKG--DYPIVGISKVERLQDALAS 299
Cdd:cd19096 201 -----NPPEALAILCGAPLSPAEWALRFLLSHPevTTVLSGMSTPEQLDENIAA 249
|
|
| AKR_DrGR-like |
cd19136 |
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ... |
14-312 |
5.68e-16 |
|
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).
Pssm-ID: 381362 [Multi-domain] Cd Length: 262 Bit Score: 76.52 E-value: 5.68e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 14 LEEEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIR----KYEIPRSSIVIMSKcFSPvrKDLiklymdlssrg 89
Cdd:cd19136 11 LRGEEEVRQAVDAALKAGYRLIDTASVYR---NEADIGKALRdllpKYGLSREDIFITSK-LAP--KDQ----------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 90 vqlhdSPELANQcglsrkhifdAVQDSVKRLGT-YIDVLQIH--------RYDP-HVSAE-EVMRALNDVVESGKVRYIG 158
Cdd:cd19136 74 -----GYEKARA----------ACLGSLERLGTdYLDLYLIHwpgvqglkPSDPrNAELRrESWRALEDLYKEGKLRAIG 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 159 AS--TMRYYQfiELQNTAEKhgwhkfISMQN---YHNLLYREEEREmipYCQKTGVGLIPWSPLARGLLtrsidaneeti 233
Cdd:cd19136 139 VSnyTVRHLE--ELLKYCEV------PPAVNqveFHPHLVQKELLK---FCKDHGIHLQAYSSLGSGDL----------- 196
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1246743210 234 rsktdlytRALEFgagykailSRVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYL 312
Cdd:cd19136 197 --------RLLED--------PTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAEL 259
|
|
| AKR_AKR5C2 |
cd19131 |
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ... |
16-308 |
4.80e-15 |
|
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.
Pssm-ID: 381357 [Multi-domain] Cd Length: 256 Bit Score: 73.56 E-value: 4.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSpvrkdliklymdlssrGVQLHDS 95
Cdd:cd19131 21 SNDEAASAVREALEVGYRSIDTAAIYG---NEEGVGKAIRASGVPREELFITTKLWN----------------SDQGYDS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 PElanqcglsrkhifDAVQDSVKRLGT-YIDVLQIH----RYDPHVsaeEVMRALNDVVESGKVRYIGASTmryYQFIEL 170
Cdd:cd19131 82 TL-------------RAFDESLRKLGLdYVDLYLIHwpvpAQDKYV---ETWKALIELKKEGRVKSIGVSN---FTIEHL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 171 QNTAEKHGWHKFISMQNYHNLLYREEEREmipYCQKTGVGLIPWSPLARGLLTRsidanEETIRsktdlytralefgagy 250
Cdd:cd19131 143 QRLIDETGVVPVVNQIELHPRFQQRELRA---FHAKHGIQTESWSPLGQGGLLS-----DPVIG---------------- 198
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246743210 251 kailsrveELAKKYNVSMATLATAWSLHKGdypIVGISKV---ERLQDALASVTLKLNEED 308
Cdd:cd19131 199 --------EIAEKHGKTPAQVVIRWHLQNG---LVVIPKSvtpSRIAENFDVFDFELDADD 248
|
|
| AKR_AKR5D1_E1 |
cd19132 |
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ... |
18-309 |
5.49e-15 |
|
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381358 [Multi-domain] Cd Length: 255 Bit Score: 73.46 E-value: 5.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 18 DEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCfspvrkdliklymdlssRGVQLHdspe 97
Cdd:cd19132 20 DEGVEAVVAALQAGYRLLDTAFNYE---NEGAVGEAVRRSGVPREELFVTTKL-----------------PGRHHG---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 98 lanqcglsRKHIFDAVQDSVKRLGT-YIDVLQIH----RYDPHVsaeEVMRALNDVVESGKVRYIGAStmryyQFIE--L 170
Cdd:cd19132 76 --------YEEALRTIEESLYRLGLdYVDLYLIHwpnpSRDLYV---EAWQALIEAREEGLVRSIGVS-----NFLPehL 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 171 QNTAEKHGWHKFISMQNYHNLLYREEEREmipYCQKTGVGLIPWSPLARGlltrsidaneetirskTDLYTRALefgagy 250
Cdd:cd19132 140 DRLIDETGVTPAVNQIELHPYFPQAEQRA---YHREHGIVTQSWSPLGRG----------------SGLLDEPV------ 194
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1246743210 251 kailsrVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDI 309
Cdd:cd19132 195 ------IKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDM 247
|
|
| AKR_AKR5A_5G |
cd19126 |
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ... |
12-309 |
1.15e-14 |
|
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.
