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Conserved domains on  [gi|1254045156|ref|NP_001343670|]
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U2A'/phosphoprotein 32 family A C-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
742-1032 9.03e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 9.03e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  742 VNDNLLKDKSDVELLKTMPKLTHLDMSNNILSSAEGYRPRVMQAAQFLISLDRQIIPLEERHVNTMKQTTRGLSLELIER 821
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  822 ICPEWKNKKELMICDQKIEQIILEKSQMEELSQIRLIDLSKNRLSSV-REISSF-NITHLILNNNCLKSIAvndgqTSLQ 899
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLtNLKELDLSNNQLTDLP-----EPLG 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  900 PFPYLENLDISNNSISN--------TSILRLGIplllklkninlSQNALSRFDCSLFDLPNLESVDLSNNSIKTIIR--R 969
Cdd:COG4886    157 NLTNLKSLDLSNNQLTDlpeelgnlTNLKELDL-----------SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEplA 225

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1254045156  970 PLKTLTSLNLQNNKLTTLTPLS-CPNLVSLDISNNKLascASLKPLCECKTLENLDCRNNSVTE 1032
Cdd:COG4886    226 NLTNLETLDLSNNQLTDLPELGnLTNLEELDLSNNQL---TDLPPLANLTNLKTLDLSNNQLTD 286
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 626-793 7.49e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 80.60  E-value: 7.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  626 MTRLTALELCDQKLTKLTGIQELVSLQFLSVRKNKLTSLKKLNRLPCLKLLDASFNHISKIEQL---------------- 689
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLenlvnlkklylggnri 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  690 --------PSSLLHVDLSHNKL---QTLVF----CQSLGNT-RHLLLHRNQIKSMKGVESCVQLETFFVNDNLLKDKSDV 753
Cdd:cd21340     81 svveglenLTNLEELHIENQRLppgEKLTFdprsLAALSNSlRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1254045156  754 -ELLKTMPKLTHLDMSNNILSSAEGYRPRVMQAAQFLISLD 793
Cdd:cd21340    161 lDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
62-213 1.21e-09

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156   62 GLKYFSHLSTLRLFGQQITCLKPLGEVAPTLEELWVCEGAVKDL-AGVDHCIRLKKLFLYDNAIEDASC-LCALTNLQYL 139
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKEL 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  140 NIASNKLKSL-TFLRDMKDLTNLSLADNKMKDsvvataiWPESI------QHLDISANCFSSnraLFSLTILSSLRSLNL 212
Cdd:COG4886    188 DLSNNQITDLpEPLGNLTNLEELDLSGNQLTD-------LPEPLanltnlETLDLSNNQLTD---LPELGNLTNLEELDL 257


                   .
gi 1254045156  213 D 213
Cdd:COG4886    258 S 258
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
742-1032 9.03e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 9.03e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  742 VNDNLLKDKSDVELLKTMPKLTHLDMSNNILSSAEGYRPRVMQAAQFLISLDRQIIPLEERHVNTMKQTTRGLSLELIER 821
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  822 ICPEWKNKKELMICDQKIEQIILEKSQMEELSQIRLIDLSKNRLSSV-REISSF-NITHLILNNNCLKSIAvndgqTSLQ 899
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLtNLKELDLSNNQLTDLP-----EPLG 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  900 PFPYLENLDISNNSISN--------TSILRLGIplllklkninlSQNALSRFDCSLFDLPNLESVDLSNNSIKTIIR--R 969
Cdd:COG4886    157 NLTNLKSLDLSNNQLTDlpeelgnlTNLKELDL-----------SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEplA 225

