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Conserved domains on  [gi|1276317415|ref|NP_001344757|]
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tropomodulin-3 isoform 2 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-178 2.25e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 2.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  71 NIPIPTLKDFAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELK 150
Cdd:COG5238   275 QIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLD 354

                          90       100
                  ....*....|....*....|....*....
gi 1276317415 151 -IDNqrqQLGTSVELEMAKMLEENTNILK 178
Cdd:COG5238   355 lSDN---QIGDEGAIALAKYLEGNTTLRE 380
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-178 2.25e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 2.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  71 NIPIPTLKDFAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELK 150
Cdd:COG5238   275 QIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLD 354

                          90       100
                  ....*....|....*....|....*....
gi 1276317415 151 -IDNqrqQLGTSVELEMAKMLEENTNILK 178
Cdd:COG5238   355 lSDN---QIGDEGAIALAKYLEGNTTLRE 380
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 60-172 4.49e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  60 RLVEVNL--NNIKNIPIPTLkdfAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALI 137
Cdd:cd00116   166 DLKELNLanNGIGDAGIRAL---AEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALA 242

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1276317415 138 DALR-DNETLMELKIDNqrqqlgTSVELEMAKMLEE 172
Cdd:cd00116   243 SALLsPNISLLTLSLSC------NDITDDGAKDLAE 272
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-178 2.25e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 62.11  E-value: 2.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  71 NIPIPTLKDFAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELK 150
Cdd:COG5238   275 QIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLD 354

                          90       100
                  ....*....|....*....|....*....
gi 1276317415 151 -IDNqrqQLGTSVELEMAKMLEENTNILK 178
Cdd:COG5238   355 lSDN---QIGDEGAIALAKYLEGNTTLRE 380
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 80-176 8.73e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.49  E-value: 8.73e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  80 FAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELKIDNqrQQLG 159
Cdd:COG5238   256 LAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAY--NGIG 333

                          90
                  ....*....|....*..
gi 1276317415 160 TSVELEMAKMLEENTNI 176
Cdd:COG5238   334 AQGAIALAKALQENTTL 350
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 58-176 4.91e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 55.18  E-value: 4.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  58 DARLVEVNLNNiKNIPIPTLKDFAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALI 137
Cdd:COG5238   179 NNSVETVYLGC-NQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALA 257

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1276317415 138 DALRDNETLMEL-----KIDNQRQQLgtsveleMAKMLEENTNI 176
Cdd:COG5238   258 EALKNNTTVETLylsgnQIGAEGAIA-------LAKALQGNTTL 294
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 77-176 2.30e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.26  E-value: 2.30e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  77 LKDFAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELKI-DNqr 155
Cdd:COG5238   225 AEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLsVN-- 302

                          90       100
                  ....*....|....*....|.
gi 1276317415 156 qQLGTSVELEMAKMLEENTNI 176
Cdd:COG5238   303 -RIGDEGAIALAEGLQGNKTL 322
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 43-174 1.11e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 51.33  E-value: 1.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  43 NPTNVEE---SLKRIRENDARLVEVNLNNIKNI--------PI--PTLKDFAKTLEANTHVKHFSLAATRSNDPVAVAFA 109
Cdd:COG5238   262 NNTTVETlylSGNQIGAEGAIALAKALQGNTTLtsldlsvnRIgdEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALA 341

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1276317415 110 DMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLmeLKIDNQRQQLGTSVELEMAKMLEENT 174
Cdd:COG5238   342 KALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTL--RELNLGKNNIGKQGAEALIDALQTNR 404
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 60-172 4.49e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.11  E-value: 4.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  60 RLVEVNL--NNIKNIPIPTLkdfAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALI 137
Cdd:cd00116   166 DLKELNLanNGIGDAGIRAL---AEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALA 242

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1276317415 138 DALR-DNETLMELKIDNqrqqlgTSVELEMAKMLEE 172
Cdd:cd00116   243 SALLsPNISLLTLSLSC------NDITDDGAKDLAE 272
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 77-153 1.29e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.29e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1276317415  77 LKDFAKTLEANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELKIDN 153
Cdd:cd00116   154 CEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGD 230
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 78-179 5.00e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 5.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  78 KDFAKTLEANTHVKHFSLAATRSNDPVAVAFAD-MLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELkiDNQRQ 156
Cdd:cd00116   211 SALAETLASLKSLEVLNLGDNNLTDAGAAALASaLLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLEL--DLRGN 288

                          90       100
                  ....*....|....*....|...
gi 1276317415 157 QLGTSVELEMAKMLEENTNILKF 179
Cdd:cd00116   289 KFGEEGAQLLAESLLEPGNELES 311
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 86-176 7.06e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 36.69  E-value: 7.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276317415  86 ANTHVKHFSLAATRSNDPVAVAFADMLKVNKTLKSLNMESNFITGAGVLALIDALRDNETLMELKIDNqrQQLGTSVELE 165
Cdd:COG5238   178 QNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSN--NQIGDEGVIA 255

                          90
                  ....*....|.
gi 1276317415 166 MAKMLEENTNI 176
Cdd:COG5238   256 LAEALKNNTTV 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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