Pssm-ID: 381352 [Multi-domain] Cd Length: 254 Bit Score: 72.47 E-value: 1.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 12 WVLEEEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSPvrkdliklymDLSSRGVQ 91
Cdd:cd19126 17 FQTPDGDETERAVQTALENGYRSIDTAAIYK---NEEGVGEAIRESGVPREELFVTTKLWND----------DQRARRTE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 92 lhdspelanqcglsrkhifDAVQDSVKRLGT-YIDVLQIHrYDPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIEL 170
Cdd:cd19126 84 -------------------DAFQESLDRLGLdYVDLYLIH-WPGKDKFIDTWKALEKLYASGKVKAIGVSNFQEHHLEEL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 171 QNTAEkhgwhkFISMQN---YHNLLYREEEREmipYCQKTGVGLIPWSPLARGLLTRSidaneetirsktdlytralefg 247
Cdd:cd19126 144 LAHAD------VVPAVNqveFHPYLTQKELRG---YCKSKGIVVEAWSPLGQGGLLSN---------------------- 192
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246743210 248 agykailSRVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDI 309
Cdd:cd19126 193 -------PVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDM 247
|
|
| AKR_AKR5F1 |
cd19133 |
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ... |
12-310 |
1.66e-14 |
|
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).
Pssm-ID: 381359 [Multi-domain] Cd Length: 255 Bit Score: 72.22 E-value: 1.66e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 12 WVLEEEDEVFKIMKAAYDAGIRTFDTANIYsagVSEELVGKFIRKYEIPRSSIVIMSKCFspvrkdliklymdlssrgvq 91
Cdd:cd19133 17 FQIPDPEECERAVLEAIKAGYRLIDTAAAY---GNEEAVGRAIKKSGIPREELFITTKLW-------------------- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 92 LHDSpelanqcglSRKHIFDAVQDSVKRLGT-YIDVLQIHRydPHVSAEEVMRALNDVVESGKVRYIGASTMRYYQFIEL 170
Cdd:cd19133 74 IQDA---------GYEKAKKAFERSLKRLGLdYLDLYLIHQ--PFGDVYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDL 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 171 QNTAEkhgwhkFISMQN---YHNLLYREEEREMIpycQKTGVGLIPWSPLARGlltRSIDANEETIRsktdlytralefg 247
Cdd:cd19133 143 ILHNE------VKPAVNqieTHPFNQQIEAVEFL---KKYGVQIEAWGPFAEG---RNNLFENPVLT------------- 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246743210 248 agykailsrveELAKKYNVSMATLATAWSLHKGdypIVGISKV---ERLQDALASVTLKLNEEDIK 310
Cdd:cd19133 198 -----------EIAEKYGKSVAQVILRWLIQRG---IVVIPKSvrpERIAENFDIFDFELSDEDME 249
|
|
| AKR_CeZK1290-like |
cd19135 |
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ... |
29-312 |
3.96e-13 |
|
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Pssm-ID: 381361 [Multi-domain] Cd Length: 265 Bit Score: 68.12 E-value: 3.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 29 DAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSPvrkDliklYMDLSSRgvqlhdspelanqcglsrkh 108
Cdd:cd19135 37 ECGYRHIDTAKRYG---CEELLGKAIKESGVPREDLFLTTKLWPS---D----YGYESTK-------------------- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 109 ifDAVQDSVKRLGT-YIDVLQIHRYDPHVSA-------EEVMRALNDVVESGKVRYIGASTMRYYQFIELQNTAE--KHg 178
Cdd:cd19135 87 --QAFEASLKRLGVdYLDLYLLHWPDCPSSGknvketrAETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSvvPH- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 179 whkfiSMQNYHNLLYREEEreMIPYCQKTGVGLIPWSPLARGLLTrsidaNEETirsktdlytralefgagykailsrVE 258
Cdd:cd19135 164 -----VNQVEFHPFQNPVE--LIEYCRDNNIVFEGYCPLAKGKAL-----EEPT------------------------VT 207
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1246743210 259 ELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYL 312
Cdd:cd19135 208 ELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDMATL 261
|
|
| AKR_AKR5A1_2 |
cd19156 |
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ... |
12-314 |
4.85e-13 |
|
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.