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1254045156  970 PLKTLTSLNLQNNKLTTLTPLS-CPNLVSLDISNNKLascASLKPLCECKTLENLDCRNNSVTE 1032
Cdd:COG4886    226 NLTNLETLDLSNNQLTDLPELGnLTNLEELDLSNNQL---TDLPPLANLTNLKTLDLSNNQLTD 286
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 626-793 7.49e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.60  E-value: 7.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  626 MTRLTALELCDQKLTKLTGIQELVSLQFLSVRKNKLTSLKKLNRLPCLKLLDASFNHISKIEQL---------------- 689
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLenlvnlkklylggnri 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  690 --------PSSLLHVDLSHNKL---QTLVF----CQSLGNT-RHLLLHRNQIKSMKGVESCVQLETFFVNDNLLKDKSDV 753
Cdd:cd21340     81 svveglenLTNLEELHIENQRLppgEKLTFdprsLAALSNSlRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1254045156  754 -ELLKTMPKLTHLDMSNNILSSAEGYRPRVMQAAQFLISLD 793
Cdd:cd21340    161 lDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 849-1058 7.07e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 7.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  849 MEELSQ---IRLIDLSKNRLSSVREISSF-NITHLILNNNCLKSIavndgqTSLQPFPYLENLDISNNSISNTSILRlgi 924
Cdd:cd21340     17 IDNLSLcknLKVLYLYDNKITKIENLEFLtNLTHLYLQNNQIEKI------ENLENLVNLKKLYLGGNRISVVEGLE--- 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  925 plllklkninlSQNALSRFDCSLFDLPNLESVDLSNNSIKTIirrpLKTLTSLNLQNNKLTTLTPLSC-PNLVSLDISNN 1003
Cdd:cd21340     88 -----------NLTNLEELHIENQRLPPGEKLTFDPRSLAAL----SNSLRVLNISGNNIDSLEPLAPlRNLEQLDASNN 152

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1254045156 1004 KLASCASLK-PLCECKTLENLDCRNNSVTERRVYVDFIKAQVPSVRKLDD-EIMSNE 1058
Cdd:cd21340    153 QISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGkEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
626-774 6.63e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 6.63e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  626 MTRLTALELCDQKltkltGIQELVSLQFLSVRKNKLTSL-KKLNRLPCLKLLDASFNHIS----KIEQLPsSLLHVDLSH 700
Cdd:COG4886     95 LTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTdlpePLGNLT-NLKSLDLSN 168

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1254045156  701 NKLQTL-VFCQSLGNTRHLLLHRNQIKSM-KGVESCVQLETFFVNDNLLKDKSDVelLKTMPKLTHLDMSNNILSS 774
Cdd:COG4886    169 NQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-213 1.21e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156   62 GLKYFSHLSTLRLFGQQITCLKPLGEVAPTLEELWVCEGAVKDL-AGVDHCIRLKKLFLYDNAIEDASC-LCALTNLQYL 139
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKEL 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  140 NIASNKLKSL-TFLRDMKDLTNLSLADNKMKDsvvataiWPESI------QHLDISANCFSSnraLFSLTILSSLRSLNL 212
Cdd:COG4886    188 DLSNNQITDLpEPLGNLTNLEELDLSGNQLTD-------LPEPLanltnlETLDLSNNQLTD---LPELGNLTNLEELDL 257


                   .
gi 1254045156  213 D 213
Cdd:COG4886    258 S 258
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 645-1005 2.24e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 2.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  645 IQELVSLQFLSVRKNKLTSL--KKLNRLPCLKLLDASFNHIS-----KIEQLpSSLLHVDLSHNKL--QTLVFCQSLGNT 715
Cdd:PLN00113   184 LTNLTSLEFLTLASNQLVGQipRELGQMKSLKWIYLGYNNLSgeipyEIGGL-TSLNHLDLVYNNLtgPIPSSLGNLKNL 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  716 RHLLLHRNQI-----KSMKGVESCVQLEtffVNDNLLKDKSDvELLKTMPKLTHLDMSNNILSsaeGYRPRVmqaaqfLI 790
Cdd:PLN00113   263 QYLFLYQNKLsgpipPSIFSLQKLISLD---LSDNSLSGEIP-ELVIQLQNLEILHLFSNNFT---GKIPVA------LT 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  791 SLDR-QIIPL--------------EERHVNTMKQTTRGLSLELIERICPEWKNKKELMICDQKIEQIILEKSQMEELSQI 855
Cdd:PLN00113   330 SLPRlQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRV 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  856 RLidlSKNRLSS--VREISSFNITHL--ILNNNCLKSIavndgQTSLQPFPYLENLDISNNSISNtsilrlGIPlllklk 931
Cdd:PLN00113   410 RL---QDNSFSGelPSEFTKLPLVYFldISNNNLQGRI-----NSRKWDMPSLQMLSLARNKFFG------GLP------ 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  932 ninlsqnalsrfdcSLFDLPNLESVDLSNNSIKTIIRRPLKTLTS---LNLQNNKLTTLTP---LSCPNLVSLDISNNKL 1005
Cdd:PLN00113   470 --------------DSFGSKRLENLDLSRNQFSGAVPRKLGSLSElmqLKLSENKLSGEIPdelSSCKKLVSLDLSHNQL 535
LRR_9 pfam14580
Leucine-rich repeat;
950-1051 6.78e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 53.61  E-value: 6.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  950 LPNLESVDLSNNSIKTIIRRP-LKTLTSLNLQNNKLTTLTP---LSCPNLVSLDISNNKLASCASLKPLCECKTLENLDC 1025
Cdd:pfam14580   41 LDQFDTIDFSDNEIRKLDGFPlLRRLKTLLLNNNRICRIGEglgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSL 120

                           90       100
                   ....*....|....*....|....*.
gi 1254045156 1026 RNNSVTERRVYVDFIKAQVPSVRKLD 1051
Cdd:pfam14580  121 LRNPVTNKPHYRLYVIYKVPQLRLLD 146
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-213 2.17e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 2.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156   63 LKYFSHLSTLRLFGQQITCLKPLgEVAPTLEELWVCEGAVKDLAGVDHCIRLKKLFLYDNAIE----------------- 125
Cdd:cd21340     20 LSLCKNLKVLYLYDNKITKIENL-EFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISvveglenltnleelhie 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  126 ------------DASCLCALTN-LQYLNIASNKLKSLTFLRDMKDLTNLSLADNK---MKDSVVATAIWPeSIQHLDISA 189
Cdd:cd21340     99 nqrlppgekltfDPRSLAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQisdLEELLDLLSSWP-SLRELDLTG 177

                          170       180
                   ....*....|....*....|....
gi 1254045156  190 NCFSSNRALFSLTILSSLRSLNLD 213
Cdd:cd21340    178 NPVCKKPKYRDKIILASKSLEVLD 201
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
618-811 1.52e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.92  E-value: 1.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  618 PIKEVSDLMTRLTALELCDQKLTKLTGIQElvSLQFLSVRKNKLTSLKKLNRLPCLklLDASFNHISKIEQLPSSLLHVD 697
Cdd:PRK15387   273 PLTHLPALPSGLCKLWIFGNQLTSLPVLPP--GLQELSVSDNQLASLPALPSELCK--LWAYNNQLTSLPTLPSGLQELS 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  698 LSHNKLQTLVFCQSlgNTRHLLLHRNQIKSMKGVEScvQLETFFVNDNLLKD----KSDV-ELLKTMPKLTHLDMSNNIL 772
Cdd:PRK15387   349 VSDNQLASLPTLPS--ELYKLWAYNNRLTSLPALPS--GLKELIVSGNRLTSlpvlPSELkELMVSGNRLTSLPMLPSGL 424

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1254045156  773 SSAEGYRPRVMQAAQFLISLDRQII------PLEERHVNTMKQTT 811
Cdd:PRK15387   425 LSLSVYRNQLTRLPESLIHLSSETTvnlegnPLSERTLQALREIT 469
LRR_9 pfam14580
Leucine-rich repeat;
676-802 9.52e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.29  E-value: 9.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  676 LDASFNHISKIEQLPSSLLH---VDLSHNKLQTLVFCQSLGNTRHLLLHRNQI-KSMKGVESCV-QLETFFVNDNLLKDK 750
Cdd:pfam14580   24 LDLRGYKIPIIENLGATLDQfdtIDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcRIGEGLGEALpNLTELILTNNNLQEL 103

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1254045156  751 SDVELLKTMPKLTHLDMSNNILSSAEGYRPRVMQAAQFLISLDRQIIPLEER 802
Cdd:pfam14580  104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKER 155
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 113-153 3.00e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 3.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1254045156  113 RLKKLFLYDNAIEDASCLCALTNLQYLNIASN-KLKSLTFLR 153
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
742-1032 9.03e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 9.03e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  742 VNDNLLKDKSDVELLKTMPKLTHLDMSNNILSSAEGYRPRVMQAAQFLISLDRQIIPLEERHVNTMKQTTRGLSLELIER 821
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  822 ICPEWKNKKELMICDQKIEQIILEKSQMEELSQIRLIDLSKNRLSSV-REISSF-NITHLILNNNCLKSIAvndgqTSLQ 899
Cdd:COG4886     82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLtNLKELDLSNNQLTDLP-----EPLG 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  900 PFPYLENLDISNNSISN--------TSILRLGIplllklkninlSQNALSRFDCSLFDLPNLESVDLSNNSIKTIIR--R 969
Cdd:COG4886    157 NLTNLKSLDLSNNQLTDlpeelgnlTNLKELDL-----------SNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEplA 225