Pssm-ID: 381382 [Multi-domain] Cd Length: 266 Bit Score: 67.93 E-value: 4.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 12 WVLEEEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSpvrkdliklymdlSSRGVQ 91
Cdd:cd19156 17 WRVQDGAEAENAVKWAIEAGYRHIDTAAIYK---NEEGVGQGIRESGVPREEVFVTTKLWN-------------SDQGYE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 92 lhdspelanqcglsrkHIFDAVQDSVKRLGT-YIDVLQIH--RYDPHVsaeEVMRALNDVVESGKVRYIGASTMRYYQFI 168
Cdd:cd19156 81 ----------------STLAAFEESLEKLGLdYVDLYLIHwpVKGKFK---DTWKAFEKLYKEKKVRAIGVSNFHEHHLE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 169 ELQNTAekhgwhKFISMQN---YHNLLYREEEREmipYCQKTGVGLIPWSPLARGLLTRSidaneetirsktdlytrale 245
Cdd:cd19156 142 ELLKSC------KVAPMVNqieLHPLLTQEPLRK---FCKEKNIAVEAWSPLGQGKLLSN-------------------- 192
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246743210 246 fgagykailSRVEELAKKYNVSMATLATAWSLHKGdypIVGISKV---ERLQDALASVTLKLNEEDIKYLEE 314
Cdd:cd19156 193 ---------PVLKAIGKKYGKSAAQVIIRWDIQHG---IITIPKSvheERIQENFDVFDFELTAEEIRQIDG 252
|
|
| AKR_ARA2 |
cd19164 |
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ... |
22-299 |
2.50e-12 |
|
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).
Pssm-ID: 381390 [Multi-domain] Cd Length: 298 Bit Score: 66.15 E-value: 2.50e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 22 KIMKAAYDAGIRTFDTANIYsaGVSEELVGKFIRKY--EIPRSSIVIMSKCfspvrkdliklymdlsSR-GVQLHD-SPE 97
Cdd:cd19164 38 DIVRRALELGIRAFDTSPYY--GPSEIILGRALKALrdEFPRDTYFIITKV----------------GRyGPDDFDySPE 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 98 lanqcglsrkHIFDAVQDSVKRLGT-YIDVLQIHRYDpHVSAEEVMRA---LNDVVESGKVRYIGAS------------- 160
Cdd:cd19164 100 ----------WIRASVERSLRRLHTdYLDLVYLHDVE-FVADEEVLEAlkeLFKLKDEGKIRNVGISgyplpvllrlael 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 161 -----------TMRYYQFiELQNTaekhgwhkfiSMQNYHNLLYREEEREMIpycqktgvglIPWSPLARGLLTRsidan 229
Cdd:cd19164 169 arttagrpldaVLSYCHY-TLQNT----------TLLAYIPKFLAAAGVKVV----------LNASPLSMGLLRS----- 222
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246743210 230 eetirsktdlyTRALEF---GAGYKAILSRVEELAKKYNVSMATLATAWSLHKGDYP---IVGISKVERLQDALAS 299
Cdd:cd19164 223 -----------QGPPEWhpaSPELRAAAAKAAEYCQAKGTDLADVALRYALREWGGEgptVVGCSNVDELEEAVEA 287
|
|
| AKR_unchar |
cd19098 |
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ... |
17-314 |
1.17e-11 |
|
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.
Pssm-ID: 381324 [Multi-domain] Cd Length: 318 Bit Score: 64.67 E-value: 1.17e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYsaGVSEELVGKFIRKYEIPRSSIVIMSKCFspvrkdliklY-------MDLSSRG 89
Cdd:cd19098 34 RAHTHAVLDAAWAAGVRYFDAARSY--GRAEEFLGSWLRSRNIAPDAVFVGSKWG----------YtytadwqVDAAVHE 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 90 VQLHDSPELANQcglsrkhifdaVQDSVKRLGTYIDVLQIHrydphvSA---------EEVMRALNDVVESGkvRYIGAS 160
Cdd:cd19098 102 VKDHSLARLLKQ-----------WEETRSLLGKHLDLYQIH------SAtlesgvledADVLAALAELKAEG--VKIGLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 161 T--MRYYQFIELQNTAEKHGWHKFISMQNYHNLLyreeEREMIPY---CQKTGVGLIPWSPLARGLLTRSIDAneetirs 235
Cdd:cd19098 163 LsgPQQAETLRRALEIEIDGARLFDSVQATWNLL----EQSAGEAleeAHEAGMGVIVKEALANGRLTDRNPS------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 236 ktdlytralefgAGYKAILSRVEELAKKYNVSMATLATAWSLHKGDYPIV--GISKVERLQDALASVTLKLNEEDIKYLE 313
Cdd:cd19098 232 ------------PELAPLMAVLKAVADRLGVTPDALALAAVLAQPFVDVVlsGAATPEQLRSNLRALDVSLDLELLAALA 299
|
.
gi 1246743210 314 E 314
Cdd:cd19098 300 D 300
|
|
| AKR_AKR3G1 |
cd19123 |
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ... |
16-314 |
1.15e-10 |
|
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.
Pssm-ID: 381349 [Multi-domain] Cd Length: 297 Bit Score: 61.27 E-value: 1.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFI----RKYEIPRSSIVIMSKCFS------PVRKDLIKLYMDL 85
Cdd:cd19123 23 KPGEVGQAVKQALEAGYRHIDCAAIYG---NEAEIGAALaevfKEGKVKREDLWITSKLWNnshapeDVLPALEKTLADL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 86 ssrgvQLhdspelaNQCGLSRKHIFDAVQDSVKRLGTYIDVLQihrYDPhVSAEEVMRALNDVVESGKVRYIGASTMRYY 165
Cdd:cd19123 100 -----QL-------DYLDLYLMHWPVALKKGVGFPESGEDLLS---LSP-IPLEDTWRAMEELVDKGLCRHIGVSNFSVK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 166 QFIELQNTAEkhgwHKFISMQ-NYHNLLyreEEREMIPYCQKTGVGLIPWSPLARGLLTRSIDANEEtirsktdlyTRAL 244
Cdd:cd19123 164 KLEDLLATAR----IKPAVNQvELHPYL---QQPELLAFCRDNGIHLTAYSPLGSGDRPAAMKAEGE---------PVLL 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 245 EFGAgykailsrVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYLEE 314
Cdd:cd19123 228 EDPV--------INKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAA 289
|
|
| AKR_GlAR-like |
cd19128 |
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ... |
16-312 |
4.31e-09 |
|
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Pssm-ID: 381354 [Multi-domain] Cd Length: 277 Bit Score: 56.38 E-value: 4.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 16 EEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRkyEIPRSSIVimskcfspVRKDLIklymdLSSRGVQLHDS 95
Cdd:cd19128 12 TESESKEAVKNAIKAGYRHIDCAYYYG---NEAFIGIAFS--EIFKDGGV--------KREDLF-----ITSKLWPTMHQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 96 PEL-ANQCglsrkhifdavQDSVKRLGT-YIDVLQIH-------------------RYDPHVSAEEVMRALNDVVESGKV 154
Cdd:cd19128 74 PENvKEQL-----------LITLQDLQLeYLDLFLIHwplafdmdtdgdprddnqiQSLSKKPLEDTWRAMEQCVDEKLT 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 155 RYIGASTMRYYQFIELQNTAEKHGWHKFISMQNYHnllyreEEREMIPYCQKTGVGLIPWSPLARglltrsidaneetir 234
Cdd:cd19128 143 KNIGVSNYSTKLLTDLLNYCKIKPFMNQIECHPYF------QNDKLIKFCIENNIHVTAYRPLGG--------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 235 sktdlytralEFGAGYKAIL--SRVEELAKKYNVSMATLATAWSLHK--GDYPIVGISK-VERLQDALASVTLKLNEEDI 309
Cdd:cd19128 202 ----------SYGDGNLTFLndSELKALATKYNTTPPQVIIAWHLQKwpKNYSVIPKSAnKSRCQQNFDINDLALTKEDM 271
|
...