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1254045156  970 PLKTLTSLNLQNNKLTTLTPLS-CPNLVSLDISNNKLascASLKPLCECKTLENLDCRNNSVTE 1032
Cdd:COG4886    226 NLTNLETLDLSNNQLTDLPELGnLTNLEELDLSNNQL---TDLPPLANLTNLKTLDLSNNQLTD 286
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 626-793 7.49e-17

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.60  E-value: 7.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  626 MTRLTALELCDQKLTKLTGIQELVSLQFLSVRKNKLTSLKKLNRLPCLKLLDASFNHISKIEQL---------------- 689
Cdd:cd21340      1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLenlvnlkklylggnri 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  690 --------PSSLLHVDLSHNKL---QTLVF----CQSLGNT-RHLLLHRNQIKSMKGVESCVQLETFFVNDNLLKDKSDV 753
Cdd:cd21340     81 svveglenLTNLEELHIENQRLppgEKLTFdprsLAALSNSlRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1254045156  754 -ELLKTMPKLTHLDMSNNILSSAEGYRPRVMQAAQFLISLD 793
Cdd:cd21340    161 lDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 849-1058 7.07e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 7.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  849 MEELSQ---IRLIDLSKNRLSSVREISSF-NITHLILNNNCLKSIavndgqTSLQPFPYLENLDISNNSISNTSILRlgi 924
Cdd:cd21340     17 IDNLSLcknLKVLYLYDNKITKIENLEFLtNLTHLYLQNNQIEKI------ENLENLVNLKKLYLGGNRISVVEGLE--- 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  925 plllklkninlSQNALSRFDCSLFDLPNLESVDLSNNSIKTIirrpLKTLTSLNLQNNKLTTLTPLSC-PNLVSLDISNN 1003
Cdd:cd21340     88 -----------NLTNLEELHIENQRLPPGEKLTFDPRSLAAL----SNSLRVLNISGNNIDSLEPLAPlRNLEQLDASNN 152

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1254045156 1004 KLASCASLK-PLCECKTLENLDCRNNSVTERRVYVDFIKAQVPSVRKLDD-EIMSNE 1058
Cdd:cd21340    153 QISDLEELLdLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGkEITDTE 209
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
758-1032 1.46e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 1.46e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  758 TMPKLTHLDMSNNILSSAEGYRPRVMQAAQFLISLDRQIIPLEERHVNTMKQTTRGLSLELIERICPEWKNKKELMICDQ 837
Cdd:COG4886      1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  838 KIEQIILEKSQMEELSQIRLIDLSKNRlssvrEISSF-NITHLILNNNCLKSIAVndgqtSLQPFPYLENLDISNNSISN 916
Cdd:COG4886     81 LLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLtNLESLDLSGNQLTDLPE-----ELANLTNLKELDLSNNQLTD 150

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  917 tsilrlgIPLllklkninlsqnalsrfdcSLFDLPNLESVDLSNNSIKTIIR--RPLKTLTSLNLQNNKLTTL-TPLS-C 992
Cdd:COG4886    151 -------LPE-------------------PLGNLTNLKSLDLSNNQLTDLPEelGNLTNLKELDLSNNQITDLpEPLGnL 204

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1254045156  993 PNLVSLDISNNKLASCASlkPLCECKTLENLDCRNNSVTE 1032
Cdd:COG4886    205 TNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
827-1072 4.47e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 4.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  827 KNKKELMICDQKIEQIILEksqMEELSQIRLIDLSKNRLSSV-REISSF-NITHLILNNNCLKSIAvndgqTSLQPFPYL 904
Cdd:COG4886    113 TNLESLDLSGNQLTDLPEE---LANLTNLKELDLSNNQLTDLpEPLGNLtNLKSLDLSNNQLTDLP-----EELGNLTNL 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  905 ENLDISNNSISNtsiLRLGIPLLLKLKNINLSQNALSRFDCSLFDLPNLESVDLSNNSIKTIIR-RPLKTLTSLNLQNNK 983
Cdd:COG4886    185 KELDLSNNQITD---LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPElGNLTNLEELDLSNNQ 261

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  984 LTTLTPLS-CPNLVSLDISNNKLASCaSLKPLCECKTLENLDCRNNSVTERRVYVDFIKAQVPSVRKLDDEIMSNEIEIT 1062
Cdd:COG4886    262 LTDLPPLAnLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340

                          250
                   ....*....|
gi 1254045156 1063 KRRLSRANDL 1072
Cdd:COG4886    341 ALSLSLLALL 350
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
626-774 6.63e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.64  E-value: 6.63e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  626 MTRLTALELCDQKltkltGIQELVSLQFLSVRKNKLTSL-KKLNRLPCLKLLDASFNHIS----KIEQLPsSLLHVDLSH 700
Cdd:COG4886     95 LTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTdlpePLGNLT-NLKSLDLSN 168

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1254045156  701 NKLQTL-VFCQSLGNTRHLLLHRNQIKSM-KGVESCVQLETFFVNDNLLKDKSDVelLKTMPKLTHLDMSNNILSS 774
Cdd:COG4886    169 NQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEP--LANLTNLETLDLSNNQLTD 242
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-213 1.21e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.21e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156   62 GLKYFSHLSTLRLFGQQITCLKPLGEVAPTLEELWVCEGAVKDL-AGVDHCIRLKKLFLYDNAIEDASC-LCALTNLQYL 139
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKEL 187

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  140 NIASNKLKSL-TFLRDMKDLTNLSLADNKMKDsvvataiWPESI------QHLDISANCFSSnraLFSLTILSSLRSLNL 212
Cdd:COG4886    188 DLSNNQITDLpEPLGNLTNLEELDLSGNQLTD-------LPEPLanltnlETLDLSNNQLTD---LPELGNLTNLEELDL 257


                   .
gi 1254045156  213 D 213
Cdd:COG4886    258 S 258
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
638-989 1.43e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 1.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  638 KLTKLTGIQELVSLQFLSVRKNKLTSLKKLNRLPCLKLLDASFNhiSKIEQLpSSLLHVDLSHNKLQTL-VFCQSLGNTR 716
Cdd:COG4886     63 SSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN--EELSNL-TNLESLDLSGNQLTDLpEELANLTNLK 139

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  717 HLLLHRNQIKSM-KGVESCVQLETFFVNDNLLKDKSDVelLKTMPKLTHLDMSNNILSSaegyrprvmqaaqflisldrq 795
Cdd:COG4886    140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITD--------------------- 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  796 iipleerhvntmkqttrgLSLELiericPEWKNKKELMICDQKIEQIileKSQMEELSQIRLIDLSKNRLSSVREISSF- 874
Cdd:COG4886    197 ------------------LPEPL-----GNLTNLEELDLSGNQLTDL---PEPLANLTNLETLDLSNNQLTDLPELGNLt 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  875 NITHLILNNNCLKSIavndgqTSLQPFPYLENLDISNNSISNTSILRLGIPLLLKLKNINLSQNALSRFDCSLFDLPNLE 954
Cdd:COG4886    251 NLEELDLSNNQLTDL------PPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1254045156  955 SVDLSNNSIKTIIRRPLKTLTSLNLQNNKLTTLTP 989
Cdd:COG4886    325 LLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLL 359
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 645-1005 2.24e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.79  E-value: 2.24e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  645 IQELVSLQFLSVRKNKLTSL--KKLNRLPCLKLLDASFNHIS-----KIEQLpSSLLHVDLSHNKL--QTLVFCQSLGNT 715
Cdd:PLN00113   184 LTNLTSLEFLTLASNQLVGQipRELGQMKSLKWIYLGYNNLSgeipyEIGGL-TSLNHLDLVYNNLtgPIPSSLGNLKNL 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  716 RHLLLHRNQI-----KSMKGVESCVQLEtffVNDNLLKDKSDvELLKTMPKLTHLDMSNNILSsaeGYRPRVmqaaqfLI 790
Cdd:PLN00113   263 QYLFLYQNKLsgpipPSIFSLQKLISLD---LSDNSLSGEIP-ELVIQLQNLEILHLFSNNFT---GKIPVA------LT 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  791 SLDR-QIIPL--------------EERHVNTMKQTTRGLSLELIERICPEWKNKKELMICDQKIEQIILEKSQMEELSQI 855
Cdd:PLN00113   330 SLPRlQVLQLwsnkfsgeipknlgKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRV 409

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  856 RLidlSKNRLSS--VREISSFNITHL--ILNNNCLKSIavndgQTSLQPFPYLENLDISNNSISNtsilrlGIPlllklk 931
Cdd:PLN00113   410 RL---QDNSFSGelPSEFTKLPLVYFldISNNNLQGRI-----NSRKWDMPSLQMLSLARNKFFG------GLP------ 469