gi 1246743210 310 KYL 312
Cdd:cd19128 272 DAI 274
|
|
| AKR_AKR2A1-2 |
cd19112 |
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ... |
108-312 |
4.47e-09 |
|
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.
Pssm-ID: 381338 [Multi-domain] Cd Length: 308 Bit Score: 56.72 E-value: 4.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 108 HIFDAVQDSVKRLG-TYIDVLQIH-----------------------RYDPHVSAEEVMRALNDVVESGKVRYIGASTmr 163
Cdd:cd19112 84 HVIEACKDSLKKLQlDYLDLYLVHfpvatkhtgvgttgsalgedgvlDIDVTISLETTWHAMEKLVSAGLVRSIGISN-- 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 164 YYQFIelqnTAEKHGWHKF---ISMQNYHNLLYREEereMIPYCQKTGVGLIPWSPLARGLltrsidANEETIRSKTDLY 240
Cdd:cd19112 162 YDIFL----TRDCLAYSKIkpaVNQIETHPYFQRDS---LVKFCQKHGISVTAHTPLGGAA------ANAEWFGSVSPLD 228
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246743210 241 TRALEfgagykailsrveELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYL 312
Cdd:cd19112 229 DPVLK-------------DLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLI 287
|
|
| AKR_AKR4C1-15 |
cd19125 |
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ... |
25-314 |
1.06e-08 |
|
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.
Pssm-ID: 381351 [Multi-domain] Cd Length: 287 Bit Score: 55.43 E-value: 1.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 25 KAAYDAGIRTFDTANIYsaGVSEElVGKFIRKyeIPRSSIVimskcfspVRKDLI---KLYMDlssrgvqlHDSPElanq 101
Cdd:cd19125 31 KTAIKEGYRHIDCAAIY--GNEKE-IGKALKK--LFEDGVV--------KREDLFitsKLWCT--------DHAPE---- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 102 cglsrkHIFDAVQDSVKRLGT-YIDVLQIH------RYDPHVSAEEVM--------RALNDVVESGKVRYIGASTMRYYQ 166
Cdd:cd19125 86 ------DVPPALEKTLKDLQLdYLDLYLIHwpvrlkKGAHMPEPEEVLppdipstwKAMEKLVDSGKVRAIGVSNFSVKK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 167 FIELQNTA---------EKH-GWhkfismqnyhnllyreEEREMIPYCQKTGVGLIPWSPLARGlltrsidaneETIRSK 236
Cdd:cd19125 160 LEDLLAVArvppavnqvECHpGW----------------QQDKLHEFCKSKGIHLSAYSPLGSP----------GTTWVK 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246743210 237 TDLYTRALefgagykailsrVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYLEE 314
Cdd:cd19125 214 KNVLKDPI------------VTKVAEKLGKTPAQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSS 279
|
|
| AKR_AKR3A1-2 |
cd19117 |
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ... |
17-314 |
1.47e-08 |
|
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.