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  932 ninlsqnalsrfdcSLFDLPNLESVDLSNNSIKTIIRRPLKTLTS---LNLQNNKLTTLTP---LSCPNLVSLDISNNKL 1005
Cdd:PLN00113   470 --------------DSFGSKRLENLDLSRNQFSGAVPRKLGSLSElmqLKLSENKLSGEIPdelSSCKKLVSLDLSHNQL 535
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
854-1031 3.54e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.25  E-value: 3.54e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  854 QIRLIDLSKNRLSSVREISSFNITHLILNNNCLKSIAVNDGQTslqpfpyLENLDISNNSISNtsiLRLGIPLLLKLKNI 933
Cdd:PRK15370   200 QITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDT-------IQEMELSINRITE---LPERLPSALQSLDL 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  934 nlSQNALSrfdCSLFDLPN-LESVDLSNNSIKTIIRRPLKTLTSLNLQNNKLTTLTPLSCPNLVSLDISNNKLASC-ASL 1011
Cdd:PRK15370   270 --FHNKIS---CLPENLPEeLRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLKTLEAGENALTSLpASL 344

                          170       180
                   ....*....|....*....|
gi 1254045156 1012 KPlceckTLENLDCRNNSVT 1031
Cdd:PRK15370   345 PP-----ELQVLDVSKNQIT 359
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
626-801 3.56e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 3.56e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  626 MTRLTALELCDQKLTKLT-GIQELVSLQFLSVRKNKLTSLKK-LNRLPCLKLLDASFNHISKI-EQLP--SSLLHVDLSH 700
Cdd:COG4886    158 LTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLAnlTNLETLDLSN 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  701 NKLQTLVFCQSLGNTRHLLLHRNQIKSMKGVESCVQLETFFVNDNLLKDKSDVELLKTMPKLTHLDMSNNILSSAEGYRP 780
Cdd:COG4886    238 NQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                          170       180
                   ....*....|....*....|.
gi 1254045156  781 RVMQAAQFLISLDRQIIPLEE 801
Cdd:COG4886    318 LLLTTLLLLLLLLKGLLVTLT 338
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 717-921 1.40e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 1.40e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  717 HLLLHRNQIKSMKGVESCVQLETFFVNDNLLkdkSDVELLKTMPKLTHLDMSNNILSSAEGyrprvmqaaqfLISLDRqi 796
Cdd:cd21340      6 HLYLNDKNITKIDNLSLCKNLKVLYLYDNKI---TKIENLEFLTNLTHLYLQNNQIEKIEN-----------LENLVN-- 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  797 ipLEERHvntmkqttrgLSLELIERI-----CPewkNKKELMICDQKI---EQIILEKSQMEELSQ-IRLIDLSKNRLSS 867
Cdd:cd21340     70 --LKKLY----------LGGNRISVVeglenLT---NLEELHIENQRLppgEKLTFDPRSLAALSNsLRVLNISGNNIDS 134

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1254045156  868 VREISSF-NITHLILNNNCLKSIavNDGQTSLQPFPYLENLDISNNSISNTSILR 921
Cdd:cd21340    135 LEPLAPLrNLEQLDASNNQISDL--EELLDLLSSWPSLRELDLTGNPVCKKPKYR 187
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-229 1.48e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.41  E-value: 1.48e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156   63 LKYFSHLSTLRLFGQQITCL-KPLGEvAPTLEELWVCEGAVKDL-AGVDHCIRLKKLFLYDNAIEDASCLCALTNLQYLN 140
Cdd:COG4886    178 LGNLTNLKELDLSNNQITDLpEPLGN-LTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELD 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  141 IASNKLKSLTFLRDMKDLTNLSLADNKMKDSVVATAIWPESIQHLDISANCFSSNRALFSLTILSSLRSLNLDPVISKST 220
Cdd:COG4886    257 LSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVT 336


                   ....*....
gi 1254045156  221 VAPNLFFAW 229
Cdd:COG4886    337 LTTLALSLS 345
LRR_9 pfam14580
Leucine-rich repeat;
950-1051 6.78e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 53.61  E-value: 6.78e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  950 LPNLESVDLSNNSIKTIIRRP-LKTLTSLNLQNNKLTTLTP---LSCPNLVSLDISNNKLASCASLKPLCECKTLENLDC 1025
Cdd:pfam14580   41 LDQFDTIDFSDNEIRKLDGFPlLRRLKTLLLNNNRICRIGEglgEALPNLTELILTNNNLQELGDLDPLASLKKLTFLSL 120