Pssm-ID: 381343 [Multi-domain] Cd Length: 284 Bit Score: 54.81 E-value: 1.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSpvrkdliklymdlssrgvQLHDSP 96
Cdd:cd19117 26 PNEVAKAVEAALKAGYRHIDTAAIYG---NEEEVGQGIKDSGVPREEIFITTKLWC------------------TWHRRV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 ElanqcglsrkhifDAVQDSVKRLGT-YIDVLQIH-------RYDPHVSAEEVMRALND--------------VVESGKV 154
Cdd:cd19117 85 E-------------EALDQSLKKLGLdYVDLYLMHwpvpldpDGNDFLFKKDDGTKDHEpdwdfiktwelmqkLPATGKV 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 155 RYIGASTMRYYQFIELQNTAEKhgwhKFISMQNYHNLLYREEEREMIPYCQKTGVGLIPWSPLArglltrSIDA---NEE 231
Cdd:cd19117 152 KAIGVSNFSIKNLEKLLASPSA----KIVPAVNQIELHPLLPQPKLVDFCKSKGIHATAYSPLG------STNApllKEP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 232 TIrsktdlytralefgagykailsrvEELAKKYNVSMATLATAWSLHKGdypIVGISK---VERLQDALASVTlkLNEED 308
Cdd:cd19117 222 VI------------------------IKIAKKHGKTPAQVIISWGLQRG---YSVLPKsvtPSRIESNFKLFT--LSDEE 272
|
....*.
gi 1246743210 309 IKYLEE 314
Cdd:cd19117 273 FKEIDE 278
|
|
| AKR_AKR5H1 |
cd19134 |
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ... |
17-312 |
3.07e-08 |
|
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.
Pssm-ID: 381360 [Multi-domain] Cd Length: 263 Bit Score: 53.71 E-value: 3.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSKCFSPvrkdliklymdlssrgvqlhdsp 96
Cdd:cd19134 23 DDEAERSVSAALEAGYRLIDTAAAYG---NEAAVGRAIAASGIPRGELFVTTKLATP----------------------- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 97 elanqcglsrKHIFDAVQD----SVKRLG-TYIDVLQIHRYDPHVSAE-EVMRALNDVVESGKVRYIGASTmryYQFIEL 170
Cdd:cd19134 77 ----------DQGFTASQAacraSLERLGlDYVDLYLIHWPAGREGKYvDSWGGLMKLREEGLARSIGVSN---FTAEHL 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 171 QNTAEKHGWHKFISMQNYHNLLYREEEREmipYCQKTGVGLIPWSPLARGlltRSIDANEetirsktdlytralefgagy 250
Cdd:cd19134 144 ENLIDLTFFTPAVNQIELHPLLNQAELRK---VNAQHGIVTQAYSPLGVG---RLLDNPA-------------------- 197
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246743210 251 kailsrVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYL 312
Cdd:cd19134 198 ------VTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDAL 253
|
|
| dkgA |
PRK11565 |
2,5-didehydrogluconate reductase DkgA; |
18-220 |
1.72e-07 |
|
2,5-didehydrogluconate reductase DkgA;
Pssm-ID: 183203 [Multi-domain] Cd Length: 275 Bit Score: 51.61 E-value: 1.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 18 DEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKYEIPRSSIVIMSkcfspvrkdliKLYMDlssrgvqlhdspe 97
Cdd:PRK11565 28 EEVITAIHKALEVGYRSIDTAAIYK---NEEGVGKALKEASVAREELFITT-----------KLWND------------- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 98 lanqcglSRKHIFDAVQDSVKRLG-TYIDVLQIHRYDPH----VSAeevMRALNDVVESGKVRYIGASTmryYQFIELQN 172
Cdd:PRK11565 81 -------DHKRPREALEESLKKLQlDYVDLYLMHWPVPAidhyVEA---WKGMIELQKEGLIKSIGVCN---FQIHHLQR 147
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1246743210 173 TAEKHGWHKFISMQNYHNLLyreEEREMIPYCQKTGVGLIPWSPLARG 220
Cdd:PRK11565 148 LIDETGVTPVINQIELHPLM---QQRQLHAWNATHKIQTESWSPLAQG 192
|
|
| AKR_AKR3C1 |
cd19119 |
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ... |
15-314 |
5.34e-07 |
|
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).
Pssm-ID: 381345 [Multi-domain] Cd Length: 294 Bit Score: 50.19 E-value: 5.34e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 15 EEEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIR----KYEIPRSSIVIMSKCFsPVRKDLIKLYMDLSSRGV 90
Cdd:cd19119 24 EDRAEVKEAVEAAIKEGYRHIDTAYAYE---TEDFVGEAIKraidDGSIKREELFITTKVW-PTFYDEVERSLDESLKAL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 91 QLHDSPELANQCGLSrkhiFDAVQDSVKRLGTYIDVLQIHRYDPHVSAEEVMRALNDVVESGKVRYIGASTmryYQFIEL 170
Cdd:cd19119 100 GLDYVDLLLVHWPVC----FEKDSDDSGKPFTPVNDDGKTRYAASGDHITTYKQLEKIYLDGRAKAIGVSN---YSIVYL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 171 QNTAEKHGWHKFISMQNYHNLLYREEEREmipYCQKTGVGLIPWSPlarglltrsidaneetirsktdlytraleFGAGY 250
Cdd:cd19119 173 ERLIKECKVVPAVNQVELHPHLPQMDLRD---FCFKHGILVTAYSP-----------------------------LGSHG 220
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246743210 251 KAILSR--VEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTlkLNEEDIKYLEE 314
Cdd:cd19119 221 APNLKNplVKKIAEKYNVSTGDILISYHVRQGVIVLPKSLKPVRIVSNGKIVS--LTKEDLQKLDD 284
|
|
| AKR_AKR1G1_CeAKR |
cd19154 |
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ... |
17-314 |
8.17e-07 |
|
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.
Pssm-ID: 381380 [Multi-domain] Cd Length: 303 Bit Score: 49.72 E-value: 8.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 17 EDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKY----EIPRSSIVIMSKCFSpvrkdliklymdlssrgvQL 92
Cdd:cd19154 24 GAEGITAVRTALKAGYRLIDTAFLYQ---NEEAIGEALAELleegVVKREDLFITTKLWT------------------HE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 93 HdspelanqcglSRKHIFDAVQDSVKRLG-TYIDVLQIH----------RYDPHVSA---------EEVMRALNDVVESG 152
Cdd:cd19154 83 H-----------APEDVEEALRESLKKLQlEYVDLYLIHapaafkddegESGTMENGmsihdavdvEDVWRGMEKVYDEG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 153 KVRYIGASTMRYYQFIELQNTAEKhgwhKFISMQ-NYHNLLYREEEREmipYCQKTGVGLIPWSPLarGLLTR-SIDANE 230
Cdd:cd19154 152 LTKAIGVSNFNNDQIQRILDNARV----KPHNNQvECHLYFPQKELVE---FCKKHNISVTSYATL--GSPGRaNFTKST 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 231 ETIRSKTDLYTralefgagykailSRVEELAKKYNVSMATLATAWSLHKGdypIVGISKV---ERLQDALASVTLKLNEE 307
Cdd:cd19154 223 GVSPAPNLLQD-------------PIVKAIAEKHGKTPAQVLLRYLLQRG---IAVIPKSatpSRIKENFNIFDFSLSEE 286
|
....*..
gi 1246743210 308 DIKYLEE 314
Cdd:cd19154 287 DMATLEE 293
|
|
| AKR_AKR2E1-5 |
cd19116 |
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ... |
12-314 |
1.26e-06 |
|
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.