                           90       100
                   ....*....|....*....|....*.
gi 1254045156 1026 RNNSVTERRVYVDFIKAQVPSVRKLD 1051
Cdd:pfam14580  121 LRNPVTNKPHYRLYVIYKVPQLRLLD 146
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 63-213 2.17e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 2.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156   63 LKYFSHLSTLRLFGQQITCLKPLgEVAPTLEELWVCEGAVKDLAGVDHCIRLKKLFLYDNAIE----------------- 125
Cdd:cd21340     20 LSLCKNLKVLYLYDNKITKIENL-EFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISvveglenltnleelhie 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  126 ------------DASCLCALTN-LQYLNIASNKLKSLTFLRDMKDLTNLSLADNK---MKDSVVATAIWPeSIQHLDISA 189
Cdd:cd21340     99 nqrlppgekltfDPRSLAALSNsLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQisdLEELLDLLSSWP-SLRELDLTG 177

                          170       180
                   ....*....|....*....|....
gi 1254045156  190 NCFSSNRALFSLTILSSLRSLNLD 213
Cdd:cd21340    178 NPVCKKPKYRDKIILASKSLEVLD 201
LRR_8 pfam13855
Leucine rich repeat;
951-1005 5.23e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 5.23e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1254045156  951 PNLESVDLSNNSIKTIIRRP---LKTLTSLNLQNNKLTTLTP---LSCPNLVSLDISNNKL 1005
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAfkgLSNLKVLDLSNNLLTTLSPgafSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 895-1006 8.66e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 8.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  895 QTSLQ-PFPYLenldiSNNSISNTSILRLGIP---LLLKLKNINLSQNALSRFDCSLFDLPNLESVDLSNNSIKTIIRRP 970
Cdd:PLN00113    38 KSSINdPLKYL-----SNWNSSADVCLWQGITcnnSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGPIPDD 112

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1254045156  971 LKTLTS----LNLQNNKLTTLTPL-SCPNLVSLDISNNKLA 1006
Cdd:PLN00113   113 IFTTSSslryLNLSNNNFTGSIPRgSIPNLETLDLSNNMLS 153
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
618-811 1.52e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.92  E-value: 1.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  618 PIKEVSDLMTRLTALELCDQKLTKLTGIQElvSLQFLSVRKNKLTSLKKLNRLPCLklLDASFNHISKIEQLPSSLLHVD 697
Cdd:PRK15387   273 PLTHLPALPSGLCKLWIFGNQLTSLPVLPP--GLQELSVSDNQLASLPALPSELCK--LWAYNNQLTSLPTLPSGLQELS 348

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  698 LSHNKLQTLVFCQSlgNTRHLLLHRNQIKSMKGVEScvQLETFFVNDNLLKD----KSDV-ELLKTMPKLTHLDMSNNIL 772
Cdd:PRK15387   349 VSDNQLASLPTLPS--ELYKLWAYNNRLTSLPALPS--GLKELIVSGNRLTSlpvlPSELkELMVSGNRLTSLPMLPSGL 424

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*
gi 1254045156  773 SSAEGYRPRVMQAAQFLISLDRQII------PLEERHVNTMKQTT 811
Cdd:PRK15387   425 LSLSVYRNQLTRLPESLIHLSSETTvnlegnPLSERTLQALREIT 469
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
650-770 1.65e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  650 SLQFLSVRKNKLTSLKKlnRLP-CLKLLDASFNHISKI-EQLPSSLLHVDLSHNKLQTLVfcQSLGN-TRHLLLHRNQIK 726
Cdd:PRK15370   221 NIKTLYANSNQLTSIPA--TLPdTIQEMELSINRITELpERLPSALQSLDLFHNKISCLP--ENLPEeLRYLSVYDNSIR 296

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1254045156  727 SMKG------VESCVQ--------------LETFFVNDNLLkdksdVELLKTM-PKLTHLDMSNN 770
Cdd:PRK15370   297 TLPAhlpsgiTHLNVQsnsltalpetlppgLKTLEAGENAL-----TSLPASLpPELQVLDVSKN 356
LRR_9 pfam14580
Leucine-rich repeat;
676-802 9.52e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.29  E-value: 9.52e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  676 LDASFNHISKIEQLPSSLLH---VDLSHNKLQTLVFCQSLGNTRHLLLHRNQI-KSMKGVESCV-QLETFFVNDNLLKDK 750
Cdd:pfam14580   24 LDLRGYKIPIIENLGATLDQfdtIDFSDNEIRKLDGFPLLRRLKTLLLNNNRIcRIGEGLGEALpNLTELILTNNNLQEL 103