Pssm-ID: 381342 [Multi-domain] Cd Length: 292 Bit Score: 49.20 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 12 WVLEEEDEVFKIMKAAYDAGIRTFDTANIYSagvSEELVGKFIRKY----EIPRSSIVIMSKC----FSP------VRKD 77
Cdd:cd19116 19 WKLKDDEGVRQAVKHAIEAGYRHIDTAYLYG---NEAEVGEAIREKiaegVVKREDLFITTKLwnsyHEReqvepaLRES 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 78 LIKL---YMDLssrgVQLHdSPELANQCGLSRKHIFDAVQDsvkrlgtyIDVLqihrydphvsaeEVMRALNDVVESGKV 154
Cdd:cd19116 96 LKRLgldYVDL----YLIH-WPVAFKENNDSESNGDGSLSD--------IDYL------------ETWRGMEDLVKLGLT 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 155 RYIGASTMRYYQfIE--LQNTAEKhgwHKFISMQNYHNLLyreeEREMIPYCQKTGVGLIPWSPLARgLLTRSIDANEET 232
Cdd:cd19116 151 RSIGVSNFNSEQ-INrlLSNCNIK---PAVNQIEVHPTLT----QEKLVAYCQSNGIVVMAYSPFGR-LVPRGQTNPPPR 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 233 IRSktdlytralefgagykailSRVEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTLKLNEEDIKYL 312
Cdd:cd19116 222 LDD-------------------PTLVAIAKKYGKTTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAAL 282
|
..
gi 1246743210 313 EE 314
Cdd:cd19116 283 NS 284
|
|
| AKR_BaDH-like |
cd19129 |
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ... |
25-227 |
8.85e-05 |
|
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.
Pssm-ID: 381355 [Multi-domain] Cd Length: 295 Bit Score: 43.60 E-value: 8.85e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 25 KAAYDAGIRTFDTANIYSagvSEELVGKFIRKY----EIPRSSIVIMSKCFSPvrkdliklymdlssrgvqlHDSPELAn 100
Cdd:cd19129 26 KAALEAGFRHFDCAERYR---NEAEVGEAMQEVfkagKIRREDLFVTTKLWNT-------------------NHRPERV- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 101 qcglsrKHIFDAvqdSVKRLG-TYIDVLQIHR--------------------YDPHVSAEEVMRALNDVVESGKVRYIGA 159
Cdd:cd19129 83 ------KPAFEA---SLKRLQlDYLDLYLIHTpfafqpgdeqdprdangnviYDDGVTLLDTWRAMERLVDEGRCKAIGL 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246743210 160 STMRYYQFIELQNTA---------EKHGWHkfismqnyhnllyreEEREMIPYCQKTGVGLIPWSPLARGLLTRSID 227
Cdd:cd19129 154 SDVSLEKLREIFEAArikpavvqvESHPYL---------------PEWELLDFCKNHGIVLQAFAPLGHGMEPKLLE 215
|
|
| AKR_AKR2C1 |
cd19114 |
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ... |
15-314 |
1.60e-03 |
|
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.
Pssm-ID: 381340 [Multi-domain] Cd Length: 302 Bit Score: 39.85 E-value: 1.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 15 EEEDEVFKIMKAAYdagiRTFDTANIYSagvSEELVGKFIRKY----EIPRSSIVIMSKCFSpvrkdliklymdlssrgv 90
Cdd:cd19114 18 ETEEVIYNAIKVGY----RLIDGALLYG---NEAEVGRGIRKAiqegLVKREDLFIVTKLWN------------------ 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 91 QLHdspelanqcglSRKHIFDAVQDSVKRLG-TYIDVLQIH-----RY-DP-------------------HVSAEEVMRA 144
Cdd:cd19114 73 NFH-----------GKDHVREAFDRQLKDYGlDYIDLYLIHfpipaAYvDPaenypflwkdkelkkfpleQSPMQECWRE 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 145 LNDVVESGKVRYIGASTMRYYQFIELQNTAEKhgwhKFISMQNYHNLlYREEEReMIPYCQKTGVGLIPWSPLArglltr 224
Cdd:cd19114 142 MEKLVDAGLVRNIGIANFNVQLILDLLTYAKI----KPAVLQIEHHP-YLQQKR-LIDWAKKQGIQITAYSSFG------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246743210 225 sidaneetirskTDLYTRALEFGAGYKAILSR--VEELAKKYNVSMATLATAWSLHKGDYPIVGISKVERLQDALASVTL 302
Cdd:cd19114 210 ------------NAVYTKVTKHLKHFTNLLEHpvVKKLADKHKRDTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSY 277
|
330
....*....|..
gi 1246743210 303 KLNEEDIKYLEE 314
Cdd:cd19114 278 KLDEEDMEALYE 289
|
|
| |