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1254045156  751 SDVELLKTMPKLTHLDMSNNILSSAEGYRPRVMQAAQFLISLDRQIIPLEER 802
Cdd:pfam14580  104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKER 155
LRR_8 pfam13855
Leucine rich repeat;
902-984 1.53e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  902 PYLENLDISNNSISNTSilrlgiplllklkninlsqnalsrfDCSLFDLPNLESVDLSNNSIKTIIRR---PLKTLTSLN 978
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLD-------------------------DGAFKGLSNLKVLDLSNNLLTTLSPGafsGLPSLRYLD 55


                   ....*.
gi 1254045156  979 LQNNKL 984
Cdd:pfam13855   56 LSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 951-991 2.86e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 2.86e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1254045156  951 PNLESVDLSNNSIKTI-IRRPLKTLTSLNL-QNNKLTTLTPLS 991
Cdd:pfam12799    1 PNLEVLDLSNNQITDIpPLAKLPNLETLDLsGNNKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 113-153 3.00e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 3.00e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1254045156  113 RLKKLFLYDNAIEDASCLCALTNLQYLNIASN-KLKSLTFLR 153
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 972-1013 3.62e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 3.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1254045156  972 KTLTSLNLQNNKLTTLTPL-SCPNLVSLDIS-NNKLASCASLKP 1013
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPPLaKLPNLETLDLSgNNKITDLSDLAN 44
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 872-1025 4.09e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  872 SSFNITHLILNNNCLKSIAvndgqTSLQPFPYLENLDISNNSISNTSILRL--GIPLLLKLKNINLSQNALSRFDCSLF- 948
Cdd:cd00116    140 EKLVLGRNRLEGASCEALA-----KALRANRDLKELNLANNGIGDAGIRALaeGLKANCNLEVLDLNNNGLTDEGASALa 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  949 ----DLPNLESVDLSNNSI--------KTIIRRPLKTLTSLNLQNNKLTTLTPLSC-------PNLVSLDISNNKLA--- 1006
Cdd:cd00116    215 etlaSLKSLEVLNLGDNNLtdagaaalASALLSPNISLLTLSLSCNDITDDGAKDLaevlaekESLLELDLRGNKFGeeg 294

                          170       180
                   ....*....|....*....|...
gi 1254045156 1007 ---SCASLK-PLCECKTLENLDC 1025
Cdd:cd00116    295 aqlLAESLLePGNELESLWVKDD 317
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 134-166 4.54e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 4.54e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1254045156  134 TNLQYLNIASNKLKSLTFLRDMKDLTNLSLADN 166
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
855-1006 6.29e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 40.84  E-value: 6.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  855 IRLIDLSKNRLSSVREISSFNITHLILNNNCLKSIAVN--DGqtslqpfpyLENLDISNNSIS----------------N 916
Cdd:PRK15370   243 IQEMELSINRITELPERLPSALQSLDLFHNKISCLPENlpEE---------LRYLSVYDNSIRtlpahlpsgithlnvqS 313

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  917 TSILRLGIPLLLKLKNINLSQNALSRFDCSLfdLPNLESVDLSNNSIKTIIRRPLKTLTSLNLQNNKLTTLtPLSCP-NL 995
Cdd:PRK15370   314 NSLTALPETLPPGLKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTNL-PENLPaAL 390

                          170
                   ....*....|.
gi 1254045156  996 VSLDISNNKLA 1006
Cdd:PRK15370   391 QIMQASRNNLV 401
LRR_8 pfam13855
Leucine rich repeat;
673-725 7.19e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 7.19e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156  673 LKLLDASFNHISKIEQL----PSSLLHVDLSHNKLQTL---VFcQSLGNTRHLLLHRNQI 725
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGafkgLSNLKVLDLSNNLLTTLspgAF-SGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-213 9.97e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 39.92  E-value: 9.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254045156   82 LKPLGEVAPTLEELWVCEGAVKDLAGVDHCIRLKKLFLYDNAIedascLCALTNLQYLNIASNKLKSL-TFLRDMKDLTN 160
Cdd:COG4886     66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE-----LSNLTNLESLDLSGNQLTDLpEELANLTNLKE 140

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1254045156  161 LSLADNKMKDsvVATAIWP-ESIQHLDISANCFSS-NRALFSLTilsSLRSLNLD 213
Cdd:COG4886    141 LDLSNNQLTD--LPEPLGNlTNLKSLDLSNNQLTDlPEELGNLT---NLKELDLS 190
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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